Q9HDD0 (HRSL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phospholipid-metabolizing enzyme A-C1
EC=2.3.1.-
EC=3.1.1.-

Alternative name(s):
HRAS-like suppressor 1
Short name=HRSL1

Gene names

Name:

HRASLS

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	168 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs. Ref.2
Subcellular location	Membrane; Single-pass membrane protein By similarity.
Tissue specificity	Abundantly expressed in testis, skeletal muscle, brain, and heart. Ref.2
Sequence similarities	Belongs to the H-rev107 family.

Ontologies

Keywords
Biological process	Lipid degradation Lipid metabolism
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ether lipid metabolic process Inferred from electronic annotation. Source: Compara lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW peroxisome organization Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nuclear envelope lumen Inferred from electronic annotation. Source: Compara peroxisome Inferred from electronic annotation. Source: Compara
Molecular_function	phospholipase activity Inferred from electronic annotation. Source: Compara transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 168	168	Phospholipid-metabolizing enzyme A-C1		PRO_0000152481
Regions
	Topological domain	1 – 139	139	Cytoplasmic Potential
	Transmembrane	140 – 163	24	Helical; Potential
	Topological domain	164 – 168	5	Lumenal Potential
Sites
	Active site	30	1	By similarity
	Active site	119	1	Acyl-thioester intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9HDD0 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 11844F8B5963D39B	FASTA	168	18,750
	10 20 30 40 50 60 MAFNDCFSLN YPGNPCPGDL IEVFRPGYQH WALYLGDGYV INIAPVDGIP ASFTSAKSVF 70 80 90 100 110 120 SSKALVKMQL LKDVVGNDTY RINNKYDETY PPLPVEEIIK RSEFVIGQEV AYNLLVNNCE 130 140 150 160 HFVTLLRYGE GVSEQANRAI STVEFVTAAV GVFSFLGLFP KGQRAKYY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Kato S. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes." Shinohara N., Uyama T., Jin X.H., Tsuboi K., Tonai T., Houchi H., Ueda N. J. Lipid Res. 52:1927-1935(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[3]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB030816 mRNA. Translation: BAB08110.1. AB510981 mRNA. Translation: BAI63210.1. CH471052 Genomic DNA. Translation: EAW78078.1.
IPI	IPI00925994.
UniGene	Hs.36761.
3D structure databases
ProteinModelPortal	Q9HDD0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000264735.
Polymorphism databases
DMDM	20138344.
Proteomic databases
PaxDb	Q9HDD0.
PRIDE	Q9HDD0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264735; ENSP00000264735; ENSG00000127252.
KEGG	hsa:57110.
UCSC	uc003fta.3. human.
Organism-specific databases
GeneCards	GC03P192958.
HGNC	HGNC:14922. HRASLS.
HPA	HPA051179.
MIM	606487. gene.
neXtProt	NX_Q9HDD0.
PharmGKB	PA29445.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43478.
HOGENOM	HOG000293227.
HOVERGEN	HBG028837.
InParanoid	Q9HDD0.
OMA	GSNCEHF.
OrthoDB	EOG43N7DV.
PhylomeDB	Q9HDD0.
Gene expression databases
ArrayExpress	Q9HDD0.
Bgee	Q9HDD0.
CleanEx	HS_HRASLS.
Genevestigator	Q9HDD0.
GermOnline	ENSG00000127252. Homo sapiens.
Family and domain databases
InterPro	IPR007053. LRAT-like_dom. [Graphical view]
Pfam	PF04970. LRAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	13651577.
SOURCE	Search...

Entry information

Entry name

HRSL1_HUMAN

Accession

Primary (citable) accession number: Q9HDD0
Secondary accession number(s): D2KX19

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.