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Q9HDD0

- HRSL1_HUMAN

UniProt

Q9HDD0 - HRSL1_HUMAN

Protein

Phospholipid-metabolizing enzyme A-C1

Gene

HRASLS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei30 – 301By similarity
    Active sitei119 – 1191Acyl-thioester intermediateBy similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW
    2. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phospholipid-metabolizing enzyme A-C1 (EC:2.3.1.-, EC:3.1.1.-)
    Alternative name(s):
    HRAS-like suppressor 1
    Short name:
    HRSL1
    Gene namesi
    Name:HRASLS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:14922. HRASLS.

    Subcellular locationi

    Membrane By similarity; Single-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29445.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 168168Phospholipid-metabolizing enzyme A-C1PRO_0000152481Add
    BLAST

    Proteomic databases

    PaxDbiQ9HDD0.
    PRIDEiQ9HDD0.

    Expressioni

    Tissue specificityi

    Abundantly expressed in testis, skeletal muscle, brain, and heart.1 Publication

    Gene expression databases

    ArrayExpressiQ9HDD0.
    BgeeiQ9HDD0.
    CleanExiHS_HRASLS.
    GenevestigatoriQ9HDD0.

    Organism-specific databases

    HPAiHPA051179.

    Interactioni

    Protein-protein interaction databases

    BioGridi121376. 1 interaction.
    STRINGi9606.ENSP00000264735.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HDD0.
    SMRiQ9HDD0. Positions 15-129.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 139139CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini164 – 1685LumenalSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei140 – 16324HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the H-rev107 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43478.
    HOGENOMiHOG000293227.
    HOVERGENiHBG028837.
    InParanoidiQ9HDD0.
    OrthoDBiEOG7B8S59.
    PhylomeDBiQ9HDD0.
    TreeFamiTF330836.

    Family and domain databases

    InterProiIPR007053. LRAT-like_dom.
    [Graphical view]
    PfamiPF04970. LRAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HDD0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFNDCFSLN YPGNPCPGDL IEVFRPGYQH WALYLGDGYV INIAPVDGIP    50
    ASFTSAKSVF SSKALVKMQL LKDVVGNDTY RINNKYDETY PPLPVEEIIK 100
    RSEFVIGQEV AYNLLVNNCE HFVTLLRYGE GVSEQANRAI STVEFVTAAV 150
    GVFSFLGLFP KGQRAKYY 168
    Length:168
    Mass (Da):18,750
    Last modified:March 1, 2001 - v1
    Checksum:i11844F8B5963D39B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB030816 mRNA. Translation: BAB08110.1.
    AB510981 mRNA. Translation: BAI63210.1.
    CH471052 Genomic DNA. Translation: EAW78078.1.
    UniGeneiHs.36761.

    Genome annotation databases

    EnsembliENST00000602513; ENSP00000473258; ENSG00000127252.
    UCSCiuc003fta.4. human.

    Polymorphism databases

    DMDMi20138344.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB030816 mRNA. Translation: BAB08110.1 .
    AB510981 mRNA. Translation: BAI63210.1 .
    CH471052 Genomic DNA. Translation: EAW78078.1 .
    UniGenei Hs.36761.

    3D structure databases

    ProteinModelPortali Q9HDD0.
    SMRi Q9HDD0. Positions 15-129.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121376. 1 interaction.
    STRINGi 9606.ENSP00000264735.

    Polymorphism databases

    DMDMi 20138344.

    Proteomic databases

    PaxDbi Q9HDD0.
    PRIDEi Q9HDD0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000602513 ; ENSP00000473258 ; ENSG00000127252 .
    UCSCi uc003fta.4. human.

    Organism-specific databases

    GeneCardsi GC03P192958.
    HGNCi HGNC:14922. HRASLS.
    HPAi HPA051179.
    MIMi 606487. gene.
    neXtProti NX_Q9HDD0.
    PharmGKBi PA29445.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43478.
    HOGENOMi HOG000293227.
    HOVERGENi HBG028837.
    InParanoidi Q9HDD0.
    OrthoDBi EOG7B8S59.
    PhylomeDBi Q9HDD0.
    TreeFami TF330836.

    Miscellaneous databases

    NextBioi 13651577.
    PROi Q9HDD0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HDD0.
    Bgeei Q9HDD0.
    CleanExi HS_HRASLS.
    Genevestigatori Q9HDD0.

    Family and domain databases

    InterProi IPR007053. LRAT-like_dom.
    [Graphical view ]
    Pfami PF04970. LRAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Kato S.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes."
      Shinohara N., Uyama T., Jin X.H., Tsuboi K., Tonai T., Houchi H., Ueda N.
      J. Lipid Res. 52:1927-1935(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiHRSL1_HUMAN
    AccessioniPrimary (citable) accession number: Q9HDD0
    Secondary accession number(s): D2KX19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3