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Protein

Autophagy-related protein 18

Gene

atg18

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct atg9 trafficking to the preautophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity). Required for the recruitment of the atg5-atg12/atg16 complex to the preautophagosomal structure.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • autophagy Source: PomBase
  • autophagy of mitochondrion Source: GO_Central
  • autophagy of nucleus Source: GO_Central
  • macroautophagy Source: PomBase
  • protein lipidation Source: GO_Central
  • protein localization to phagophore assembly site Source: GO_Central
  • protein targeting to vacuole Source: PomBase

Keywordsi

Biological processAutophagy, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-SPO-1632852 Macroautophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 18
Gene namesi
Name:atg18
Synonyms:atg18a
ORF Names:SPAC589.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC589.07c
PomBaseiSPAC589.07c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane, Vacuole

Pathology & Biotechi

Disruption phenotypei

Impairs atg8-processing.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi228R → T: Impairs localization and pre-autophagosomal structure formation; when associated with Thr-229. 1 Publication1
Mutagenesisi229R → T: Impairs localization and pre-autophagosomal structure formation; when associated with Thr-228. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508721 – 373Autophagy-related protein 18Add BLAST373

Proteomic databases

MaxQBiQ9HDZ7
PaxDbiQ9HDZ7
PRIDEiQ9HDZ7

Interactioni

Subunit structurei

Component of the PI(3,5)P2 regulatory complex (By similarity). Interacts with atg5.By similarity1 Publication

Protein-protein interaction databases

BioGridi278655, 52 interactors
STRINGi4896.SPAC589.07c.1

Structurei

3D structure databases

ProteinModelPortaliQ9HDZ7
SMRiQ9HDZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati144 – 183WD 1Add BLAST40
Repeati186 – 226WD 2Add BLAST41
Repeati231 – 270WD 3Add BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi227 – 231FRRGT-motif5

Domaini

The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.By similarity
The FRRGT-motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of atg8 and atg16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions.1 Publication

Sequence similaritiesi

Belongs to the WD repeat SVP1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000217543
InParanoidiQ9HDZ7
KOiK17908
OMAiSTWTGYM
OrthoDBiEOG092C3UKJ
PhylomeDBiQ9HDZ7

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HDZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFFVRKYRG KAALLSIGTF DGYKIYNCDP FGKCFHKIQG ATSIVEMLFS
60 70 80 90 100
TSLVALVEKD DGNNRKLKLI NTKKSTTICE LTFPTPLLAV KLNRKRLLAV
110 120 130 140 150
LEEQIYVYDI SNMLLLHTIE TTSNVFAVCA LSPNSENCYL AYPDSRDHEP
160 170 180 190 200
RTEGESSSPN VSNSAVSGQV ILWDVINCKQ ITKIEAHKDS LACLAFNSDG
210 220 230 240 250
TMLATASDNG RIIRVFAIPS GQRLYQFRRG SLPAQIYSIA FHPDSSLLTV
260 270 280 290 300
TSSTQTVHIF RLKEVYSNLE RQGLLPSSPP PKESLLRRSS RSLIGTVGGY
310 320 330 340 350
LPQSVSGMLD PERDFAYAHI PGDKVTSIAA FGPDNTIVNV ATYDGNLYSF
360 370
RVNLRTGGEC AMVNHFCVGL TAA
Length:373
Mass (Da):41,109
Last modified:March 1, 2001 - v1
Checksum:iB7609062573AF159
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAC19764.1
RefSeqiNP_594055.1, NM_001019479.2

Genome annotation databases

EnsemblFungiiSPAC589.07c.1; SPAC589.07c.1:pep; SPAC589.07c
GeneIDi2542180
KEGGispo:SPAC589.07c

Similar proteinsi

Entry informationi

Entry nameiATG18_SCHPO
AccessioniPrimary (citable) accession number: Q9HDZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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