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Protein

Adipocyte plasma membrane-associated protein

Gene

APMAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation.1 Publication

GO - Molecular functioni

  • arylesterase activity Source: UniProtKB
  • strictosidine synthase activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Adipocyte plasma membrane-associated protein
Alternative name(s):
Protein BSCv
Gene namesi
Name:APMAP
Synonyms:C20orf3
ORF Names:UNQ1869/PRO4305
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:13238. APMAP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 4039CytoplasmicSequence analysisAdd
BLAST
Transmembranei41 – 6121Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini62 – 416355ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • endoplasmic reticulum Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25745.

Polymorphism and mutation databases

BioMutaiAPMAP.
DMDMi24211474.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 416415Adipocyte plasma membrane-associated proteinPRO_0000205945Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Modified residuei19 – 191PhosphothreonineCombined sources
Glycosylationi160 – 1601N-linked (GlcNAc...)3 Publications
Glycosylationi196 – 1961N-linked (GlcNAc...)3 Publications

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9HDC9.
MaxQBiQ9HDC9.
PaxDbiQ9HDC9.
PeptideAtlasiQ9HDC9.
PRIDEiQ9HDC9.

PTM databases

iPTMnetiQ9HDC9.
PhosphoSiteiQ9HDC9.
SwissPalmiQ9HDC9.

Expressioni

Tissue specificityi

Liver, glomerular and tubular structures of the kidney, endothelial cells, arterial wall and pancreatic islets of Langerhans (at protein level). Found ubiquitously in adult as well as in embryonic tissues. In adult tissue, the highest expression is found in the liver, placenta and heart. Found on the cell surface of monocytes. In embryonic tissue, the highest expression levels is found in the liver and the kidney.1 Publication

Gene expression databases

BgeeiENSG00000101474.
CleanExiHS_C20orf3.
ExpressionAtlasiQ9HDC9. baseline and differential.
GenevisibleiQ9HDC9. HS.

Organism-specific databases

HPAiHPA012863.

Interactioni

Protein-protein interaction databases

BioGridi121397. 13 interactions.
IntActiQ9HDC9. 14 interactions.
MINTiMINT-1427236.
STRINGi9606.ENSP00000217456.

Structurei

3D structure databases

ProteinModelPortaliQ9HDC9.
SMRiQ9HDC9. Positions 113-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the strictosidine synthase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1520. Eukaryota.
COG3386. LUCA.
GeneTreeiENSGT00440000039984.
HOGENOMiHOG000223914.
HOVERGENiHBG050543.
InParanoidiQ9HDC9.
OMAiAHIGDVM.
OrthoDBiEOG091G0C44.
PhylomeDBiQ9HDC9.
TreeFamiTF316475.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR018119. Strictosidine_synth_cons-reg.
IPR004141. Strictosidine_synthase.
[Graphical view]
PANTHERiPTHR10426. PTHR10426. 1 hit.
PfamiPF03088. Str_synth. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HDC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEADGLRQR RPLRPQVVTD DDGQAPEAKD GSSFSGRVFR VTFLMLAVSL
60 70 80 90 100
TVPLLGAMML LESPIDPQPL SFKEPPLLLG VLHPNTKLRQ AERLFENQLV
110 120 130 140 150
GPESIAHIGD VMFTGTADGR VVKLENGEIE TIARFGSGPC KTRDDEPVCG
160 170 180 190 200
RPLGIRAGPN GTLFVADAYK GLFEVNPWKR EVKLLLSSET PIEGKNMSFV
210 220 230 240 250
NDLTVTQDGR KIYFTDSSSK WQRRDYLLLV MEGTDDGRLL EYDTVTREVK
260 270 280 290 300
VLLDQLRFPN GVQLSPAEDF VLVAETTMAR IRRVYVSGLM KGGADLFVEN
310 320 330 340 350
MPGFPDNIRP SSSGGYWVGM STIRPNPGFS MLDFLSERPW IKRMIFKLFS
360 370 380 390 400
QETVMKFVPR YSLVLELSDS GAFRRSLHDP DGLVATYISE VHEHDGHLYL
410
GSFRSPFLCR LSLQAV
Length:416
Mass (Da):46,480
Last modified:October 19, 2002 - v2
Checksum:iC88E2DF2DF6093C4
GO
Isoform 2 (identifier: Q9HDC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-289: RVYVSGL → SSLVKRR
     290-416: Missing.

Show »
Length:289
Mass (Da):32,161
Checksum:i548C7BAA8D6FE9F2
GO

Sequence cautioni

The sequence AAQ89435 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB11885 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB15253 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB15578 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121P → A in BAG63373 (PubMed:14702039).Curated
Sequence conflicti74 – 741E → G in BAF83818 (PubMed:14702039).Curated
Sequence conflicti295 – 2951D → G in BAF83818 (PubMed:14702039).Curated
Sequence conflicti416 – 4161V → A in BAF83818 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651I → V.
Corresponds to variant rs17298715 [ dbSNP | Ensembl ].
VAR_014128
Natural varianti282 – 2821R → Q.1 Publication
Corresponds to variant rs35097515 [ dbSNP | Ensembl ].
VAR_055039
Natural varianti374 – 3741R → W.1 Publication
Corresponds to variant rs28364786 [ dbSNP | Ensembl ].
VAR_055040

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei283 – 2897RVYVSGL → SSLVKRR in isoform 2. 1 PublicationVSP_036992
Alternative sequencei290 – 416127Missing in isoform 2. 1 PublicationVSP_036993Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033767 mRNA. Translation: BAB11885.1. Different initiation.
AK291129 mRNA. Translation: BAF83818.1.
AK301959 mRNA. Translation: BAG63373.1.
AL035661 Genomic DNA. Translation: CAB75499.1.
BC003501 mRNA. Translation: AAH03501.1.
AY359076 mRNA. Translation: AAQ89435.1. Different initiation.
AK025834 mRNA. Translation: BAB15253.1. Different initiation.
AK026866 mRNA. Translation: BAB15578.1. Different initiation.
CCDSiCCDS13166.1. [Q9HDC9-1]
RefSeqiNP_065392.1. NM_020531.2. [Q9HDC9-1]
XP_005260820.1. XM_005260763.3. [Q9HDC9-2]
UniGeneiHs.472330.

Genome annotation databases

EnsembliENST00000217456; ENSP00000217456; ENSG00000101474. [Q9HDC9-1]
GeneIDi57136.
KEGGihsa:57136.
UCSCiuc002wty.4. human. [Q9HDC9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033767 mRNA. Translation: BAB11885.1. Different initiation.
AK291129 mRNA. Translation: BAF83818.1.
AK301959 mRNA. Translation: BAG63373.1.
AL035661 Genomic DNA. Translation: CAB75499.1.
BC003501 mRNA. Translation: AAH03501.1.
AY359076 mRNA. Translation: AAQ89435.1. Different initiation.
AK025834 mRNA. Translation: BAB15253.1. Different initiation.
AK026866 mRNA. Translation: BAB15578.1. Different initiation.
CCDSiCCDS13166.1. [Q9HDC9-1]
RefSeqiNP_065392.1. NM_020531.2. [Q9HDC9-1]
XP_005260820.1. XM_005260763.3. [Q9HDC9-2]
UniGeneiHs.472330.

3D structure databases

ProteinModelPortaliQ9HDC9.
SMRiQ9HDC9. Positions 113-403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121397. 13 interactions.
IntActiQ9HDC9. 14 interactions.
MINTiMINT-1427236.
STRINGi9606.ENSP00000217456.

PTM databases

iPTMnetiQ9HDC9.
PhosphoSiteiQ9HDC9.
SwissPalmiQ9HDC9.

Polymorphism and mutation databases

BioMutaiAPMAP.
DMDMi24211474.

Proteomic databases

EPDiQ9HDC9.
MaxQBiQ9HDC9.
PaxDbiQ9HDC9.
PeptideAtlasiQ9HDC9.
PRIDEiQ9HDC9.

Protocols and materials databases

DNASUi57136.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217456; ENSP00000217456; ENSG00000101474. [Q9HDC9-1]
GeneIDi57136.
KEGGihsa:57136.
UCSCiuc002wty.4. human. [Q9HDC9-1]

Organism-specific databases

CTDi57136.
GeneCardsiAPMAP.
H-InvDBHIX0174724.
HGNCiHGNC:13238. APMAP.
HPAiHPA012863.
MIMi615884. gene.
neXtProtiNX_Q9HDC9.
PharmGKBiPA25745.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1520. Eukaryota.
COG3386. LUCA.
GeneTreeiENSGT00440000039984.
HOGENOMiHOG000223914.
HOVERGENiHBG050543.
InParanoidiQ9HDC9.
OMAiAHIGDVM.
OrthoDBiEOG091G0C44.
PhylomeDBiQ9HDC9.
TreeFamiTF316475.

Miscellaneous databases

GeneWikiiC20orf3.
GenomeRNAii57136.
PROiQ9HDC9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101474.
CleanExiHS_C20orf3.
ExpressionAtlasiQ9HDC9. baseline and differential.
GenevisibleiQ9HDC9. HS.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR018119. Strictosidine_synth_cons-reg.
IPR004141. Strictosidine_synthase.
[Graphical view]
PANTHERiPTHR10426. PTHR10426. 1 hit.
PfamiPF03088. Str_synth. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPMAP_HUMAN
AccessioniPrimary (citable) accession number: Q9HDC9
Secondary accession number(s): A8K514
, B4DXG1, Q6UVZ8, Q9GZS8, Q9NUB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: September 7, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.