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Protein

Adipocyte plasma membrane-associated protein

Gene

APMAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation.1 Publication

GO - Molecular functioni

  • arylesterase activity Source: UniProtKB
  • strictosidine synthase activity Source: InterPro

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Adipocyte plasma membrane-associated protein
Alternative name(s):
Protein BSCv
Gene namesi
Name:APMAP
Synonyms:C20orf3
ORF Names:UNQ1869/PRO4305
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101474.11
HGNCiHGNC:13238 APMAP
MIMi615884 gene
neXtProtiNX_Q9HDC9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 40CytoplasmicSequence analysisAdd BLAST39
Transmembranei41 – 61Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini62 – 416ExtracellularSequence analysisAdd BLAST355

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57136
OpenTargetsiENSG00000101474
PharmGKBiPA25745

Polymorphism and mutation databases

BioMutaiAPMAP
DMDMi24211474

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002059452 – 416Adipocyte plasma membrane-associated proteinAdd BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei19PhosphothreonineCombined sources1
Glycosylationi160N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi196N-linked (GlcNAc...) asparagine3 Publications1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9HDC9
MaxQBiQ9HDC9
PaxDbiQ9HDC9
PeptideAtlasiQ9HDC9
PRIDEiQ9HDC9
ProteomicsDBi81851
81852 [Q9HDC9-2]

PTM databases

GlyConnecti797
iPTMnetiQ9HDC9
PhosphoSitePlusiQ9HDC9
SwissPalmiQ9HDC9

Expressioni

Tissue specificityi

Liver, glomerular and tubular structures of the kidney, endothelial cells, arterial wall and pancreatic islets of Langerhans (at protein level). Found ubiquitously in adult as well as in embryonic tissues. In adult tissue, the highest expression is found in the liver, placenta and heart. Found on the cell surface of monocytes. In embryonic tissue, the highest expression levels is found in the liver and the kidney.1 Publication

Gene expression databases

BgeeiENSG00000101474
CleanExiHS_C20orf3
ExpressionAtlasiQ9HDC9 baseline and differential
GenevisibleiQ9HDC9 HS

Organism-specific databases

HPAiHPA012863
HPA064700

Interactioni

Protein-protein interaction databases

BioGridi121397, 14 interactors
IntActiQ9HDC9, 15 interactors
MINTiQ9HDC9
STRINGi9606.ENSP00000217456

Structurei

3D structure databases

ProteinModelPortaliQ9HDC9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the strictosidine synthase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1520 Eukaryota
COG3386 LUCA
GeneTreeiENSGT00440000039984
HOGENOMiHOG000223914
HOVERGENiHBG050543
InParanoidiQ9HDC9
KOiK21407
OMAiGPESIAH
OrthoDBiEOG091G0C44
PhylomeDBiQ9HDC9
TreeFamiTF316475

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR018119 Strictosidine_synth_cons-reg
IPR004141 Strictosidine_synthase
PANTHERiPTHR10426 PTHR10426, 1 hit
PfamiView protein in Pfam
PF03088 Str_synth, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HDC9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEADGLRQR RPLRPQVVTD DDGQAPEAKD GSSFSGRVFR VTFLMLAVSL
60 70 80 90 100
TVPLLGAMML LESPIDPQPL SFKEPPLLLG VLHPNTKLRQ AERLFENQLV
110 120 130 140 150
GPESIAHIGD VMFTGTADGR VVKLENGEIE TIARFGSGPC KTRDDEPVCG
160 170 180 190 200
RPLGIRAGPN GTLFVADAYK GLFEVNPWKR EVKLLLSSET PIEGKNMSFV
210 220 230 240 250
NDLTVTQDGR KIYFTDSSSK WQRRDYLLLV MEGTDDGRLL EYDTVTREVK
260 270 280 290 300
VLLDQLRFPN GVQLSPAEDF VLVAETTMAR IRRVYVSGLM KGGADLFVEN
310 320 330 340 350
MPGFPDNIRP SSSGGYWVGM STIRPNPGFS MLDFLSERPW IKRMIFKLFS
360 370 380 390 400
QETVMKFVPR YSLVLELSDS GAFRRSLHDP DGLVATYISE VHEHDGHLYL
410
GSFRSPFLCR LSLQAV
Length:416
Mass (Da):46,480
Last modified:October 19, 2002 - v2
Checksum:iC88E2DF2DF6093C4
GO
Isoform 2 (identifier: Q9HDC9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-289: RVYVSGL → SSLVKRR
     290-416: Missing.

Show »
Length:289
Mass (Da):32,161
Checksum:i548C7BAA8D6FE9F2
GO

Sequence cautioni

The sequence AAQ89435 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB11885 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15253 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15578 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12P → A in BAG63373 (PubMed:14702039).Curated1
Sequence conflicti74E → G in BAF83818 (PubMed:14702039).Curated1
Sequence conflicti295D → G in BAF83818 (PubMed:14702039).Curated1
Sequence conflicti416V → A in BAF83818 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01412865I → V. Corresponds to variant dbSNP:rs12242Ensembl.1
Natural variantiVAR_055039282R → Q1 PublicationCorresponds to variant dbSNP:rs35097515Ensembl.1
Natural variantiVAR_055040374R → W1 PublicationCorresponds to variant dbSNP:rs28364786Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036992283 – 289RVYVSGL → SSLVKRR in isoform 2. 1 Publication7
Alternative sequenceiVSP_036993290 – 416Missing in isoform 2. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033767 mRNA Translation: BAB11885.1 Different initiation.
AK291129 mRNA Translation: BAF83818.1
AK301959 mRNA Translation: BAG63373.1
AL035661 Genomic DNA No translation available.
BC003501 mRNA Translation: AAH03501.1
AY359076 mRNA Translation: AAQ89435.1 Different initiation.
AK025834 mRNA Translation: BAB15253.1 Different initiation.
AK026866 mRNA Translation: BAB15578.1 Different initiation.
CCDSiCCDS13166.1 [Q9HDC9-1]
RefSeqiNP_065392.1, NM_020531.2 [Q9HDC9-1]
XP_005260820.1, XM_005260763.3 [Q9HDC9-2]
UniGeneiHs.472330

Genome annotation databases

EnsembliENST00000217456; ENSP00000217456; ENSG00000101474 [Q9HDC9-1]
GeneIDi57136
KEGGihsa:57136
UCSCiuc002wty.4 human [Q9HDC9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAPMAP_HUMAN
AccessioniPrimary (citable) accession number: Q9HDC9
Secondary accession number(s): A8K514
, B4DXG1, Q6UVZ8, Q9GZS8, Q9NUB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: June 20, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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