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Q9HD64

- XAGE1_HUMAN

UniProt

Q9HD64 - XAGE1_HUMAN

Protein

X antigen family member 1

Gene

XAGE1A

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    X antigen family member 1
    Short name:
    XAGE-1
    Alternative name(s):
    Cancer/testis antigen 12.1
    Short name:
    CT12.1
    G antigen family D member 2
    Gene namesi
    Name:XAGE1A
    Synonyms:GAGED2, XAGE1
    AND
    Name:XAGE1B
    AND
    Name:XAGE1C
    AND
    Name:XAGE1D
    AND
    Name:XAGE1E
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:4111. XAGE1A.
    HGNC:25400. XAGE1B.
    HGNC:30679. XAGE1C.
    HGNC:21508. XAGE1D.
    HGNC:18372. XAGE1E.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28526.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8181X antigen family member 1PRO_0000148349Add
    BLAST

    Proteomic databases

    MaxQBiQ9HD64.
    PaxDbiQ9HD64.
    PRIDEiQ9HD64.

    PTM databases

    PhosphoSiteiQ9HD64.

    Expressioni

    Tissue specificityi

    In normal tissues, highly expressed in testis. Expressed also in many different types of cancers: highly expressed in breast cancer, prostate cancer and many types of lung cancers, including squamous cell carcinoma, small cell carcinoma, non-small cell carcinoma, and adenocarcinoma, as well as in Ewing's cell lines, in some Ewing's sarcoma patient samples, and in one of one alveolar rhabdomyosarcoma patient sample.2 Publications

    Gene expression databases

    BgeeiQ9HD64.
    CleanExiHS_XAGE1D.
    GenevestigatoriQ9HD64.

    Organism-specific databases

    HPAiHPA050858.

    Interactioni

    Protein-protein interaction databases

    BioGridi114882. 2 interactions.
    575486. 1 interaction.
    IntActiQ9HD64. 1 interaction.
    STRINGi9606.ENSP00000342190.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HD64.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GAGE family.Curated

    Phylogenomic databases

    eggNOGiNOG81371.
    InParanoidiQ9HD64.
    OrthoDBiEOG78PVBW.
    TreeFamiTF342350.

    Family and domain databases

    InterProiIPR008625. GAGE.
    [Graphical view]
    PfamiPF05831. GAGE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform B (identifier: Q9HD64-2) [UniParc]FASTAAdd to Basket

    Also known as: XAGE-1a, XAGE-1b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESPKKKNQQ LKVGILHLGS RQKKIRIQLR SQCATWKVIC KSCISQTPGI   50
    NLDLGSGVKV KIIPKEEHCK MPEAGEEQPQ V 81

    Note: XAGE-1a and XAGE-1b mRNAs are produced by alternative promoter usage. However, for both isoforms, the translation initiator codon remains the same, generating an identical protein. XAGE-1b is the predominant transcript, compared to XAGE-1a.

    Length:81
    Mass (Da):9,078
    Last modified:May 31, 2011 - v3
    Checksum:iC73337C4C94C01D1
    GO
    Isoform D (identifier: Q9HD64-4) [UniParc]FASTAAdd to Basket

    Also known as: XAGE-1d

    The sequence of this isoform differs from the canonical sequence as follows:
         33-81: CATWKVICKS...PEAGEEQPQV → VLGREMRDME...GFRRQGEDNT

    Show »
    Length:69
    Mass (Da):7,965
    Checksum:i0480A160F893AF81
    GO

    Sequence cautioni

    The sequence AAG01401.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAH09538.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAC82986.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAI40888.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI40895.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI41526.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI41531.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI41534.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei33 – 8149CATWK…EQPQV → VLGREMRDMEGDLQELHQSN TGDKSGFGFRRQGEDNT in isoform D. 1 PublicationVSP_001596Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF251237 mRNA. Translation: AAG01401.1. Different initiation.
    AJ290447 mRNA. Translation: CAC38107.1.
    AJ400997 Genomic DNA. Translation: CAC38108.1.
    AJ318878 mRNA. Translation: CAC82986.1. Different initiation.
    AJ318879 mRNA. Translation: CAC82987.1.
    BT007099 mRNA. Translation: AAP35763.1.
    AL772246 Genomic DNA. Translation: CAI41526.1. Sequence problems.
    AL772246 Genomic DNA. Translation: CAI41527.1.
    AL772246 Genomic DNA. Translation: CAI41528.1.
    AL772246 Genomic DNA. Translation: CAI41530.1.
    AL772246 Genomic DNA. Translation: CAI41531.1. Sequence problems.
    AL772246 Genomic DNA. Translation: CAI41532.1.
    AL772246 Genomic DNA. Translation: CAI41533.1.
    AL772246 Genomic DNA. Translation: CAI41534.1. Sequence problems.
    BX088602 Genomic DNA. Translation: CAI40888.1. Sequence problems.
    BX088602 Genomic DNA. Translation: CAI40889.1.
    BX088602 Genomic DNA. Translation: CAI40890.1.
    BX088602 Genomic DNA. Translation: CAI40893.1.
    BX088602 Genomic DNA. Translation: CAI40894.1.
    BX088602 Genomic DNA. Translation: CAI40895.1. Sequence problems.
    BC009538 mRNA. Translation: AAH09538.2. Different initiation.
    CCDSiCCDS48117.2. [Q9HD64-2]
    CCDS48119.1. [Q9HD64-4]
    CCDS48126.2. [Q9HD64-2]
    CCDS48128.1. [Q9HD64-4]
    RefSeqiNP_001091063.2. NM_001097594.2. [Q9HD64-2]
    NP_001091065.1. NM_001097596.2. [Q9HD64-4]
    NP_001091073.2. NM_001097604.2. [Q9HD64-2]
    NP_001091074.1. NM_001097605.2. [Q9HD64-4]
    XP_006724659.1. XM_006724596.1.
    XP_006724661.1. XM_006724598.1.
    UniGeneiHs.112208.
    Hs.546096.
    Hs.584511.

    Genome annotation databases

    EnsembliENST00000375600; ENSP00000364750; ENSG00000204379. [Q9HD64-4]
    ENST00000375602; ENSP00000364752; ENSG00000204379. [Q9HD64-2]
    ENST00000375613; ENSP00000364763; ENSG00000204382. [Q9HD64-4]
    ENST00000375616; ENSP00000364766; ENSG00000204382. [Q9HD64-2]
    ENST00000518075; ENSP00000430130; ENSG00000204382. [Q9HD64-2]
    GeneIDi653067.
    653220.
    KEGGihsa:653048.
    hsa:653067.
    hsa:653219.
    hsa:653220.
    hsa:9503.
    UCSCiuc004dqf.3. human. [Q9HD64-2]
    uc004dqg.3. human. [Q9HD64-4]

    Polymorphism databases

    DMDMi334302901.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF251237 mRNA. Translation: AAG01401.1 . Different initiation.
    AJ290447 mRNA. Translation: CAC38107.1 .
    AJ400997 Genomic DNA. Translation: CAC38108.1 .
    AJ318878 mRNA. Translation: CAC82986.1 . Different initiation.
    AJ318879 mRNA. Translation: CAC82987.1 .
    BT007099 mRNA. Translation: AAP35763.1 .
    AL772246 Genomic DNA. Translation: CAI41526.1 . Sequence problems.
    AL772246 Genomic DNA. Translation: CAI41527.1 .
    AL772246 Genomic DNA. Translation: CAI41528.1 .
    AL772246 Genomic DNA. Translation: CAI41530.1 .
    AL772246 Genomic DNA. Translation: CAI41531.1 . Sequence problems.
    AL772246 Genomic DNA. Translation: CAI41532.1 .
    AL772246 Genomic DNA. Translation: CAI41533.1 .
    AL772246 Genomic DNA. Translation: CAI41534.1 . Sequence problems.
    BX088602 Genomic DNA. Translation: CAI40888.1 . Sequence problems.
    BX088602 Genomic DNA. Translation: CAI40889.1 .
    BX088602 Genomic DNA. Translation: CAI40890.1 .
    BX088602 Genomic DNA. Translation: CAI40893.1 .
    BX088602 Genomic DNA. Translation: CAI40894.1 .
    BX088602 Genomic DNA. Translation: CAI40895.1 . Sequence problems.
    BC009538 mRNA. Translation: AAH09538.2 . Different initiation.
    CCDSi CCDS48117.2. [Q9HD64-2 ]
    CCDS48119.1. [Q9HD64-4 ]
    CCDS48126.2. [Q9HD64-2 ]
    CCDS48128.1. [Q9HD64-4 ]
    RefSeqi NP_001091063.2. NM_001097594.2. [Q9HD64-2 ]
    NP_001091065.1. NM_001097596.2. [Q9HD64-4 ]
    NP_001091073.2. NM_001097604.2. [Q9HD64-2 ]
    NP_001091074.1. NM_001097605.2. [Q9HD64-4 ]
    XP_006724659.1. XM_006724596.1.
    XP_006724661.1. XM_006724598.1.
    UniGenei Hs.112208.
    Hs.546096.
    Hs.584511.

    3D structure databases

    ProteinModelPortali Q9HD64.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114882. 2 interactions.
    575486. 1 interaction.
    IntActi Q9HD64. 1 interaction.
    STRINGi 9606.ENSP00000342190.

    PTM databases

    PhosphoSitei Q9HD64.

    Polymorphism databases

    DMDMi 334302901.

    Proteomic databases

    MaxQBi Q9HD64.
    PaxDbi Q9HD64.
    PRIDEi Q9HD64.

    Protocols and materials databases

    DNASUi 9503.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375600 ; ENSP00000364750 ; ENSG00000204379 . [Q9HD64-4 ]
    ENST00000375602 ; ENSP00000364752 ; ENSG00000204379 . [Q9HD64-2 ]
    ENST00000375613 ; ENSP00000364763 ; ENSG00000204382 . [Q9HD64-4 ]
    ENST00000375616 ; ENSP00000364766 ; ENSG00000204382 . [Q9HD64-2 ]
    ENST00000518075 ; ENSP00000430130 ; ENSG00000204382 . [Q9HD64-2 ]
    GeneIDi 653067.
    653220.
    KEGGi hsa:653048.
    hsa:653067.
    hsa:653219.
    hsa:653220.
    hsa:9503.
    UCSCi uc004dqf.3. human. [Q9HD64-2 ]
    uc004dqg.3. human. [Q9HD64-4 ]

    Organism-specific databases

    CTDi 653067.
    653220.
    GeneCardsi GC0XM052255.
    GC0XM052545.
    GC0XM052559.
    GC0XP052239.
    GC0XP052511.
    HGNCi HGNC:4111. XAGE1A.
    HGNC:25400. XAGE1B.
    HGNC:30679. XAGE1C.
    HGNC:21508. XAGE1D.
    HGNC:18372. XAGE1E.
    HPAi HPA050858.
    MIMi 300289. gene.
    300742. gene.
    300743. gene.
    300744. gene.
    300745. gene.
    neXtProti NX_Q9HD64.
    PharmGKBi PA28526.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG81371.
    InParanoidi Q9HD64.
    OrthoDBi EOG78PVBW.
    TreeFami TF342350.

    Miscellaneous databases

    NextBioi 122635.
    PROi Q9HD64.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9HD64.
    CleanExi HS_XAGE1D.
    Genevestigatori Q9HD64.

    Family and domain databases

    InterProi IPR008625. GAGE.
    [Graphical view ]
    Pfami PF05831. GAGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma."
      Liu X.F., Helman L.J., Yeung C., Bera T.K., Lee B., Pastan I.
      Cancer Res. 60:4752-4755(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
      Tissue: Testis.
    2. "The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma."
      Zendman A.J.W., van Kraats A.A., Weidle U.H., Ruiter D.J., van Muijen G.N.P.
      Int. J. Cancer 99:361-369(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS B AND D).
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
    4. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
      Tissue: Lung.
    6. "Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers."
      Egland K.A., Kumar V., Duray P., Pastan I.
      Mol. Cancer Ther. 1:441-450(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, IDENTIFICATION OF INITIATOR METHIONINE (ISOFORM B).
    7. "Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors."
      Sato S., Noguchi Y., Ohara N., Uenaka A., Shimono M., Nakagawa K., Koizumi F., Ishida T., Yoshino T., Shiratori Y., Nakayama E.
      Cancer Immun. 7:5-5(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, ALTERNATIVE SPLICING (ISOFORMS B AND D), IDENTIFICATION OF INITIATOR METHIONINE (ISOFORM B).

    Entry informationi

    Entry nameiXAGE1_HUMAN
    AccessioniPrimary (citable) accession number: Q9HD64
    Secondary accession number(s): A6NJ94
    , Q5JPN8, Q5JPP0, Q5JPP3, Q8WWG5, Q8WWG6, Q969J6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: May 31, 2011
    Last modified: October 1, 2014
    This is version 114 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    According to PubMed:11992404, the transcription of XAGE1A is regulated by methylation of the CpG island in the promoter, and four alternative RNA splicing variants, XAGE-1a, b, c have been identified.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3