Q9HD89 (RETN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Resistin

Alternative name(s):
Adipose tissue-specific secretory factor
Short name=ADSF
C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein
Cysteine-rich secreted protein A12-alpha-like 2
Cysteine-rich secreted protein FIZZ3

Gene names

Name:	RETN
Synonyms:	FIZZ3, HXCP1, RSTN
ORF Names:	UNQ407/PRO1199

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.
Subunit structure	Homodimer; disulfide-linked By similarity.
Subcellular location	Secreted.
Tissue specificity	Expressed only in fatty tissues.
Sequence similarities	Belongs to the resistin/FIZZ family.

Ontologies

Keywords
Cellular component	Secreted
Disease	Diabetes mellitus Obesity
Domain	Signal
Molecular function	Hormone
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fat cell differentiation Inferred from electronic annotation. Source: Compara response to insulin stimulus Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular region Non-traceable author statement. Source: UniProtKB extracellular space Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	hormone activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 18

18

Potential

Chain

19 – 108

90

Resistin

PRO_0000030341

Amino acid modifications

Disulfide bond

22

Interchain Probable

Disulfide bond

51 ↔ 104

By similarity

Disulfide bond

63 ↔ 103

By similarity

Disulfide bond

72 ↔ 89

By similarity

Disulfide bond

74 ↔ 91

By similarity

Disulfide bond

78 ↔ 93

By similarity

Secondary structure

1

.

.

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108

Helix Strand Turn

Details...

Helix

9 – 18

10

Helix

30 – 39

10

Beta strand

46 – 48

3

Helix

58 – 61

4

Beta strand

68 – 70

3

Turn

75 – 78

4

Helix

81 – 89

9

Beta strand

90 – 92

3

Helix

96 – 99

4

Beta strand

102 – 105

4

Sequences

	Sequence		Length	Mass (Da)
	Q9HD89 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 9B127DFE1699B4F1	FASTA	108	11,419
	10 20 30 40 50 60 MKALCLLLLP VLGLLVSSKT LCSMEEAINE RIQEVAGSLI FRAISSIGLE CQSVTSRGDL 70 80 90 100 ATCPRGFAVT GCTCGSACGS WDVRAETTCH CQCAGMDWTG ARCCRVQP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family." Holcomb I.N., Kabakoff R.C., Chan B., Baker T.W., Gurney A., Henzel W., Nelson C., Lowman H.B., Wright B.D., Skelton N.J., Frantz G.D., Tumas D.B., Peale F.V. Jr., Shelton D.L., Hebert C.C. EMBO J. 19:4046-4055(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The hormone resistin links obesity to diabetes." Steppan C.M., Bailey S.T., Bhat S., Brown E.J., Banerjee R.R., Wright C.M., Patel H.R., Ahima R.S., Lazar M.A. Nature 409:307-312(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Representational difference analysis using myeloid cells from C/EBP epsilon deletional mice." Kubota T., Kawano S., Chih D.Y., Hisatake Y., Chumakov A.M., Taguchi H., Koeffler H.P. Blood 96:3953-3957(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Identification of a novel cysteine-rich secreted A12-alpha related protein." Rajala M.W., Scherer P.E. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"Homo sapiens resistin mRNA found in lymphocytes." Li M., Wu Y.C., Deng Y.J., Yang J. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	NIEHS SNPs program Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF205952 mRNA. Translation: AAG02144.1.
AF323081 mRNA. Translation: AAG59824.1.
AF352730 Genomic DNA. Translation: AAK18621.1.
AF290874 mRNA. Translation: AAK83106.1.
AY207314 mRNA. Translation: AAO38860.1.
AY359066 mRNA. Translation: AAQ89425.1.
DQ301958 Genomic DNA. Translation: ABB96251.1.
CH471139 Genomic DNA. Translation: EAW69015.1.
CH471139 Genomic DNA. Translation: EAW69016.1.
BC069302 mRNA. Translation: AAH69302.1.
BC101554 mRNA. Translation: AAI01555.1.
BC101560 mRNA. Translation: AAI01561.1.

IPI

IPI00006988.

RefSeq

NP_001180303.1. NM_001193374.1.
NP_065148.1. NM_020415.3.

UniGene

Hs.283091.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1LV6	model	-	A	1-108	[»]

ProteinModelPortal

Q9HD89.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000221515.

Polymorphism databases

DMDM

18202962.

Proteomic databases

PaxDb

Q9HD89.

PRIDE

Q9HD89.

Protocols and materials databases

DNASU

56729.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000221515; ENSP00000221515; ENSG00000104918.

GeneID

56729.

KEGG

hsa:56729.

UCSC

uc002mhf.1. human.

Organism-specific databases

CTD

56729.

GeneCards

GC19P007733.

HGNC

HGNC:20389. RETN.

MIM

605565. gene.

neXtProt

NX_Q9HD89.

PharmGKB

PA422.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG46608.

HOGENOM

HOG000137607.

HOVERGEN

HBG018297.

InParanoid

Q9HD89.

KO

K13438.

OMA

CQSVTSR.

PhylomeDB

Q9HD89.

Gene expression databases

ArrayExpress

Q9HD89.

Bgee

Q9HD89.

CleanEx

HS_RETN.

Genevestigator

Q9HD89.

GermOnline

ENSG00000104918. Homo sapiens.

Family and domain databases

InterPro

IPR009714. Resistin.
[Graphical view]

PANTHER

PTHR21101. PTHR21101. 1 hit.

Pfam

PF06954. Resistin. 1 hit.
[Graphical view]

SUPFAM

SSF111423. Resistin. 1 hit.

ProtoNet

Search...

Other

GenomeRNAi

56729.

NextBio

62204.

SOURCE

Search...

Entry information

Entry name

RETN_HUMAN

Accession

Primary (citable) accession number: Q9HD89
Secondary accession number(s): D6W649, Q540D9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.