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Protein

Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

Gene

gpi12

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol (By similarity).By similarity

Catalytic activityi

6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate.

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiR-SPO-162710 Synthesis of glycosylphosphatidylinositol (GPI)
UniPathwayiUPA00196

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (EC:3.5.1.89)
Gene namesi
Name:gpi12
ORF Names:SPAPB2B4.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:SPAPB2B4.01c
PomBaseiSPAPB2B4.01c gpi12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7LumenalSequence analysis7
Transmembranei8 – 24HelicalSequence analysisAdd BLAST17
Topological domaini25 – 248CytoplasmicSequence analysisAdd BLAST224

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002071691 – 248Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylaseAdd BLAST248

Proteomic databases

MaxQBiQ9HDW9
PaxDbiQ9HDW9
PRIDEiQ9HDW9

PTM databases

iPTMnetiQ9HDW9
SwissPalmiQ9HDW9

Interactioni

Protein-protein interaction databases

STRINGi4896.SPAPB2B4.01c.1

Structurei

3D structure databases

ProteinModelPortaliQ9HDW9
SMRiQ9HDW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGL family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000176611
InParanoidiQ9HDW9
KOiK03434
OMAiLVWFRWL
OrthoDBiEOG092C3E4U
PhylomeDBiQ9HDW9

Family and domain databases

Gene3Di3.40.50.10320, 1 hit
InterProiView protein in InterPro
IPR003737 GlcNAc_PI_deacetylase-related
IPR024078 LmbE-like_dom_sf
PANTHERiPTHR12993 PTHR12993, 1 hit
PfamiView protein in Pfam
PF02585 PIG-L, 1 hit
SUPFAMiSSF102588 SSF102588, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HDW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIWFWSTLLV TAIAVLSTAN ESSSGQEKLA VESILFVFAH PDDESMFFGP
60 70 80 90 100
TIDYLGNQHS TRVHVLCLSN GNADGLGSVR EKELVVAASK YQIDKTNVHV
110 120 130 140 150
VSDPQLQDGM QAKWDPTDVA KHISQIIERY NIKTLITFDN KGISGHPNHI
160 170 180 190 200
ACYEGAMKIV KATPQVQVFV LESVNIFRKY ISYLDTIPTL VQSQAGRNDT
210 220 230 240
IIIHADRKST QRIRDAMVRG HKSQMVWFRY GWIYLSKYMS NNVLKRAT
Length:248
Mass (Da):28,006
Last modified:March 1, 2001 - v1
Checksum:i4DD8E6DF5DCFD1FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAC21467.1
RefSeqiNP_593887.1, NM_001019317.2

Genome annotation databases

EnsemblFungiiSPAPB2B4.01c.1; SPAPB2B4.01c.1:pep; SPAPB2B4.01c
GeneIDi2543490
KEGGispo:SPAPB2B4.01c

Entry informationi

Entry nameiGPI12_SCHPO
AccessioniPrimary (citable) accession number: Q9HDW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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