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Protein

Phospholipid-metabolizing enzyme A-C1

Gene

HRASLS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei30By similarity1
Active sitei119Acyl-thioester intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Transferase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-1482839 Acyl chain remodelling of PE

Chemistry databases

SwissLipidsiSLP:000000688

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-metabolizing enzyme A-C1 (EC:2.3.1.-, EC:3.1.1.-)
Alternative name(s):
HRAS-like suppressor 1
Short name:
HRSL1
Gene namesi
Name:HRASLS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:14922 HRASLS
MIMi606487 gene
neXtProtiNX_Q9HDD0

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 139CytoplasmicSequence analysisAdd BLAST139
Transmembranei140 – 163HelicalSequence analysisAdd BLAST24
Topological domaini164 – 168LumenalSequence analysis5

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57110
PharmGKBiPA29445

Polymorphism and mutation databases

DMDMi20138344

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001524811 – 168Phospholipid-metabolizing enzyme A-C1Add BLAST168

Proteomic databases

PaxDbiQ9HDD0
PRIDEiQ9HDD0
ProteomicsDBi81853

PTM databases

PhosphoSitePlusiQ9HDD0

Expressioni

Tissue specificityi

Abundantly expressed in testis, skeletal muscle, brain, and heart.1 Publication

Gene expression databases

CleanExiHS_HRASLS

Organism-specific databases

HPAiHPA051179

Interactioni

Protein-protein interaction databases

IntActiQ9HDD0, 2 interactors
STRINGi9606.ENSP00000264735

Structurei

3D structure databases

ProteinModelPortaliQ9HDD0
SMRiQ9HDD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the H-rev107 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWFR Eukaryota
ENOG4111G30 LUCA
HOGENOMiHOG000293227
HOVERGENiHBG028837
InParanoidiQ9HDD0
PhylomeDBiQ9HDD0
TreeFamiTF330836

Family and domain databases

InterProiView protein in InterPro
IPR007053 LRAT-like_dom
PfamiView protein in Pfam
PF04970 LRAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HDD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFNDCFSLN YPGNPCPGDL IEVFRPGYQH WALYLGDGYV INIAPVDGIP
60 70 80 90 100
ASFTSAKSVF SSKALVKMQL LKDVVGNDTY RINNKYDETY PPLPVEEIIK
110 120 130 140 150
RSEFVIGQEV AYNLLVNNCE HFVTLLRYGE GVSEQANRAI STVEFVTAAV
160
GVFSFLGLFP KGQRAKYY
Length:168
Mass (Da):18,750
Last modified:March 1, 2001 - v1
Checksum:i11844F8B5963D39B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030816 mRNA Translation: BAB08110.1
AB510981 mRNA Translation: BAI63210.1
CH471052 Genomic DNA Translation: EAW78078.1
RefSeqiXP_016862412.1, XM_017006923.1
UniGeneiHs.36761

Genome annotation databases

EnsembliENST00000602513; ENSP00000473258; ENSG00000127252
GeneIDi57110

Similar proteinsi

Entry informationi

Entry nameiHRSL1_HUMAN
AccessioniPrimary (citable) accession number: Q9HDD0
Secondary accession number(s): D2KX19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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