##gff-version 3 Q9HD47 UniProtKB Chain 1 186 . . . ID=PRO_0000330636;Note=Ran guanine nucleotide release factor Q9HD47 UniProtKB Region 27 70 . . . Note=Interaction with RAN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29040603;Dbxref=PMID:29040603 Q9HD47 UniProtKB Alternative sequence 118 118 . . . ID=VSP_033057;Note=In isoform 4. V->P;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 Q9HD47 UniProtKB Alternative sequence 119 186 . . . ID=VSP_033058;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005 Q9HD47 UniProtKB Alternative sequence 119 163 . . . ID=VSP_033059;Note=In isoform 3. AKDVTLHQALLRLPQYQTDLLLTFNQPPPDNRSSLGPENLSPAPW->RARECVMSWKGGSGDAEIQVSILTLIPLGSKGRDTSSGLAEAAPVPD;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9HD47 UniProtKB Alternative sequence 147 186 . . . ID=VSP_033060;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:11290418,ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:11290418,PMID:14702039,PMID:15489334 Q9HD47 UniProtKB Alternative sequence 164 186 . . . ID=VSP_033061;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9HD47 UniProtKB Natural variant 61 186 . . . ID=VAR_080079;Note=Found in patients with cardiac arrhythmias including Brugada syndrome%3B uncertain significance%3B loss of function in enhancing the expression of SCN5A at the cell membrane. Missing;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21621375,ECO:0000269|PubMed:24142675;Dbxref=PMID:21621375,PMID:24142675 Q9HD47 UniProtKB Natural variant 83 83 . . . ID=VAR_080080;Note=Found in patients with Brugada syndrome%3B uncertain significance%3B loss of function in enhancing the expression of SCN5A at the cell membrane. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21447824;Dbxref=dbSNP:rs751751942,PMID:21447824 Q9HD47 UniProtKB Mutagenesis 27 27 . . . Note=Decreased binding to RAN. D->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29040603;Dbxref=PMID:29040603 Q9HD47 UniProtKB Mutagenesis 50 50 . . . Note=Strongly decreased binding to RAN. Abolishes binding to RAN%3B when associated with K-53. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29040603;Dbxref=PMID:29040603 Q9HD47 UniProtKB Mutagenesis 53 53 . . . Note=Decreased binding to RAN. Abolishes binding to RAN%3B when associated with K-50. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29040603;Dbxref=PMID:29040603 Q9HD47 UniProtKB Mutagenesis 70 70 . . . Note=Decreased binding to RAN. D->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29040603;Dbxref=PMID:29040603 Q9HD47 UniProtKB Sequence conflict 94 96 . . . Note=ALR->PE;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9HD47 UniProtKB Beta strand 6 8 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5YFG Q9HD47 UniProtKB Turn 10 12 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5YFG Q9HD47 UniProtKB Beta strand 13 17 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5YFG Q9HD47 UniProtKB Helix 25 27 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5YFG Q9HD47 UniProtKB Beta strand 35 40 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5YFG Q9HD47 UniProtKB Turn 41 44 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5YFG Q9HD47 UniProtKB Beta strand 45 50 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5YFG Q9HD47 UniProtKB Helix 61 71 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5YFG Q9HD47 UniProtKB Turn 72 74 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5YFG Q9HD47 UniProtKB Beta strand 81 87 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5YFG Q9HD47 UniProtKB Helix 90 92 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5YFG Q9HD47 UniProtKB Beta strand 100 108 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5YFG Q9HD47 UniProtKB Beta strand 123 131 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5YFG Q9HD47 UniProtKB Turn 132 135 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5YFG Q9HD47 UniProtKB Beta strand 136 144 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5YFG Q9HD47 UniProtKB Beta strand 156 159 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5YFG Q9HD47 UniProtKB Helix 165 172 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5YFG Q9HD47 UniProtKB Helix 173 175 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5YFG