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Q9HDW9

- GPI12_SCHPO

UniProt

Q9HDW9 - GPI12_SCHPO

Protein

Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

Gene

gpi12

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol By similarity.By similarity

    Catalytic activityi

    6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate.

    Pathwayi

    GO - Molecular functioni

    1. N-acetylglucosaminylphosphatidylinositol deacetylase activity Source: PomBase

    GO - Biological processi

    1. GPI anchor biosynthetic process Source: PomBase

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    GPI-anchor biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00196.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (EC:3.5.1.89)
    Gene namesi
    Name:gpi12
    ORF Names:SPAPB2B4.01c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAPB2B4.01c.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Single-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: PomBase
    2. endoplasmic reticulum membrane Source: PomBase
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 248248Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylasePRO_0000207169Add
    BLAST

    Proteomic databases

    MaxQBiQ9HDW9.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4702669.
    STRINGi4896.SPAPB2B4.01c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HDW9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77LumenalSequence Analysis
    Topological domaini25 – 248224CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2417HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PIGL family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2120.
    HOGENOMiHOG000176611.
    KOiK03434.
    OMAiHTQDVLF.
    OrthoDBiEOG7DFXPJ.
    PhylomeDBiQ9HDW9.

    Family and domain databases

    Gene3Di3.40.50.10320. 1 hit.
    InterProiIPR003737. GlcNAc_PI_deacetylase-related.
    IPR024078. LmbE-like_dom.
    [Graphical view]
    PANTHERiPTHR12993. PTHR12993. 1 hit.
    PfamiPF02585. PIG-L. 1 hit.
    [Graphical view]
    SUPFAMiSSF102588. SSF102588. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9HDW9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIWFWSTLLV TAIAVLSTAN ESSSGQEKLA VESILFVFAH PDDESMFFGP    50
    TIDYLGNQHS TRVHVLCLSN GNADGLGSVR EKELVVAASK YQIDKTNVHV 100
    VSDPQLQDGM QAKWDPTDVA KHISQIIERY NIKTLITFDN KGISGHPNHI 150
    ACYEGAMKIV KATPQVQVFV LESVNIFRKY ISYLDTIPTL VQSQAGRNDT 200
    IIIHADRKST QRIRDAMVRG HKSQMVWFRY GWIYLSKYMS NNVLKRAT 248
    Length:248
    Mass (Da):28,006
    Last modified:March 1, 2001 - v1
    Checksum:i4DD8E6DF5DCFD1FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAC21467.1.
    RefSeqiNP_593887.1. NM_001019317.2.

    Genome annotation databases

    EnsemblFungiiSPAPB2B4.01c.1; SPAPB2B4.01c.1:pep; SPAPB2B4.01c.
    GeneIDi2543490.
    KEGGispo:SPAPB2B4.01c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAC21467.1 .
    RefSeqi NP_593887.1. NM_001019317.2.

    3D structure databases

    ProteinModelPortali Q9HDW9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4702669.
    STRINGi 4896.SPAPB2B4.01c-1.

    Proteomic databases

    MaxQBi Q9HDW9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAPB2B4.01c.1 ; SPAPB2B4.01c.1:pep ; SPAPB2B4.01c .
    GeneIDi 2543490.
    KEGGi spo:SPAPB2B4.01c.

    Organism-specific databases

    PomBasei SPAPB2B4.01c.

    Phylogenomic databases

    eggNOGi COG2120.
    HOGENOMi HOG000176611.
    KOi K03434.
    OMAi HTQDVLF.
    OrthoDBi EOG7DFXPJ.
    PhylomeDBi Q9HDW9.

    Enzyme and pathway databases

    UniPathwayi UPA00196 .

    Miscellaneous databases

    NextBioi 20804502.
    PROi Q9HDW9.

    Family and domain databases

    Gene3Di 3.40.50.10320. 1 hit.
    InterProi IPR003737. GlcNAc_PI_deacetylase-related.
    IPR024078. LmbE-like_dom.
    [Graphical view ]
    PANTHERi PTHR12993. PTHR12993. 1 hit.
    Pfami PF02585. PIG-L. 1 hit.
    [Graphical view ]
    SUPFAMi SSF102588. SSF102588. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGPI12_SCHPO
    AccessioniPrimary (citable) accession number: Q9HDW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3