ID   GAGD2_HUMAN             Reviewed;         160 AA.
AC   Q9HD64; A6NJ94; Q5JPP0; Q5JPP3; Q8WWG5; Q8WWG6; Q969J6;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 2.
DT   03-MAR-2009, entry version 66.
DE   RecName: Full=G antigen family D member 2;
DE   AltName: Full=Protein XAGE-1;
DE   AltName: Full=Cancer/testis antigen 12.1;
DE            Short=CT12.1;
GN   Name=XAGE1; Synonyms=GAGED2, XAGE1A;
GN   and
GN   Name=XAGE1B;
GN   and
GN   Name=XAGE1C;
GN   and
GN   Name=XAGE1D;
GN   and
GN   Name=XAGE1E;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
RC   TISSUE=Testis;
RX   MEDLINE=20441565; PubMed=10987281;
RA   Liu X.F., Helman L.J., Yeung C., Bera T.K., Lee B., Pastan I.;
RT   "XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma.";
RL   Cancer Res. 60:4752-4755(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS B; C AND D).
RX   MEDLINE=22021429; PubMed=11992404; DOI=10.1002/ijc.10371;
RA   Zendman A.J.W., van Kraats A.A., Weidle U.H., Ruiter D.J.,
RA   van Muijen G.N.P.;
RT   "The XAGE family of cancer/testis-associated genes: alignment and
RT   expression profile in normal tissues, melanoma lesions and Ewing's
RT   sarcoma.";
RL   Int. J. Cancer 99:361-369(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT   vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A.,
RA   Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G.,
RA   Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S.,
RA   Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R.,
RA   Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L.,
RA   Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A.,
RA   Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S.,
RA   Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R.,
RA   Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M.,
RA   Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N.,
RA   Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D.,
RA   Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W.,
RA   Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C.,
RA   Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C.,
RA   Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J.,
RA   Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S.,
RA   Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I.,
RA   Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L.,
RA   Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P.,
RA   Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S.,
RA   Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A.,
RA   Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J.,
RA   Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J.,
RA   Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S.,
RA   de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z.,
RA   Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C.,
RA   Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W.,
RA   Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T.,
RA   Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I.,
RA   Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N.,
RA   Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J.,
RA   Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E.,
RA   Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S.,
RA   Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T.,
RA   Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S.,
RA   Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L.,
RA   Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A.,
RA   Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L.,
RA   Williams G., Williams L., Williamson A., Williamson H., Wilming L.,
RA   Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H.,
RA   Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A.,
RA   Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A.,
RA   Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T.,
RA   Gibbs R.A., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   TISSUE SPECIFICITY, AND ISOFORM B INITIATOR METHIONINE.
RX   PubMed=12479262;
RA   Egland K.A., Kumar V., Duray P., Pastan I.;
RT   "Characterization of overlapping XAGE-1 transcripts encoding a cancer
RT   testis antigen expressed in lung, breast, and other types of
RT   cancers.";
RL   Mol. Cancer Ther. 1:441-450(2002).
CC   -!- FUNCTION: Unknown.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=C; Synonyms=XAGE-1c;
CC         IsoId=Q9HD64-3; Sequence=Displayed;
CC       Name=B; Synonyms=XAGE-1a, XAGE-1b;
CC         IsoId=Q9HD64-2; Sequence=VSP_001595;
CC         Note=XAGE-1a and XAGE-1b mRNAs are produced by alternative
CC         promoter usage. However, for both isoforms, the translation
CC         initiator codon remains the same, generating an identical
CC         protein. XAGE-1b is the predominant transcript, compared to
CC         XAGE-1a;
CC       Name=D; Synonyms=XAGE-1d;
CC         IsoId=Q9HD64-4; Sequence=VSP_001595, VSP_001596;
CC   -!- TISSUE SPECIFICITY: In normal tissues, highly expressed in testis.
CC       Expressed also in many different types of cancers: highly
CC       expressed in breast cancer, prostate cancer and many types of lung
CC       cancers, including squamous cell carcinoma, small cell carcinoma,
CC       non-small cell carcinoma, and adenocarcinoma, as well as in
CC       Ewing's cell lines, in some Ewing's sarcoma patient samples, and
CC       in one of one alveolar rhabdomyosarcoma patient sample.
CC   -!- SIMILARITY: Belongs to the GAGE family.
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DR   EMBL; AF251237; AAG01401.1; ALT_INIT; mRNA.
DR   EMBL; AJ318878; CAC82986.1; -; mRNA.
DR   EMBL; AJ318879; CAC82987.1; -; mRNA.
DR   EMBL; AJ290447; CAC38107.1; -; mRNA.
DR   EMBL; BT007099; AAP35763.1; -; mRNA.
DR   EMBL; AJ400997; CAC38108.1; -; Genomic_DNA.
DR   EMBL; AL772246; CAI41526.1; -; Genomic_DNA.
DR   EMBL; AL772246; CAI41528.1; -; Genomic_DNA.
DR   EMBL; AL772246; CAI41530.1; -; Genomic_DNA.
DR   EMBL; AL772246; CAI41531.1; -; Genomic_DNA.
DR   EMBL; AL772246; CAI41533.1; -; Genomic_DNA.
DR   EMBL; AL772246; CAI41534.1; -; Genomic_DNA.
DR   EMBL; BX088602; CAI40888.1; -; Genomic_DNA.
DR   EMBL; BX088602; CAI40890.1; -; Genomic_DNA.
DR   EMBL; BX088602; CAI40894.1; -; Genomic_DNA.
DR   EMBL; BX088602; CAI40895.1; -; Genomic_DNA.
DR   EMBL; BC009538; AAH09538.1; -; mRNA.
DR   IPI; IPI00006982; -.
DR   IPI; IPI00219938; -.
DR   IPI; IPI00219939; -.
DR   RefSeq; NP_001091060.1; -.
DR   RefSeq; NP_001091064.1; -.
DR   RefSeq; NP_001091071.1; -.
DR   RefSeq; NP_001091072.1; -.
DR   RefSeq; NP_065144.1; -.
DR   RefSeq; NP_597673.1; -.
DR   RefSeq; NP_597674.1; -.
DR   UniGene; Hs.112208; -.
DR   UniGene; Hs.546096; -.
DR   PRIDE; Q9HD64; -.
DR   Ensembl; ENSG00000183461; Homo sapiens.
DR   Ensembl; ENSG00000204375; Homo sapiens.
DR   Ensembl; ENSG00000204376; Homo sapiens.
DR   Ensembl; ENSG00000204379; Homo sapiens.
DR   Ensembl; ENSG00000204382; Homo sapiens.
DR   GeneID; 653048; -.
DR   GeneID; 653067; -.
DR   GeneID; 653219; -.
DR   GeneID; 653220; -.
DR   GeneID; 9503; -.
DR   KEGG; hsa:653067; -.
DR   KEGG; hsa:653219; -.
DR   KEGG; hsa:9503; -.
DR   GeneCards; GC0XM052545; -.
DR   GeneCards; GC0XM052561; -.
DR   GeneCards; GC0XP052257; -.
DR   GeneCards; GC0XP052529; -.
DR   GeneCards; GC0XP052532; -.
DR   H-InvDB; HIX0020425; -.
DR   H-InvDB; HIX0077113; -.
DR   H-InvDB; HIX0077114; -.
DR   H-InvDB; HIX0077115; -.
DR   H-InvDB; HIX0077116; -.
DR   HGNC; HGNC:4111; XAGE1.
DR   HGNC; HGNC:25400; XAGE1B.
DR   HGNC; HGNC:30679; XAGE1C.
DR   HGNC; HGNC:21508; XAGE1D.
DR   HGNC; HGNC:18372; XAGE1E.
DR   MIM; 300289; gene.
DR   PharmGKB; PA28526; -.
DR   HOGENOM; Q9HD64; -.
DR   HOVERGEN; Q9HD64; -.
DR   LinkHub; Q9HD64; -.
DR   NextBio; 122635; -.
DR   Bgee; Q9HD64; -.
DR   CleanEx; HS_XAGE1B; -.
DR   CleanEx; HS_XAGE1D; -.
DR   GermOnline; ENSG00000183461; Homo sapiens.
DR   GermOnline; ENSG00000204375; Homo sapiens.
DR   GermOnline; ENSG00000204376; Homo sapiens.
DR   GermOnline; ENSG00000204379; Homo sapiens.
DR   GermOnline; ENSG00000204382; Homo sapiens.
DR   InterPro; IPR008625; GAGE.
DR   Pfam; PF05831; GAGE; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing.
FT   CHAIN         1    160       G antigen family D member 2.
FT                                /FTId=PRO_0000148349.
FT   VAR_SEQ       1     79       Missing (in isoform B and isoform D).
FT                                /FTId=VSP_001595.
FT   VAR_SEQ     112    160       CATWKVICKSCISQTPGINLDLGSGVKVKIIPKEEHCKMPE
FT                                AGEEQPQV -> VLGREMRDMEGDLQELHQSNTGDKSGFGF
FT                                RRQGEDNT (in isoform D).
FT                                /FTId=VSP_001596.
SQ   SEQUENCE   160 AA;  17751 MW;  8EF00D22A67008A7 CRC64;
     MRCHAHGPSC LVTAITREEG GPRSGGAQAK LGCCWGYPSP RSTWNPDRRF WTPQTGPGEG
     RHERHTQTQN HTASPRSPVM ESPKKKNQQL KVGILHLGSR QKKIRIQLRS QCATWKVICK
     SCISQTPGIN LDLGSGVKVK IIPKEEHCKM PEAGEEQPQV
//