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Protein

Uncharacterized lactate 2-monooxygenase PB1A11.03

Gene

SPAPB1A11.03

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + O2 = acetate + CO2 + H2O.

Cofactori

FMNPROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54SubstratePROSITE-ProRule annotation1
Binding sitei136FMNPROSITE-ProRule annotation1
Binding sitei158FMNPROSITE-ProRule annotation1
Binding sitei160SubstratePROSITE-ProRule annotation1
Binding sitei188FMNPROSITE-ProRule annotation1
Binding sitei197SubstratePROSITE-ProRule annotation1
Binding sitei277FMNPROSITE-ProRule annotation1
Active sitei301Proton acceptorPROSITE-ProRule annotation1
Binding sitei304SubstratePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi332 – 356FMNPROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandFlavoprotein, FMN

Enzyme and pathway databases

ReactomeiR-SPO-389661 Glyoxylate metabolism and glycine degradation
R-SPO-390918 Peroxisomal lipid metabolism
R-SPO-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized lactate 2-monooxygenase PB1A11.03 (EC:1.13.12.4)
Gene namesi
ORF Names:SPAPB1A11.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:SPAPB1A11.03
PomBaseiSPAPB1A11.03

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003165821 – 407Uncharacterized lactate 2-monooxygenase PB1A11.03Add BLAST407

Proteomic databases

MaxQBiQ9HDX2
PaxDbiQ9HDX2
PRIDEiQ9HDX2

PTM databases

iPTMnetiQ9HDX2

Interactioni

Protein-protein interaction databases

BioGridi279823, 2 interactors
STRINGi4896.SPAPB1A11.03.1

Structurei

3D structure databases

ProteinModelPortaliQ9HDX2
SMRiQ9HDX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 406FMN hydroxy acid dehydrogenasePROSITE-ProRule annotationAdd BLAST379

Sequence similaritiesi

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000217463
InParanoidiQ9HDX2
KOiK00467
OMAiAVEYGMQ
OrthoDBiEOG092C285Z
PhylomeDBiQ9HDX2

Family and domain databases

CDDicd03332 LMO_FMN, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR012133 Alpha-hydoxy_acid_DH_FMN
IPR000262 FMN-dep_DH
IPR037396 FMN_HAD
IPR008259 FMN_hydac_DH_AS
IPR037350 LMO_FMN
PfamiView protein in Pfam
PF01070 FMN_dh, 1 hit
PIRSFiPIRSF000138 Al-hdrx_acd_dh, 1 hit
PROSITEiView protein in PROSITE
PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit
PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HDX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRNYNWFDA KEPISYESEI YAKGLKFQRP QITVDGRHWE QLAVERMTKD
60 70 80 90 100
AAGYVYGCAG KRETYDKNME SFKKWSIIPN RLIKSGFPDL STTVFGQKYP
110 120 130 140 150
FPIALAPVGV QKIFNPEGES GSCAAATREH IPYIISTASA TSFEDIEKAS
160 170 180 190 200
GPGERWYQLY WPSNDHQDIT ISLLNRAKKT GCRVLIVTLD TFILGWRPSD
210 220 230 240 250
MDNGYDPFLN PDSIGVEHGF SDPVFRKQFK EKHGVEVEEN MLEAAKEFAG
260 270 280 290 300
IVFPGISHDW EDLKFLRKHW DGPIVLKGIM NVPDAKKAVE YGMQGIVVSN
310 320 330 340 350
HGGRQQDGGV ASLTMLPKIV DAVGDKLDVL FDSGVRSGAD IAKALALGAK
360 370 380 390 400
MVLIGRPYVY GLALEGSSGV SHVIRCLLGD LELTLHLSGI VSVKPKDLNR

DVLYKEE
Length:407
Mass (Da):45,311
Last modified:March 1, 2001 - v1
Checksum:iB0039309D1093CA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAC19728.1
RefSeqiNP_593999.1, NM_001019425.2

Genome annotation databases

EnsemblFungiiSPAPB1A11.03.1; SPAPB1A11.03.1:pep; SPAPB1A11.03
GeneIDi2543401
KEGGispo:SPAPB1A11.03

Entry informationi

Entry nameiYKN3_SCHPO
AccessioniPrimary (citable) accession number: Q9HDX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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