ID   GGD2_HUMAN     STANDARD;      PRT;   146 AA.
AC   Q9HD64; Q8WWG5; Q8WWG6; Q969J6;
DT   16-OCT-2001 (Rel. 40, Created)
DT   16-OCT-2001 (Rel. 40, Last sequence update)
DT   15-JUN-2002 (Rel. 41, Last annotation update)
DE   G antigen family D 2 protein (XAGE-1 protein).
GN   GAGED2 OR XAGE1.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A. (ISOFORM A).
RC   TISSUE=Testis;
RX   MEDLINE=20441565; PubMed=10987281;
RA   Liu X.F., Helman L.J., Yeung C., Bera T.K., Lee B., Pastan I.;
RT   "XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma.";
RL   Cancer Res. 60:4752-4755(2000).
RN   [2]
RP   SEQUENCE FROM N.A. (ISOFORMS B; C AND D).
RX   PubMed=11992404;
RA   Zendman A.J.W., Van Kraats A.A., Weidle U.H., Ruiter D.J.,
RA   Van Muijen G.N.P.;
RT   "The XAGE family of cancer/testis-associated genes: alignment and
RT   expression profile in normal tissues, melanoma lesions and Ewing's
RT   sarcoma.";
RL   Int. J. Cancer 99:361-369(2002).
RN   [3]
RP   SEQUENCE FROM N.A. (ISOFORM B).
RC   TISSUE=Lung;
RA   Strausberg R.;
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: UNKNOWN.
CC   -!- ALTERNATIVE PRODUCTS: 4 isoforms; A/XAGE-1a (shown here), B/XAGE-
CC       1b, C/XAGE-1c and D/XAGE-1d; are produced by alternative splicing.
CC   -!- TISSUE SPECIFICITY: Highly expressed in normal testis, in Ewing's
CC       cell lines, in some Ewing's sarcoma patient samples, and in one of
CC       one alveolar rhabdomyosarcoma patient sample.
CC   -!- SIMILARITY: BELONGS TO THE GAGE FAMILY.
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DR   EMBL; AF251237; AAG01401.1; -.
DR   EMBL; AJ318878; CAC82986.1; -.
DR   EMBL; AJ318879; CAC82987.1; -.
DR   EMBL; AJ290447; CAC38107.1; -.
DR   EMBL; AJ400997; CAC38108.1; -.
DR   EMBL; BC009538; AAH09538.1; -.
DR   Genew; HGNC:4111; GAGED2.
DR   MIM; 300289; -.
KW   Alternative splicing; Multigene family.
FT   VARSPLIC      1     50       MLLWCPPQCACSLGVFPSAPSPVWGTRRSCEPATRVPEVWI
FT                                LSPLLRHGG -> MRCHAHGPSCLVTAITREEGGPRSGGAQ
FT                                AKLGCCWGYPSPRSTWNPDRRFWTPQTGPGEGRHER (IN
FT                                ISOFORM C).
FT   VARSPLIC      1     65       MISSING (IN ISOFORM B AND ISOFORM D).
FT   VARSPLIC     98    146       CATWKVICKSCISQTPGINLDLGSGVKVKIIPKEEHCKMPE
FT                                AGEEQPQV -> VLGREMRDMEGDLQELHQSNTGDKSGFGF
FT                                RRQGEDNT (IN ISOFORM D).
SQ   SEQUENCE   146 AA;  16163 MW;  4B4FC1E5C7434F21 CRC64;
     MLLWCPPQCA CSLGVFPSAP SPVWGTRRSC EPATRVPEVW ILSPLLRHGG HTQTQNHTAS
     PRSPVMESPK KKNQQLKVGI LHLGSRQKKI RIQLRSQCAT WKVICKSCIS QTPGINLDLG
     SGVKVKIIPK EEHCKMPEAG EEQPQV
//