ID   GGD2_HUMAN     STANDARD;      PRT;   146 AA.
AC   Q9HD64; Q8WWG5; Q8WWG6; Q969J6;
DT   16-OCT-2001 (Rel. 40, Created)
DT   16-OCT-2001 (Rel. 40, Last sequence update)
DT   05-JUL-2004 (Rel. 44, Last annotation update)
DE   G antigen family D 2 protein (XAGE-1 protein).
GN   Name=GAGED2; Synonyms=XAGE1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A. (ISOFORM A).
RC   TISSUE=Testis;
RX   MEDLINE=20441565; PubMed=10987281;
RA   Liu X.F., Helman L.J., Yeung C., Bera T.K., Lee B., Pastan I.;
RT   "XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma.";
RL   Cancer Res. 60:4752-4755(2000).
RN   [2]
RP   SEQUENCE FROM N.A. (ISOFORMS B; C AND D).
RX   MEDLINE=22021429; PubMed=11992404; DOI=10.1002/ijc.10371;
RA   Zendman A.J.W., Van Kraats A.A., Weidle U.H., Ruiter D.J.,
RA   Van Muijen G.N.P.;
RT   "The XAGE family of cancer/testis-associated genes: alignment and
RT   expression profile in normal tissues, melanoma lesions and Ewing's
RT   sarcoma.";
RL   Int. J. Cancer 99:361-369(2002).
RN   [3]
RP   SEQUENCE FROM N.A. (ISOFORM B).
RC   TISSUE=Lung;
RX   MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA   Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA   Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
CC   -!- FUNCTION: Unknown.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=A; Synonyms=XAGE-1a;
CC         IsoId=Q9HD64-1; Sequence=Displayed;
CC       Name=B; Synonyms=XAGE-1b;
CC         IsoId=Q9HD64-2; Sequence=VSP_001595;
CC       Name=C; Synonyms=XAGE-1c;
CC         IsoId=Q9HD64-3; Sequence=VSP_001594;
CC       Name=D; Synonyms=XAGE-1d;
CC         IsoId=Q9HD64-4; Sequence=VSP_001595, VSP_001596;
CC   -!- TISSUE SPECIFICITY: Highly expressed in normal testis, in Ewing's
CC       cell lines, in some Ewing's sarcoma patient samples, and in one of
CC       one alveolar rhabdomyosarcoma patient sample.
CC   -!- SIMILARITY: Belongs to the GAGE family.
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DR   EMBL; AF251237; AAG01401.1; -.
DR   EMBL; AJ318878; CAC82986.1; -.
DR   EMBL; AJ318879; CAC82987.1; -.
DR   EMBL; AJ290447; CAC38107.1; -.
DR   EMBL; AJ400997; CAC38108.1; -.
DR   EMBL; BC009538; AAH09538.1; -.
DR   Genew; HGNC:4111; GAGED2.
DR   MIM; 300289; -.
DR   InterPro; IPR008625; GAGE.
DR   Pfam; PF05831; GAGE; 1.
KW   Alternative splicing; Multigene family.
FT   VARSPLIC      1     50       MLLWCPPQCACSLGVFPSAPSPVWGTRRSCEPATRVPEVWI
FT                                LSPLLRHGG -> MRCHAHGPSCLVTAITREEGGPRSGGAQ
FT                                AKLGCCWGYPSPRSTWNPDRRFWTPQTGPGEGRHER (in
FT                                isoform C).
FT                                /FTId=VSP_001594.
FT   VARSPLIC      1     65       Missing (in isoform B and isoform D).
FT                                /FTId=VSP_001595.
FT   VARSPLIC     98    146       CATWKVICKSCISQTPGINLDLGSGVKVKIIPKEEHCKMPE
FT                                AGEEQPQV -> VLGREMRDMEGDLQELHQSNTGDKSGFGF
FT                                RRQGEDNT (in isoform D).
FT                                /FTId=VSP_001596.
SQ   SEQUENCE   146 AA;  16163 MW;  4B4FC1E5C7434F21 CRC64;
     MLLWCPPQCA CSLGVFPSAP SPVWGTRRSC EPATRVPEVW ILSPLLRHGG HTQTQNHTAS
     PRSPVMESPK KKNQQLKVGI LHLGSRQKKI RIQLRSQCAT WKVICKSCIS QTPGINLDLG
     SGVKVKIIPK EEHCKMPEAG EEQPQV
//