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Q9HDX2 (YKN3_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized lactate 2-monooxygenase PB1A11.03

EC=1.13.12.4
Gene names
ORF Names:SPAPB1A11.03
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-lactate + O2 = acetate + CO2 + H2O.

Cofactor

FMN By similarity.

Subcellular location

Cytoplasm. Nucleus Ref.2.

Sequence similarities

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Contains 1 FMN hydroxy acid dehydrogenase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407Uncharacterized lactate 2-monooxygenase PB1A11.03
PRO_0000316582

Regions

Domain28 – 406379FMN hydroxy acid dehydrogenase
Nucleotide binding332 – 35625FMN By similarity

Sites

Active site3011Proton acceptor By similarity
Binding site541Substrate Potential
Binding site1361FMN By similarity
Binding site1581FMN By similarity
Binding site1601Substrate By similarity
Binding site1881FMN By similarity
Binding site1971Substrate By similarity
Binding site2771FMN By similarity
Binding site3041Substrate Potential

Sequences

Sequence LengthMass (Da)Tools
Q9HDX2 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: B0039309D1093CA4

FASTA40745,311
        10         20         30         40         50         60 
MFRNYNWFDA KEPISYESEI YAKGLKFQRP QITVDGRHWE QLAVERMTKD AAGYVYGCAG 

        70         80         90        100        110        120 
KRETYDKNME SFKKWSIIPN RLIKSGFPDL STTVFGQKYP FPIALAPVGV QKIFNPEGES 

       130        140        150        160        170        180 
GSCAAATREH IPYIISTASA TSFEDIEKAS GPGERWYQLY WPSNDHQDIT ISLLNRAKKT 

       190        200        210        220        230        240 
GCRVLIVTLD TFILGWRPSD MDNGYDPFLN PDSIGVEHGF SDPVFRKQFK EKHGVEVEEN 

       250        260        270        280        290        300 
MLEAAKEFAG IVFPGISHDW EDLKFLRKHW DGPIVLKGIM NVPDAKKAVE YGMQGIVVSN 

       310        320        330        340        350        360 
HGGRQQDGGV ASLTMLPKIV DAVGDKLDVL FDSGVRSGAD IAKALALGAK MVLIGRPYVY 

       370        380        390        400 
GLALEGSSGV SHVIRCLLGD LELTLHLSGI VSVKPKDLNR DVLYKEE 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAC19728.1.
RefSeqNP_593999.1. NM_001019425.2.

3D structure databases

ProteinModelPortalQ9HDX2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid279823. 1 interaction.
MINTMINT-4702677.
STRING4896.SPAPB1A11.03-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAPB1A11.03.1; SPAPB1A11.03.1:pep; SPAPB1A11.03.
GeneID2543401.
KEGGspo:SPAPB1A11.03.

Organism-specific databases

PomBaseSPAPB1A11.03.

Phylogenomic databases

eggNOGCOG1304.
HOGENOMHOG000217463.
KOK00101.
OMAAVEYGMQ.
OrthoDBEOG7M3J8P.
PhylomeDBQ9HDX2.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view]
PfamPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20804416.
PROQ9HDX2.

Entry information

Entry nameYKN3_SCHPO
AccessionPrimary (citable) accession number: Q9HDX2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names