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Protein

Uncharacterized lactate 2-monooxygenase PB1A11.03

Gene

SPAPB1A11.03

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + O2 = acetate + CO2 + H2O.

Cofactori

FMNPROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54SubstratePROSITE-ProRule annotation1
Binding sitei136FMNPROSITE-ProRule annotation1
Binding sitei158FMNPROSITE-ProRule annotation1
Binding sitei160SubstratePROSITE-ProRule annotation1
Binding sitei188FMNPROSITE-ProRule annotation1
Binding sitei197SubstratePROSITE-ProRule annotation1
Binding sitei277FMNPROSITE-ProRule annotation1
Active sitei301Proton acceptorPROSITE-ProRule annotation1
Binding sitei304SubstratePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi332 – 356FMNPROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

ReactomeiR-SPO-389661. Glyoxylate metabolism and glycine degradation.
R-SPO-390918. Peroxisomal lipid metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized lactate 2-monooxygenase PB1A11.03 (EC:1.13.12.4)
Gene namesi
ORF Names:SPAPB1A11.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAPB1A11.03.
PomBaseiSPAPB1A11.03.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003165821 – 407Uncharacterized lactate 2-monooxygenase PB1A11.03Add BLAST407

Proteomic databases

MaxQBiQ9HDX2.
PRIDEiQ9HDX2.

Interactioni

Protein-protein interaction databases

BioGridi279823. 2 interactors.
MINTiMINT-4702677.

Structurei

3D structure databases

ProteinModelPortaliQ9HDX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 406FMN hydroxy acid dehydrogenasePROSITE-ProRule annotationAdd BLAST379

Sequence similaritiesi

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.PROSITE-ProRule annotation
Contains 1 FMN hydroxy acid dehydrogenase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000217463.
InParanoidiQ9HDX2.
OMAiAVEYGMQ.
OrthoDBiEOG092C285Z.
PhylomeDBiQ9HDX2.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view]
PfamiPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HDX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRNYNWFDA KEPISYESEI YAKGLKFQRP QITVDGRHWE QLAVERMTKD
60 70 80 90 100
AAGYVYGCAG KRETYDKNME SFKKWSIIPN RLIKSGFPDL STTVFGQKYP
110 120 130 140 150
FPIALAPVGV QKIFNPEGES GSCAAATREH IPYIISTASA TSFEDIEKAS
160 170 180 190 200
GPGERWYQLY WPSNDHQDIT ISLLNRAKKT GCRVLIVTLD TFILGWRPSD
210 220 230 240 250
MDNGYDPFLN PDSIGVEHGF SDPVFRKQFK EKHGVEVEEN MLEAAKEFAG
260 270 280 290 300
IVFPGISHDW EDLKFLRKHW DGPIVLKGIM NVPDAKKAVE YGMQGIVVSN
310 320 330 340 350
HGGRQQDGGV ASLTMLPKIV DAVGDKLDVL FDSGVRSGAD IAKALALGAK
360 370 380 390 400
MVLIGRPYVY GLALEGSSGV SHVIRCLLGD LELTLHLSGI VSVKPKDLNR

DVLYKEE
Length:407
Mass (Da):45,311
Last modified:March 1, 2001 - v1
Checksum:iB0039309D1093CA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAC19728.1.
RefSeqiNP_593999.1. NM_001019425.2.

Genome annotation databases

EnsemblFungiiSPAPB1A11.03.1; SPAPB1A11.03.1:pep; SPAPB1A11.03.
GeneIDi2543401.
KEGGispo:SPAPB1A11.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAC19728.1.
RefSeqiNP_593999.1. NM_001019425.2.

3D structure databases

ProteinModelPortaliQ9HDX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279823. 2 interactors.
MINTiMINT-4702677.

Proteomic databases

MaxQBiQ9HDX2.
PRIDEiQ9HDX2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAPB1A11.03.1; SPAPB1A11.03.1:pep; SPAPB1A11.03.
GeneIDi2543401.
KEGGispo:SPAPB1A11.03.

Organism-specific databases

EuPathDBiFungiDB:SPAPB1A11.03.
PomBaseiSPAPB1A11.03.

Phylogenomic databases

HOGENOMiHOG000217463.
InParanoidiQ9HDX2.
OMAiAVEYGMQ.
OrthoDBiEOG092C285Z.
PhylomeDBiQ9HDX2.

Enzyme and pathway databases

ReactomeiR-SPO-389661. Glyoxylate metabolism and glycine degradation.
R-SPO-390918. Peroxisomal lipid metabolism.

Miscellaneous databases

PROiQ9HDX2.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view]
PfamiPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYKN3_SCHPO
AccessioniPrimary (citable) accession number: Q9HDX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.