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Q9HD89

- RETN_HUMAN

UniProt

Q9HD89 - RETN_HUMAN

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Protein

Resistin

Gene

RETN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.

GO - Biological processi

  1. aging Source: Ensembl
  2. fat cell differentiation Source: Ensembl
  3. negative regulation of feeding behavior Source: Ensembl
  4. positive regulation of collagen metabolic process Source: Ensembl
  5. positive regulation of progesterone secretion Source: Ensembl
  6. positive regulation of smooth muscle cell migration Source: Ensembl
  7. positive regulation of smooth muscle cell proliferation Source: Ensembl
  8. positive regulation of synaptic transmission Source: Ensembl
  9. response to insulin Source: Ensembl
  10. response to mechanical stimulus Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Resistin
Alternative name(s):
Adipose tissue-specific secretory factor
Short name:
ADSF
C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein
Cysteine-rich secreted protein A12-alpha-like 2
Cysteine-rich secreted protein FIZZ3
Gene namesi
Name:RETN
Synonyms:FIZZ3, HXCP1, RSTN
ORF Names:UNQ407/PRO1199
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:20389. RETN.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. extracellular vesicular exosome Source: UniProtKB
  3. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Diabetes mellitus, Obesity

Organism-specific databases

PharmGKBiPA422.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 10890ResistinPRO_0000030341Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 – 22InterchainCurated
Disulfide bondi51 ↔ 104By similarity
Disulfide bondi63 ↔ 103By similarity
Disulfide bondi72 ↔ 89By similarity
Disulfide bondi74 ↔ 91By similarity
Disulfide bondi78 ↔ 93By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9HD89.
PaxDbiQ9HD89.
PRIDEiQ9HD89.

Expressioni

Tissue specificityi

Expressed only in fatty tissues.

Gene expression databases

BgeeiQ9HD89.
CleanExiHS_RETN.
ExpressionAtlasiQ9HD89. baseline and differential.
GenevestigatoriQ9HD89.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

BioGridi121192. 2 interactions.
STRINGi9606.ENSP00000221515.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LV6model-A1-108[»]
ProteinModelPortaliQ9HD89.
SMRiQ9HD89. Positions 17-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the resistin/FIZZ family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46608.
GeneTreeiENSGT00390000016177.
HOGENOMiHOG000137607.
HOVERGENiHBG018297.
InParanoidiQ9HD89.
KOiK13438.
OMAiCQSVTSR.
OrthoDBiEOG7CVQ14.
PhylomeDBiQ9HD89.
TreeFamiTF337024.

Family and domain databases

InterProiIPR009714. Resistin.
[Graphical view]
PANTHERiPTHR21101. PTHR21101. 1 hit.
PfamiPF06954. Resistin. 1 hit.
[Graphical view]
SUPFAMiSSF111423. SSF111423. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9HD89-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKALCLLLLP VLGLLVSSKT LCSMEEAINE RIQEVAGSLI FRAISSIGLE
60 70 80 90 100
CQSVTSRGDL ATCPRGFAVT GCTCGSACGS WDVRAETTCH CQCAGMDWTG

ARCCRVQP
Length:108
Mass (Da):11,419
Last modified:March 1, 2001 - v1
Checksum:i9B127DFE1699B4F1
GO
Isoform 2 (identifier: Q9HD89-2) [UniParc]FASTAAdd to Basket

Also known as: delta2ASV

The sequence of this isoform differs from the canonical sequence as follows:
     40-66: IFRAISSIGLECQSVTSRGDLATCPRG → S

Show »
Length:82
Mass (Da):8,686
Checksum:i1CB39ECD07235A0A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei40 – 6627IFRAI…TCPRG → S in isoform 2. 1 PublicationVSP_055861Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205952 mRNA. Translation: AAG02144.1.
AF323081 mRNA. Translation: AAG59824.1.
AF352730 Genomic DNA. Translation: AAK18621.1.
AB111910 mRNA. Translation: BAD04068.1.
AF290874 mRNA. Translation: AAK83106.1.
AY207314 mRNA. Translation: AAO38860.1.
AY359066 mRNA. Translation: AAQ89425.1.
DQ301958 Genomic DNA. Translation: ABB96251.1.
AC008763 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69015.1.
CH471139 Genomic DNA. Translation: EAW69016.1.
BC069302 mRNA. Translation: AAH69302.1.
BC101554 mRNA. Translation: AAI01555.1.
BC101560 mRNA. Translation: AAI01561.1.
CCDSiCCDS12182.1. [Q9HD89-1]
RefSeqiNP_001180303.1. NM_001193374.1. [Q9HD89-1]
NP_065148.1. NM_020415.3. [Q9HD89-1]
UniGeneiHs.283091.

Genome annotation databases

EnsembliENST00000221515; ENSP00000221515; ENSG00000104918. [Q9HD89-1]
ENST00000381324; ENSP00000370725; ENSG00000104918. [Q9HD89-2]
GeneIDi56729.
KEGGihsa:56729.
UCSCiuc002mhf.1. human. [Q9HD89-1]

Polymorphism databases

DMDMi18202962.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205952 mRNA. Translation: AAG02144.1 .
AF323081 mRNA. Translation: AAG59824.1 .
AF352730 Genomic DNA. Translation: AAK18621.1 .
AB111910 mRNA. Translation: BAD04068.1 .
AF290874 mRNA. Translation: AAK83106.1 .
AY207314 mRNA. Translation: AAO38860.1 .
AY359066 mRNA. Translation: AAQ89425.1 .
DQ301958 Genomic DNA. Translation: ABB96251.1 .
AC008763 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69015.1 .
CH471139 Genomic DNA. Translation: EAW69016.1 .
BC069302 mRNA. Translation: AAH69302.1 .
BC101554 mRNA. Translation: AAI01555.1 .
BC101560 mRNA. Translation: AAI01561.1 .
CCDSi CCDS12182.1. [Q9HD89-1 ]
RefSeqi NP_001180303.1. NM_001193374.1. [Q9HD89-1 ]
NP_065148.1. NM_020415.3. [Q9HD89-1 ]
UniGenei Hs.283091.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1LV6 model - A 1-108 [» ]
ProteinModelPortali Q9HD89.
SMRi Q9HD89. Positions 17-107.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121192. 2 interactions.
STRINGi 9606.ENSP00000221515.

Polymorphism databases

DMDMi 18202962.

Proteomic databases

MaxQBi Q9HD89.
PaxDbi Q9HD89.
PRIDEi Q9HD89.

Protocols and materials databases

DNASUi 56729.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000221515 ; ENSP00000221515 ; ENSG00000104918 . [Q9HD89-1 ]
ENST00000381324 ; ENSP00000370725 ; ENSG00000104918 . [Q9HD89-2 ]
GeneIDi 56729.
KEGGi hsa:56729.
UCSCi uc002mhf.1. human. [Q9HD89-1 ]

Organism-specific databases

CTDi 56729.
GeneCardsi GC19P007733.
HGNCi HGNC:20389. RETN.
MIMi 605565. gene.
neXtProti NX_Q9HD89.
PharmGKBi PA422.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46608.
GeneTreei ENSGT00390000016177.
HOGENOMi HOG000137607.
HOVERGENi HBG018297.
InParanoidi Q9HD89.
KOi K13438.
OMAi CQSVTSR.
OrthoDBi EOG7CVQ14.
PhylomeDBi Q9HD89.
TreeFami TF337024.

Miscellaneous databases

GeneWikii Resistin.
GenomeRNAii 56729.
NextBioi 35540739.
PROi Q9HD89.
SOURCEi Search...

Gene expression databases

Bgeei Q9HD89.
CleanExi HS_RETN.
ExpressionAtlasi Q9HD89. baseline and differential.
Genevestigatori Q9HD89.

Family and domain databases

InterProi IPR009714. Resistin.
[Graphical view ]
PANTHERi PTHR21101. PTHR21101. 1 hit.
Pfami PF06954. Resistin. 1 hit.
[Graphical view ]
SUPFAMi SSF111423. SSF111423. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family."
    Holcomb I.N., Kabakoff R.C., Chan B., Baker T.W., Gurney A., Henzel W., Nelson C., Lowman H.B., Wright B.D., Skelton N.J., Frantz G.D., Tumas D.B., Peale F.V. Jr., Shelton D.L., Hebert C.C.
    EMBO J. 19:4046-4055(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Representational difference analysis using myeloid cells from C/EBP epsilon deletional mice."
    Kubota T., Kawano S., Chih D.Y., Hisatake Y., Chumakov A.M., Taguchi H., Koeffler H.P.
    Blood 96:3953-3957(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Identification of an alternative splicing transcript for the resistin gene and distribution of its mRNA in human tissue."
    Nohira T., Nagao K., Kameyama K., Nakai H., Fukumine N., Okabe K., Kitano S., Hisatomi H.
    Eur. J. Endocrinol. 151:151-154(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
  5. "Identification of a novel cysteine-rich secreted A12-alpha related protein."
    Rajala M.W., Scherer P.E.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  6. "Homo sapiens resistin mRNA found in lymphocytes."
    Li M., Wu Y.C., Deng Y.J., Yang J.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. NIEHS SNPs program
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  9. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiRETN_HUMAN
AccessioniPrimary (citable) accession number: Q9HD89
Secondary accession number(s): D6W649, Q540D9, Q76B53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: November 26, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3