Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9HDX2

- YKN3_SCHPO

UniProt

Q9HDX2 - YKN3_SCHPO

Protein

Uncharacterized lactate 2-monooxygenase PB1A11.03

Gene

SPAPB1A11.03

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    (S)-lactate + O2 = acetate + CO2 + H2O.

    Cofactori

    FMN.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei54 – 541SubstratePROSITE-ProRule annotation
    Binding sitei136 – 1361FMNPROSITE-ProRule annotation
    Binding sitei158 – 1581FMNPROSITE-ProRule annotation
    Binding sitei160 – 1601SubstratePROSITE-ProRule annotation
    Binding sitei188 – 1881FMNPROSITE-ProRule annotation
    Binding sitei197 – 1971SubstratePROSITE-ProRule annotation
    Binding sitei277 – 2771FMNPROSITE-ProRule annotation
    Active sitei301 – 3011Proton acceptorPROSITE-ProRule annotation
    Binding sitei304 – 3041SubstratePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi332 – 35625FMNPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. FMN binding Source: InterPro
    2. lactate 2-monooxygenase activity Source: UniProtKB-EC
    3. L-lactate dehydrogenase (cytochrome) activity Source: PomBase

    GO - Biological processi

    1. cellular response to oxidative stress Source: PomBase
    2. lactate metabolic process Source: PomBase

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Flavoprotein, FMN

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized lactate 2-monooxygenase PB1A11.03 (EC:1.13.12.4)
    Gene namesi
    ORF Names:SPAPB1A11.03
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAPB1A11.03.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. mitochondrial intermembrane space Source: PomBase
    3. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 407407Uncharacterized lactate 2-monooxygenase PB1A11.03PRO_0000316582Add
    BLAST

    Proteomic databases

    MaxQBiQ9HDX2.

    Interactioni

    Protein-protein interaction databases

    BioGridi279823. 1 interaction.
    MINTiMINT-4702677.
    STRINGi4896.SPAPB1A11.03-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HDX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 406379FMN hydroxy acid dehydrogenasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.PROSITE-ProRule annotation
    Contains 1 FMN hydroxy acid dehydrogenase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1304.
    HOGENOMiHOG000217463.
    KOiK00101.
    OMAiAVEYGMQ.
    OrthoDBiEOG7M3J8P.
    PhylomeDBiQ9HDX2.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR012133. Alpha-hydoxy_acid_DH_FMN.
    IPR000262. FMN-dep_DH.
    IPR008259. FMN_hydac_DH_AS.
    [Graphical view]
    PfamiPF01070. FMN_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
    PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
    PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HDX2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFRNYNWFDA KEPISYESEI YAKGLKFQRP QITVDGRHWE QLAVERMTKD    50
    AAGYVYGCAG KRETYDKNME SFKKWSIIPN RLIKSGFPDL STTVFGQKYP 100
    FPIALAPVGV QKIFNPEGES GSCAAATREH IPYIISTASA TSFEDIEKAS 150
    GPGERWYQLY WPSNDHQDIT ISLLNRAKKT GCRVLIVTLD TFILGWRPSD 200
    MDNGYDPFLN PDSIGVEHGF SDPVFRKQFK EKHGVEVEEN MLEAAKEFAG 250
    IVFPGISHDW EDLKFLRKHW DGPIVLKGIM NVPDAKKAVE YGMQGIVVSN 300
    HGGRQQDGGV ASLTMLPKIV DAVGDKLDVL FDSGVRSGAD IAKALALGAK 350
    MVLIGRPYVY GLALEGSSGV SHVIRCLLGD LELTLHLSGI VSVKPKDLNR 400
    DVLYKEE 407
    Length:407
    Mass (Da):45,311
    Last modified:March 1, 2001 - v1
    Checksum:iB0039309D1093CA4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAC19728.1.
    RefSeqiNP_593999.1. NM_001019425.2.

    Genome annotation databases

    EnsemblFungiiSPAPB1A11.03.1; SPAPB1A11.03.1:pep; SPAPB1A11.03.
    GeneIDi2543401.
    KEGGispo:SPAPB1A11.03.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAC19728.1 .
    RefSeqi NP_593999.1. NM_001019425.2.

    3D structure databases

    ProteinModelPortali Q9HDX2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279823. 1 interaction.
    MINTi MINT-4702677.
    STRINGi 4896.SPAPB1A11.03-1.

    Proteomic databases

    MaxQBi Q9HDX2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAPB1A11.03.1 ; SPAPB1A11.03.1:pep ; SPAPB1A11.03 .
    GeneIDi 2543401.
    KEGGi spo:SPAPB1A11.03.

    Organism-specific databases

    PomBasei SPAPB1A11.03.

    Phylogenomic databases

    eggNOGi COG1304.
    HOGENOMi HOG000217463.
    KOi K00101.
    OMAi AVEYGMQ.
    OrthoDBi EOG7M3J8P.
    PhylomeDBi Q9HDX2.

    Miscellaneous databases

    NextBioi 20804416.
    PROi Q9HDX2.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR012133. Alpha-hydoxy_acid_DH_FMN.
    IPR000262. FMN-dep_DH.
    IPR008259. FMN_hydac_DH_AS.
    [Graphical view ]
    Pfami PF01070. FMN_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
    PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
    PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYKN3_SCHPO
    AccessioniPrimary (citable) accession number: Q9HDX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3