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Q9HDD0

- HRSL1_HUMAN

UniProt

Q9HDD0 - HRSL1_HUMAN

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Protein

Phospholipid-metabolizing enzyme A-C1

Gene

HRASLS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei30 – 301By similarity
Active sitei119 – 1191Acyl-thioester intermediateBy similarity

GO - Molecular functioni

  1. phospholipase activity Source: Ensembl
  2. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. ether lipid metabolic process Source: Ensembl
  2. lipid catabolic process Source: UniProtKB-KW
  3. peroxisome organization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-metabolizing enzyme A-C1 (EC:2.3.1.-, EC:3.1.1.-)
Alternative name(s):
HRAS-like suppressor 1
Short name:
HRSL1
Gene namesi
Name:HRASLS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:14922. HRASLS.

Subcellular locationi

Membrane By similarity; Single-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nuclear envelope lumen Source: Ensembl
  3. peroxisome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29445.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 168168Phospholipid-metabolizing enzyme A-C1PRO_0000152481Add
BLAST

Proteomic databases

PaxDbiQ9HDD0.
PRIDEiQ9HDD0.

Expressioni

Tissue specificityi

Abundantly expressed in testis, skeletal muscle, brain, and heart.1 Publication

Gene expression databases

BgeeiQ9HDD0.
CleanExiHS_HRASLS.
ExpressionAtlasiQ9HDD0. baseline and differential.
GenevestigatoriQ9HDD0.

Organism-specific databases

HPAiHPA051179.

Interactioni

Protein-protein interaction databases

BioGridi121376. 1 interaction.
STRINGi9606.ENSP00000264735.

Structurei

3D structure databases

ProteinModelPortaliQ9HDD0.
SMRiQ9HDD0. Positions 15-129.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 139139CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini164 – 1685LumenalSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei140 – 16324HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the H-rev107 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43478.
HOGENOMiHOG000293227.
HOVERGENiHBG028837.
InParanoidiQ9HDD0.
OrthoDBiEOG7B8S59.
PhylomeDBiQ9HDD0.
TreeFamiTF330836.

Family and domain databases

InterProiIPR007053. LRAT-like_dom.
[Graphical view]
PfamiPF04970. LRAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HDD0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFNDCFSLN YPGNPCPGDL IEVFRPGYQH WALYLGDGYV INIAPVDGIP
60 70 80 90 100
ASFTSAKSVF SSKALVKMQL LKDVVGNDTY RINNKYDETY PPLPVEEIIK
110 120 130 140 150
RSEFVIGQEV AYNLLVNNCE HFVTLLRYGE GVSEQANRAI STVEFVTAAV
160
GVFSFLGLFP KGQRAKYY
Length:168
Mass (Da):18,750
Last modified:March 1, 2001 - v1
Checksum:i11844F8B5963D39B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB030816 mRNA. Translation: BAB08110.1.
AB510981 mRNA. Translation: BAI63210.1.
CH471052 Genomic DNA. Translation: EAW78078.1.
UniGeneiHs.36761.

Genome annotation databases

EnsembliENST00000602513; ENSP00000473258; ENSG00000127252.
UCSCiuc003fta.4. human.

Polymorphism databases

DMDMi20138344.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB030816 mRNA. Translation: BAB08110.1 .
AB510981 mRNA. Translation: BAI63210.1 .
CH471052 Genomic DNA. Translation: EAW78078.1 .
UniGenei Hs.36761.

3D structure databases

ProteinModelPortali Q9HDD0.
SMRi Q9HDD0. Positions 15-129.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121376. 1 interaction.
STRINGi 9606.ENSP00000264735.

Polymorphism databases

DMDMi 20138344.

Proteomic databases

PaxDbi Q9HDD0.
PRIDEi Q9HDD0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000602513 ; ENSP00000473258 ; ENSG00000127252 .
UCSCi uc003fta.4. human.

Organism-specific databases

GeneCardsi GC03P192958.
HGNCi HGNC:14922. HRASLS.
HPAi HPA051179.
MIMi 606487. gene.
neXtProti NX_Q9HDD0.
PharmGKBi PA29445.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43478.
HOGENOMi HOG000293227.
HOVERGENi HBG028837.
InParanoidi Q9HDD0.
OrthoDBi EOG7B8S59.
PhylomeDBi Q9HDD0.
TreeFami TF330836.

Miscellaneous databases

NextBioi 13651577.
PROi Q9HDD0.
SOURCEi Search...

Gene expression databases

Bgeei Q9HDD0.
CleanExi HS_HRASLS.
ExpressionAtlasi Q9HDD0. baseline and differential.
Genevestigatori Q9HDD0.

Family and domain databases

InterProi IPR007053. LRAT-like_dom.
[Graphical view ]
Pfami PF04970. LRAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Kato S.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes."
    Shinohara N., Uyama T., Jin X.H., Tsuboi K., Tonai T., Houchi H., Ueda N.
    J. Lipid Res. 52:1927-1935(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiHRSL1_HUMAN
AccessioniPrimary (citable) accession number: Q9HDD0
Secondary accession number(s): D2KX19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3