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Protein

Phospholipid-metabolizing enzyme A-C1

Gene

HRASLS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei30 – 301By similarity
Active sitei119 – 1191Acyl-thioester intermediateBy similarity

GO - Molecular functioni

  1. phospholipase activity Source: Ensembl
  2. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. ether lipid metabolic process Source: Ensembl
  2. lipid catabolic process Source: UniProtKB-KW
  3. peroxisome organization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-metabolizing enzyme A-C1 (EC:2.3.1.-, EC:3.1.1.-)
Alternative name(s):
HRAS-like suppressor 1
Short name:
HRSL1
Gene namesi
Name:HRASLS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:14922. HRASLS.

Subcellular locationi

Membrane By similarity; Single-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 139139CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16324HelicalSequence AnalysisAdd
BLAST
Topological domaini164 – 1685LumenalSequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nuclear envelope lumen Source: Ensembl
  3. peroxisome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29445.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 168168Phospholipid-metabolizing enzyme A-C1PRO_0000152481Add
BLAST

Proteomic databases

PaxDbiQ9HDD0.
PRIDEiQ9HDD0.

Expressioni

Tissue specificityi

Abundantly expressed in testis, skeletal muscle, brain, and heart.1 Publication

Gene expression databases

BgeeiQ9HDD0.
CleanExiHS_HRASLS.
ExpressionAtlasiQ9HDD0. baseline and differential.
GenevestigatoriQ9HDD0.

Organism-specific databases

HPAiHPA051179.

Interactioni

Protein-protein interaction databases

BioGridi121376. 1 interaction.
STRINGi9606.ENSP00000264735.

Structurei

3D structure databases

ProteinModelPortaliQ9HDD0.
SMRiQ9HDD0. Positions 15-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the H-rev107 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43478.
HOGENOMiHOG000293227.
HOVERGENiHBG028837.
InParanoidiQ9HDD0.
OrthoDBiEOG7B8S59.
PhylomeDBiQ9HDD0.
TreeFamiTF330836.

Family and domain databases

InterProiIPR007053. LRAT-like_dom.
[Graphical view]
PfamiPF04970. LRAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HDD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFNDCFSLN YPGNPCPGDL IEVFRPGYQH WALYLGDGYV INIAPVDGIP
60 70 80 90 100
ASFTSAKSVF SSKALVKMQL LKDVVGNDTY RINNKYDETY PPLPVEEIIK
110 120 130 140 150
RSEFVIGQEV AYNLLVNNCE HFVTLLRYGE GVSEQANRAI STVEFVTAAV
160
GVFSFLGLFP KGQRAKYY
Length:168
Mass (Da):18,750
Last modified:March 1, 2001 - v1
Checksum:i11844F8B5963D39B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030816 mRNA. Translation: BAB08110.1.
AB510981 mRNA. Translation: BAI63210.1.
CH471052 Genomic DNA. Translation: EAW78078.1.
UniGeneiHs.36761.

Genome annotation databases

EnsembliENST00000602513; ENSP00000473258; ENSG00000127252.
UCSCiuc003fta.4. human.

Polymorphism databases

DMDMi20138344.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030816 mRNA. Translation: BAB08110.1.
AB510981 mRNA. Translation: BAI63210.1.
CH471052 Genomic DNA. Translation: EAW78078.1.
UniGeneiHs.36761.

3D structure databases

ProteinModelPortaliQ9HDD0.
SMRiQ9HDD0. Positions 15-129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121376. 1 interaction.
STRINGi9606.ENSP00000264735.

Polymorphism databases

DMDMi20138344.

Proteomic databases

PaxDbiQ9HDD0.
PRIDEiQ9HDD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000602513; ENSP00000473258; ENSG00000127252.
UCSCiuc003fta.4. human.

Organism-specific databases

GeneCardsiGC03P192958.
HGNCiHGNC:14922. HRASLS.
HPAiHPA051179.
MIMi606487. gene.
neXtProtiNX_Q9HDD0.
PharmGKBiPA29445.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG43478.
HOGENOMiHOG000293227.
HOVERGENiHBG028837.
InParanoidiQ9HDD0.
OrthoDBiEOG7B8S59.
PhylomeDBiQ9HDD0.
TreeFamiTF330836.

Miscellaneous databases

NextBioi13651577.
PROiQ9HDD0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HDD0.
CleanExiHS_HRASLS.
ExpressionAtlasiQ9HDD0. baseline and differential.
GenevestigatoriQ9HDD0.

Family and domain databases

InterProiIPR007053. LRAT-like_dom.
[Graphical view]
PfamiPF04970. LRAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Kato S.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes."
    Shinohara N., Uyama T., Jin X.H., Tsuboi K., Tonai T., Houchi H., Ueda N.
    J. Lipid Res. 52:1927-1935(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiHRSL1_HUMAN
AccessioniPrimary (citable) accession number: Q9HDD0
Secondary accession number(s): D2KX19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.