Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9HDU6

- PANE_SCHPO

UniProt

Q9HDU6 - PANE_SCHPO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable 2-dehydropantoate 2-reductase

Gene

SPBPB2B2.09c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei115 – 1151NADP; via amide nitrogenBy similarity
Binding sitei115 – 1151SubstrateBy similarity
Active sitei213 – 2131Proton donorBy similarity
Binding sitei217 – 2171SubstrateBy similarity
Binding sitei221 – 2211SubstrateBy similarity
Binding sitei295 – 2951SubstrateBy similarity
Binding sitei307 – 3071NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146NADPBy similarity

GO - Molecular functioni

  1. 2-dehydropantoate 2-reductase activity Source: PomBase
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pantothenate biosynthetic process Source: PomBase
  2. pyrimidine nucleotide biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis, Pyrimidine biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
ORF Names:SPBPB2B2.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBPB2B2.09c.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Probable 2-dehydropantoate 2-reductasePRO_0000157327Add
BLAST

Proteomic databases

MaxQBiQ9HDU6.

Interactioni

Protein-protein interaction databases

BioGridi277900. 50 interactions.
MINTiMINT-4702481.
STRINGi4896.SPBPB2B2.09c-1.

Structurei

3D structure databases

ProteinModelPortaliQ9HDU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000000875.
InParanoidiQ9HDU6.
KOiK00077.
OMAiGAVGCHI.
OrthoDBiEOG7VQJPR.
PhylomeDBiQ9HDU6.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HDU6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNTIYILGA GSIGSLLAYE LASLKSINNR VILLLRDKSR VNSFKDKNST
60 70 80 90 100
LKIDRLFEEN VPHLCCQVTA SEPSQLNVQS IENMIVTTKA GQTENALSKY
110 120 130 140 150
LPYLSKNSNI LFVQNGMGAV ENVCGKLWPE EQNKPSIYQG VISHGCFQTA
160 170 180 190 200
PFHFSHAGLG DLKISKVPKN PKKILPDEAA ETPCEMIKSL GKSELLRLRY
210 220 230 240 250
MNYPELLVNQ CEKLVINACI NPTTATLDCV NGELYNDESA KELFRCIIKE
260 270 280 290 300
CVDIFFKCIP LFKNNEEAEK ILNVNRLLDR VMFVGTKVNG ANSSSTRQDC
310 320 330 340 350
LLLRETEIDA INGYVVKLAE NNGFQATVNK TMMLLTKSRL GLNRCRAHAR
Length:350
Mass (Da):39,114
Last modified:March 1, 2001 - v1
Checksum:i1129E750CB1BA754
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAC21411.1.
RefSeqiNP_596855.1. NM_001023878.2.

Genome annotation databases

EnsemblFungiiSPBPB2B2.09c.1; SPBPB2B2.09c.1:pep; SPBPB2B2.09c.
GeneIDi2541389.
KEGGispo:SPBPB2B2.09c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAC21411.1 .
RefSeqi NP_596855.1. NM_001023878.2.

3D structure databases

ProteinModelPortali Q9HDU6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277900. 50 interactions.
MINTi MINT-4702481.
STRINGi 4896.SPBPB2B2.09c-1.

Proteomic databases

MaxQBi Q9HDU6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBPB2B2.09c.1 ; SPBPB2B2.09c.1:pep ; SPBPB2B2.09c .
GeneIDi 2541389.
KEGGi spo:SPBPB2B2.09c.

Organism-specific databases

PomBasei SPBPB2B2.09c.

Phylogenomic databases

eggNOGi COG1893.
HOGENOMi HOG000000875.
InParanoidi Q9HDU6.
KOi K00077.
OMAi GAVGCHI.
OrthoDBi EOG7VQJPR.
PhylomeDBi Q9HDU6.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00004 .

Miscellaneous databases

NextBioi 20802498.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPANE_SCHPO
AccessioniPrimary (citable) accession number: Q9HDU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3