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Q9HD47

- MOG1_HUMAN

UniProt

Q9HD47 - MOG1_HUMAN

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Protein
Ran guanine nucleotide release factor
Gene
RANGRF, MOG1, RANGNRF, HSPC165, HSPC236, MDS5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A.2 Publications

GO - Molecular functioni

  1. Ran GTPase binding Source: BHF-UCL
  2. guanyl-nucleotide exchange factor activity Source: BHF-UCL
  3. ion channel binding Source: BHF-UCL
  4. protein transporter activity Source: BHF-UCL
  5. sodium channel regulator activity Source: BHF-UCL
Complete GO annotation...

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: BHF-UCL
  2. positive regulation of establishment of protein localization to plasma membrane Source: BHF-UCL
  3. positive regulation of protein localization to cell surface Source: BHF-UCL
  4. protein exit from endoplasmic reticulum Source: BHF-UCL
  5. regulation of GTPase activity Source: GOC
  6. regulation of heart rate Source: BHF-UCL
  7. regulation of membrane depolarization Source: BHF-UCL
  8. regulation of membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
  9. regulation of membrane potential Source: BHF-UCL
  10. regulation of sodium ion transmembrane transport Source: BHF-UCL
  11. regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ran guanine nucleotide release factor
Short name:
RanGNRF
Alternative name(s):
Ran-binding protein MOG1
Gene namesi
Name:RANGRF
Synonyms:MOG1, RANGNRF
ORF Names:HSPC165, HSPC236, MDS5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:17679. RANGRF.

Subcellular locationi

Nucleus. Cytoplasm
Note: Shuttles between the nucleus and cytoplasm.1 Publication

GO - Cellular componenti

  1. caveola Source: BHF-UCL
  2. cytoplasm Source: BHF-UCL
  3. intercalated disc Source: BHF-UCL
  4. nucleoplasm Source: BHF-UCL
  5. nucleus Source: BHF-UCL
  6. plasma membrane Source: BHF-UCL
  7. rough endoplasmic reticulum Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400661.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186Ran guanine nucleotide release factor
PRO_0000330636Add
BLAST

Proteomic databases

MaxQBiQ9HD47.
PaxDbiQ9HD47.
PRIDEiQ9HD47.

PTM databases

PhosphoSiteiQ9HD47.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ9HD47.
CleanExiHS_RANGRF.
GenevestigatoriQ9HD47.

Organism-specific databases

HPAiHPA057280.
HPA057888.

Interactioni

Subunit structurei

Monomer By similarity. Interacts with RAN, RAN-GTP and RAN-GDP. Forms a complex with RAN-GTP and RANBP1 By similarity. Interacts with the cytoplasmic loop 2 of SCN5A.1 Publication

Protein-protein interaction databases

BioGridi118866. 5 interactions.
IntActiQ9HD47. 1 interaction.
STRINGi9606.ENSP00000226105.

Structurei

3D structure databases

ProteinModelPortaliQ9HD47.
SMRiQ9HD47. Positions 5-161.

Family & Domainsi

Sequence similaritiesi

Belongs to the MOG1 family.

Phylogenomic databases

eggNOGiNOG287645.
HOVERGENiHBG075266.
InParanoidiQ9HD47.
OMAiNQPPPDN.
OrthoDBiEOG7992RS.
PhylomeDBiQ9HD47.
TreeFamiTF332074.

Family and domain databases

Gene3Di3.40.1000.10. 1 hit.
InterProiIPR007681. Mog1.
IPR016123. Mog1/PsbP_a/b/a-sand.
[Graphical view]
PfamiPF04603. Mog1. 1 hit.
[Graphical view]
SUPFAMiSSF55724. SSF55724. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9HD47-1) [UniParc]FASTAAdd to Basket

Also known as: MOG1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEPTRDCPLF GGAFSAILPM GAIDVSDLRP VPDNQEVFCH PVTDQSLIVE    50
LLELQAHVRG EAAARYHFED VGGVQGARAV HVESVQPLSL ENLALRGRCQ 100
EAWVLSGKQQ IAKENQQVAK DVTLHQALLR LPQYQTDLLL TFNQPPPDNR 150
SSLGPENLSP APWSLGDFEQ LVTSLTLHDP NIFGPQ 186
Length:186
Mass (Da):20,448
Last modified:March 1, 2001 - v1
Checksum:iBE2C459C90459042
GO
Isoform 2 (identifier: Q9HD47-2) [UniParc]FASTAAdd to Basket

Also known as: MOG1b

The sequence of this isoform differs from the canonical sequence as follows:
     147-186: Missing.

Show »
Length:146
Mass (Da):16,118
Checksum:i2EA661B68733EF9B
GO
Isoform 3 (identifier: Q9HD47-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-163: AKDVTLHQAL...GPENLSPAPW → RARECVMSWK...GLAEAAPVPD
     164-186: Missing.

Show »
Length:165
Mass (Da):17,711
Checksum:iE69ECDD84D5B4011
GO
Isoform 4 (identifier: Q9HD47-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-118: V → P
     119-186: Missing.

Show »
Length:118
Mass (Da):12,900
Checksum:i464DE437624F7A9B
GO

Sequence cautioni

The sequence AAF29129.1 differs from that shown. Reason: Frameshift at positions 62 and 93.
The sequence AAF87316.1 differs from that shown. Reason: Frameshift at position 62.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei118 – 1181V → P in isoform 4.
VSP_033057
Alternative sequencei119 – 18668Missing in isoform 4.
VSP_033058Add
BLAST
Alternative sequencei119 – 16345AKDVT…SPAPW → RARECVMSWKGGSGDAEIQV SILTLIPLGSKGRDTSSGLA EAAPVPD in isoform 3.
VSP_033059Add
BLAST
Alternative sequencei147 – 18640Missing in isoform 2.
VSP_033060Add
BLAST
Alternative sequencei164 – 18623Missing in isoform 3.
VSP_033061Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 963ALR → PE in AAF36156. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF265205 mRNA. Translation: AAG01291.1.
AF265206 mRNA. Translation: AAG01292.1.
AF168714 mRNA. Translation: AAF87316.1. Frameshift.
AF151070 mRNA. Translation: AAF36156.1.
AF161514 mRNA. Translation: AAF29129.1. Frameshift.
AK290399 mRNA. Translation: BAF83088.1.
CR457206 mRNA. Translation: CAG33487.1.
CR749387 mRNA. Translation: CAH18237.1.
CH471108 Genomic DNA. Translation: EAW90064.1.
CH471108 Genomic DNA. Translation: EAW90065.1.
CH471108 Genomic DNA. Translation: EAW90066.1.
BC006486 mRNA. Translation: AAH06486.1.
BC012552 mRNA. Translation: AAH12552.1.
BC100017 mRNA. Translation: AAI00018.1.
CCDSiCCDS11137.1. [Q9HD47-1]
CCDS54086.1. [Q9HD47-2]
CCDS54087.1. [Q9HD47-3]
RefSeqiNP_001171272.1. NM_001177801.1. [Q9HD47-2]
NP_001171273.1. NM_001177802.1. [Q9HD47-3]
NP_057576.2. NM_016492.4. [Q9HD47-1]
XP_005256675.1. XM_005256618.2. [Q9HD47-4]
UniGeneiHs.408233.

Genome annotation databases

EnsembliENST00000226105; ENSP00000226105; ENSG00000108961. [Q9HD47-1]
ENST00000407006; ENSP00000383940; ENSG00000108961. [Q9HD47-2]
ENST00000439238; ENSP00000413190; ENSG00000108961. [Q9HD47-3]
ENST00000580434; ENSP00000462310; ENSG00000108961. [Q9HD47-4]
GeneIDi29098.
KEGGihsa:29098.
UCSCiuc002gkv.3. human. [Q9HD47-1]
uc002gkw.3. human. [Q9HD47-4]
uc002gky.3. human. [Q9HD47-3]

Polymorphism databases

DMDMi74718913.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF265205 mRNA. Translation: AAG01291.1 .
AF265206 mRNA. Translation: AAG01292.1 .
AF168714 mRNA. Translation: AAF87316.1 . Frameshift.
AF151070 mRNA. Translation: AAF36156.1 .
AF161514 mRNA. Translation: AAF29129.1 . Frameshift.
AK290399 mRNA. Translation: BAF83088.1 .
CR457206 mRNA. Translation: CAG33487.1 .
CR749387 mRNA. Translation: CAH18237.1 .
CH471108 Genomic DNA. Translation: EAW90064.1 .
CH471108 Genomic DNA. Translation: EAW90065.1 .
CH471108 Genomic DNA. Translation: EAW90066.1 .
BC006486 mRNA. Translation: AAH06486.1 .
BC012552 mRNA. Translation: AAH12552.1 .
BC100017 mRNA. Translation: AAI00018.1 .
CCDSi CCDS11137.1. [Q9HD47-1 ]
CCDS54086.1. [Q9HD47-2 ]
CCDS54087.1. [Q9HD47-3 ]
RefSeqi NP_001171272.1. NM_001177801.1. [Q9HD47-2 ]
NP_001171273.1. NM_001177802.1. [Q9HD47-3 ]
NP_057576.2. NM_016492.4. [Q9HD47-1 ]
XP_005256675.1. XM_005256618.2. [Q9HD47-4 ]
UniGenei Hs.408233.

3D structure databases

ProteinModelPortali Q9HD47.
SMRi Q9HD47. Positions 5-161.
ModBasei Search...

Protein-protein interaction databases

BioGridi 118866. 5 interactions.
IntActi Q9HD47. 1 interaction.
STRINGi 9606.ENSP00000226105.

PTM databases

PhosphoSitei Q9HD47.

Polymorphism databases

DMDMi 74718913.

Proteomic databases

MaxQBi Q9HD47.
PaxDbi Q9HD47.
PRIDEi Q9HD47.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000226105 ; ENSP00000226105 ; ENSG00000108961 . [Q9HD47-1 ]
ENST00000407006 ; ENSP00000383940 ; ENSG00000108961 . [Q9HD47-2 ]
ENST00000439238 ; ENSP00000413190 ; ENSG00000108961 . [Q9HD47-3 ]
ENST00000580434 ; ENSP00000462310 ; ENSG00000108961 . [Q9HD47-4 ]
GeneIDi 29098.
KEGGi hsa:29098.
UCSCi uc002gkv.3. human. [Q9HD47-1 ]
uc002gkw.3. human. [Q9HD47-4 ]
uc002gky.3. human. [Q9HD47-3 ]

Organism-specific databases

CTDi 29098.
GeneCardsi GC17P008191.
H-InvDBi HIX0013522.
HGNCi HGNC:17679. RANGRF.
HPAi HPA057280.
HPA057888.
MIMi 607954. gene.
neXtProti NX_Q9HD47.
PharmGKBi PA162400661.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG287645.
HOVERGENi HBG075266.
InParanoidi Q9HD47.
OMAi NQPPPDN.
OrthoDBi EOG7992RS.
PhylomeDBi Q9HD47.
TreeFami TF332074.

Miscellaneous databases

GenomeRNAii 29098.
NextBioi 52124.
PROi Q9HD47.
SOURCEi Search...

Gene expression databases

Bgeei Q9HD47.
CleanExi HS_RANGRF.
Genevestigatori Q9HD47.

Family and domain databases

Gene3Di 3.40.1000.10. 1 hit.
InterProi IPR007681. Mog1.
IPR016123. Mog1/PsbP_a/b/a-sand.
[Graphical view ]
Pfami PF04603. Mog1. 1 hit.
[Graphical view ]
SUPFAMi SSF55724. SSF55724. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the human MOG1 gene."
    Marfatia K.A., Harreman M.T., Fanara P., Vertino P.M., Corbett A.H.
    Gene 266:45-56(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Novel genes expressed in hematopoietic stem/progenitor cells from Myelodysplastic Syndromes patient."
    Huang C., Zhang C., Tu Y., Gu W., Wang Y., Han Z., Chen Z., Zhou J., Gu J., Huang Q., Yu Y., Xu S., Ren S., Fu G.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hematopoietic stem cell.
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Umbilical cord blood.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Prostate.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Bone marrow, Lung and Uterus.
  10. "Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav1.5."
    Wu L., Yong S.L., Fan C., Ni Y., Yoo S., Zhang T., Zhang X., Obejero-Paz C.A., Rho H.J., Ke T., Szafranski P., Jones S.W., Chen Q., Wang Q.K.
    J. Biol. Chem. 283:6968-6978(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SCN5A.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMOG1_HUMAN
AccessioniPrimary (citable) accession number: Q9HD47
Secondary accession number(s): D3DTR6
, Q68DI3, Q9BR68, Q9HD48, Q9NRU9, Q9P001, Q9P0P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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