Q9HD47D3DTR6Q68DI3Q9BR68Q9HD48Q9NRU9Q9P001Q9P0P2MOG1_HUMANRan guanine nucleotide release factorRanGNRFRan-binding protein MOG1RANGRFMOG1RANGNRFHSPC165HSPC236MDS5Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoIdentification and characterization of the human MOG1 gene.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)FUNCTIONINTERACTION WITH RANSUBCELLULAR LOCATIONTISSUE SPECIFICITYNovel genes expressed in hematopoietic stem/progenitor cells from Myelodysplastic Syndromes patient.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)Complete sequencing and characterization of 21,243 full-length human cDNAs.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)The full-ORF clone resource of the German cDNA consortium.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav1.5.FUNCTIONINTERACTION WITH SCN5AInitial characterization of the human central proteome.IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]MOG1 rescues defective trafficking of Na(v)1.5 mutations in Brugada syndrome and sick sinus syndrome.FUNCTIONA novel nonsense variant in Nav1.5 cofactor MOG1 eliminates its sodium current increasing effect and may increase the risk of arrhythmias.VARIANT 61-GLU--GLN-186 DELCHARACTERIZATION OF VARIANT 61-GLU--GLN-186 DELFUNCTIONTISSUE SPECIFICITYMOG1: a new susceptibility gene for Brugada syndrome.VARIANT ASP-83CHARACTERIZATION OF VARIANT ASP-83FUNCTIONSUBCELLULAR LOCATIONBrugada syndrome and p.E61X_RANGRF.VARIANT 61-GLU--GLN-186 DELMitosis-specific acetylation tunes Ran effector binding for chromosome segregation.STRUCTURE BY NMRFUNCTIONINTERACTION WITH RANMUTAGENESIS OF ASP-27; GLU-50; GLU-53 AND ASP-70May regulate the intracellular trafficking of RAN (PubMed:11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830, PubMed:21621375).Monomer. Interacts with RAN, both RAN-GTP and RAN-GDP (PubMed:11290418, PubMed:29040603). Competes with RCC1 for a common binding site on RAN and thereby inhibits RCC1-mediated nucleotide exchange (PubMed:29040603). Forms a complex with RAN-GTP and RANBP1 (By similarity). Interacts with the cytoplasmic loop 2 of SCN5A (PubMed:18184654).Q9HD47-3P55212false3Q9HD47-3P41091false3Q9HD47-3P22607false3Q9HD47-3Q0VDC6false3Q9HD47-3P06396false3Q9HD47-3P54652false3Q9HD47-3P13473-2false3Q9HD47-3P62826false3NucleusCytoplasmPerinuclear regionCytoplasmCell membranePeripheral membrane proteinCytoplasmic sideMay shuttle between the nucleus and cytoplasm.Q9HD47-11MOG1aQ9HD47-22MOG1bQ9HD47-33Q9HD47-44Isoform 1 and isoform 2 are ubiquitously expressed (PubMed:11290418). Detected in heart and brain (PubMed:21621375).Overexpression can rescue the trafficking defect caused by some SCN5A mutations that impair trafficking to the cell membrane.Belongs to the MOG1 family.3D-structureAlternative splicingCell membraneCytoplasmGuanine-nucleotide releasing factorMembraneNucleusProtein transportReference proteomeTransportVPAKDVTLHQALLRLPQYQTDLLLTFNQPPPDNRSSLGPENLSPAPWRARECVMSWKGGSGDAEIQVSILTLIPLGSKGRDTSSGLAEAAPVPDEDDKEKEKDKALRPEMEPTRDCPLFGGAFSAILPMGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLELQAHVRGEAAARYHFEDVGGVQGARAVHVESVQPLSLENLALRGRCQEAWVLSGKQQIAKENQQVAKDVTLHQALLRLPQYQTDLLLTFNQPPPDNRSSLGPENLSPAPWSLGDFEQLVTSLTLHDPNIFGPQ
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