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Q9HD89 (RETN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Resistin
Alternative name(s):
Adipose tissue-specific secretory factor
Short name=ADSF
C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein
Cysteine-rich secreted protein A12-alpha-like 2
Cysteine-rich secreted protein FIZZ3
Gene names
Name:RETN
Synonyms:FIZZ3, HXCP1, RSTN
ORF Names:UNQ407/PRO1199
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length108 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Secreted.

Tissue specificity

Expressed only in fatty tissues.

Sequence similarities

Belongs to the resistin/FIZZ family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 10890Resistin
PRO_0000030341

Amino acid modifications

Disulfide bond22Interchain Probable
Disulfide bond51 ↔ 104 By similarity
Disulfide bond63 ↔ 103 By similarity
Disulfide bond72 ↔ 89 By similarity
Disulfide bond74 ↔ 91 By similarity
Disulfide bond78 ↔ 93 By similarity

Secondary structure

.................... 108
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9HD89 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 9B127DFE1699B4F1

FASTA10811,419
        10         20         30         40         50         60 
MKALCLLLLP VLGLLVSSKT LCSMEEAINE RIQEVAGSLI FRAISSIGLE CQSVTSRGDL 

        70         80         90        100 
ATCPRGFAVT GCTCGSACGS WDVRAETTCH CQCAGMDWTG ARCCRVQP 

« Hide

References

« Hide 'large scale' references
[1]"FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family."
Holcomb I.N., Kabakoff R.C., Chan B., Baker T.W., Gurney A., Henzel W., Nelson C., Lowman H.B., Wright B.D., Skelton N.J., Frantz G.D., Tumas D.B., Peale F.V. Jr., Shelton D.L., Hebert C.C.
EMBO J. 19:4046-4055(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The hormone resistin links obesity to diabetes."
Steppan C.M., Bailey S.T., Bhat S., Brown E.J., Banerjee R.R., Wright C.M., Patel H.R., Ahima R.S., Lazar M.A.
Nature 409:307-312(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Representational difference analysis using myeloid cells from C/EBP epsilon deletional mice."
Kubota T., Kawano S., Chih D.Y., Hisatake Y., Chumakov A.M., Taguchi H., Koeffler H.P.
Blood 96:3953-3957(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Identification of a novel cysteine-rich secreted A12-alpha related protein."
Rajala M.W., Scherer P.E.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Homo sapiens resistin mRNA found in lymphocytes."
Li M., Wu Y.C., Deng Y.J., Yang J.
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]NIEHS SNPs program
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF205952 mRNA. Translation: AAG02144.1.
AF323081 mRNA. Translation: AAG59824.1.
AF352730 Genomic DNA. Translation: AAK18621.1.
AF290874 mRNA. Translation: AAK83106.1.
AY207314 mRNA. Translation: AAO38860.1.
AY359066 mRNA. Translation: AAQ89425.1.
DQ301958 Genomic DNA. Translation: ABB96251.1.
CH471139 Genomic DNA. Translation: EAW69015.1.
CH471139 Genomic DNA. Translation: EAW69016.1.
BC069302 mRNA. Translation: AAH69302.1.
BC101554 mRNA. Translation: AAI01555.1.
BC101560 mRNA. Translation: AAI01561.1.
RefSeqNP_001180303.1. NM_001193374.1.
NP_065148.1. NM_020415.3.
UniGeneHs.283091.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1LV6model-A1-108[»]
ProteinModelPortalQ9HD89.
SMRQ9HD89. Positions 17-107.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121192. 2 interactions.
STRING9606.ENSP00000221515.

Polymorphism databases

DMDM18202962.

Proteomic databases

PaxDbQ9HD89.
PRIDEQ9HD89.

Protocols and materials databases

DNASU56729.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000221515; ENSP00000221515; ENSG00000104918.
GeneID56729.
KEGGhsa:56729.
UCSCuc002mhf.1. human.

Organism-specific databases

CTD56729.
GeneCardsGC19P007733.
HGNCHGNC:20389. RETN.
MIM605565. gene.
neXtProtNX_Q9HD89.
PharmGKBPA422.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46608.
HOGENOMHOG000137607.
HOVERGENHBG018297.
InParanoidQ9HD89.
KOK13438.
OMACQSVTSR.
OrthoDBEOG7CVQ14.
PhylomeDBQ9HD89.
TreeFamTF337024.

Gene expression databases

ArrayExpressQ9HD89.
BgeeQ9HD89.
CleanExHS_RETN.
GenevestigatorQ9HD89.

Family and domain databases

InterProIPR009714. Resistin.
[Graphical view]
PANTHERPTHR21101. PTHR21101. 1 hit.
PfamPF06954. Resistin. 1 hit.
[Graphical view]
SUPFAMSSF111423. SSF111423. 1 hit.
ProtoNetSearch...

Other

GeneWikiResistin.
GenomeRNAi56729.
NextBio62204.
PROQ9HD89.
SOURCESearch...

Entry information

Entry nameRETN_HUMAN
AccessionPrimary (citable) accession number: Q9HD89
Secondary accession number(s): D6W649, Q540D9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: March 19, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM