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Q9HDX8

- ALO_SCHPO

UniProt

Q9HDX8 - ALO_SCHPO

Protein

D-arabinono-1,4-lactone oxidase

Gene

alo1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2.

    Cofactori

    FAD.By similarity

    Pathwayi

    GO - Molecular functioni

    1. D-arabinono-1,4-lactone oxidase activity Source: PomBase
    2. flavin adenine dinucleotide binding Source: InterPro
    3. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro

    GO - Biological processi

    1. biosynthetic process Source: InterPro
    2. cellular response to oxidative stress Source: PomBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00771; UER00766.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-arabinono-1,4-lactone oxidase (EC:1.1.3.37)
    Short name:
    ALO
    Alternative name(s):
    L-galactono-gamma-lactone oxidase
    Gene namesi
    Name:alo1
    ORF Names:SPAPB1A10.12c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAPB1A10.12c.

    Subcellular locationi

    Mitochondrion membrane By similarity
    Note: Membrane-embedded.By similarity

    GO - Cellular componenti

    1. integral component of mitochondrial outer membrane Source: PomBase
    2. mitochondrion Source: PomBase

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 461461D-arabinono-1,4-lactone oxidasePRO_0000128169Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei61 – 611Pros-8alpha-FAD histidineBy similarity

    Proteomic databases

    MaxQBiQ9HDX8.
    PaxDbiQ9HDX8.

    Interactioni

    Protein-protein interaction databases

    BioGridi279850. 4 interactions.
    MINTiMINT-4702705.
    STRINGi4896.SPAPB1A10.12c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HDX8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 194171FAD-binding PCMH-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FAD-binding PCMH-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0277.
    HOGENOMiHOG000204635.
    OMAiWAIPISK.
    OrthoDBiEOG7JX3CZ.
    PhylomeDBiQ9HDX8.

    Family and domain databases

    Gene3Di3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    InterProiIPR007173. ALO.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR010031. FAD_lactone_oxidase.
    IPR023595. LGO_GLO.
    IPR006094. Oxid_FAD_bind_N.
    [Graphical view]
    PfamiPF04030. ALO. 1 hit.
    PF01565. FAD_binding_4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000136. LGO_GLO. 1 hit.
    SUPFAMiSSF56176. SSF56176. 1 hit.
    TIGRFAMsiTIGR01678. FAD_lactone_ox. 1 hit.
    PROSITEiPS51387. FAD_PCMH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HDX8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIPHINKLS QDGRVRFSNW AKTFSAISLG LRCPKTEEQL REILVDANSN    50
    GKKIRVVGAG HSPSDIVCTS GYLLSLDKMN KVVSFDPDSL SITVQAGIRF 100
    YQVQEILQNL GYSLPIVGSI SETSVSGIMS TCTHGSSLQH QVLPHYIKSM 150
    RIMLADGSIV TCSRELQKDM FAAAQVSLGA LGVIVDITIS VVPAFDLVAT 200
    EDVTTVTDLF QDWKNNLIWE SAEFVRVHVF PYANRAVVWR ANKVEPNTVP 250
    HTPKPSLFRL KLDSFVYQCL LFVGKCVNRV TPYLERFWFK CHYGSKLGTA 300
    LQVAGPGFDV LQMFCYFSQH VSEWGIPLES APDALEKLIN YTVDDAGKIG 350
    AYTHWPIEVR VCAPTPEDEC WLSTDCKVPT CYIEAIMYRP FSTSINYKPY 400
    FKALEDIANQ YNGKPHWAKE YSLTKEQLLE RYPNLSKWLS LRKLLDPKGV 450
    FWNDYLQRHL G 461
    Length:461
    Mass (Da):52,028
    Last modified:March 1, 2001 - v1
    Checksum:iA3BE6D8D08E2F273
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAC21485.1.
    RefSeqiNP_593526.1. NM_001018960.2.

    Genome annotation databases

    EnsemblFungiiSPAPB1A10.12c.1; SPAPB1A10.12c.1:pep; SPAPB1A10.12c.
    GeneIDi2543430.
    KEGGispo:SPAPB1A10.12c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAC21485.1 .
    RefSeqi NP_593526.1. NM_001018960.2.

    3D structure databases

    ProteinModelPortali Q9HDX8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279850. 4 interactions.
    MINTi MINT-4702705.
    STRINGi 4896.SPAPB1A10.12c-1.

    Proteomic databases

    MaxQBi Q9HDX8.
    PaxDbi Q9HDX8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAPB1A10.12c.1 ; SPAPB1A10.12c.1:pep ; SPAPB1A10.12c .
    GeneIDi 2543430.
    KEGGi spo:SPAPB1A10.12c.

    Organism-specific databases

    PomBasei SPAPB1A10.12c.

    Phylogenomic databases

    eggNOGi COG0277.
    HOGENOMi HOG000204635.
    OMAi WAIPISK.
    OrthoDBi EOG7JX3CZ.
    PhylomeDBi Q9HDX8.

    Enzyme and pathway databases

    UniPathwayi UPA00771 ; UER00766 .

    Miscellaneous databases

    NextBioi 20804443.
    PROi Q9HDX8.

    Family and domain databases

    Gene3Di 3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    InterProi IPR007173. ALO.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR010031. FAD_lactone_oxidase.
    IPR023595. LGO_GLO.
    IPR006094. Oxid_FAD_bind_N.
    [Graphical view ]
    Pfami PF04030. ALO. 1 hit.
    PF01565. FAD_binding_4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000136. LGO_GLO. 1 hit.
    SUPFAMi SSF56176. SSF56176. 1 hit.
    TIGRFAMsi TIGR01678. FAD_lactone_ox. 1 hit.
    PROSITEi PS51387. FAD_PCMH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiALO_SCHPO
    AccessioniPrimary (citable) accession number: Q9HDX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3