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Protein

Enolase

Gene

ENO

Organism
Alternaria alternata (Alternaria rot fungus) (Torula alternata)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

2-phospho-D-glycerate = phosphoenolpyruvate + H2O.

Cofactori

Mg2+By similarityNote: Mg2+ is required for catalysis and for stabilizing the dimer.By similarity

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (CC77DRAFT_1011328)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Enolase (ENO)
  5. Pyruvate kinase (CC77DRAFT_60210)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei159SubstrateBy similarity1
Binding sitei168SubstrateBy similarity1
Active sitei211Proton donorBy similarity1
Metal bindingi246MagnesiumBy similarity1
Metal bindingi297MagnesiumBy similarity1
Binding sitei297SubstrateBy similarity1
Metal bindingi322MagnesiumBy similarity1
Binding sitei322SubstrateBy similarity1
Active sitei347Proton acceptorBy similarity1
Binding sitei398SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00187

Names & Taxonomyi

Protein namesi
Recommended name:
Enolase (EC:4.2.1.11)
Alternative name(s):
2-phospho-D-glycerate hydro-lyase
2-phosphoglycerate dehydratase
Allergen Alt a 11
Allergen Alt a 5
Allergen Alt a XI
Allergen: Alt a 6
Gene namesi
Name:ENO
Synonyms:ALTA11, ALTA6
OrganismiAlternaria alternata (Alternaria rot fungus) (Torula alternata)
Taxonomic identifieri5599 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeAlternariaAlternaria alternata group

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.2 Publications

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei14 Alt a 6
3063 Alt a 6.0101

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001340391 – 438EnolaseAdd BLAST438

Proteomic databases

PRIDEiQ9HDT3

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9HDT3
SMRiQ9HDT3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni374 – 377Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the enolase family.Curated

Phylogenomic databases

KOiK01689

Family and domain databases

CDDicd03313 enolase, 1 hit
Gene3Di3.20.20.120, 1 hit
3.30.390.10, 1 hit
HAMAPiMF_00318 Enolase, 1 hit
InterProiView protein in InterPro
IPR000941 Enolase
IPR036849 Enolase-like_C_sf
IPR029017 Enolase-like_N
IPR034390 Enolase-like_superfamily
IPR020810 Enolase_C
IPR020809 Enolase_CS
IPR020811 Enolase_N
PANTHERiPTHR11902 PTHR11902, 1 hit
PfamiView protein in Pfam
PF00113 Enolase_C, 1 hit
PF03952 Enolase_N, 1 hit
PIRSFiPIRSF001400 Enolase, 1 hit
PRINTSiPR00148 ENOLASE
SFLDiSFLDG00178 enolase, 1 hit
SFLDS00001 Enolase, 1 hit
SMARTiView protein in SMART
SM01192 Enolase_C, 1 hit
SM01193 Enolase_N, 1 hit
SUPFAMiSSF51604 SSF51604, 1 hit
TIGRFAMsiTIGR01060 eno, 1 hit
PROSITEiView protein in PROSITE
PS00164 ENOLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HDT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITKIHARS VYDSRGNPTV EVDIVTETGL HRAIVPSGAS TGSHEACELR
60 70 80 90 100
DGDKSKWGGK GVTKAVANVN DTIAPALIKE KLDVKDQSAV DAFLNKLDGT
110 120 130 140 150
TNKTNLGANA ILGVSMAIAK AAAAEKGVPL YAHISDLAGT KKPYVLPVPF
160 170 180 190 200
QNVLNGGSHA GGRLAFQEFM IVPCEAPTFS EAMRQGAEVY QKLKALAKKT
210 220 230 240 250
YGQSAGNVGD EGGVAPDIQT AEEALDLITK AIEEAGYTGK IKIAMDVASS
260 270 280 290 300
EFYKADEKKY DLDFKNPDSD KSKWLTYEQL AEMYKSLAEK YPIVSIEDPF
310 320 330 340 350
AEDDWEAWSY FFKTYDGQIV GDDLTVTNPE FIKKAIELKS CNALLLKVNQ
360 370 380 390 400
IGTITEAIQA AKDAFGAGWG VMVSHRSGET EDVTIADIVV GLRSGQIKTG
410 420 430
APARSERLAK LNQILRIEEE LGDNAVYAGN NFRTAVNL
Length:438
Mass (Da):47,205
Last modified:June 20, 2001 - v2
Checksum:iD60900100A72AF83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82437 mRNA Translation: AAG42022.2
RefSeqiXP_018379265.1, XM_018535292.1

Genome annotation databases

GeneIDi29120886
KEGGiaalt:CC77DRAFT_949988

Similar proteinsi

Entry informationi

Entry nameiENO_ALTAL
AccessioniPrimary (citable) accession number: Q9HDT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: May 23, 2018
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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