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Protein

Ran guanine nucleotide release factor

Gene

RANGRF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A.2 Publications

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: BHF-UCL
  • ion channel binding Source: BHF-UCL
  • protein transporter activity Source: BHF-UCL
  • Ran GTPase binding Source: BHF-UCL
  • Ran guanyl-nucleotide exchange factor activity Source: BHF-UCL
  • sodium channel regulator activity Source: BHF-UCL

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: BHF-UCL
  • positive regulation of GTPase activity Source: BHF-UCL
  • positive regulation of protein localization to cell surface Source: BHF-UCL
  • positive regulation of protein localization to plasma membrane Source: BHF-UCL
  • protein exit from endoplasmic reticulum Source: BHF-UCL
  • regulation of bundle of His cell action potential Source: BHF-UCL
  • regulation of cardiac muscle cell action potential involved in regulation of contraction Source: BHF-UCL
  • regulation of heart rate Source: BHF-UCL
  • regulation of membrane depolarization Source: BHF-UCL
  • regulation of membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
  • regulation of membrane potential Source: BHF-UCL
  • regulation of sodium ion transmembrane transport Source: BHF-UCL
  • regulation of sodium ion transmembrane transporter activity Source: BHF-UCL

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-5576892. Phase 0 - rapid depolarisation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ran guanine nucleotide release factor
Short name:
RanGNRF
Alternative name(s):
Ran-binding protein MOG1
Gene namesi
Name:RANGRF
Synonyms:MOG1, RANGNRF
ORF Names:HSPC165, HSPC236, MDS5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108961.13.
HGNCiHGNC:17679. RANGRF.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi29098.
MalaCardsiRANGRF.
OpenTargetsiENSG00000108961.
PharmGKBiPA162400661.

Polymorphism and mutation databases

BioMutaiRANGRF.
DMDMi74718913.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003306361 – 186Ran guanine nucleotide release factorAdd BLAST186

Proteomic databases

EPDiQ9HD47.
MaxQBiQ9HD47.
PaxDbiQ9HD47.
PeptideAtlasiQ9HD47.
PRIDEiQ9HD47.

PTM databases

iPTMnetiQ9HD47.
PhosphoSitePlusiQ9HD47.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000108961.
CleanExiHS_RANGRF.
GenevisibleiQ9HD47. HS.

Organism-specific databases

HPAiHPA057280.
HPA057888.

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with RAN, RAN-GTP and RAN-GDP. Forms a complex with RAN-GTP and RANBP1 (By similarity). Interacts with the cytoplasmic loop 2 of SCN5A.By similarity1 Publication

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: BHF-UCL
  • ion channel binding Source: BHF-UCL
  • Ran GTPase binding Source: BHF-UCL
  • Ran guanyl-nucleotide exchange factor activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi118866. 27 interactors.
IntActiQ9HD47. 2 interactors.
STRINGi9606.ENSP00000226105.

Structurei

3D structure databases

ProteinModelPortaliQ9HD47.
SMRiQ9HD47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MOG1 family.Curated

Phylogenomic databases

eggNOGiKOG3329. Eukaryota.
ENOG4111I9Z. LUCA.
GeneTreeiENSGT00390000013834.
HOVERGENiHBG075266.
InParanoidiQ9HD47.
OMAiNQPPPDN.
OrthoDBiEOG091G0KIN.
PhylomeDBiQ9HD47.
TreeFamiTF332074.

Family and domain databases

CDDicd00224. Mog1. 1 hit.
Gene3Di3.40.1000.10. 1 hit.
InterProiView protein in InterPro
IPR007681. Mog1.
IPR016123. Mog1/PsbP_a/b/a-sand.
PANTHERiPTHR15837. PTHR15837. 1 hit.
PfamiView protein in Pfam
PF04603. Mog1. 1 hit.
SUPFAMiSSF55724. SSF55724. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HD47-1) [UniParc]FASTAAdd to basket
Also known as: MOG1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPTRDCPLF GGAFSAILPM GAIDVSDLRP VPDNQEVFCH PVTDQSLIVE
60 70 80 90 100
LLELQAHVRG EAAARYHFED VGGVQGARAV HVESVQPLSL ENLALRGRCQ
110 120 130 140 150
EAWVLSGKQQ IAKENQQVAK DVTLHQALLR LPQYQTDLLL TFNQPPPDNR
160 170 180
SSLGPENLSP APWSLGDFEQ LVTSLTLHDP NIFGPQ
Length:186
Mass (Da):20,448
Last modified:March 1, 2001 - v1
Checksum:iBE2C459C90459042
GO
Isoform 2 (identifier: Q9HD47-2) [UniParc]FASTAAdd to basket
Also known as: MOG1b

The sequence of this isoform differs from the canonical sequence as follows:
     147-186: Missing.

Show »
Length:146
Mass (Da):16,118
Checksum:i2EA661B68733EF9B
GO
Isoform 3 (identifier: Q9HD47-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-163: AKDVTLHQAL...GPENLSPAPW → RARECVMSWK...GLAEAAPVPD
     164-186: Missing.

Show »
Length:165
Mass (Da):17,711
Checksum:iE69ECDD84D5B4011
GO
Isoform 4 (identifier: Q9HD47-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-118: V → P
     119-186: Missing.

Show »
Length:118
Mass (Da):12,900
Checksum:i464DE437624F7A9B
GO

Sequence cautioni

The sequence AAF29129 differs from that shown. Reason: Frameshift at positions 62 and 93.Curated
The sequence AAF87316 differs from that shown. Reason: Frameshift at position 62.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94 – 96ALR → PE in AAF36156 (PubMed:11042152).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033057118V → P in isoform 4. 1 Publication1
Alternative sequenceiVSP_033058119 – 186Missing in isoform 4. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_033059119 – 163AKDVT…SPAPW → RARECVMSWKGGSGDAEIQV SILTLIPLGSKGRDTSSGLA EAAPVPD in isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_033060147 – 186Missing in isoform 2. 4 PublicationsAdd BLAST40
Alternative sequenceiVSP_033061164 – 186Missing in isoform 3. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF265205 mRNA. Translation: AAG01291.1.
AF265206 mRNA. Translation: AAG01292.1.
AF168714 mRNA. Translation: AAF87316.1. Frameshift.
AF151070 mRNA. Translation: AAF36156.1.
AF161514 mRNA. Translation: AAF29129.1. Frameshift.
AK290399 mRNA. Translation: BAF83088.1.
CR457206 mRNA. Translation: CAG33487.1.
CR749387 mRNA. Translation: CAH18237.1.
CH471108 Genomic DNA. Translation: EAW90064.1.
CH471108 Genomic DNA. Translation: EAW90065.1.
CH471108 Genomic DNA. Translation: EAW90066.1.
BC006486 mRNA. Translation: AAH06486.1.
BC012552 mRNA. Translation: AAH12552.1.
BC100017 mRNA. Translation: AAI00018.1.
CCDSiCCDS11137.1. [Q9HD47-1]
CCDS54086.1. [Q9HD47-2]
CCDS54087.1. [Q9HD47-3]
CCDS82066.1. [Q9HD47-4]
RefSeqiNP_001171272.1. NM_001177801.1. [Q9HD47-2]
NP_001171273.1. NM_001177802.1. [Q9HD47-3]
NP_001317056.1. NM_001330127.1. [Q9HD47-4]
NP_057576.2. NM_016492.4. [Q9HD47-1]
UniGeneiHs.408233.

Genome annotation databases

EnsembliENST00000226105; ENSP00000226105; ENSG00000108961. [Q9HD47-1]
ENST00000407006; ENSP00000383940; ENSG00000108961. [Q9HD47-2]
ENST00000439238; ENSP00000413190; ENSG00000108961. [Q9HD47-3]
ENST00000580434; ENSP00000462310; ENSG00000108961. [Q9HD47-4]
GeneIDi29098.
KEGGihsa:29098.
UCSCiuc002gkv.4. human. [Q9HD47-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMOG1_HUMAN
AccessioniPrimary (citable) accession number: Q9HD47
Secondary accession number(s): D3DTR6
, Q68DI3, Q9BR68, Q9HD48, Q9NRU9, Q9P001, Q9P0P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2001
Last modified: November 22, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families