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Protein

Probable 2-dehydropantoate 2-reductase

Gene

SPBPB2B2.09c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Probable 3-methyl-2-oxobutanoate hydroxymethyltransferase (SPAC5H10.09c)
  2. Probable 2-dehydropantoate 2-reductase (SPBPB2B2.09c)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei115NADP; via amide nitrogenBy similarity1
Binding sitei115SubstrateBy similarity1
Active sitei213Proton donorBy similarity1
Binding sitei217SubstrateBy similarity1
Binding sitei221SubstrateBy similarity1
Binding sitei295SubstrateBy similarity1
Binding sitei307NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 14NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPantothenate biosynthesis, Pyrimidine biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
ORF Names:SPBPB2B2.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBPB2B2.09c
PomBaseiSPBPB2B2.09c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001573271 – 350Probable 2-dehydropantoate 2-reductaseAdd BLAST350

Proteomic databases

MaxQBiQ9HDU6
PaxDbiQ9HDU6
PRIDEiQ9HDU6

Interactioni

Protein-protein interaction databases

BioGridi277900, 52 interactors
STRINGi4896.SPBPB2B2.09c.1

Structurei

3D structure databases

ProteinModelPortaliQ9HDU6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

HOGENOMiHOG000000875
InParanoidiQ9HDU6
KOiK00077
OMAiVINACIN
OrthoDBiEOG092C5SUP
PhylomeDBiQ9HDU6

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR003710 ApbA
IPR013752 KPA_reductase
IPR013332 KPR_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02558 ApbA, 1 hit
PF08546 ApbA_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00745 apbA_panE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HDU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNTIYILGA GSIGSLLAYE LASLKSINNR VILLLRDKSR VNSFKDKNST
60 70 80 90 100
LKIDRLFEEN VPHLCCQVTA SEPSQLNVQS IENMIVTTKA GQTENALSKY
110 120 130 140 150
LPYLSKNSNI LFVQNGMGAV ENVCGKLWPE EQNKPSIYQG VISHGCFQTA
160 170 180 190 200
PFHFSHAGLG DLKISKVPKN PKKILPDEAA ETPCEMIKSL GKSELLRLRY
210 220 230 240 250
MNYPELLVNQ CEKLVINACI NPTTATLDCV NGELYNDESA KELFRCIIKE
260 270 280 290 300
CVDIFFKCIP LFKNNEEAEK ILNVNRLLDR VMFVGTKVNG ANSSSTRQDC
310 320 330 340 350
LLLRETEIDA INGYVVKLAE NNGFQATVNK TMMLLTKSRL GLNRCRAHAR
Length:350
Mass (Da):39,114
Last modified:March 1, 2001 - v1
Checksum:i1129E750CB1BA754
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAC21411.1
RefSeqiNP_596855.1, NM_001023878.2

Genome annotation databases

EnsemblFungiiSPBPB2B2.09c.1; SPBPB2B2.09c.1:pep; SPBPB2B2.09c
GeneIDi2541389
KEGGispo:SPBPB2B2.09c

Entry informationi

Entry nameiPANE_SCHPO
AccessioniPrimary (citable) accession number: Q9HDU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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