ID   GAGD2_HUMAN    STANDARD;      PRT;   160 AA.
AC   Q9HD64; Q8WWG5; Q8WWG6; Q969J6;
DT   16-OCT-2001 (Rel. 40, Created)
DT   25-OCT-2004 (Rel. 45, Last sequence update)
DT   24-JAN-2006 (Rel. 49, Last annotation update)
DE   G antigen family D 2 protein (XAGE-1 protein).
GN   Name=XAGE1; Synonyms=GAGED2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE (ISOFORM B).
RC   TISSUE=Testis;
RX   MEDLINE=20441565; PubMed=10987281;
RA   Liu X.F., Helman L.J., Yeung C., Bera T.K., Lee B., Pastan I.;
RT   "XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma.";
RL   Cancer Res. 60:4752-4755(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE (ISOFORMS B; C AND D).
RX   MEDLINE=22021429; PubMed=11992404; DOI=10.1002/ijc.10371;
RA   Zendman A.J.W., Van Kraats A.A., Weidle U.H., Ruiter D.J.,
RA   Van Muijen G.N.P.;
RT   "The XAGE family of cancer/testis-associated genes: alignment and
RT   expression profile in normal tissues, melanoma lesions and Ewing's
RT   sarcoma.";
RL   Int. J. Cancer 99:361-369(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
RC   TISSUE=Lung;
RX   MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA   Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA   Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN   [4]
RP   TISSUE SPECIFICITY, AND ISOFORM B INITIATOR METHIONINE.
RX   PubMed=12479262;
RA   Egland K.A., Kumar V., Duray P., Pastan I.;
RT   "Characterization of overlapping XAGE-1 transcripts encoding a cancer
RT   testis antigen expressed in lung, breast, and other types of
RT   cancers.";
RL   Mol. Cancer Ther. 1:441-450(2002).
CC   -!- FUNCTION: Unknown.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=C; Synonyms=XAGE-1c;
CC         IsoId=Q9HD64-3; Sequence=Displayed;
CC       Name=B; Synonyms=XAGE-1a, XAGE-1b;
CC         IsoId=Q9HD64-2; Sequence=VSP_001595;
CC         Note=XAGE-1a and XAGE-1b mRNAs are produced by alternative
CC         promoter usage. However, for both isoforms, the translation
CC         initiator codon remains the same, generating an identical
CC         protein. XAGE-1b is the predominant transcript, compared to
CC         XAGE-1a;
CC       Name=D; Synonyms=XAGE-1d;
CC         IsoId=Q9HD64-4; Sequence=VSP_001595, VSP_001596;
CC   -!- TISSUE SPECIFICITY: In normal tissues, highly expressed in testis.
CC       Expressed also in many different types of cancers: highly
CC       expressed in breast cancer, prostate cancer and many types of lung
CC       cancers, including squamous cell carcinoma, small cell carcinoma,
CC       non-small cell carcinoma, and adenocarcinoma, as well as in
CC       Ewing's cell lines, in some Ewing's sarcoma patient samples, and
CC       in one of one alveolar rhabdomyosarcoma patient sample.
CC   -!- SIMILARITY: Belongs to the GAGE family.
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DR   EMBL; AF251237; AAG01401.1; ALT_INIT; mRNA.
DR   EMBL; AJ318878; CAC82986.1; -; mRNA.
DR   EMBL; AJ318879; CAC82987.1; -; mRNA.
DR   EMBL; AJ290447; CAC38107.1; -; mRNA.
DR   EMBL; AJ400997; CAC38108.1; -; Genomic_DNA.
DR   EMBL; BC009538; AAH09538.1; -; mRNA.
DR   Ensembl; ENSG00000183461; Homo sapiens.
DR   HGNC; HGNC:4111; XAGE1.
DR   MIM; 300289; -.
DR   LinkHub; Q9HD64; -.
DR   InterPro; IPR008625; GAGE.
DR   Pfam; PF05831; GAGE; 1.
KW   Alternative splicing.
FT   VARSPLIC      1     79       Missing (in isoform B and isoform D).
FT                                /FTId=VSP_001595.
FT   VARSPLIC    112    160       CATWKVICKSCISQTPGINLDLGSGVKVKIIPKEEHCKMPE
FT                                AGEEQPQV -> VLGREMRDMEGDLQELHQSNTGDKSGFGF
FT                                RRQGEDNT (in isoform D).
FT                                /FTId=VSP_001596.
SQ   SEQUENCE   160 AA;  17751 MW;  8EF00D22A67008A7 CRC64;
     MRCHAHGPSC LVTAITREEG GPRSGGAQAK LGCCWGYPSP RSTWNPDRRF WTPQTGPGEG
     RHERHTQTQN HTASPRSPVM ESPKKKNQQL KVGILHLGSR QKKIRIQLRS QCATWKVICK
     SCISQTPGIN LDLGSGVKVK IIPKEEHCKM PEAGEEQPQV
//