Reviewed, UniProtKB/Swiss-Prot Q9HDU5 (GAL7_SCHPO)

Names and origin

Protein names

Recommended name:
    Galactose-1-phosphate uridylyltransferase
      Short name=Gal-1-P uridylyltransferase
    EC=2.7.7.12
Alternative name(s):
    UDP-glucose--hexose-1-phosphate uridylyltransferase

Gene names

Name:	gal7
ORF Names:	SPBPB2B2.10c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Pathway	Carbohydrate metabolism; galactose metabolism.
Sequence similarities	Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Ligand	Iron Metal-binding Zinc
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular response to stress Inferred from expression pattern. Source: GeneDB_SPombe galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_SPombe nucleus Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	UDP-glucose:hexose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 369	369	Galactose-1-phosphate uridylyltransferase		PRO_0000169891
Sites
	Active site	185	1	Tele-UMP-histidine intermediate By similarity
	Metal binding	54	1	Zinc By similarity
	Metal binding	57	1	Zinc By similarity
	Metal binding	127	1	Zinc By similarity
	Metal binding	183	1	Zinc By similarity
	Metal binding	201	1	Iron By similarity
	Metal binding	300	1	Iron By similarity
	Metal binding	317	1	Iron By similarity
	Metal binding	319	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9HDU5-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: B075514E2F9FDC63	FASTA	369	42,822
	10 20 30 40 50 60 MTSKKFDFTE YSHRRYNPLT DSYVLCSPHR AKRPWQGAKE EIKKDDTVKY DPTCYLCPGN 70 80 90 100 110 120 IRATGFENPK YETTYVFPND YPAVRVDQPD YMQDESEITK GNTLKTRMFK TEGVKGKCFV 130 140 150 160 170 180 ICFCPNHNLT LPLMSAEAIC NVVETWKHLY VTLKKESLEG PIRYKYLQIF ENKGSAMGCS 190 200 210 220 230 240 NPHPHGQAWC LDVIPSVVAQ EMCNMTKYFE LNNSHLLGDY VKLEMLEKER IVVENDSFIV 250 260 270 280 290 300 VVPYWALWPF ETLLIAKEHL KSLEEFEEKQ KVDLASALKM LTTKYDNLFN TSFPYSMGLH 310 320 330 340 350 360 QAPLYGSNEE VENSWFHMHF YPPLLRSATV KKFCVGFEML GEPQRDLTSE QAAARLQELD GQKHYKNLL

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329671 Genomic DNA. Translation: CAC21412.1.
RefSeq	NP_596856.1.
3D structure databases
SMR	Q9HDU5. Positions 5-367.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9HDU5.
Genome annotation databases
GeneID	2541407.
GenomeReviews	Gene locus gal7 in contig CU329671_GR.
KEGG	spo:SPBPB2B2.10c.
NMPDR	fig|4896.1.peg.2722.
Organism-specific databases
GeneDB_Spombe	SPBPB2B2.10c.
Phylogenomic databases
eggNOG	fuNOG06817.
HOGENOM	HBG600409.
OMA	HRRLNPL.
OrthoDB	EOG9Q2FXT.
PhylomeDB	Q9HDU5.
Enzyme and pathway databases
BRENDA	2.7.7.12. 653.
Gene expression databases
ArrayExpress	Q9HDU5.
Family and domain databases
InterPro	IPR001937. GalP_UDPtransf1. IPR019779. GalP_UDPtransf1_His-AS. IPR005850. GalP_Utransf_C. IPR005849. GalP_Utransf_N. IPR011146. His_triad-like_motif. IPR011151. His_triad_motif. [Graphical view]
Gene3D	G3DSA:3.30.428.10. His_triad_motif. 2 hits.
PANTHER	PTHR11943. GalP_UDPtransf1. 1 hit.
Pfam	PF02744. GalP_UDP_tr_C. 1 hit. PF01087. GalP_UDP_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000808. GalT. 1 hit.
TIGRFAMs	TIGR00209. galT_1. 1 hit.
PROSITE	PS00117. GAL_P_UDP_TRANSF_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAL7_SCHPO

Accession

Primary (citable) accession number: Q9HDU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	March 1, 2001
Last modified:	February 9, 2010
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)