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Protein

Galactokinase

Gene

gal1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + alpha-D-galactose = ADP + alpha-D-galactose 1-phosphate.

Pathwayi: galactose metabolism

This protein is involved in the pathway galactose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway galactose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei47Transition state stabilizerBy similarity1
Active sitei209Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi157 – 167ATPSequence analysisAdd BLAST11

GO - Molecular functioni

GO - Biological processi

  • galactose catabolic process via UDP-galactose Source: PomBase
  • galactose metabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Galactose metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00214.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactokinase (EC:2.7.1.6)
Alternative name(s):
Galactose kinase
Gene namesi
Name:gal1
ORF Names:SPBPB2B2.13
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBPB2B2.13.
PomBaseiSPBPB2B2.13. gal1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001846561 – 519GalactokinaseAdd BLAST519

Proteomic databases

MaxQBiQ9HDU2.
PRIDEiQ9HDU2.

Interactioni

Protein-protein interaction databases

BioGridi277891. 36 interactors.
MINTiMINT-4702433.

Structurei

3D structure databases

ProteinModelPortaliQ9HDU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GHMP kinase family. GalK subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000241099.
InParanoidiQ9HDU2.
KOiK00849.
OMAiFMLRQRA.
OrthoDBiEOG092C193C.
PhylomeDBiQ9HDU2.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 2 hits.
InterProiIPR000705. Galactokinase.
IPR019741. Galactokinase_CS.
IPR019539. GalKase_gal-bd.
IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10457. PTHR10457. 2 hits.
PfamiPF10509. GalKase_gal_bdg. 1 hit.
PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000530. Galactokinase. 1 hit.
PRINTSiPR00473. GALCTOKINASE.
PR00959. MEVGALKINASE.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 2 hits.
TIGRFAMsiTIGR00131. gal_kin. 1 hit.
PROSITEiPS00106. GALACTOKINASE. 1 hit.
PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HDU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVPTYHDL SFYSNPKENK ARYAKLLNSF EQKYHCKPDF FSRSPGRVNI
60 70 80 90 100
IGEHIDYNYF SVLPMAIDVD VIVSVTTSDD AKVELNNTNP EFKEEILELP
110 120 130 140 150
SDGAVIEINK THHTWGNYFR CSMIVAHKYI LEKYPELVSG GKKPLKGLKL
160 170 180 190 200
IFDGNVPTGG GLSSSAAFCV ASILAILKAN GINTITKEDL VKISVVSEHY
210 220 230 240 250
VGVNTGGMDQ CASIYGEQNK ALLVQFKPKL MATPFKMPVL KPHDMVFLIS
260 270 280 290 300
NTLVEANKQE TALTNYNLRV VEMAVASEFL AKKFNLELPK ESNLHTGTLR
310 320 330 340 350
GFMDEYYEKH LKQPHWDGSD IDMGVQRMQE MLRLTEIMFS EEQKVGFKTE
360 370 380 390 400
ELAKELGLSV EEFTKVFLTK IPVKYERMKI YQRTVHVYSD AMRVLQVLKL
410 420 430 440 450
FHQHKDSDDP QKFMLAFGRL LNDSQRSEDI YNNSSSPELR EVCKISLANG
460 470 480 490 500
GYGARTTGAG WGGSAVHLTT HDKLAKLVEA LTEQYYKKQF PKITQSELNA
510
AVVVSKPAAG SCIVQLAEY
Length:519
Mass (Da):58,385
Last modified:March 1, 2001 - v1
Checksum:i5EE9C129896F8C40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAC21415.1.
RefSeqiNP_596859.1. NM_001023882.2.

Genome annotation databases

EnsemblFungiiSPBPB2B2.13.1; SPBPB2B2.13.1:pep; SPBPB2B2.13.
GeneIDi2541380.
KEGGispo:SPBPB2B2.13.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAC21415.1.
RefSeqiNP_596859.1. NM_001023882.2.

3D structure databases

ProteinModelPortaliQ9HDU2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277891. 36 interactors.
MINTiMINT-4702433.

Proteomic databases

MaxQBiQ9HDU2.
PRIDEiQ9HDU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBPB2B2.13.1; SPBPB2B2.13.1:pep; SPBPB2B2.13.
GeneIDi2541380.
KEGGispo:SPBPB2B2.13.

Organism-specific databases

EuPathDBiFungiDB:SPBPB2B2.13.
PomBaseiSPBPB2B2.13. gal1.

Phylogenomic databases

HOGENOMiHOG000241099.
InParanoidiQ9HDU2.
KOiK00849.
OMAiFMLRQRA.
OrthoDBiEOG092C193C.
PhylomeDBiQ9HDU2.

Enzyme and pathway databases

UniPathwayiUPA00214.

Miscellaneous databases

PROiQ9HDU2.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 2 hits.
InterProiIPR000705. Galactokinase.
IPR019741. Galactokinase_CS.
IPR019539. GalKase_gal-bd.
IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10457. PTHR10457. 2 hits.
PfamiPF10509. GalKase_gal_bdg. 1 hit.
PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000530. Galactokinase. 1 hit.
PRINTSiPR00473. GALCTOKINASE.
PR00959. MEVGALKINASE.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 2 hits.
TIGRFAMsiTIGR00131. gal_kin. 1 hit.
PROSITEiPS00106. GALACTOKINASE. 1 hit.
PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAL1_SCHPO
AccessioniPrimary (citable) accession number: Q9HDU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.