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Protein

D-arabinono-1,4-lactone oxidase

Gene

alo1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2.

Cofactori

FADBy similarity

Pathwayi: D-erythroascorbate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dehydro-D-arabinono-1,4-lactone from D-arabinose.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. D-arabinono-1,4-lactone oxidase (alo1)
This subpathway is part of the pathway D-erythroascorbate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dehydro-D-arabinono-1,4-lactone from D-arabinose, the pathway D-erythroascorbate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00771; UER00766

Names & Taxonomyi

Protein namesi
Recommended name:
D-arabinono-1,4-lactone oxidase (EC:1.1.3.37)
Short name:
ALO
Alternative name(s):
L-galactono-gamma-lactone oxidase
Gene namesi
Name:alo1
ORF Names:SPAPB1A10.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAPB1A10.12c
PomBaseiSPAPB1A10.12c alo1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001281691 – 461D-arabinono-1,4-lactone oxidaseAdd BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61Pros-8alpha-FAD histidineBy similarity1

Proteomic databases

MaxQBiQ9HDX8
PaxDbiQ9HDX8
PRIDEiQ9HDX8

Interactioni

Protein-protein interaction databases

BioGridi279850, 3 interactors
STRINGi4896.SPAPB1A10.12c.1

Structurei

3D structure databases

ProteinModelPortaliQ9HDX8
SMRiQ9HDX8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 194FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST171

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000204635
InParanoidiQ9HDX8
KOiK00107
OMAiFRFLWFP
OrthoDBiEOG092C14O7
PhylomeDBiQ9HDX8

Family and domain databases

Gene3Di3.30.43.10, 1 hit
InterProiView protein in InterPro
IPR007173 ALO
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR016167 FAD-bd_2_sub1
IPR010031 FAD_lactone_oxidase
IPR006094 Oxid_FAD_bind_N
IPR030654 Sugar_lactone_oxidase
PANTHERiPTHR43762 PTHR43762, 1 hit
PfamiView protein in Pfam
PF04030 ALO, 1 hit
PF01565 FAD_binding_4, 1 hit
PIRSFiPIRSF000136 LGO_GLO, 1 hit
SUPFAMiSSF56176 SSF56176, 1 hit
TIGRFAMsiTIGR01678 FAD_lactone_ox, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HDX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIPHINKLS QDGRVRFSNW AKTFSAISLG LRCPKTEEQL REILVDANSN
60 70 80 90 100
GKKIRVVGAG HSPSDIVCTS GYLLSLDKMN KVVSFDPDSL SITVQAGIRF
110 120 130 140 150
YQVQEILQNL GYSLPIVGSI SETSVSGIMS TCTHGSSLQH QVLPHYIKSM
160 170 180 190 200
RIMLADGSIV TCSRELQKDM FAAAQVSLGA LGVIVDITIS VVPAFDLVAT
210 220 230 240 250
EDVTTVTDLF QDWKNNLIWE SAEFVRVHVF PYANRAVVWR ANKVEPNTVP
260 270 280 290 300
HTPKPSLFRL KLDSFVYQCL LFVGKCVNRV TPYLERFWFK CHYGSKLGTA
310 320 330 340 350
LQVAGPGFDV LQMFCYFSQH VSEWGIPLES APDALEKLIN YTVDDAGKIG
360 370 380 390 400
AYTHWPIEVR VCAPTPEDEC WLSTDCKVPT CYIEAIMYRP FSTSINYKPY
410 420 430 440 450
FKALEDIANQ YNGKPHWAKE YSLTKEQLLE RYPNLSKWLS LRKLLDPKGV
460
FWNDYLQRHL G
Length:461
Mass (Da):52,028
Last modified:March 1, 2001 - v1
Checksum:iA3BE6D8D08E2F273
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAC21485.1
RefSeqiNP_593526.1, NM_001018960.2

Genome annotation databases

EnsemblFungiiSPAPB1A10.12c.1; SPAPB1A10.12c.1:pep; SPAPB1A10.12c
GeneIDi2543430
KEGGispo:SPAPB1A10.12c

Similar proteinsi

Entry informationi

Entry nameiALO_SCHPO
AccessioniPrimary (citable) accession number: Q9HDX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health