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Protein

X antigen family member 1

Gene

XAGE1A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

According to PubMed:11992404, the transcription of XAGE1A is regulated by methylation of the CpG island in the promoter, and four alternative RNA splicing variants, XAGE-1a, b, c have been identified.

Names & Taxonomyi

Protein namesi
Recommended name:
X antigen family member 1
Short name:
XAGE-1
Alternative name(s):
Cancer/testis antigen 12.1
Short name:
CT12.1
G antigen family D member 2
Gene namesi
Name:XAGE1A
Synonyms:GAGED2, XAGE1
AND
Name:XAGE1B
AND
Name:XAGE1C
AND
Name:XAGE1D
AND
Name:XAGE1E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000204379.10.
HostDB:ENSG00000204382.11.
HGNCiHGNC:4111. XAGE1A.
HGNC:25400. XAGE1B.
HGNC:30679. XAGE1C.
HGNC:21508. XAGE1D.
HGNC:18372. XAGE1E.

Pathology & Biotechi

Organism-specific databases

DisGeNETi653067.
653220.
OpenTargetsiENSG00000204382.
PharmGKBiPA28526.

Polymorphism and mutation databases

DMDMi334302901.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483491 – 81X antigen family member 1Add BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei20PhosphoserineCombined sources1
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki65Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9HD64.
PaxDbiQ9HD64.
PeptideAtlasiQ9HD64.
PRIDEiQ9HD64.

PTM databases

iPTMnetiQ9HD64.
PhosphoSitePlusiQ9HD64.

Expressioni

Tissue specificityi

In normal tissues, highly expressed in testis. Expressed also in many different types of cancers: highly expressed in breast cancer, prostate cancer and many types of lung cancers, including squamous cell carcinoma, small cell carcinoma, non-small cell carcinoma, and adenocarcinoma, as well as in Ewing's cell lines, in some Ewing's sarcoma patient samples, and in one of one alveolar rhabdomyosarcoma patient sample.2 Publications

Gene expression databases

BgeeiENSG00000204379.
CleanExiHS_XAGE1D.
GenevisibleiQ9HD64. HS.

Organism-specific databases

HPAiHPA077164.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi575500. 6 interactors.
575617. 38 interactors.
IntActiQ9HD64. 5 interactors.
STRINGi9606.ENSP00000364766.

Structurei

3D structure databases

ProteinModelPortaliQ9HD64.
SMRiQ9HD64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000003361.
InParanoidiQ9HD64.
OMAiVICKSCV.
OrthoDBiEOG091G0PP6.
TreeFamiTF342350.

Family and domain databases

InterProiView protein in InterPro
IPR008625. GAGE_fam.
PANTHERiPTHR14047. PTHR14047. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: Q9HD64-2) [UniParc]FASTAAdd to basket
Also known as: XAGE-1a, XAGE-1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESPKKKNQQ LKVGILHLGS RQKKIRIQLR SQCATWKVIC KSCISQTPGI
60 70 80
NLDLGSGVKV KIIPKEEHCK MPEAGEEQPQ V
Note: XAGE-1a and XAGE-1b mRNAs are produced by alternative promoter usage. However, for both isoforms, the translation initiator codon remains the same, generating an identical protein. XAGE-1b is the predominant transcript, compared to XAGE-1a.
Length:81
Mass (Da):9,078
Last modified:May 31, 2011 - v3
Checksum:iC73337C4C94C01D1
GO
Isoform D (identifier: Q9HD64-4) [UniParc]FASTAAdd to basket
Also known as: XAGE-1d

The sequence of this isoform differs from the canonical sequence as follows:
     33-81: CATWKVICKS...PEAGEEQPQV → VLGREMRDME...GFRRQGEDNT

Show »
Length:69
Mass (Da):7,965
Checksum:i0480A160F893AF81
GO

Sequence cautioni

The sequence AAG01401 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH09538 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAC82986 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAI40888 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI40895 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41526 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41531 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41534 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00159633 – 81CATWK…EQPQV → VLGREMRDMEGDLQELHQSN TGDKSGFGFRRQGEDNT in isoform D. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251237 mRNA. Translation: AAG01401.1. Different initiation.
AJ290447 mRNA. Translation: CAC38107.1.
AJ400997 Genomic DNA. Translation: CAC38108.1.
AJ318878 mRNA. Translation: CAC82986.1. Different initiation.
AJ318879 mRNA. Translation: CAC82987.1.
BT007099 mRNA. Translation: AAP35763.1.
AL772246 Genomic DNA. Translation: CAI41526.1. Sequence problems.
AL772246 Genomic DNA. Translation: CAI41527.1.
AL772246 Genomic DNA. Translation: CAI41528.1.
AL772246 Genomic DNA. Translation: CAI41530.1.
AL772246 Genomic DNA. Translation: CAI41531.1. Sequence problems.
AL772246 Genomic DNA. Translation: CAI41532.1.
AL772246 Genomic DNA. Translation: CAI41533.1.
AL772246 Genomic DNA. Translation: CAI41534.1. Sequence problems.
BX088602 Genomic DNA. Translation: CAI40888.1. Sequence problems.
BX088602 Genomic DNA. Translation: CAI40889.1.
BX088602 Genomic DNA. Translation: CAI40890.1.
BX088602 Genomic DNA. Translation: CAI40893.1.
BX088602 Genomic DNA. Translation: CAI40894.1.
BX088602 Genomic DNA. Translation: CAI40895.1. Sequence problems.
BC009538 mRNA. Translation: AAH09538.2. Different initiation.
CCDSiCCDS48126.2. [Q9HD64-2]
CCDS48128.1. [Q9HD64-4]
CCDS75982.1. [Q9HD64-2]
CCDS75983.1. [Q9HD64-4]
RefSeqiNP_001091063.2. NM_001097594.2. [Q9HD64-2]
NP_001091065.1. NM_001097596.2. [Q9HD64-4]
NP_001091073.2. NM_001097604.2. [Q9HD64-2]
NP_001091074.1. NM_001097605.2. [Q9HD64-4]
XP_016885236.1. XM_017029747.1.
XP_016885238.1. XM_017029749.1.
UniGeneiHs.112208.
Hs.546096.
Hs.584511.

Genome annotation databases

EnsembliENST00000375600; ENSP00000364750; ENSG00000204379. [Q9HD64-4]
ENST00000375602; ENSP00000364752; ENSG00000204379. [Q9HD64-2]
ENST00000375613; ENSP00000364763; ENSG00000204382. [Q9HD64-4]
ENST00000375616; ENSP00000364766; ENSG00000204382. [Q9HD64-2]
ENST00000518075; ENSP00000430130; ENSG00000204382. [Q9HD64-2]
GeneIDi653067.
653220.
KEGGihsa:653067.
hsa:653220.
UCSCiuc004dqf.4. human. [Q9HD64-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiXAGE1_HUMAN
AccessioniPrimary (citable) accession number: Q9HD64
Secondary accession number(s): A6NJ94
, Q5JPN8, Q5JPP0, Q5JPP3, Q8WWG5, Q8WWG6, Q969J6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 31, 2011
Last modified: September 27, 2017
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

PubMed:17335148, examines the translation products of theses four XAGE1A transcripts, and finds that the XAGE-1c transcript is possibly translated to 9- and 17-aa polypeptides and not to a protein consisting of 160 amino acids as shown in PubMed:11992404.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families