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Reviewed, UniProtKB/Swiss-Prot Q9HDW7 (ATC2_SCHPO)

Last modified November 3, 2009. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Calcium-transporting ATPase 2
    EC=3.6.3.8
Gene names
Name: pmc1
ORF Names: SPAPB2B4.04c
OrganismSchizosaccharomyces pombe (Fission yeast) [Complete proteome]
Taxonomic identifier4896 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

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Protein attributes

Sequence length1292 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium. Ref.3

Catalytic activity

ATP + H2O + Ca2+(Cis) = ADP + phosphate + Ca2+(Trans).

Subcellular location

Vacuole membrane; Multi-pass membrane protein. Ref.3

Sequence similarities

Belongs to the cation transport ATPase (P-type) family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12921292Calcium-transporting ATPase 2
PRO_0000362141

Regions

Topological domain1 – 236236Cytoplasmic Potential
Transmembrane237 – 25721 Potential
Topological domain258 – 27316Extracellular Potential
Transmembrane274 – 29421 Potential
Topological domain295 – 448154Cytoplasmic Potential
Transmembrane449 – 46921 Potential
Topological domain470 – 48819Extracellular Potential
Transmembrane489 – 50921 Potential
Topological domain510 – 938429Cytoplasmic Potential
Transmembrane939 – 95921 Potential
Topological domain960 – 9667Extracellular Potential
Transmembrane967 – 98721 Potential
Topological domain988 – 101629Cytoplasmic Potential
Transmembrane1017 – 103721 Potential
Topological domain1038 – 108447Extracellular Potential
Transmembrane1085 – 110521 Potential
Topological domain1106 – 111510Cytoplasmic Potential
Transmembrane1116 – 113621 Potential
Topological domain1137 – 1292156Extracellular Potential
Compositional bias6 – 94Poly-Asp
Compositional bias10 – 10596Ser-rich

Sites

Active site54514-aspartylphosphate intermediate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9HDW7-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 1499E90144A2B07B

FASTA1,292142,235
        10         20         30         40         50         60 
MPTYNDDDDS SRPPSVHSER NQKPSSSQFL GVPSSNYNQR ENSSRSGSST ISREPSSSGT 

        70         80         90        100        110        120 
MYPMASRDSM KESYDKNKGT PPDYTSYVSH SDAEPEQASS KSSTSIEDLL HTEYDDAPFA 

       130        140        150        160        170        180 
FSIPLLQRLQ DPKNTSLLHA IHGLKGLCKG LKVDPSTGIS THEPHYADKL QMSDILNDDS 

       190        200        210        220        230        240 
NPKLVVHLDR IRSQDNNPEA KVSHDSDRVK YYGKNVLPEH DSKGLIRLML EAFKDKVLIL 

       250        260        270        280        290        300 
LSIAAVVSLA LGLYQTFGQP PTLDPITGKP EPRVEWVEGV AIMAAIVIVV TVGGVNDWQK 

       310        320        330        340        350        360 
ELQFKKLNAK VSNFDVQVLR DGAVHSTSVF DLVVGDVLFV EAGDVVPVDG VLIESNNLVL 

       370        380        390        400        410        420 
DESAMTGETD NIKKVDANTA IERTSPDVEY RKNADPYLIS GTTILEGNGK LLVTAVGVNS 

       430        440        450        460        470        480 
FNGRTTMAMR TEGQATPLQL RLSRVADAIA KLGGAASALL FIVLLIEFLV RLKSNDSSSK 

       490        500        510        520        530        540 
NKGQEFLQIL IVSVTLLVVA VPEGLPLAVT LALAFATNRM QKDNNLVRHL QACETMGTAT 

       550        560        570        580        590        600 
NICSDKTGTL TQNRMTVVAG GFGTDVLFFD HNDETPTNVD QGSDSSKFED AGASAFAFKR 

       610        620        630        640        650        660 
LSPELRDLTL YSIAVNSTCR QLFEDNSDTP RFIGSKTETA LLDMSVKELG LTNVDSMRSS 

       670        680        690        700        710        720 
VDIKQFFSFS SDRKASGAIF EYKDKYYFVV KGMPERVLQQ STSVITNGSL DEVEDMHSHA 

       730        740        750        760        770        780 
DYFKEMITGY AKRSLRTLGL CYRVFDSWPP KDIPTNDEDS SNPLKWEDAF TDMTFLGFFG 

       790        800        810        820        830        840 
IMDPIRPDVP LAVKVCQGAG VTVRMVTGDN IVTAKAIASQ CGIYTEDGIS MEGPEFRSLS 

       850        860        870        880        890        900 
DEKRLEILPK LDVLARSSPL DKQLLIEGLQ KLGNVVAVTG DGTNDAPALK KANVGFSMGK 

       910        920        930        940        950        960 
SGTEVAKEAS DIILMDDNFS SIVKAIAWGR TVNDAVKKFL QFQITVNITA VFLTIISAVA 

       970        980        990       1000       1010       1020 
STDQSSVLTA VQLLWVNLIM DTLAALALAT DPPTPEVLKR KPEKPGASLF TFDMWKMIIC 

      1030       1040       1050       1060       1070       1080 
QSMYQLAVTL VLHFAGNSIF HYPSNTADMN TIVFNTFVWL QLFNEINNRR LDNKLNIFER 

      1090       1100       1110       1120       1130       1140 
INHNFLFIAI FVIVAGIQVI IVFFGGAAFS VKRIDGKGWA ISIVFGVISI PLGALIRCVP 

      1150       1160       1170       1180       1190       1200 
NNFLRKVLPV KTIDTVFSWI LNPRFRSKRR STDHDVESLS LIPYEPTSPN EVIDSIRHSL 

      1210       1220       1230       1240       1250       1260 
GFVQRIRGGR IRHLLNNSKF DKQMEALPER LRPRVKQRFM KIRSPSVSSA TSVALMIPIS 

      1270       1280       1290 
TLVSEASGRL GGHDIWISHN RQALDKKSSN VH

« Hide

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References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 38366 / 972.
[2]"An inventory of the P-type ATPases in the fission yeast Schizosaccharomyces pombe."
Okorokova-Facanha A.L., Okorokov L.A., Ekwall K.
Curr. Genet. 43:273-280(2003) [PubMed: 12707717] [Abstract]
Cited for: IDENTIFICATION.
[3]"Schizosaccharomyces pombe Pmr1p is essential for cell wall integrity and is required for polarized cell growth and cytokinesis."
Cortes J.C.G., Katoh-Fukui R., Moto K., Ribas J.C., Ishiguro J.
Eukaryot. Cell 3:1124-1135(2004) [PubMed: 15470240] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.

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Cross-references

Sequence databases

CU329670 Genomic DNA. Translation: CAC21470.1.
RefSeqNP_593890.1.

3D structure databases

HSSPHSSP built from PDB template 1SU4 based on UniProtKB P04191.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9HDW7.

Genome annotation databases

GeneID2543477.
GenomeReviewsGene locus pmc1 in contig CU329670_GR.
KEGGspo:SPAPB2B4.04c.
NMPDRfig|4896.1.peg.3860.

Organism-specific databases

GeneDB_SpombeSPAPB2B4.04c.

Phylogenomic databases

OMAGISTHEP.

Gene expression databases

ArrayExpressQ9HDW7.

Family and domain databases

InterProIPR008250. ATPase_P-typ_ATPase-assoc-reg.
IPR006408. ATPase_P-typ_Ca-transp_PMCA.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR005834. Dehalogen-like_hydro.
[Graphical view]
PANTHERPTHR11939. ATPase_P. 1 hit.
PfamPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
TIGRFAMsTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameATC2_SCHPO
AccessionPrimary (citable) accession number: Q9HDW7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: March 1, 2001
Last modified: November 3, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents