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Q9HDW9 (GPI12_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

EC=3.5.1.89
Gene names
Name:gpi12
ORF Names:SPAPB2B4.01c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol By similarity.

Catalytic activity

6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate.

Pathway

Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein Ref.2.

Sequence similarities

Belongs to the PIGL family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 248248Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
PRO_0000207169

Regions

Topological domain1 – 77Lumenal Potential
Transmembrane8 – 2417Helical; Potential
Topological domain25 – 248224Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q9HDW9 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 4DD8E6DF5DCFD1FF

FASTA24828,006
        10         20         30         40         50         60 
MIWFWSTLLV TAIAVLSTAN ESSSGQEKLA VESILFVFAH PDDESMFFGP TIDYLGNQHS 

        70         80         90        100        110        120 
TRVHVLCLSN GNADGLGSVR EKELVVAASK YQIDKTNVHV VSDPQLQDGM QAKWDPTDVA 

       130        140        150        160        170        180 
KHISQIIERY NIKTLITFDN KGISGHPNHI ACYEGAMKIV KATPQVQVFV LESVNIFRKY 

       190        200        210        220        230        240 
ISYLDTIPTL VQSQAGRNDT IIIHADRKST QRIRDAMVRG HKSQMVWFRY GWIYLSKYMS 


NNVLKRAT 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAC21467.1.
RefSeqNP_593887.1. NM_001019317.2.

3D structure databases

ProteinModelPortalQ9HDW9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4702669.
STRING4896.SPAPB2B4.01c-1.

Proteomic databases

MaxQBQ9HDW9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAPB2B4.01c.1; SPAPB2B4.01c.1:pep; SPAPB2B4.01c.
GeneID2543490.
KEGGspo:SPAPB2B4.01c.

Organism-specific databases

PomBaseSPAPB2B4.01c.

Phylogenomic databases

eggNOGCOG2120.
HOGENOMHOG000176611.
KOK03434.
OMAHTQDVLF.
OrthoDBEOG7DFXPJ.
PhylomeDBQ9HDW9.

Enzyme and pathway databases

UniPathwayUPA00196.

Family and domain databases

Gene3D3.40.50.10320. 1 hit.
InterProIPR003737. GlcNAc_PI_deacetylase-related.
IPR024078. LmbE-like_dom.
[Graphical view]
PANTHERPTHR12993. PTHR12993. 1 hit.
PfamPF02585. PIG-L. 1 hit.
[Graphical view]
SUPFAMSSF102588. SSF102588. 1 hit.
ProtoNetSearch...

Other

NextBio20804502.
PROQ9HDW9.

Entry information

Entry nameGPI12_SCHPO
AccessionPrimary (citable) accession number: Q9HDW9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways