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Q9HDW9

- GPI12_SCHPO

UniProt

Q9HDW9 - GPI12_SCHPO

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Protein

Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

Gene

gpi12

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol (By similarity).By similarity

Catalytic activityi

6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate.

Pathwayi

GO - Molecular functioni

  1. N-acetylglucosaminylphosphatidylinositol deacetylase activity Source: PomBase

GO - Biological processi

  1. GPI anchor biosynthetic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiREACT_261328. Synthesis of glycosylphosphatidylinositol (GPI).
UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (EC:3.5.1.89)
Gene namesi
Name:gpi12
ORF Names:SPAPB2B4.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAPB2B4.01c.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Single-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77LumenalSequence Analysis
Transmembranei8 – 2417HelicalSequence AnalysisAdd
BLAST
Topological domaini25 – 248224CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: PomBase
  2. endoplasmic reticulum membrane Source: PomBase
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylasePRO_0000207169Add
BLAST

Proteomic databases

MaxQBiQ9HDW9.

Interactioni

Protein-protein interaction databases

MINTiMINT-4702669.
STRINGi4896.SPAPB2B4.01c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9HDW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGL family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2120.
HOGENOMiHOG000176611.
InParanoidiQ9HDW9.
KOiK03434.
OMAiHTQDVLF.
OrthoDBiEOG7DFXPJ.
PhylomeDBiQ9HDW9.

Family and domain databases

Gene3Di3.40.50.10320. 1 hit.
InterProiIPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
[Graphical view]
PANTHERiPTHR12993. PTHR12993. 1 hit.
PfamiPF02585. PIG-L. 1 hit.
[Graphical view]
SUPFAMiSSF102588. SSF102588. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HDW9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIWFWSTLLV TAIAVLSTAN ESSSGQEKLA VESILFVFAH PDDESMFFGP
60 70 80 90 100
TIDYLGNQHS TRVHVLCLSN GNADGLGSVR EKELVVAASK YQIDKTNVHV
110 120 130 140 150
VSDPQLQDGM QAKWDPTDVA KHISQIIERY NIKTLITFDN KGISGHPNHI
160 170 180 190 200
ACYEGAMKIV KATPQVQVFV LESVNIFRKY ISYLDTIPTL VQSQAGRNDT
210 220 230 240
IIIHADRKST QRIRDAMVRG HKSQMVWFRY GWIYLSKYMS NNVLKRAT
Length:248
Mass (Da):28,006
Last modified:March 1, 2001 - v1
Checksum:i4DD8E6DF5DCFD1FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAC21467.1.
RefSeqiNP_593887.1. NM_001019317.2.

Genome annotation databases

EnsemblFungiiSPAPB2B4.01c.1; SPAPB2B4.01c.1:pep; SPAPB2B4.01c.
GeneIDi2543490.
KEGGispo:SPAPB2B4.01c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAC21467.1 .
RefSeqi NP_593887.1. NM_001019317.2.

3D structure databases

ProteinModelPortali Q9HDW9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4702669.
STRINGi 4896.SPAPB2B4.01c-1.

Proteomic databases

MaxQBi Q9HDW9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAPB2B4.01c.1 ; SPAPB2B4.01c.1:pep ; SPAPB2B4.01c .
GeneIDi 2543490.
KEGGi spo:SPAPB2B4.01c.

Organism-specific databases

PomBasei SPAPB2B4.01c.

Phylogenomic databases

eggNOGi COG2120.
HOGENOMi HOG000176611.
InParanoidi Q9HDW9.
KOi K03434.
OMAi HTQDVLF.
OrthoDBi EOG7DFXPJ.
PhylomeDBi Q9HDW9.

Enzyme and pathway databases

UniPathwayi UPA00196 .
Reactomei REACT_261328. Synthesis of glycosylphosphatidylinositol (GPI).

Miscellaneous databases

NextBioi 20804502.
PROi Q9HDW9.

Family and domain databases

Gene3Di 3.40.50.10320. 1 hit.
InterProi IPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
[Graphical view ]
PANTHERi PTHR12993. PTHR12993. 1 hit.
Pfami PF02585. PIG-L. 1 hit.
[Graphical view ]
SUPFAMi SSF102588. SSF102588. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGPI12_SCHPO
AccessioniPrimary (citable) accession number: Q9HDW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: March 1, 2001
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3