Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phospholipid-metabolizing enzyme A-C1

Gene

HRASLS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei30By similarity1
Active sitei119Acyl-thioester intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127252-MONOMER.
ReactomeiR-HSA-1482839. Acyl chain remodelling of PE.

Chemistry databases

SwissLipidsiSLP:000000688.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-metabolizing enzyme A-C1 (EC:2.3.1.-, EC:3.1.1.-)
Alternative name(s):
HRAS-like suppressor 1
Short name:
HRSL1
Gene namesi
Name:HRASLS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:14922. HRASLS.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 139CytoplasmicSequence analysisAdd BLAST139
Transmembranei140 – 163HelicalSequence analysisAdd BLAST24
Topological domaini164 – 168LumenalSequence analysis5

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57110.
PharmGKBiPA29445.

Polymorphism and mutation databases

DMDMi20138344.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001524811 – 168Phospholipid-metabolizing enzyme A-C1Add BLAST168

Proteomic databases

PaxDbiQ9HDD0.
PRIDEiQ9HDD0.

PTM databases

PhosphoSitePlusiQ9HDD0.

Expressioni

Tissue specificityi

Abundantly expressed in testis, skeletal muscle, brain, and heart.1 Publication

Gene expression databases

BgeeiENSG00000127252.
CleanExiHS_HRASLS.

Organism-specific databases

HPAiHPA051179.

Interactioni

Protein-protein interaction databases

IntActiQ9HDD0. 1 interactor.
STRINGi9606.ENSP00000264735.

Structurei

3D structure databases

ProteinModelPortaliQ9HDD0.
SMRiQ9HDD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the H-rev107 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWFR. Eukaryota.
ENOG4111G30. LUCA.
HOGENOMiHOG000293227.
HOVERGENiHBG028837.
InParanoidiQ9HDD0.
PhylomeDBiQ9HDD0.
TreeFamiTF330836.

Family and domain databases

InterProiIPR007053. LRAT-like_dom.
[Graphical view]
PfamiPF04970. LRAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HDD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFNDCFSLN YPGNPCPGDL IEVFRPGYQH WALYLGDGYV INIAPVDGIP
60 70 80 90 100
ASFTSAKSVF SSKALVKMQL LKDVVGNDTY RINNKYDETY PPLPVEEIIK
110 120 130 140 150
RSEFVIGQEV AYNLLVNNCE HFVTLLRYGE GVSEQANRAI STVEFVTAAV
160
GVFSFLGLFP KGQRAKYY
Length:168
Mass (Da):18,750
Last modified:March 1, 2001 - v1
Checksum:i11844F8B5963D39B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030816 mRNA. Translation: BAB08110.1.
AB510981 mRNA. Translation: BAI63210.1.
CH471052 Genomic DNA. Translation: EAW78078.1.
RefSeqiXP_016862412.1. XM_017006923.1.
UniGeneiHs.36761.

Genome annotation databases

EnsembliENST00000602513; ENSP00000473258; ENSG00000127252.
GeneIDi57110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030816 mRNA. Translation: BAB08110.1.
AB510981 mRNA. Translation: BAI63210.1.
CH471052 Genomic DNA. Translation: EAW78078.1.
RefSeqiXP_016862412.1. XM_017006923.1.
UniGeneiHs.36761.

3D structure databases

ProteinModelPortaliQ9HDD0.
SMRiQ9HDD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9HDD0. 1 interactor.
STRINGi9606.ENSP00000264735.

Chemistry databases

SwissLipidsiSLP:000000688.

PTM databases

PhosphoSitePlusiQ9HDD0.

Polymorphism and mutation databases

DMDMi20138344.

Proteomic databases

PaxDbiQ9HDD0.
PRIDEiQ9HDD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000602513; ENSP00000473258; ENSG00000127252.
GeneIDi57110.

Organism-specific databases

DisGeNETi57110.
GeneCardsiHRASLS.
HGNCiHGNC:14922. HRASLS.
HPAiHPA051179.
MIMi606487. gene.
neXtProtiNX_Q9HDD0.
PharmGKBiPA29445.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWFR. Eukaryota.
ENOG4111G30. LUCA.
HOGENOMiHOG000293227.
HOVERGENiHBG028837.
InParanoidiQ9HDD0.
PhylomeDBiQ9HDD0.
TreeFamiTF330836.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127252-MONOMER.
ReactomeiR-HSA-1482839. Acyl chain remodelling of PE.

Miscellaneous databases

PROiQ9HDD0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127252.
CleanExiHS_HRASLS.

Family and domain databases

InterProiIPR007053. LRAT-like_dom.
[Graphical view]
PfamiPF04970. LRAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHRSL1_HUMAN
AccessioniPrimary (citable) accession number: Q9HDD0
Secondary accession number(s): D2KX19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.