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Q9HD64

- XAGE1_HUMAN

UniProt

Q9HD64 - XAGE1_HUMAN

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Protein

X antigen family member 1

Gene

XAGE1A

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
X antigen family member 1
Short name:
XAGE-1
Alternative name(s):
Cancer/testis antigen 12.1
Short name:
CT12.1
G antigen family D member 2
Gene namesi
Name:XAGE1A
Synonyms:GAGED2, XAGE1
AND
Name:XAGE1B
AND
Name:XAGE1C
AND
Name:XAGE1D
AND
Name:XAGE1E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:4111. XAGE1A.
HGNC:25400. XAGE1B.
HGNC:30679. XAGE1C.
HGNC:21508. XAGE1D.
HGNC:18372. XAGE1E.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28526.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8181X antigen family member 1PRO_0000148349Add
BLAST

Proteomic databases

MaxQBiQ9HD64.
PaxDbiQ9HD64.
PRIDEiQ9HD64.

PTM databases

PhosphoSiteiQ9HD64.

Expressioni

Tissue specificityi

In normal tissues, highly expressed in testis. Expressed also in many different types of cancers: highly expressed in breast cancer, prostate cancer and many types of lung cancers, including squamous cell carcinoma, small cell carcinoma, non-small cell carcinoma, and adenocarcinoma, as well as in Ewing's cell lines, in some Ewing's sarcoma patient samples, and in one of one alveolar rhabdomyosarcoma patient sample.2 Publications

Gene expression databases

BgeeiQ9HD64.
CleanExiHS_XAGE1D.
GenevestigatoriQ9HD64.

Organism-specific databases

HPAiHPA050858.

Interactioni

Protein-protein interaction databases

BioGridi114882. 2 interactions.
575486. 1 interaction.
575500. 1 interaction.
IntActiQ9HD64. 1 interaction.
STRINGi9606.ENSP00000342190.

Structurei

3D structure databases

ProteinModelPortaliQ9HD64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiNOG81371.
GeneTreeiENSGT00390000003361.
InParanoidiQ9HD64.
OrthoDBiEOG78PVBW.
TreeFamiTF342350.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform B (identifier: Q9HD64-2) [UniParc]FASTAAdd to Basket

Also known as: XAGE-1a, XAGE-1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESPKKKNQQ LKVGILHLGS RQKKIRIQLR SQCATWKVIC KSCISQTPGI
60 70 80
NLDLGSGVKV KIIPKEEHCK MPEAGEEQPQ V

Note: XAGE-1a and XAGE-1b mRNAs are produced by alternative promoter usage. However, for both isoforms, the translation initiator codon remains the same, generating an identical protein. XAGE-1b is the predominant transcript, compared to XAGE-1a.

Length:81
Mass (Da):9,078
Last modified:May 31, 2011 - v3
Checksum:iC73337C4C94C01D1
GO
Isoform D (identifier: Q9HD64-4) [UniParc]FASTAAdd to Basket

Also known as: XAGE-1d

The sequence of this isoform differs from the canonical sequence as follows:
     33-81: CATWKVICKS...PEAGEEQPQV → VLGREMRDME...GFRRQGEDNT

Show »
Length:69
Mass (Da):7,965
Checksum:i0480A160F893AF81
GO

Sequence cautioni

The sequence AAG01401.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH09538.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAC82986.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAI40888.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI40895.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI41526.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI41531.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI41534.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei33 – 8149CATWK…EQPQV → VLGREMRDMEGDLQELHQSN TGDKSGFGFRRQGEDNT in isoform D. 1 PublicationVSP_001596Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251237 mRNA. Translation: AAG01401.1. Different initiation.
AJ290447 mRNA. Translation: CAC38107.1.
AJ400997 Genomic DNA. Translation: CAC38108.1.
AJ318878 mRNA. Translation: CAC82986.1. Different initiation.
AJ318879 mRNA. Translation: CAC82987.1.
BT007099 mRNA. Translation: AAP35763.1.
AL772246 Genomic DNA. Translation: CAI41526.1. Sequence problems.
AL772246 Genomic DNA. Translation: CAI41527.1.
AL772246 Genomic DNA. Translation: CAI41528.1.
AL772246 Genomic DNA. Translation: CAI41530.1.
AL772246 Genomic DNA. Translation: CAI41531.1. Sequence problems.
AL772246 Genomic DNA. Translation: CAI41532.1.
AL772246 Genomic DNA. Translation: CAI41533.1.
AL772246 Genomic DNA. Translation: CAI41534.1. Sequence problems.
BX088602 Genomic DNA. Translation: CAI40888.1. Sequence problems.
BX088602 Genomic DNA. Translation: CAI40889.1.
BX088602 Genomic DNA. Translation: CAI40890.1.
BX088602 Genomic DNA. Translation: CAI40893.1.
BX088602 Genomic DNA. Translation: CAI40894.1.
BX088602 Genomic DNA. Translation: CAI40895.1. Sequence problems.
BC009538 mRNA. Translation: AAH09538.2. Different initiation.
CCDSiCCDS48126.2. [Q9HD64-2]
CCDS48128.1. [Q9HD64-4]
CCDS75982.1. [Q9HD64-2]
CCDS75983.1. [Q9HD64-4]
RefSeqiNP_001091063.2. NM_001097594.2. [Q9HD64-2]
NP_001091065.1. NM_001097596.2. [Q9HD64-4]
NP_001091073.2. NM_001097604.2. [Q9HD64-2]
NP_001091074.1. NM_001097605.2. [Q9HD64-4]
XP_006724659.1. XM_006724596.1.
XP_006724661.1. XM_006724598.1.
UniGeneiHs.112208.
Hs.546096.
Hs.584511.

Genome annotation databases

EnsembliENST00000375600; ENSP00000364750; ENSG00000204379. [Q9HD64-4]
ENST00000375602; ENSP00000364752; ENSG00000204379. [Q9HD64-2]
ENST00000375613; ENSP00000364763; ENSG00000204382. [Q9HD64-4]
ENST00000375616; ENSP00000364766; ENSG00000204382. [Q9HD64-2]
ENST00000518075; ENSP00000430130; ENSG00000204382. [Q9HD64-2]
GeneIDi653067.
653220.
KEGGihsa:653067.
hsa:653220.
UCSCiuc004dqf.3. human. [Q9HD64-2]
uc004dqg.3. human. [Q9HD64-4]

Polymorphism databases

DMDMi334302901.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251237 mRNA. Translation: AAG01401.1 . Different initiation.
AJ290447 mRNA. Translation: CAC38107.1 .
AJ400997 Genomic DNA. Translation: CAC38108.1 .
AJ318878 mRNA. Translation: CAC82986.1 . Different initiation.
AJ318879 mRNA. Translation: CAC82987.1 .
BT007099 mRNA. Translation: AAP35763.1 .
AL772246 Genomic DNA. Translation: CAI41526.1 . Sequence problems.
AL772246 Genomic DNA. Translation: CAI41527.1 .
AL772246 Genomic DNA. Translation: CAI41528.1 .
AL772246 Genomic DNA. Translation: CAI41530.1 .
AL772246 Genomic DNA. Translation: CAI41531.1 . Sequence problems.
AL772246 Genomic DNA. Translation: CAI41532.1 .
AL772246 Genomic DNA. Translation: CAI41533.1 .
AL772246 Genomic DNA. Translation: CAI41534.1 . Sequence problems.
BX088602 Genomic DNA. Translation: CAI40888.1 . Sequence problems.
BX088602 Genomic DNA. Translation: CAI40889.1 .
BX088602 Genomic DNA. Translation: CAI40890.1 .
BX088602 Genomic DNA. Translation: CAI40893.1 .
BX088602 Genomic DNA. Translation: CAI40894.1 .
BX088602 Genomic DNA. Translation: CAI40895.1 . Sequence problems.
BC009538 mRNA. Translation: AAH09538.2 . Different initiation.
CCDSi CCDS48126.2. [Q9HD64-2 ]
CCDS48128.1. [Q9HD64-4 ]
CCDS75982.1. [Q9HD64-2 ]
CCDS75983.1. [Q9HD64-4 ]
RefSeqi NP_001091063.2. NM_001097594.2. [Q9HD64-2 ]
NP_001091065.1. NM_001097596.2. [Q9HD64-4 ]
NP_001091073.2. NM_001097604.2. [Q9HD64-2 ]
NP_001091074.1. NM_001097605.2. [Q9HD64-4 ]
XP_006724659.1. XM_006724596.1.
XP_006724661.1. XM_006724598.1.
UniGenei Hs.112208.
Hs.546096.
Hs.584511.

3D structure databases

ProteinModelPortali Q9HD64.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114882. 2 interactions.
575486. 1 interaction.
575500. 1 interaction.
IntActi Q9HD64. 1 interaction.
STRINGi 9606.ENSP00000342190.

PTM databases

PhosphoSitei Q9HD64.

Polymorphism databases

DMDMi 334302901.

Proteomic databases

MaxQBi Q9HD64.
PaxDbi Q9HD64.
PRIDEi Q9HD64.

Protocols and materials databases

DNASUi 9503.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375600 ; ENSP00000364750 ; ENSG00000204379 . [Q9HD64-4 ]
ENST00000375602 ; ENSP00000364752 ; ENSG00000204379 . [Q9HD64-2 ]
ENST00000375613 ; ENSP00000364763 ; ENSG00000204382 . [Q9HD64-4 ]
ENST00000375616 ; ENSP00000364766 ; ENSG00000204382 . [Q9HD64-2 ]
ENST00000518075 ; ENSP00000430130 ; ENSG00000204382 . [Q9HD64-2 ]
GeneIDi 653067.
653220.
KEGGi hsa:653067.
hsa:653220.
UCSCi uc004dqf.3. human. [Q9HD64-2 ]
uc004dqg.3. human. [Q9HD64-4 ]

Organism-specific databases

CTDi 653067.
653220.
GeneCardsi GC0XM052255.
GC0XM052545.
GC0XM052559.
GC0XP052239.
GC0XP052511.
HGNCi HGNC:4111. XAGE1A.
HGNC:25400. XAGE1B.
HGNC:30679. XAGE1C.
HGNC:21508. XAGE1D.
HGNC:18372. XAGE1E.
HPAi HPA050858.
MIMi 300289. gene.
300742. gene.
300743. gene.
300744. gene.
300745. gene.
neXtProti NX_Q9HD64.
PharmGKBi PA28526.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG81371.
GeneTreei ENSGT00390000003361.
InParanoidi Q9HD64.
OrthoDBi EOG78PVBW.
TreeFami TF342350.

Miscellaneous databases

NextBioi 122635.
PROi Q9HD64.
SOURCEi Search...

Gene expression databases

Bgeei Q9HD64.
CleanExi HS_XAGE1D.
Genevestigatori Q9HD64.

Family and domain databases

InterProi IPR008625. GAGE.
[Graphical view ]
Pfami PF05831. GAGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma."
    Liu X.F., Helman L.J., Yeung C., Bera T.K., Lee B., Pastan I.
    Cancer Res. 60:4752-4755(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
    Tissue: Testis.
  2. "The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma."
    Zendman A.J.W., van Kraats A.A., Weidle U.H., Ruiter D.J., van Muijen G.N.P.
    Int. J. Cancer 99:361-369(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS B AND D).
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
    Tissue: Lung.
  6. "Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers."
    Egland K.A., Kumar V., Duray P., Pastan I.
    Mol. Cancer Ther. 1:441-450(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, IDENTIFICATION OF INITIATOR METHIONINE (ISOFORM B).
  7. "Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors."
    Sato S., Noguchi Y., Ohara N., Uenaka A., Shimono M., Nakagawa K., Koizumi F., Ishida T., Yoshino T., Shiratori Y., Nakayama E.
    Cancer Immun. 7:5-5(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, ALTERNATIVE SPLICING (ISOFORMS B AND D), IDENTIFICATION OF INITIATOR METHIONINE (ISOFORM B).

Entry informationi

Entry nameiXAGE1_HUMAN
AccessioniPrimary (citable) accession number: Q9HD64
Secondary accession number(s): A6NJ94
, Q5JPN8, Q5JPP0, Q5JPP3, Q8WWG5, Q8WWG6, Q969J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 31, 2011
Last modified: November 26, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

According to PubMed:11992404, the transcription of XAGE1A is regulated by methylation of the CpG island in the promoter, and four alternative RNA splicing variants, XAGE-1a, b, c have been identified.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3