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Protein

Bifunctional protein gal10

Gene

gal10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity).By similarity

Catalytic activityi

UDP-alpha-D-glucose = UDP-alpha-D-galactose.
Alpha-D-glucose = beta-D-glucose.PROSITE-ProRule annotation

Cofactori

Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Pathwayi: hexose metabolism

This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei532For mutarotase activitySequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 38NADSequence analysisAdd BLAST32

GO - Molecular functioni

GO - Biological processi

  • galactose metabolic process Source: PomBase
  • protein galactosylation Source: PomBase

Keywordsi

Molecular functionIsomerase, Multifunctional enzyme
Biological processCarbohydrate metabolism, Galactose metabolism
LigandNAD

Enzyme and pathway databases

BRENDAi5.1.3.2 5613
ReactomeiR-SPO-70370 Galactose catabolism
UniPathwayiUPA00214
UPA00242

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein gal10
Including the following 2 domains:
UDP-glucose 4-epimerase (EC:5.1.3.2)
Alternative name(s):
Galactowaldenase
Aldose 1-epimerase (EC:5.1.3.3)
Alternative name(s):
Galactose mutarotase
Gene namesi
Name:gal10
ORF Names:SPBPB2B2.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBPB2B2.12c
PomBaseiSPBPB2B2.12c gal10

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001974411 – 713Bifunctional protein gal10Add BLAST713

Proteomic databases

MaxQBiQ9HDU3
PaxDbiQ9HDU3
PRIDEiQ9HDU3

PTM databases

iPTMnetiQ9HDU3

Interactioni

Protein-protein interaction databases

BioGridi277919, 5 interactors
STRINGi4896.SPBPB2B2.12c.1

Structurei

3D structure databases

ProteinModelPortaliQ9HDU3
SMRiQ9HDU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 350GalactowaldenaseAdd BLAST350
Regioni351 – 713MutarotaseAdd BLAST363

Sequence similaritiesi

In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.Curated
In the C-terminal section; belongs to the aldose epimerase family.Curated

Phylogenomic databases

HOGENOMiHOG000247896
InParanoidiQ9HDU3
KOiK01784
K01785
OMAiYREWNLG
OrthoDBiEOG092C4CZ3
PhylomeDBiQ9HDU3

Family and domain databases

CDDicd05247 UDP_G4E_1_SDR_e, 1 hit
Gene3Di2.70.98.10, 1 hit
InterProiView protein in InterPro
IPR018052 Ald1_epimerase_CS
IPR008183 Aldose_1/G6P_1-epimerase
IPR011013 Gal_mutarotase_sf_dom
IPR014718 GH-type_carb-bd
IPR016040 NAD(P)-bd_dom
IPR036291 NAD(P)-bd_dom_sf
IPR005886 UDP_G4E
PfamiView protein in Pfam
PF01263 Aldose_epim, 1 hit
PF16363 GDP_Man_Dehyd, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF74650 SSF74650, 1 hit
TIGRFAMsiTIGR01179 galE, 1 hit
PROSITEiView protein in PROSITE
PS00545 ALDOSE_1_EPIMERASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HDU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVQDEYILV TGGAGYIGSH TVIELINHGY KVIIVDNLCN SCYDAVARVE
60 70 80 90 100
FIVRKSIKFF KLDLRDKEGL AQIFDTFKIK GVIHFAALKA VGESMKLPLE
110 120 130 140 150
YYDNNICGTI TLLNVMREHR VKTVVFSSSA TVYGDATRFD NMIPIPESCP
160 170 180 190 200
NDPTNPYGKT KYAIENIIKD LHTSDNTWRG AILRYFNPIG AHPSGLLGED
210 220 230 240 250
PLGIPNNLLP FLAQVAIGRR EKLLVFGDDY DSHDGTPIRD YIHVVDLAKG
260 270 280 290 300
HIAALNYLNK INNSEGMYRE WNLGTGKGSS VFDIYHAFCK EVGKDLPYEV
310 320 330 340 350
VGRRTGDVLN LTASPNRANS ELKWKAELSI TDACRDLWKW TIENPFGFQI
360 370 380 390 400
DNYKWKLFNT LGIMDYKNRL HTICFQDLEV SIANYGALVQ AVRYKGRNLV
410 420 430 440 450
NGFNDFSRYK LKENPFFGAT IGRFANRIAN GQFEVDGHLY TLCKNENNKT
460 470 480 490 500
TLHGGNNGFD KQFFLGPIAR QYEDYNTLEF ILVDKDGNNG FPSDLETLVK
510 520 530 540 550
YTIKNNSLEI EYKSVIPEYS KLNVTAVNLT NHSYWNLASP NKTIDGTIIK
560 570 580 590 600
STTNVYLKVN SETSLPTGDI VEWQNDITKP TKLDPNISFD NCFIVDREAS
610 620 630 640 650
KFCLDTRKYS LKNIVEVIHP SVPVKLVVST TEPAFQLYTG DGNDICEFQS
660 670 680 690 700
RSGFCVETGR FINALNNEKW SKQVILRKGE VYGARSKFSL YAQDLEENKH
710
FLDSASYNSG EYY
Length:713
Mass (Da):80,666
Last modified:March 1, 2001 - v1
Checksum:i51C89DA0843A8556
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAC21414.1
RefSeqiNP_596858.1, NM_001023881.2

Genome annotation databases

EnsemblFungiiSPBPB2B2.12c.1; SPBPB2B2.12c.1:pep; SPBPB2B2.12c
GeneIDi2541411
KEGGispo:SPBPB2B2.12c

Similar proteinsi

Entry informationi

Entry nameiGAL10_SCHPO
AccessioniPrimary (citable) accession number: Q9HDU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health