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Protein

D-arabinono-1,4-lactone oxidase

Gene

alo1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2.

Cofactori

FADBy similarity

Pathway:iD-erythroascorbate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dehydro-D-arabinono-1,4-lactone from D-arabinose.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. D-arabinono-1,4-lactone oxidase (alo1)
This subpathway is part of the pathway D-erythroascorbate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dehydro-D-arabinono-1,4-lactone from D-arabinose, the pathway D-erythroascorbate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • cellular response to oxidative stress Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00771; UER00766.

Names & Taxonomyi

Protein namesi
Recommended name:
D-arabinono-1,4-lactone oxidase (EC:1.1.3.37)
Short name:
ALO
Alternative name(s):
L-galactono-gamma-lactone oxidase
Gene namesi
Name:alo1
ORF Names:SPAPB1A10.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAPB1A10.12c.
PomBaseiSPAPB1A10.12c. alo1.

Subcellular locationi

GO - Cellular componenti

  • integral component of mitochondrial outer membrane Source: PomBase
  • mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461D-arabinono-1,4-lactone oxidasePRO_0000128169Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611Pros-8alpha-FAD histidineBy similarity

Proteomic databases

MaxQBiQ9HDX8.
PaxDbiQ9HDX8.

Interactioni

Protein-protein interaction databases

BioGridi279850. 2 interactions.
MINTiMINT-4702705.

Structurei

3D structure databases

ProteinModelPortaliQ9HDX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 194171FAD-binding PCMH-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FAD-binding PCMH-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0277.
HOGENOMiHOG000204635.
InParanoidiQ9HDX8.
KOiK00107.
OMAiWSEYERI.
OrthoDBiEOG7JX3CZ.
PhylomeDBiQ9HDX8.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR007173. ALO.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR010031. FAD_lactone_oxidase.
IPR006094. Oxid_FAD_bind_N.
IPR030654. Sugar_lactone_oxidase.
[Graphical view]
PfamiPF04030. ALO. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view]
PIRSFiPIRSF000136. LGO_GLO. 1 hit.
SUPFAMiSSF56176. SSF56176. 1 hit.
TIGRFAMsiTIGR01678. FAD_lactone_ox. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HDX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIPHINKLS QDGRVRFSNW AKTFSAISLG LRCPKTEEQL REILVDANSN
60 70 80 90 100
GKKIRVVGAG HSPSDIVCTS GYLLSLDKMN KVVSFDPDSL SITVQAGIRF
110 120 130 140 150
YQVQEILQNL GYSLPIVGSI SETSVSGIMS TCTHGSSLQH QVLPHYIKSM
160 170 180 190 200
RIMLADGSIV TCSRELQKDM FAAAQVSLGA LGVIVDITIS VVPAFDLVAT
210 220 230 240 250
EDVTTVTDLF QDWKNNLIWE SAEFVRVHVF PYANRAVVWR ANKVEPNTVP
260 270 280 290 300
HTPKPSLFRL KLDSFVYQCL LFVGKCVNRV TPYLERFWFK CHYGSKLGTA
310 320 330 340 350
LQVAGPGFDV LQMFCYFSQH VSEWGIPLES APDALEKLIN YTVDDAGKIG
360 370 380 390 400
AYTHWPIEVR VCAPTPEDEC WLSTDCKVPT CYIEAIMYRP FSTSINYKPY
410 420 430 440 450
FKALEDIANQ YNGKPHWAKE YSLTKEQLLE RYPNLSKWLS LRKLLDPKGV
460
FWNDYLQRHL G
Length:461
Mass (Da):52,028
Last modified:March 1, 2001 - v1
Checksum:iA3BE6D8D08E2F273
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAC21485.1.
RefSeqiNP_593526.1. NM_001018960.2.

Genome annotation databases

EnsemblFungiiSPAPB1A10.12c.1; SPAPB1A10.12c.1:pep; SPAPB1A10.12c.
GeneIDi2543430.
KEGGispo:SPAPB1A10.12c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAC21485.1.
RefSeqiNP_593526.1. NM_001018960.2.

3D structure databases

ProteinModelPortaliQ9HDX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279850. 2 interactions.
MINTiMINT-4702705.

Proteomic databases

MaxQBiQ9HDX8.
PaxDbiQ9HDX8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAPB1A10.12c.1; SPAPB1A10.12c.1:pep; SPAPB1A10.12c.
GeneIDi2543430.
KEGGispo:SPAPB1A10.12c.

Organism-specific databases

EuPathDBiFungiDB:SPAPB1A10.12c.
PomBaseiSPAPB1A10.12c. alo1.

Phylogenomic databases

eggNOGiCOG0277.
HOGENOMiHOG000204635.
InParanoidiQ9HDX8.
KOiK00107.
OMAiWSEYERI.
OrthoDBiEOG7JX3CZ.
PhylomeDBiQ9HDX8.

Enzyme and pathway databases

UniPathwayiUPA00771; UER00766.

Miscellaneous databases

NextBioi20804443.
PROiQ9HDX8.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR007173. ALO.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR010031. FAD_lactone_oxidase.
IPR006094. Oxid_FAD_bind_N.
IPR030654. Sugar_lactone_oxidase.
[Graphical view]
PfamiPF04030. ALO. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view]
PIRSFiPIRSF000136. LGO_GLO. 1 hit.
SUPFAMiSSF56176. SSF56176. 1 hit.
TIGRFAMsiTIGR01678. FAD_lactone_ox. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiALO_SCHPO
AccessioniPrimary (citable) accession number: Q9HDX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2001
Last modified: July 22, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.