Q9HDW1 (PGPS1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
EC=2.7.8.5

Alternative name(s):
Phosphatidylglycerophosphate synthase
Short name=PGP synthase

Gene names

Name:	pgs1
ORF Names:	SPBP18G5.02

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	534 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin By similarity.
Catalytic activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-II family. Contains 2 PLD phosphodiesterase domains.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Mitochondrion
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cardiolipin biosynthetic process Inferred from sequence or structural similarity. Source: GeneDB_Spombe glycerol-3-phosphate catabolic process Inferred from sequence or structural similarity. Source: GeneDB_Spombe mitochondrial membrane organization Inferred by curator. Source: GeneDB_Spombe
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_Spombe mitochondrion Inferred from sequence or structural similarity. Source: GeneDB_Spombe nucleus Inferred from direct assay. Source: GeneDB_Spombe
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 534	534	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase		PRO_0000350817
Regions
	Domain	143 – 169	27	PLD phosphodiesterase 1
	Domain	421 – 475	55	PLD phosphodiesterase 2
	Nucleotide binding	58 – 65	8	ATP Potential
Sites
	Active site	148	1	Potential
	Active site	150	1	Potential
	Active site	155	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9HDW1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 1027C2573F4CDBCD	FASTA	534	61,429
	10 20 30 40 50 60 MDEGIEKNIF VNLESQIDGV CPKFYVNVDD IDIIHEPPEF YQRLKKLIKK AQKRIFLSTL 70 80 90 100 110 120 YIGKEERELI NCLSNALSNN PSLHVHILAD QLRCTRESPG CCSASLLMQL KKKFPDRCEI 130 140 150 160 170 180 KLYHTPNLRG LRKQLVPHRF NEGWGLQHMK IYGADDNLII SGANLSRDYF TNRKDRYYLF 190 200 210 220 230 240 SDKGLADFFF KTHFLFSQLS FECIPHLSDS SIQLSSTSPV IPFTLKWNNS CPNPLTNPQE 250 260 270 280 290 300 FRVAASAKIQ QLLQGNREKF LSRNPSKPLS SVYGSELINQ AGDDNNKPFH KYEESAIVYP 310 320 330 340 350 360 LFQCVPILTS DVHSTEEKVL SIIGTLLSRK EVNWTLTAGY FNVYPALRKQ LLKSEGIGEV 370 380 390 400 410 420 IVASQQANGF YRSPGPSKLI PPAYQYIAEQ FLKDSRKKKR NIDVLQWQNK GNTYHAKGKH 430 440 450 460 470 480 YSLSFSIINI FWSTALKSYI FEKFTNTILG FWLSTQHHKH PFLTTIGSSN YTSRSQQLDL 490 500 510 520 530 ESTLVVMTQN EKLKRKFSTE IELIKQHTKP MNTCQLEKVP MYVKALTSLM KKKL

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329671 Genomic DNA. Translation: CAC21490.1.
RefSeq	NP_595992.1. NM_001021899.1.
3D structure databases
ProteinModelPortal	Q9HDW1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9HDW1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2541243.
GenomeReviews	Gene locus pgs1 in contig CU329671_GR.
KEGG	spo:SPBP18G5.02.
NMPDR	fig|4896.1.peg.1858.
Organism-specific databases
GeneDB_Spombe	SPBP18G5.02.
Phylogenomic databases
eggNOG	fuNOG07754.
GeneTree	EFGT00050000005202.
HOGENOM	HBG737293.
OMA	RQDRYVL.
OrthoDB	EOG45B4QV.
Gene expression databases
ArrayExpress	Q9HDW1.
Family and domain databases
InterPro	IPR016270. PLipase-D_PtdSer-synthase-type. [Graphical view]
KO	K00995.
PANTHER	PTHR12586. PTHR12586. 1 hit.
PIRSF	PIRSF000850. Phospholipase_D_PSS. 1 hit.
PROSITE	PS50035. PLD. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGPS1_SCHPO

Accession

Primary (citable) accession number: Q9HDW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 23, 2008
Last sequence update:	March 1, 2001
Last modified:	December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program