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Q9HDX2

- YKN3_SCHPO

UniProt

Q9HDX2 - YKN3_SCHPO

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Protein
Uncharacterized lactate 2-monooxygenase PB1A11.03
Gene
SPAPB1A11.03
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + O2 = acetate + CO2 + H2O.

Cofactori

FMN By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541Substrate Reviewed prediction
Binding sitei136 – 1361FMN By similarity
Binding sitei158 – 1581FMN By similarity
Binding sitei160 – 1601Substrate By similarity
Binding sitei188 – 1881FMN By similarity
Binding sitei197 – 1971Substrate By similarity
Binding sitei277 – 2771FMN By similarity
Active sitei301 – 3011Proton acceptor By similarity
Binding sitei304 – 3041Substrate Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi332 – 35625FMN By similarity
Add
BLAST

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. L-lactate dehydrogenase (cytochrome) activity Source: PomBase
  3. lactate 2-monooxygenase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellular response to oxidative stress Source: PomBase
  2. lactate metabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized lactate 2-monooxygenase PB1A11.03 (EC:1.13.12.4)
Gene namesi
ORF Names:SPAPB1A11.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAPB1A11.03.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. mitochondrial intermembrane space Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Uncharacterized lactate 2-monooxygenase PB1A11.03
PRO_0000316582Add
BLAST

Proteomic databases

MaxQBiQ9HDX2.

Interactioni

Protein-protein interaction databases

BioGridi279823. 1 interaction.
MINTiMINT-4702677.
STRINGi4896.SPAPB1A11.03-1.

Structurei

3D structure databases

ProteinModelPortaliQ9HDX2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 406379FMN hydroxy acid dehydrogenase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1304.
HOGENOMiHOG000217463.
KOiK00101.
OMAiAVEYGMQ.
OrthoDBiEOG7M3J8P.
PhylomeDBiQ9HDX2.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view]
PfamiPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HDX2-1 [UniParc]FASTAAdd to Basket

« Hide

MFRNYNWFDA KEPISYESEI YAKGLKFQRP QITVDGRHWE QLAVERMTKD    50
AAGYVYGCAG KRETYDKNME SFKKWSIIPN RLIKSGFPDL STTVFGQKYP 100
FPIALAPVGV QKIFNPEGES GSCAAATREH IPYIISTASA TSFEDIEKAS 150
GPGERWYQLY WPSNDHQDIT ISLLNRAKKT GCRVLIVTLD TFILGWRPSD 200
MDNGYDPFLN PDSIGVEHGF SDPVFRKQFK EKHGVEVEEN MLEAAKEFAG 250
IVFPGISHDW EDLKFLRKHW DGPIVLKGIM NVPDAKKAVE YGMQGIVVSN 300
HGGRQQDGGV ASLTMLPKIV DAVGDKLDVL FDSGVRSGAD IAKALALGAK 350
MVLIGRPYVY GLALEGSSGV SHVIRCLLGD LELTLHLSGI VSVKPKDLNR 400
DVLYKEE 407
Length:407
Mass (Da):45,311
Last modified:March 1, 2001 - v1
Checksum:iB0039309D1093CA4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAC19728.1.
RefSeqiNP_593999.1. NM_001019425.2.

Genome annotation databases

EnsemblFungiiSPAPB1A11.03.1; SPAPB1A11.03.1:pep; SPAPB1A11.03.
GeneIDi2543401.
KEGGispo:SPAPB1A11.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAC19728.1 .
RefSeqi NP_593999.1. NM_001019425.2.

3D structure databases

ProteinModelPortali Q9HDX2.
ModBasei Search...

Protein-protein interaction databases

BioGridi 279823. 1 interaction.
MINTi MINT-4702677.
STRINGi 4896.SPAPB1A11.03-1.

Proteomic databases

MaxQBi Q9HDX2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAPB1A11.03.1 ; SPAPB1A11.03.1:pep ; SPAPB1A11.03 .
GeneIDi 2543401.
KEGGi spo:SPAPB1A11.03.

Organism-specific databases

PomBasei SPAPB1A11.03.

Phylogenomic databases

eggNOGi COG1304.
HOGENOMi HOG000217463.
KOi K00101.
OMAi AVEYGMQ.
OrthoDBi EOG7M3J8P.
PhylomeDBi Q9HDX2.

Miscellaneous databases

NextBioi 20804416.
PROi Q9HDX2.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view ]
Pfami PF01070. FMN_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYKN3_SCHPO
AccessioniPrimary (citable) accession number: Q9HDX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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