Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ran guanine nucleotide release factor

Gene

RANGRF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A.2 Publications

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: BHF-UCL
  • ion channel binding Source: BHF-UCL
  • protein transporter activity Source: BHF-UCL
  • Ran GTPase binding Source: BHF-UCL
  • Ran guanyl-nucleotide exchange factor activity Source: BHF-UCL
  • sodium channel regulator activity Source: BHF-UCL

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: BHF-UCL
  • positive regulation of establishment of protein localization to plasma membrane Source: BHF-UCL
  • positive regulation of GTPase activity Source: BHF-UCL
  • positive regulation of protein localization to cell surface Source: BHF-UCL
  • protein exit from endoplasmic reticulum Source: BHF-UCL
  • regulation of heart rate Source: BHF-UCL
  • regulation of membrane depolarization Source: BHF-UCL
  • regulation of membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
  • regulation of membrane potential Source: BHF-UCL
  • regulation of sodium ion transmembrane transport Source: BHF-UCL
  • regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ran guanine nucleotide release factor
Short name:
RanGNRF
Alternative name(s):
Ran-binding protein MOG1
Gene namesi
Name:RANGRF
Synonyms:MOG1, RANGNRF
ORF Names:HSPC165, HSPC236, MDS5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:17679. RANGRF.

Subcellular locationi

GO - Cellular componenti

  • caveola Source: BHF-UCL
  • cytoplasm Source: BHF-UCL
  • intercalated disc Source: BHF-UCL
  • nucleoplasm Source: BHF-UCL
  • nucleus Source: UniProtKB
  • plasma membrane Source: BHF-UCL
  • rough endoplasmic reticulum Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400661.

Polymorphism and mutation databases

BioMutaiRANGRF.
DMDMi74718913.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186Ran guanine nucleotide release factorPRO_0000330636Add
BLAST

Proteomic databases

MaxQBiQ9HD47.
PaxDbiQ9HD47.
PRIDEiQ9HD47.

PTM databases

PhosphoSiteiQ9HD47.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ9HD47.
CleanExiHS_RANGRF.
GenevisibleiQ9HD47. HS.

Organism-specific databases

HPAiHPA057280.
HPA057888.

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with RAN, RAN-GTP and RAN-GDP. Forms a complex with RAN-GTP and RANBP1 (By similarity). Interacts with the cytoplasmic loop 2 of SCN5A.By similarity1 Publication

Protein-protein interaction databases

BioGridi118866. 10 interactions.
IntActiQ9HD47. 1 interaction.
STRINGi9606.ENSP00000226105.

Structurei

3D structure databases

ProteinModelPortaliQ9HD47.
SMRiQ9HD47. Positions 5-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MOG1 family.Curated

Phylogenomic databases

eggNOGiNOG287645.
GeneTreeiENSGT00390000013834.
HOVERGENiHBG075266.
InParanoidiQ9HD47.
OMAiNQPPPDN.
OrthoDBiEOG7992RS.
PhylomeDBiQ9HD47.
TreeFamiTF332074.

Family and domain databases

Gene3Di3.40.1000.10. 1 hit.
InterProiIPR007681. Mog1.
IPR016123. Mog1/PsbP_a/b/a-sand.
[Graphical view]
PfamiPF04603. Mog1. 1 hit.
[Graphical view]
SUPFAMiSSF55724. SSF55724. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HD47-1) [UniParc]FASTAAdd to basket

Also known as: MOG1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPTRDCPLF GGAFSAILPM GAIDVSDLRP VPDNQEVFCH PVTDQSLIVE
60 70 80 90 100
LLELQAHVRG EAAARYHFED VGGVQGARAV HVESVQPLSL ENLALRGRCQ
110 120 130 140 150
EAWVLSGKQQ IAKENQQVAK DVTLHQALLR LPQYQTDLLL TFNQPPPDNR
160 170 180
SSLGPENLSP APWSLGDFEQ LVTSLTLHDP NIFGPQ
Length:186
Mass (Da):20,448
Last modified:March 1, 2001 - v1
Checksum:iBE2C459C90459042
GO
Isoform 2 (identifier: Q9HD47-2) [UniParc]FASTAAdd to basket

Also known as: MOG1b

The sequence of this isoform differs from the canonical sequence as follows:
     147-186: Missing.

Show »
Length:146
Mass (Da):16,118
Checksum:i2EA661B68733EF9B
GO
Isoform 3 (identifier: Q9HD47-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-163: AKDVTLHQAL...GPENLSPAPW → RARECVMSWK...GLAEAAPVPD
     164-186: Missing.

Show »
Length:165
Mass (Da):17,711
Checksum:iE69ECDD84D5B4011
GO
Isoform 4 (identifier: Q9HD47-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-118: V → P
     119-186: Missing.

Show »
Length:118
Mass (Da):12,900
Checksum:i464DE437624F7A9B
GO

Sequence cautioni

The sequence AAF29129.1 differs from that shown. Reason: Frameshift at positions 62 and 93. Curated
The sequence AAF87316.1 differs from that shown. Reason: Frameshift at position 62. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 963ALR → PE in AAF36156 (PubMed:11042152).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei118 – 1181V → P in isoform 4. 1 PublicationVSP_033057
Alternative sequencei119 – 18668Missing in isoform 4. 1 PublicationVSP_033058Add
BLAST
Alternative sequencei119 – 16345AKDVT…SPAPW → RARECVMSWKGGSGDAEIQV SILTLIPLGSKGRDTSSGLA EAAPVPD in isoform 3. 1 PublicationVSP_033059Add
BLAST
Alternative sequencei147 – 18640Missing in isoform 2. 4 PublicationsVSP_033060Add
BLAST
Alternative sequencei164 – 18623Missing in isoform 3. 1 PublicationVSP_033061Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF265205 mRNA. Translation: AAG01291.1.
AF265206 mRNA. Translation: AAG01292.1.
AF168714 mRNA. Translation: AAF87316.1. Frameshift.
AF151070 mRNA. Translation: AAF36156.1.
AF161514 mRNA. Translation: AAF29129.1. Frameshift.
AK290399 mRNA. Translation: BAF83088.1.
CR457206 mRNA. Translation: CAG33487.1.
CR749387 mRNA. Translation: CAH18237.1.
CH471108 Genomic DNA. Translation: EAW90064.1.
CH471108 Genomic DNA. Translation: EAW90065.1.
CH471108 Genomic DNA. Translation: EAW90066.1.
BC006486 mRNA. Translation: AAH06486.1.
BC012552 mRNA. Translation: AAH12552.1.
BC100017 mRNA. Translation: AAI00018.1.
CCDSiCCDS11137.1. [Q9HD47-1]
CCDS54086.1. [Q9HD47-2]
CCDS54087.1. [Q9HD47-3]
RefSeqiNP_001171272.1. NM_001177801.1. [Q9HD47-2]
NP_001171273.1. NM_001177802.1. [Q9HD47-3]
NP_057576.2. NM_016492.4. [Q9HD47-1]
XP_005256675.1. XM_005256618.3. [Q9HD47-4]
UniGeneiHs.408233.

Genome annotation databases

EnsembliENST00000226105; ENSP00000226105; ENSG00000108961. [Q9HD47-1]
ENST00000407006; ENSP00000383940; ENSG00000108961. [Q9HD47-2]
ENST00000439238; ENSP00000413190; ENSG00000108961. [Q9HD47-3]
ENST00000580434; ENSP00000462310; ENSG00000108961. [Q9HD47-4]
GeneIDi29098.
KEGGihsa:29098.
UCSCiuc002gkv.3. human. [Q9HD47-1]
uc002gkw.3. human. [Q9HD47-4]
uc002gky.3. human. [Q9HD47-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF265205 mRNA. Translation: AAG01291.1.
AF265206 mRNA. Translation: AAG01292.1.
AF168714 mRNA. Translation: AAF87316.1. Frameshift.
AF151070 mRNA. Translation: AAF36156.1.
AF161514 mRNA. Translation: AAF29129.1. Frameshift.
AK290399 mRNA. Translation: BAF83088.1.
CR457206 mRNA. Translation: CAG33487.1.
CR749387 mRNA. Translation: CAH18237.1.
CH471108 Genomic DNA. Translation: EAW90064.1.
CH471108 Genomic DNA. Translation: EAW90065.1.
CH471108 Genomic DNA. Translation: EAW90066.1.
BC006486 mRNA. Translation: AAH06486.1.
BC012552 mRNA. Translation: AAH12552.1.
BC100017 mRNA. Translation: AAI00018.1.
CCDSiCCDS11137.1. [Q9HD47-1]
CCDS54086.1. [Q9HD47-2]
CCDS54087.1. [Q9HD47-3]
RefSeqiNP_001171272.1. NM_001177801.1. [Q9HD47-2]
NP_001171273.1. NM_001177802.1. [Q9HD47-3]
NP_057576.2. NM_016492.4. [Q9HD47-1]
XP_005256675.1. XM_005256618.3. [Q9HD47-4]
UniGeneiHs.408233.

3D structure databases

ProteinModelPortaliQ9HD47.
SMRiQ9HD47. Positions 5-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118866. 10 interactions.
IntActiQ9HD47. 1 interaction.
STRINGi9606.ENSP00000226105.

PTM databases

PhosphoSiteiQ9HD47.

Polymorphism and mutation databases

BioMutaiRANGRF.
DMDMi74718913.

Proteomic databases

MaxQBiQ9HD47.
PaxDbiQ9HD47.
PRIDEiQ9HD47.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000226105; ENSP00000226105; ENSG00000108961. [Q9HD47-1]
ENST00000407006; ENSP00000383940; ENSG00000108961. [Q9HD47-2]
ENST00000439238; ENSP00000413190; ENSG00000108961. [Q9HD47-3]
ENST00000580434; ENSP00000462310; ENSG00000108961. [Q9HD47-4]
GeneIDi29098.
KEGGihsa:29098.
UCSCiuc002gkv.3. human. [Q9HD47-1]
uc002gkw.3. human. [Q9HD47-4]
uc002gky.3. human. [Q9HD47-3]

Organism-specific databases

CTDi29098.
GeneCardsiGC17P008191.
H-InvDBHIX0013522.
HGNCiHGNC:17679. RANGRF.
HPAiHPA057280.
HPA057888.
MIMi607954. gene.
neXtProtiNX_Q9HD47.
PharmGKBiPA162400661.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG287645.
GeneTreeiENSGT00390000013834.
HOVERGENiHBG075266.
InParanoidiQ9HD47.
OMAiNQPPPDN.
OrthoDBiEOG7992RS.
PhylomeDBiQ9HD47.
TreeFamiTF332074.

Miscellaneous databases

GenomeRNAii29098.
NextBioi52124.
PROiQ9HD47.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HD47.
CleanExiHS_RANGRF.
GenevisibleiQ9HD47. HS.

Family and domain databases

Gene3Di3.40.1000.10. 1 hit.
InterProiIPR007681. Mog1.
IPR016123. Mog1/PsbP_a/b/a-sand.
[Graphical view]
PfamiPF04603. Mog1. 1 hit.
[Graphical view]
SUPFAMiSSF55724. SSF55724. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the human MOG1 gene."
    Marfatia K.A., Harreman M.T., Fanara P., Vertino P.M., Corbett A.H.
    Gene 266:45-56(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Novel genes expressed in hematopoietic stem/progenitor cells from Myelodysplastic Syndromes patient."
    Huang C., Zhang C., Tu Y., Gu W., Wang Y., Han Z., Chen Z., Zhou J., Gu J., Huang Q., Yu Y., Xu S., Ren S., Fu G.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hematopoietic stem cell.
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Umbilical cord blood.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Prostate.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Bone marrow, Lung and Uterus.
  10. "Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav1.5."
    Wu L., Yong S.L., Fan C., Ni Y., Yoo S., Zhang T., Zhang X., Obejero-Paz C.A., Rho H.J., Ke T., Szafranski P., Jones S.W., Chen Q., Wang Q.K.
    J. Biol. Chem. 283:6968-6978(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SCN5A.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMOG1_HUMAN
AccessioniPrimary (citable) accession number: Q9HD47
Secondary accession number(s): D3DTR6
, Q68DI3, Q9BR68, Q9HD48, Q9NRU9, Q9P001, Q9P0P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2001
Last modified: June 24, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.