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Q9HD89

- RETN_HUMAN

UniProt

Q9HD89 - RETN_HUMAN

Protein

Resistin

Gene

RETN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.

    GO - Biological processi

    1. aging Source: Ensembl
    2. fat cell differentiation Source: Ensembl
    3. negative regulation of feeding behavior Source: Ensembl
    4. positive regulation of collagen metabolic process Source: Ensembl
    5. positive regulation of progesterone secretion Source: Ensembl
    6. positive regulation of smooth muscle cell migration Source: Ensembl
    7. positive regulation of smooth muscle cell proliferation Source: Ensembl
    8. positive regulation of synaptic transmission Source: Ensembl
    9. response to insulin Source: Ensembl
    10. response to mechanical stimulus Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Resistin
    Alternative name(s):
    Adipose tissue-specific secretory factor
    Short name:
    ADSF
    C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein
    Cysteine-rich secreted protein A12-alpha-like 2
    Cysteine-rich secreted protein FIZZ3
    Gene namesi
    Name:RETN
    Synonyms:FIZZ3, HXCP1, RSTN
    ORF Names:UNQ407/PRO1199
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:20389. RETN.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: InterPro
    2. extracellular space Source: Ensembl
    3. extracellular vesicular exosome Source: UniProt
    4. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Keywords - Diseasei

    Diabetes mellitus, Obesity

    Organism-specific databases

    PharmGKBiPA422.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 10890ResistinPRO_0000030341Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi22 – 22InterchainCurated
    Disulfide bondi51 ↔ 104By similarity
    Disulfide bondi63 ↔ 103By similarity
    Disulfide bondi72 ↔ 89By similarity
    Disulfide bondi74 ↔ 91By similarity
    Disulfide bondi78 ↔ 93By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ9HD89.
    PaxDbiQ9HD89.
    PRIDEiQ9HD89.

    Expressioni

    Tissue specificityi

    Expressed only in fatty tissues.

    Gene expression databases

    ArrayExpressiQ9HD89.
    BgeeiQ9HD89.
    CleanExiHS_RETN.
    GenevestigatoriQ9HD89.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    BioGridi121192. 2 interactions.
    STRINGi9606.ENSP00000221515.

    Structurei

    Secondary structure

    1
    108
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi9 – 1810
    Helixi30 – 3910
    Beta strandi46 – 483
    Helixi58 – 614
    Beta strandi68 – 703
    Turni75 – 784
    Helixi81 – 899
    Beta strandi90 – 923
    Helixi96 – 994
    Beta strandi102 – 1054

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1LV6model-A1-108[»]
    ProteinModelPortaliQ9HD89.
    SMRiQ9HD89. Positions 17-107.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the resistin/FIZZ family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46608.
    HOGENOMiHOG000137607.
    HOVERGENiHBG018297.
    InParanoidiQ9HD89.
    KOiK13438.
    OMAiCQSVTSR.
    OrthoDBiEOG7CVQ14.
    PhylomeDBiQ9HD89.
    TreeFamiTF337024.

    Family and domain databases

    InterProiIPR009714. Resistin.
    [Graphical view]
    PANTHERiPTHR21101. PTHR21101. 1 hit.
    PfamiPF06954. Resistin. 1 hit.
    [Graphical view]
    SUPFAMiSSF111423. SSF111423. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HD89-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKALCLLLLP VLGLLVSSKT LCSMEEAINE RIQEVAGSLI FRAISSIGLE    50
    CQSVTSRGDL ATCPRGFAVT GCTCGSACGS WDVRAETTCH CQCAGMDWTG 100
    ARCCRVQP 108
    Length:108
    Mass (Da):11,419
    Last modified:March 1, 2001 - v1
    Checksum:i9B127DFE1699B4F1
    GO
    Isoform 2 (identifier: Q9HD89-2) [UniParc]FASTAAdd to Basket

    Also known as: delta2ASV

    The sequence of this isoform differs from the canonical sequence as follows:
         40-66: IFRAISSIGLECQSVTSRGDLATCPRG → S

    Show »
    Length:82
    Mass (Da):8,686
    Checksum:i1CB39ECD07235A0A
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei40 – 6627IFRAI…TCPRG → S in isoform 2. 1 PublicationVSP_055861Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF205952 mRNA. Translation: AAG02144.1.
    AF323081 mRNA. Translation: AAG59824.1.
    AF352730 Genomic DNA. Translation: AAK18621.1.
    AB111910 mRNA. Translation: BAD04068.1.
    AF290874 mRNA. Translation: AAK83106.1.
    AY207314 mRNA. Translation: AAO38860.1.
    AY359066 mRNA. Translation: AAQ89425.1.
    DQ301958 Genomic DNA. Translation: ABB96251.1.
    AC008763 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69015.1.
    CH471139 Genomic DNA. Translation: EAW69016.1.
    BC069302 mRNA. Translation: AAH69302.1.
    BC101554 mRNA. Translation: AAI01555.1.
    BC101560 mRNA. Translation: AAI01561.1.
    CCDSiCCDS12182.1.
    RefSeqiNP_001180303.1. NM_001193374.1.
    NP_065148.1. NM_020415.3.
    UniGeneiHs.283091.

    Genome annotation databases

    EnsembliENST00000221515; ENSP00000221515; ENSG00000104918. [Q9HD89-1]
    ENST00000381324; ENSP00000370725; ENSG00000104918. [Q9HD89-2]
    GeneIDi56729.
    KEGGihsa:56729.
    UCSCiuc002mhf.1. human.

    Polymorphism databases

    DMDMi18202962.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF205952 mRNA. Translation: AAG02144.1 .
    AF323081 mRNA. Translation: AAG59824.1 .
    AF352730 Genomic DNA. Translation: AAK18621.1 .
    AB111910 mRNA. Translation: BAD04068.1 .
    AF290874 mRNA. Translation: AAK83106.1 .
    AY207314 mRNA. Translation: AAO38860.1 .
    AY359066 mRNA. Translation: AAQ89425.1 .
    DQ301958 Genomic DNA. Translation: ABB96251.1 .
    AC008763 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69015.1 .
    CH471139 Genomic DNA. Translation: EAW69016.1 .
    BC069302 mRNA. Translation: AAH69302.1 .
    BC101554 mRNA. Translation: AAI01555.1 .
    BC101560 mRNA. Translation: AAI01561.1 .
    CCDSi CCDS12182.1.
    RefSeqi NP_001180303.1. NM_001193374.1.
    NP_065148.1. NM_020415.3.
    UniGenei Hs.283091.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1LV6 model - A 1-108 [» ]
    ProteinModelPortali Q9HD89.
    SMRi Q9HD89. Positions 17-107.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121192. 2 interactions.
    STRINGi 9606.ENSP00000221515.

    Polymorphism databases

    DMDMi 18202962.

    Proteomic databases

    MaxQBi Q9HD89.
    PaxDbi Q9HD89.
    PRIDEi Q9HD89.

    Protocols and materials databases

    DNASUi 56729.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000221515 ; ENSP00000221515 ; ENSG00000104918 . [Q9HD89-1 ]
    ENST00000381324 ; ENSP00000370725 ; ENSG00000104918 . [Q9HD89-2 ]
    GeneIDi 56729.
    KEGGi hsa:56729.
    UCSCi uc002mhf.1. human.

    Organism-specific databases

    CTDi 56729.
    GeneCardsi GC19P007733.
    HGNCi HGNC:20389. RETN.
    MIMi 605565. gene.
    neXtProti NX_Q9HD89.
    PharmGKBi PA422.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46608.
    HOGENOMi HOG000137607.
    HOVERGENi HBG018297.
    InParanoidi Q9HD89.
    KOi K13438.
    OMAi CQSVTSR.
    OrthoDBi EOG7CVQ14.
    PhylomeDBi Q9HD89.
    TreeFami TF337024.

    Miscellaneous databases

    GeneWikii Resistin.
    GenomeRNAii 56729.
    NextBioi 62204.
    PROi Q9HD89.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HD89.
    Bgeei Q9HD89.
    CleanExi HS_RETN.
    Genevestigatori Q9HD89.

    Family and domain databases

    InterProi IPR009714. Resistin.
    [Graphical view ]
    PANTHERi PTHR21101. PTHR21101. 1 hit.
    Pfami PF06954. Resistin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111423. SSF111423. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family."
      Holcomb I.N., Kabakoff R.C., Chan B., Baker T.W., Gurney A., Henzel W., Nelson C., Lowman H.B., Wright B.D., Skelton N.J., Frantz G.D., Tumas D.B., Peale F.V. Jr., Shelton D.L., Hebert C.C.
      EMBO J. 19:4046-4055(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Representational difference analysis using myeloid cells from C/EBP epsilon deletional mice."
      Kubota T., Kawano S., Chih D.Y., Hisatake Y., Chumakov A.M., Taguchi H., Koeffler H.P.
      Blood 96:3953-3957(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Identification of an alternative splicing transcript for the resistin gene and distribution of its mRNA in human tissue."
      Nohira T., Nagao K., Kameyama K., Nakai H., Fukumine N., Okabe K., Kitano S., Hisatomi H.
      Eur. J. Endocrinol. 151:151-154(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
    5. "Identification of a novel cysteine-rich secreted A12-alpha related protein."
      Rajala M.W., Scherer P.E.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    6. "Homo sapiens resistin mRNA found in lymphocytes."
      Li M., Wu Y.C., Deng Y.J., Yang J.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    8. NIEHS SNPs program
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    9. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiRETN_HUMAN
    AccessioniPrimary (citable) accession number: Q9HD89
    Secondary accession number(s): D6W649, Q540D9, Q76B53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3