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Q9HDU6

- PANE_SCHPO

UniProt

Q9HDU6 - PANE_SCHPO

Protein

Probable 2-dehydropantoate 2-reductase

Gene

SPBPB2B2.09c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

    Catalytic activityi

    (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei115 – 1151NADP; via amide nitrogenBy similarity
    Binding sitei115 – 1151SubstrateBy similarity
    Active sitei213 – 2131Proton donorBy similarity
    Binding sitei217 – 2171SubstrateBy similarity
    Binding sitei221 – 2211SubstrateBy similarity
    Binding sitei295 – 2951SubstrateBy similarity
    Binding sitei307 – 3071NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 146NADPBy similarity

    GO - Molecular functioni

    1. 2-dehydropantoate 2-reductase activity Source: PomBase
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pantothenate biosynthetic process Source: PomBase
    2. pyrimidine nucleotide biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pantothenate biosynthesis, Pyrimidine biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00028; UER00004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 2-dehydropantoate 2-reductase (EC:1.1.1.169)
    Alternative name(s):
    Ketopantoate reductase
    Short name:
    KPA reductase
    Short name:
    KPR
    Gene namesi
    ORF Names:SPBPB2B2.09c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBPB2B2.09c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 350350Probable 2-dehydropantoate 2-reductasePRO_0000157327Add
    BLAST

    Proteomic databases

    MaxQBiQ9HDU6.

    Interactioni

    Protein-protein interaction databases

    BioGridi277900. 50 interactions.
    MINTiMINT-4702481.
    STRINGi4896.SPBPB2B2.09c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HDU6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketopantoate reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG1893.
    HOGENOMiHOG000000875.
    KOiK00077.
    OMAiGAVGCHI.
    OrthoDBiEOG7VQJPR.
    PhylomeDBiQ9HDU6.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9HDU6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNTIYILGA GSIGSLLAYE LASLKSINNR VILLLRDKSR VNSFKDKNST    50
    LKIDRLFEEN VPHLCCQVTA SEPSQLNVQS IENMIVTTKA GQTENALSKY 100
    LPYLSKNSNI LFVQNGMGAV ENVCGKLWPE EQNKPSIYQG VISHGCFQTA 150
    PFHFSHAGLG DLKISKVPKN PKKILPDEAA ETPCEMIKSL GKSELLRLRY 200
    MNYPELLVNQ CEKLVINACI NPTTATLDCV NGELYNDESA KELFRCIIKE 250
    CVDIFFKCIP LFKNNEEAEK ILNVNRLLDR VMFVGTKVNG ANSSSTRQDC 300
    LLLRETEIDA INGYVVKLAE NNGFQATVNK TMMLLTKSRL GLNRCRAHAR 350
    Length:350
    Mass (Da):39,114
    Last modified:March 1, 2001 - v1
    Checksum:i1129E750CB1BA754
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAC21411.1.
    RefSeqiNP_596855.1. NM_001023878.2.

    Genome annotation databases

    EnsemblFungiiSPBPB2B2.09c.1; SPBPB2B2.09c.1:pep; SPBPB2B2.09c.
    GeneIDi2541389.
    KEGGispo:SPBPB2B2.09c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAC21411.1 .
    RefSeqi NP_596855.1. NM_001023878.2.

    3D structure databases

    ProteinModelPortali Q9HDU6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277900. 50 interactions.
    MINTi MINT-4702481.
    STRINGi 4896.SPBPB2B2.09c-1.

    Proteomic databases

    MaxQBi Q9HDU6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBPB2B2.09c.1 ; SPBPB2B2.09c.1:pep ; SPBPB2B2.09c .
    GeneIDi 2541389.
    KEGGi spo:SPBPB2B2.09c.

    Organism-specific databases

    PomBasei SPBPB2B2.09c.

    Phylogenomic databases

    eggNOGi COG1893.
    HOGENOMi HOG000000875.
    KOi K00077.
    OMAi GAVGCHI.
    OrthoDBi EOG7VQJPR.
    PhylomeDBi Q9HDU6.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00004 .

    Miscellaneous databases

    NextBioi 20802498.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiPANE_SCHPO
    AccessioniPrimary (citable) accession number: Q9HDU6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3