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Protein

Lid2 complex component lid2

Gene

lid2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri268 – 31851PHD-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1093 – 114553PHD-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1096 – 114348RING-type 1; degenerateSequence analysisAdd
BLAST
Zinc fingeri1352 – 140352PHD-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1354 – 140148RING-type 2; degenerateSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • chromatin remodeling Source: PomBase
  • chromatin silencing at centromere Source: PomBase
  • chromatin silencing at silent mating-type cassette Source: PomBase
  • heterochromatin assembly Source: PomBase
  • histone H3-K9 methylation Source: PomBase
  • mitotic sister chromatid segregation Source: PomBase
  • negative regulation of histone H3-K4 methylation Source: PomBase
  • RITS complex localization Source: PomBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Lid2 complex component lid2
Short name:
Lid2C component lid2
Gene namesi
Name:lid2
ORF Names:SPBP19A11.06, SPBP4H10.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBP19A11.06.
PomBaseiSPBP19A11.06. lid2.

Subcellular locationi

GO - Cellular componenti

  • Lid2 complex Source: PomBase
  • mating-type region heterochromatin Source: PomBase
  • nuclear pericentric heterochromatin Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15131513Lid2 complex component lid2PRO_0000200599Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei722 – 7221Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9HDV4.

PTM databases

iPTMnetiQ9HDV4.

Interactioni

Subunit structurei

Component of the Lid2 complex composed of ash2, jmj3, lid2, sdc1 and snt2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
raf1O749102EBI-2105919,EBI-904913
set1Q9Y7R42EBI-2105919,EBI-2106005

Protein-protein interaction databases

BioGridi277811. 6 interactions.
IntActiQ9HDV4. 7 interactions.
MINTiMINT-4702556.

Structurei

3D structure databases

ProteinModelPortaliQ9HDV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 9742JmjNPROSITE-ProRule annotationAdd
BLAST
Domaini121 – 21292ARIDPROSITE-ProRule annotationAdd
BLAST
Domaini408 – 574167JmjCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ARID domain.PROSITE-ProRule annotation
Contains 1 JmjC domain.PROSITE-ProRule annotation
Contains 1 JmjN domain.PROSITE-ProRule annotation
Contains 3 PHD-type zinc fingers.PROSITE-ProRule annotation
Contains 2 RING-type zinc fingers.Sequence analysis

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri268 – 31851PHD-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1093 – 114553PHD-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1096 – 114348RING-type 1; degenerateSequence analysisAdd
BLAST
Zinc fingeri1352 – 140352PHD-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1354 – 140148RING-type 2; degenerateSequence analysisAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

InParanoidiQ9HDV4.
KOiK11446.
OMAiMIANESA.
OrthoDBiEOG7SXWBR.
PhylomeDBiQ9HDV4.

Family and domain databases

Gene3Di1.10.150.60. 1 hit.
3.30.40.10. 3 hits.
InterProiIPR001606. ARID_dom.
IPR003347. JmjC_dom.
IPR013637. Lys_sp_deMease-like_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR004198. Znf_C5HC2.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01388. ARID. 1 hit.
PF02373. JmjC. 1 hit.
PF00628. PHD. 1 hit.
PF08429. PLU-1. 1 hit.
PF02928. zf-C5HC2. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
SM00249. PHD. 3 hits.
[Graphical view]
SUPFAMiSSF46774. SSF46774. 1 hit.
SSF57903. SSF57903. 3 hits.
PROSITEiPS51011. ARID. 1 hit.
PS51184. JMJC. 1 hit.
PS51183. JMJN. 1 hit.
PS01359. ZF_PHD_1. 3 hits.
PS50016. ZF_PHD_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HDV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MICQLLWHEH NSMGSGREKK IRKLGDNFSL PYLKFDCDHN DKNYRASNRP
60 70 80 90 100
FGLSTGLSVQ LNASNMTDPF KFLLDNWHTI FKNGAIKLLP PEGWQIPVVL
110 120 130 140 150
DQGAFEFQSK RQCLNKGCLN YEKNYDYFKK LKAFHESRGL YFYHPPIIGN
160 170 180 190 200
RPVDFLRLRN AISKFTNSGS SLNNEILHKV IIYLRLEDTK EVRQVLTRCY
210 220 230 240 250
DRYIKPFERD SSPSFKSKRS ESSTRKIRNT RSSAQQESPI PETSAQSPVQ
260 270 280 290 300
TIQVNGSTSL KRPLIERGEQ CEYCGLDKNP ETILLCDGCE AAYHTSCLDP
310 320 330 340 350
PLTSIPKEDW YCDACKFNIS DYDPRKGFKW KLSSLKERSA EIFNTLGERN
360 370 380 390 400
SSSKLTNLTE DDIELFYWSS LAESNSGFAP LELEGLSQAY TSTIQSSLPS
410 420 430 440 450
KEVFPLEKYS SEPWNLHNLP FENPCLFNYS FSDLSSLTIT RLSIGMVFYT
460 470 480 490 500
HGWTKSSLST GLLHHHRFGD TVTWYVLPPD ESDAFERYLI SSYPQYTMED
510 520 530 540 550
LNRSNGLPVI VSPSSLIENG FHPIAIDLRP NEFLVVSPNS YHMGFHQGFS
560 570 580 590 600
SFESVNFATV NWIKDGLLNS SISVLKSMRI PSSVSYEAVI ISMVLSKNPC
610 620 630 640 650
FSSEWLIKCF EDMIANESAS KNEIMKLVPN IQALKLESSV PLEIRCSNCK
660 670 680 690 700
QPCFLSFMQC HEPKKFICLG DCVKEVSLNA TSWMLFYRWD VHELSNLAER
710 720 730 740 750
FVSLIRGPEE WTNRLRSVLS TSPKPQLKVL KSLLVDAEKA MLTTPETVNL
760 770 780 790 800
RDFVQNANSW IDSVNECLKV ASLKRKKDKK PPLFKAHDHW NNTSNLKDSA
810 820 830 840 850
VLFKVLQTSR SMAFTCQEIE NMKQKAFDLL EFRNRLINSF SGPLDKNTCQ
860 870 880 890 900
RLLTEAELLG FTIPELGIIQ KYLIQFEWLD MFYSFETTRT TDSDLERLIT
910 920 930 940 950
YGVSAGIPED NDYMIFAKAM KGRAEIWENQ VYDTLSKSNI SYDKLSLLRD
960 970 980 990 1000
EAMNLCVNKE LFSKVVGILN NAEEIKNKIA TLCERSQEKD FALRPSIDEV
1010 1020 1030 1040 1050
KEALASAEKL PILSESTVTL QKMYDVVLEW IRRGKRLFGK ANAPLEILGQ
1060 1070 1080 1090 1100
HLDYVEKRNS ASLSLNDRPG PPMEPASRET SPDSEGRLTI RKKKGCIFCF
1110 1120 1130 1140 1150
CRLPESGVMI ECEICHEWYH AKCLKMSKKK LRQDEKFTCP ICDYRVEIPR
1160 1170 1180 1190 1200
LSNRPKLEDL QSLYKDVKLL PFQPKETETL RKVVDLASKF RQEMQALAHN
1210 1220 1230 1240 1250
PFGLTMAEVP LARFYLRKME GAEILLVDET NLFRQKLHEC VPIAPNPPPI
1260 1270 1280 1290 1300
IGESKSTRKP RPTKRQRQIM KQVAEGLLPA SAIAPPKSSN EKKSSNNVKA
1310 1320 1330 1340 1350
VEAETKSKSE KSPKKNGTNI SDANNKNESH VSLMKNWKLG SPAFVTLVKE
1360 1370 1380 1390 1400
KNSSCLCGEE FSPRDSFIDC TICERRFHYD CVGLNNEIAD SVSKFTCPIC
1410 1420 1430 1440 1450
MEQSGGIYPW QLRPRNGMHP DHISGFSKEV ETDPKLGSSG YTLNNSKFDK
1460 1470 1480 1490 1500
AAVSKTLSAQ DVSRLQKVSC GEHLYFGTDV FTPLGDMATS ASMFSLDDSS
1510
EKTDAFTENF LNV
Length:1,513
Mass (Da):172,259
Last modified:March 1, 2001 - v1
Checksum:iB8787624F9E7DFAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAC19756.1.
PIRiT50313.
RefSeqiNP_596174.1. NM_001022094.2.

Genome annotation databases

EnsemblFungiiSPBP19A11.06.1; SPBP19A11.06.1:pep; SPBP19A11.06.
GeneIDi2541299.
KEGGispo:SPBP19A11.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAC19756.1.
PIRiT50313.
RefSeqiNP_596174.1. NM_001022094.2.

3D structure databases

ProteinModelPortaliQ9HDV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277811. 6 interactions.
IntActiQ9HDV4. 7 interactions.
MINTiMINT-4702556.

PTM databases

iPTMnetiQ9HDV4.

Proteomic databases

MaxQBiQ9HDV4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBP19A11.06.1; SPBP19A11.06.1:pep; SPBP19A11.06.
GeneIDi2541299.
KEGGispo:SPBP19A11.06.

Organism-specific databases

EuPathDBiFungiDB:SPBP19A11.06.
PomBaseiSPBP19A11.06. lid2.

Phylogenomic databases

InParanoidiQ9HDV4.
KOiK11446.
OMAiMIANESA.
OrthoDBiEOG7SXWBR.
PhylomeDBiQ9HDV4.

Miscellaneous databases

PROiQ9HDV4.

Family and domain databases

Gene3Di1.10.150.60. 1 hit.
3.30.40.10. 3 hits.
InterProiIPR001606. ARID_dom.
IPR003347. JmjC_dom.
IPR013637. Lys_sp_deMease-like_dom.
IPR019786. Zinc_finger_PHD-type_CS.
IPR004198. Znf_C5HC2.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01388. ARID. 1 hit.
PF02373. JmjC. 1 hit.
PF00628. PHD. 1 hit.
PF08429. PLU-1. 1 hit.
PF02928. zf-C5HC2. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
SM00249. PHD. 3 hits.
[Graphical view]
SUPFAMiSSF46774. SSF46774. 1 hit.
SSF57903. SSF57903. 3 hits.
PROSITEiPS51011. ARID. 1 hit.
PS51184. JMJC. 1 hit.
PS51183. JMJN. 1 hit.
PS01359. ZF_PHD_1. 3 hits.
PS50016. ZF_PHD_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation in budding and fission yeasts."
    Roguev A., Schaft D., Shevchenko A., Aasland R., Shevchenko A., Stewart A.F.
    J. Biol. Chem. 278:8487-8493(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPOSITION OF THE LID2 COMPLEX.
  3. "A comparative analysis of an orthologous proteomic environment in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe."
    Roguev A., Shevchenko A., Schaft D., Thomas H., Stewart A.F., Shevchenko A.
    Mol. Cell. Proteomics 3:125-132(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPOSITION OF THE LID2 COMPLEX.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-722, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiLID2_SCHPO
AccessioniPrimary (citable) accession number: Q9HDV4
Secondary accession number(s): Q9P7E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.