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Protein

Bifunctional protein gal10

Gene

gal10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity).By similarity

Catalytic activityi

UDP-alpha-D-glucose = UDP-alpha-D-galactose.
Alpha-D-glucose = beta-D-glucose.PROSITE-ProRule annotation

Cofactori

Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Pathwayi: hexose metabolism

This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei532 – 5321For mutarotase activitySequence analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 3832NADSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • galactose metabolic process Source: PomBase
  • protein galactosylation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Galactose metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi5.1.3.2. 5613.
ReactomeiR-SPO-70370. Galactose catabolism.
UniPathwayiUPA00214.
UPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein gal10
Including the following 2 domains:
UDP-glucose 4-epimerase (EC:5.1.3.2)
Alternative name(s):
Galactowaldenase
Aldose 1-epimerase (EC:5.1.3.3)
Alternative name(s):
Galactose mutarotase
Gene namesi
Name:gal10
ORF Names:SPBPB2B2.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBPB2B2.12c.
PomBaseiSPBPB2B2.12c. gal10.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 713713Bifunctional protein gal10PRO_0000197441Add
BLAST

Proteomic databases

MaxQBiQ9HDU3.

Interactioni

Protein-protein interaction databases

BioGridi277919. 5 interactions.
MINTiMINT-4702446.

Structurei

3D structure databases

ProteinModelPortaliQ9HDU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 350350GalactowaldenaseAdd
BLAST
Regioni351 – 713363MutarotaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.Curated
In the C-terminal section; belongs to the aldose epimerase family.Curated

Phylogenomic databases

HOGENOMiHOG000247896.
InParanoidiQ9HDU3.
KOiK01784.
K01785.
OMAiDLWKWTT.
OrthoDBiEOG77T1F2.
PhylomeDBiQ9HDU3.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR018052. Ald1_epimerase_CS.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR005886. GalE.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
PF16363. GDP_Man_Dehyd. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF74650. SSF74650. 1 hit.
TIGRFAMsiTIGR01179. galE. 1 hit.
PROSITEiPS00545. ALDOSE_1_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HDU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVQDEYILV TGGAGYIGSH TVIELINHGY KVIIVDNLCN SCYDAVARVE
60 70 80 90 100
FIVRKSIKFF KLDLRDKEGL AQIFDTFKIK GVIHFAALKA VGESMKLPLE
110 120 130 140 150
YYDNNICGTI TLLNVMREHR VKTVVFSSSA TVYGDATRFD NMIPIPESCP
160 170 180 190 200
NDPTNPYGKT KYAIENIIKD LHTSDNTWRG AILRYFNPIG AHPSGLLGED
210 220 230 240 250
PLGIPNNLLP FLAQVAIGRR EKLLVFGDDY DSHDGTPIRD YIHVVDLAKG
260 270 280 290 300
HIAALNYLNK INNSEGMYRE WNLGTGKGSS VFDIYHAFCK EVGKDLPYEV
310 320 330 340 350
VGRRTGDVLN LTASPNRANS ELKWKAELSI TDACRDLWKW TIENPFGFQI
360 370 380 390 400
DNYKWKLFNT LGIMDYKNRL HTICFQDLEV SIANYGALVQ AVRYKGRNLV
410 420 430 440 450
NGFNDFSRYK LKENPFFGAT IGRFANRIAN GQFEVDGHLY TLCKNENNKT
460 470 480 490 500
TLHGGNNGFD KQFFLGPIAR QYEDYNTLEF ILVDKDGNNG FPSDLETLVK
510 520 530 540 550
YTIKNNSLEI EYKSVIPEYS KLNVTAVNLT NHSYWNLASP NKTIDGTIIK
560 570 580 590 600
STTNVYLKVN SETSLPTGDI VEWQNDITKP TKLDPNISFD NCFIVDREAS
610 620 630 640 650
KFCLDTRKYS LKNIVEVIHP SVPVKLVVST TEPAFQLYTG DGNDICEFQS
660 670 680 690 700
RSGFCVETGR FINALNNEKW SKQVILRKGE VYGARSKFSL YAQDLEENKH
710
FLDSASYNSG EYY
Length:713
Mass (Da):80,666
Last modified:March 1, 2001 - v1
Checksum:i51C89DA0843A8556
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAC21414.1.
RefSeqiNP_596858.1. NM_001023881.2.

Genome annotation databases

EnsemblFungiiSPBPB2B2.12c.1; SPBPB2B2.12c.1:pep; SPBPB2B2.12c.
GeneIDi2541411.
KEGGispo:SPBPB2B2.12c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAC21414.1.
RefSeqiNP_596858.1. NM_001023881.2.

3D structure databases

ProteinModelPortaliQ9HDU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277919. 5 interactions.
MINTiMINT-4702446.

Proteomic databases

MaxQBiQ9HDU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBPB2B2.12c.1; SPBPB2B2.12c.1:pep; SPBPB2B2.12c.
GeneIDi2541411.
KEGGispo:SPBPB2B2.12c.

Organism-specific databases

EuPathDBiFungiDB:SPBPB2B2.12c.
PomBaseiSPBPB2B2.12c. gal10.

Phylogenomic databases

HOGENOMiHOG000247896.
InParanoidiQ9HDU3.
KOiK01784.
K01785.
OMAiDLWKWTT.
OrthoDBiEOG77T1F2.
PhylomeDBiQ9HDU3.

Enzyme and pathway databases

UniPathwayiUPA00214.
UPA00242.
BRENDAi5.1.3.2. 5613.
ReactomeiR-SPO-70370. Galactose catabolism.

Miscellaneous databases

PROiQ9HDU3.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR018052. Ald1_epimerase_CS.
IPR008183. Aldose_1/G6P_1-epimerase.
IPR011013. Gal_mutarotase_SF_dom.
IPR005886. GalE.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01263. Aldose_epim. 1 hit.
PF16363. GDP_Man_Dehyd. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF74650. SSF74650. 1 hit.
TIGRFAMsiTIGR01179. galE. 1 hit.
PROSITEiPS00545. ALDOSE_1_EPIMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiGAL10_SCHPO
AccessioniPrimary (citable) accession number: Q9HDU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.