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Protein

Resistin

Gene

RETN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (By similarity). Potentially links obesity to diabetes (By similarity). Promotes chemotaxis in myeloid cells (PubMed:15064728).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-6798695. Neutrophil degranulation.
SIGNORiQ9HD89.

Names & Taxonomyi

Protein namesi
Recommended name:
Resistin
Alternative name(s):
Adipose tissue-specific secretory factor
Short name:
ADSF
C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein
Cysteine-rich secreted protein A12-alpha-like 2
Cysteine-rich secreted protein FIZZ3
Gene namesi
Name:RETN
Synonyms:FIZZ3, HXCP1, RSTN
ORF Names:UNQ407/PRO1199
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104918.7.
HGNCiHGNC:20389. RETN.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Diabetes mellitus, Obesity

Organism-specific databases

DisGeNETi56729.
MalaCardsiRETN.
OpenTargetsiENSG00000104918.
PharmGKBiPA422.

Polymorphism and mutation databases

BioMutaiRETN.
DMDMi18202962.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003034119 – 108ResistinAdd BLAST90

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22InterchainBy similarity
Disulfide bondi51 ↔ 104By similarity
Disulfide bondi63 ↔ 103By similarity
Disulfide bondi72 ↔ 89By similarity
Disulfide bondi74 ↔ 91By similarity
Disulfide bondi78 ↔ 93By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ9HD89.
MaxQBiQ9HD89.
PaxDbiQ9HD89.
PeptideAtlasiQ9HD89.
PRIDEiQ9HD89.

Expressioni

Tissue specificityi

Expressed in white adipose tissue (at protein level) (PubMed:11201732). Widely expressed, with particularly strong expression in lung, bone marrow, breast and peripheral blood (PubMed:15248836). Expressed strongly in bone marrow and at lower levels in lung, but not detected in other tissues (PubMed:15064728). Isoform 2 is detected in adipose tissue, bone marrow, brain, lung, peripheral blood, placenta and thymus (PubMed:15248836).3 Publications

Gene expression databases

BgeeiENSG00000104918.
CleanExiHS_RETN.
GenevisibleiQ9HD89. HS.

Interactioni

Subunit structurei

Homodimer; disulfide-linked (By similarity). Interacts with DEFA1 (PubMed:15064728).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121192. 7 interactors.
IntActiQ9HD89. 2 interactors.
STRINGi9606.ENSP00000221515.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LV6model-A1-108[»]
ProteinModelPortaliQ9HD89.
SMRiQ9HD89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the resistin/FIZZ family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J40Z. Eukaryota.
ENOG410ZE8R. LUCA.
GeneTreeiENSGT00390000016177.
HOGENOMiHOG000137607.
HOVERGENiHBG018297.
InParanoidiQ9HD89.
KOiK13438.
OMAiLECQSVT.
OrthoDBiEOG091G112J.
PhylomeDBiQ9HD89.
TreeFamiTF337024.

Family and domain databases

CDDicd16333. RELM. 1 hit.
InterProiView protein in InterPro
IPR009714. Resistin.
IPR036262. Resistin-like_sf.
PANTHERiPTHR21101. PTHR21101. 1 hit.
PfamiView protein in Pfam
PF06954. Resistin. 1 hit.
SUPFAMiSSF111423. SSF111423. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HD89-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKALCLLLLP VLGLLVSSKT LCSMEEAINE RIQEVAGSLI FRAISSIGLE
60 70 80 90 100
CQSVTSRGDL ATCPRGFAVT GCTCGSACGS WDVRAETTCH CQCAGMDWTG

ARCCRVQP
Length:108
Mass (Da):11,419
Last modified:March 1, 2001 - v1
Checksum:i9B127DFE1699B4F1
GO
Isoform 2 (identifier: Q9HD89-2) [UniParc]FASTAAdd to basket
Also known as: delta2ASV

The sequence of this isoform differs from the canonical sequence as follows:
     40-66: IFRAISSIGLECQSVTSRGDLATCPRG → S

Show »
Length:82
Mass (Da):8,686
Checksum:i1CB39ECD07235A0A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05586140 – 66IFRAI…TCPRG → S in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205952 mRNA. Translation: AAG02144.1.
AF323081 mRNA. Translation: AAG59824.1.
AF352730 Genomic DNA. Translation: AAK18621.1.
AB111910 mRNA. Translation: BAD04068.1.
AF290874 mRNA. Translation: AAK83106.1.
AY207314 mRNA. Translation: AAO38860.1.
AY359066 mRNA. Translation: AAQ89425.1.
DQ301958 Genomic DNA. Translation: ABB96251.1.
AC008763 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69015.1.
CH471139 Genomic DNA. Translation: EAW69016.1.
BC069302 mRNA. Translation: AAH69302.1.
BC101554 mRNA. Translation: AAI01555.1.
BC101560 mRNA. Translation: AAI01561.1.
CCDSiCCDS12182.1. [Q9HD89-1]
RefSeqiNP_001180303.1. NM_001193374.1. [Q9HD89-1]
NP_065148.1. NM_020415.3. [Q9HD89-1]
UniGeneiHs.283091.

Genome annotation databases

EnsembliENST00000221515; ENSP00000221515; ENSG00000104918. [Q9HD89-1]
ENST00000381324; ENSP00000370725; ENSG00000104918. [Q9HD89-2]
ENST00000629642; ENSP00000485998; ENSG00000104918. [Q9HD89-2]
GeneIDi56729.
KEGGihsa:56729.
UCSCiuc002mhf.2. human. [Q9HD89-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRETN_HUMAN
AccessioniPrimary (citable) accession number: Q9HD89
Secondary accession number(s): D6W649, Q540D9, Q76B53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families