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Q9HD47

- MOG1_HUMAN

UniProt

Q9HD47 - MOG1_HUMAN

Protein

Ran guanine nucleotide release factor

Gene

RANGRF

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A.2 Publications

    GO - Molecular functioni

    1. guanyl-nucleotide exchange factor activity Source: BHF-UCL
    2. ion channel binding Source: BHF-UCL
    3. protein transporter activity Source: BHF-UCL
    4. Ran GTPase binding Source: BHF-UCL
    5. sodium channel regulator activity Source: BHF-UCL

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: BHF-UCL
    2. positive regulation of establishment of protein localization to plasma membrane Source: BHF-UCL
    3. positive regulation of GTPase activity Source: GOC
    4. positive regulation of protein localization to cell surface Source: BHF-UCL
    5. protein exit from endoplasmic reticulum Source: BHF-UCL
    6. regulation of heart rate Source: BHF-UCL
    7. regulation of membrane depolarization Source: BHF-UCL
    8. regulation of membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
    9. regulation of membrane potential Source: BHF-UCL
    10. regulation of sodium ion transmembrane transport Source: BHF-UCL
    11. regulation of sodium ion transmembrane transporter activity Source: BHF-UCL

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ran guanine nucleotide release factor
    Short name:
    RanGNRF
    Alternative name(s):
    Ran-binding protein MOG1
    Gene namesi
    Name:RANGRF
    Synonyms:MOG1, RANGNRF
    ORF Names:HSPC165, HSPC236, MDS5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:17679. RANGRF.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication
    Note: Shuttles between the nucleus and cytoplasm.

    GO - Cellular componenti

    1. caveola Source: BHF-UCL
    2. cytoplasm Source: BHF-UCL
    3. intercalated disc Source: BHF-UCL
    4. nucleoplasm Source: BHF-UCL
    5. nucleus Source: BHF-UCL
    6. plasma membrane Source: BHF-UCL
    7. rough endoplasmic reticulum Source: BHF-UCL

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162400661.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 186186Ran guanine nucleotide release factorPRO_0000330636Add
    BLAST

    Proteomic databases

    MaxQBiQ9HD47.
    PaxDbiQ9HD47.
    PRIDEiQ9HD47.

    PTM databases

    PhosphoSiteiQ9HD47.

    Expressioni

    Tissue specificityi

    Isoform 1 and isoform 2 are ubiquitously expressed.1 Publication

    Gene expression databases

    BgeeiQ9HD47.
    CleanExiHS_RANGRF.
    GenevestigatoriQ9HD47.

    Organism-specific databases

    HPAiHPA057280.
    HPA057888.

    Interactioni

    Subunit structurei

    Monomer By similarity. Interacts with RAN, RAN-GTP and RAN-GDP. Forms a complex with RAN-GTP and RANBP1 By similarity. Interacts with the cytoplasmic loop 2 of SCN5A.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi118866. 5 interactions.
    IntActiQ9HD47. 1 interaction.
    STRINGi9606.ENSP00000226105.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HD47.
    SMRiQ9HD47. Positions 5-161.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MOG1 family.Curated

    Phylogenomic databases

    eggNOGiNOG287645.
    HOVERGENiHBG075266.
    InParanoidiQ9HD47.
    OMAiNQPPPDN.
    OrthoDBiEOG7992RS.
    PhylomeDBiQ9HD47.
    TreeFamiTF332074.

    Family and domain databases

    Gene3Di3.40.1000.10. 1 hit.
    InterProiIPR007681. Mog1.
    IPR016123. Mog1/PsbP_a/b/a-sand.
    [Graphical view]
    PfamiPF04603. Mog1. 1 hit.
    [Graphical view]
    SUPFAMiSSF55724. SSF55724. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HD47-1) [UniParc]FASTAAdd to Basket

    Also known as: MOG1a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPTRDCPLF GGAFSAILPM GAIDVSDLRP VPDNQEVFCH PVTDQSLIVE    50
    LLELQAHVRG EAAARYHFED VGGVQGARAV HVESVQPLSL ENLALRGRCQ 100
    EAWVLSGKQQ IAKENQQVAK DVTLHQALLR LPQYQTDLLL TFNQPPPDNR 150
    SSLGPENLSP APWSLGDFEQ LVTSLTLHDP NIFGPQ 186
    Length:186
    Mass (Da):20,448
    Last modified:March 1, 2001 - v1
    Checksum:iBE2C459C90459042
    GO
    Isoform 2 (identifier: Q9HD47-2) [UniParc]FASTAAdd to Basket

    Also known as: MOG1b

    The sequence of this isoform differs from the canonical sequence as follows:
         147-186: Missing.

    Show »
    Length:146
    Mass (Da):16,118
    Checksum:i2EA661B68733EF9B
    GO
    Isoform 3 (identifier: Q9HD47-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         119-163: AKDVTLHQAL...GPENLSPAPW → RARECVMSWK...GLAEAAPVPD
         164-186: Missing.

    Show »
    Length:165
    Mass (Da):17,711
    Checksum:iE69ECDD84D5B4011
    GO
    Isoform 4 (identifier: Q9HD47-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         118-118: V → P
         119-186: Missing.

    Show »
    Length:118
    Mass (Da):12,900
    Checksum:i464DE437624F7A9B
    GO

    Sequence cautioni

    The sequence AAF29129.1 differs from that shown. Reason: Frameshift at positions 62 and 93.
    The sequence AAF87316.1 differs from that shown. Reason: Frameshift at position 62.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti94 – 963ALR → PE in AAF36156. (PubMed:11042152)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei118 – 1181V → P in isoform 4. 1 PublicationVSP_033057
    Alternative sequencei119 – 18668Missing in isoform 4. 1 PublicationVSP_033058Add
    BLAST
    Alternative sequencei119 – 16345AKDVT…SPAPW → RARECVMSWKGGSGDAEIQV SILTLIPLGSKGRDTSSGLA EAAPVPD in isoform 3. 1 PublicationVSP_033059Add
    BLAST
    Alternative sequencei147 – 18640Missing in isoform 2. 4 PublicationsVSP_033060Add
    BLAST
    Alternative sequencei164 – 18623Missing in isoform 3. 1 PublicationVSP_033061Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF265205 mRNA. Translation: AAG01291.1.
    AF265206 mRNA. Translation: AAG01292.1.
    AF168714 mRNA. Translation: AAF87316.1. Frameshift.
    AF151070 mRNA. Translation: AAF36156.1.
    AF161514 mRNA. Translation: AAF29129.1. Frameshift.
    AK290399 mRNA. Translation: BAF83088.1.
    CR457206 mRNA. Translation: CAG33487.1.
    CR749387 mRNA. Translation: CAH18237.1.
    CH471108 Genomic DNA. Translation: EAW90064.1.
    CH471108 Genomic DNA. Translation: EAW90065.1.
    CH471108 Genomic DNA. Translation: EAW90066.1.
    BC006486 mRNA. Translation: AAH06486.1.
    BC012552 mRNA. Translation: AAH12552.1.
    BC100017 mRNA. Translation: AAI00018.1.
    CCDSiCCDS11137.1. [Q9HD47-1]
    CCDS54086.1. [Q9HD47-2]
    CCDS54087.1. [Q9HD47-3]
    RefSeqiNP_001171272.1. NM_001177801.1. [Q9HD47-2]
    NP_001171273.1. NM_001177802.1. [Q9HD47-3]
    NP_057576.2. NM_016492.4. [Q9HD47-1]
    XP_005256675.1. XM_005256618.2. [Q9HD47-4]
    UniGeneiHs.408233.

    Genome annotation databases

    EnsembliENST00000226105; ENSP00000226105; ENSG00000108961. [Q9HD47-1]
    ENST00000407006; ENSP00000383940; ENSG00000108961. [Q9HD47-2]
    ENST00000439238; ENSP00000413190; ENSG00000108961. [Q9HD47-3]
    ENST00000580434; ENSP00000462310; ENSG00000108961. [Q9HD47-4]
    GeneIDi29098.
    KEGGihsa:29098.
    UCSCiuc002gkv.3. human. [Q9HD47-1]
    uc002gkw.3. human. [Q9HD47-4]
    uc002gky.3. human. [Q9HD47-3]

    Polymorphism databases

    DMDMi74718913.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF265205 mRNA. Translation: AAG01291.1 .
    AF265206 mRNA. Translation: AAG01292.1 .
    AF168714 mRNA. Translation: AAF87316.1 . Frameshift.
    AF151070 mRNA. Translation: AAF36156.1 .
    AF161514 mRNA. Translation: AAF29129.1 . Frameshift.
    AK290399 mRNA. Translation: BAF83088.1 .
    CR457206 mRNA. Translation: CAG33487.1 .
    CR749387 mRNA. Translation: CAH18237.1 .
    CH471108 Genomic DNA. Translation: EAW90064.1 .
    CH471108 Genomic DNA. Translation: EAW90065.1 .
    CH471108 Genomic DNA. Translation: EAW90066.1 .
    BC006486 mRNA. Translation: AAH06486.1 .
    BC012552 mRNA. Translation: AAH12552.1 .
    BC100017 mRNA. Translation: AAI00018.1 .
    CCDSi CCDS11137.1. [Q9HD47-1 ]
    CCDS54086.1. [Q9HD47-2 ]
    CCDS54087.1. [Q9HD47-3 ]
    RefSeqi NP_001171272.1. NM_001177801.1. [Q9HD47-2 ]
    NP_001171273.1. NM_001177802.1. [Q9HD47-3 ]
    NP_057576.2. NM_016492.4. [Q9HD47-1 ]
    XP_005256675.1. XM_005256618.2. [Q9HD47-4 ]
    UniGenei Hs.408233.

    3D structure databases

    ProteinModelPortali Q9HD47.
    SMRi Q9HD47. Positions 5-161.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118866. 5 interactions.
    IntActi Q9HD47. 1 interaction.
    STRINGi 9606.ENSP00000226105.

    PTM databases

    PhosphoSitei Q9HD47.

    Polymorphism databases

    DMDMi 74718913.

    Proteomic databases

    MaxQBi Q9HD47.
    PaxDbi Q9HD47.
    PRIDEi Q9HD47.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000226105 ; ENSP00000226105 ; ENSG00000108961 . [Q9HD47-1 ]
    ENST00000407006 ; ENSP00000383940 ; ENSG00000108961 . [Q9HD47-2 ]
    ENST00000439238 ; ENSP00000413190 ; ENSG00000108961 . [Q9HD47-3 ]
    ENST00000580434 ; ENSP00000462310 ; ENSG00000108961 . [Q9HD47-4 ]
    GeneIDi 29098.
    KEGGi hsa:29098.
    UCSCi uc002gkv.3. human. [Q9HD47-1 ]
    uc002gkw.3. human. [Q9HD47-4 ]
    uc002gky.3. human. [Q9HD47-3 ]

    Organism-specific databases

    CTDi 29098.
    GeneCardsi GC17P008191.
    H-InvDB HIX0013522.
    HGNCi HGNC:17679. RANGRF.
    HPAi HPA057280.
    HPA057888.
    MIMi 607954. gene.
    neXtProti NX_Q9HD47.
    PharmGKBi PA162400661.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG287645.
    HOVERGENi HBG075266.
    InParanoidi Q9HD47.
    OMAi NQPPPDN.
    OrthoDBi EOG7992RS.
    PhylomeDBi Q9HD47.
    TreeFami TF332074.

    Miscellaneous databases

    GenomeRNAii 29098.
    NextBioi 52124.
    PROi Q9HD47.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9HD47.
    CleanExi HS_RANGRF.
    Genevestigatori Q9HD47.

    Family and domain databases

    Gene3Di 3.40.1000.10. 1 hit.
    InterProi IPR007681. Mog1.
    IPR016123. Mog1/PsbP_a/b/a-sand.
    [Graphical view ]
    Pfami PF04603. Mog1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55724. SSF55724. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of the human MOG1 gene."
      Marfatia K.A., Harreman M.T., Fanara P., Vertino P.M., Corbett A.H.
      Gene 266:45-56(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "Novel genes expressed in hematopoietic stem/progenitor cells from Myelodysplastic Syndromes patient."
      Huang C., Zhang C., Tu Y., Gu W., Wang Y., Han Z., Chen Z., Zhou J., Gu J., Huang Q., Yu Y., Xu S., Ren S., Fu G.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Hematopoietic stem cell.
    3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Umbilical cord blood.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Umbilical cord blood.
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Prostate.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Bone marrow, Lung and Uterus.
    10. "Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav1.5."
      Wu L., Yong S.L., Fan C., Ni Y., Yoo S., Zhang T., Zhang X., Obejero-Paz C.A., Rho H.J., Ke T., Szafranski P., Jones S.W., Chen Q., Wang Q.K.
      J. Biol. Chem. 283:6968-6978(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SCN5A.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMOG1_HUMAN
    AccessioniPrimary (citable) accession number: Q9HD47
    Secondary accession number(s): D3DTR6
    , Q68DI3, Q9BR68, Q9HD48, Q9NRU9, Q9P001, Q9P0P2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3