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Q9HD47 (MOG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ran guanine nucleotide release factor

Short name=RanGNRF
Alternative name(s):
Ran-binding protein MOG1
Gene names
Name:RANGRF
Synonyms:MOG1, RANGNRF
ORF Names:HSPC165, HSPC236, MDS5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length186 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A. Ref.1 Ref.10

Subunit structure

Monomer By similarity. Interacts with RAN, RAN-GTP and RAN-GDP. Forms a complex with RAN-GTP and RANBP1 By similarity. Interacts with the cytoplasmic loop 2 of SCN5A. Ref.10

Subcellular location

Nucleus. Cytoplasm. Note: Shuttles between the nucleus and cytoplasm. Ref.1

Tissue specificity

Isoform 1 and isoform 2 are ubiquitously expressed. Ref.1

Sequence similarities

Belongs to the MOG1 family.

Sequence caution

The sequence AAF29129.1 differs from that shown. Reason: Frameshift at positions 62 and 93.

The sequence AAF87316.1 differs from that shown. Reason: Frameshift at position 62.

Ontologies

Keywords
   Biological processProtein transport
Transport
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
   Molecular functionGuanine-nucleotide releasing factor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processER to Golgi vesicle-mediated transport

Inferred from mutant phenotype PubMed 23420830. Source: BHF-UCL

positive regulation of establishment of protein localization to plasma membrane

Inferred from mutant phenotype PubMed 23420830. Source: BHF-UCL

positive regulation of protein localization to cell surface

Inferred from direct assay Ref.10. Source: BHF-UCL

protein exit from endoplasmic reticulum

Inferred from mutant phenotype PubMed 23420830. Source: BHF-UCL

regulation of GTPase activity

Inferred from sequence or structural similarity. Source: GOC

regulation of heart rate

Traceable author statement PubMed 21621375. Source: BHF-UCL

regulation of membrane depolarization

Inferred from direct assay Ref.10. Source: BHF-UCL

regulation of membrane depolarization during cardiac muscle cell action potential

Traceable author statement PubMed 21621375. Source: BHF-UCL

regulation of membrane potential

Inferred from direct assay Ref.10. Source: BHF-UCL

regulation of sodium ion transmembrane transport

Inferred from direct assay Ref.10. Source: BHF-UCL

regulation of sodium ion transmembrane transporter activity

Inferred from direct assay Ref.10. Source: BHF-UCL

   Cellular_componentcaveola

Inferred from direct assay PubMed 23420830. Source: BHF-UCL

cytoplasm

Inferred from direct assay Ref.1. Source: BHF-UCL

intercalated disc

Inferred from sequence or structural similarity Ref.10. Source: BHF-UCL

nucleoplasm

Inferred from sequence or structural similarity. Source: BHF-UCL

nucleus

Inferred from direct assay Ref.1. Source: BHF-UCL

plasma membrane

Inferred by curator Ref.10. Source: BHF-UCL

rough endoplasmic reticulum

Inferred from direct assay PubMed 23420830. Source: BHF-UCL

   Molecular_functionRan GTPase binding

Inferred from physical interaction Ref.1. Source: BHF-UCL

guanyl-nucleotide exchange factor activity

Inferred from sequence or structural similarity. Source: BHF-UCL

ion channel binding

Inferred from physical interaction Ref.10. Source: BHF-UCL

protein transporter activity

Inferred from mutant phenotype PubMed 23420830. Source: BHF-UCL

sodium channel regulator activity

Inferred from direct assay Ref.10. Source: BHF-UCL

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9HD47-1)

Also known as: MOG1a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9HD47-2)

Also known as: MOG1b;

The sequence of this isoform differs from the canonical sequence as follows:
     147-186: Missing.
Isoform 3 (identifier: Q9HD47-3)

The sequence of this isoform differs from the canonical sequence as follows:
     119-163: AKDVTLHQAL...GPENLSPAPW → RARECVMSWK...GLAEAAPVPD
     164-186: Missing.
Isoform 4 (identifier: Q9HD47-4)

The sequence of this isoform differs from the canonical sequence as follows:
     118-118: V → P
     119-186: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 186186Ran guanine nucleotide release factor
PRO_0000330636

Natural variations

Alternative sequence1181V → P in isoform 4.
VSP_033057
Alternative sequence119 – 18668Missing in isoform 4.
VSP_033058
Alternative sequence119 – 16345AKDVT…SPAPW → RARECVMSWKGGSGDAEIQV SILTLIPLGSKGRDTSSGLA EAAPVPD in isoform 3.
VSP_033059
Alternative sequence147 – 18640Missing in isoform 2.
VSP_033060
Alternative sequence164 – 18623Missing in isoform 3.
VSP_033061

Experimental info

Sequence conflict94 – 963ALR → PE in AAF36156. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (MOG1a) [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: BE2C459C90459042

FASTA18620,448
        10         20         30         40         50         60 
MEPTRDCPLF GGAFSAILPM GAIDVSDLRP VPDNQEVFCH PVTDQSLIVE LLELQAHVRG 

        70         80         90        100        110        120 
EAAARYHFED VGGVQGARAV HVESVQPLSL ENLALRGRCQ EAWVLSGKQQ IAKENQQVAK 

       130        140        150        160        170        180 
DVTLHQALLR LPQYQTDLLL TFNQPPPDNR SSLGPENLSP APWSLGDFEQ LVTSLTLHDP 


NIFGPQ 

« Hide

Isoform 2 (MOG1b) [UniParc].

Checksum: 2EA661B68733EF9B
Show »

FASTA14616,118
Isoform 3 [UniParc].

Checksum: E69ECDD84D5B4011
Show »

FASTA16517,711
Isoform 4 [UniParc].

Checksum: 464DE437624F7A9B
Show »

FASTA11812,900

References

« Hide 'large scale' references
[1]"Identification and characterization of the human MOG1 gene."
Marfatia K.A., Harreman M.T., Fanara P., Vertino P.M., Corbett A.H.
Gene 266:45-56(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"Novel genes expressed in hematopoietic stem/progenitor cells from Myelodysplastic Syndromes patient."
Huang C., Zhang C., Tu Y., Gu W., Wang Y., Han Z., Chen Z., Zhou J., Gu J., Huang Q., Yu Y., Xu S., Ren S., Fu G.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Hematopoietic stem cell.
[3]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Umbilical cord blood.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Umbilical cord blood.
[5]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Prostate.
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Bone marrow, Lung and Uterus.
[10]"Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav1.5."
Wu L., Yong S.L., Fan C., Ni Y., Yoo S., Zhang T., Zhang X., Obejero-Paz C.A., Rho H.J., Ke T., Szafranski P., Jones S.W., Chen Q., Wang Q.K.
J. Biol. Chem. 283:6968-6978(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH SCN5A.
[11]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF265205 mRNA. Translation: AAG01291.1.
AF265206 mRNA. Translation: AAG01292.1.
AF168714 mRNA. Translation: AAF87316.1. Frameshift.
AF151070 mRNA. Translation: AAF36156.1.
AF161514 mRNA. Translation: AAF29129.1. Frameshift.
AK290399 mRNA. Translation: BAF83088.1.
CR457206 mRNA. Translation: CAG33487.1.
CR749387 mRNA. Translation: CAH18237.1.
CH471108 Genomic DNA. Translation: EAW90064.1.
CH471108 Genomic DNA. Translation: EAW90065.1.
CH471108 Genomic DNA. Translation: EAW90066.1.
BC006486 mRNA. Translation: AAH06486.1.
BC012552 mRNA. Translation: AAH12552.1.
BC100017 mRNA. Translation: AAI00018.1.
CCDSCCDS11137.1. [Q9HD47-1]
CCDS54086.1. [Q9HD47-2]
CCDS54087.1. [Q9HD47-3]
RefSeqNP_001171272.1. NM_001177801.1. [Q9HD47-2]
NP_001171273.1. NM_001177802.1. [Q9HD47-3]
NP_057576.2. NM_016492.4. [Q9HD47-1]
XP_005256675.1. XM_005256618.2. [Q9HD47-4]
UniGeneHs.408233.

3D structure databases

ProteinModelPortalQ9HD47.
SMRQ9HD47. Positions 5-161.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118866. 5 interactions.
IntActQ9HD47. 1 interaction.
STRING9606.ENSP00000226105.

PTM databases

PhosphoSiteQ9HD47.

Polymorphism databases

DMDM74718913.

Proteomic databases

MaxQBQ9HD47.
PaxDbQ9HD47.
PRIDEQ9HD47.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000226105; ENSP00000226105; ENSG00000108961. [Q9HD47-1]
ENST00000407006; ENSP00000383940; ENSG00000108961. [Q9HD47-2]
ENST00000439238; ENSP00000413190; ENSG00000108961. [Q9HD47-3]
ENST00000580434; ENSP00000462310; ENSG00000108961. [Q9HD47-4]
GeneID29098.
KEGGhsa:29098.
UCSCuc002gkv.3. human. [Q9HD47-1]
uc002gkw.3. human. [Q9HD47-4]
uc002gky.3. human. [Q9HD47-3]

Organism-specific databases

CTD29098.
GeneCardsGC17P008191.
H-InvDBHIX0013522.
HGNCHGNC:17679. RANGRF.
HPAHPA057280.
HPA057888.
MIM607954. gene.
neXtProtNX_Q9HD47.
PharmGKBPA162400661.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG287645.
HOVERGENHBG075266.
InParanoidQ9HD47.
OMANQPPPDN.
OrthoDBEOG7992RS.
PhylomeDBQ9HD47.
TreeFamTF332074.

Gene expression databases

BgeeQ9HD47.
CleanExHS_RANGRF.
GenevestigatorQ9HD47.

Family and domain databases

Gene3D3.40.1000.10. 1 hit.
InterProIPR007681. Mog1.
IPR016123. Mog1/PsbP_a/b/a-sand.
[Graphical view]
PfamPF04603. Mog1. 1 hit.
[Graphical view]
SUPFAMSSF55724. SSF55724. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi29098.
NextBio52124.
PROQ9HD47.
SOURCESearch...

Entry information

Entry nameMOG1_HUMAN
AccessionPrimary (citable) accession number: Q9HD47
Secondary accession number(s): D3DTR6 expand/collapse secondary AC list , Q68DI3, Q9BR68, Q9HD48, Q9NRU9, Q9P001, Q9P0P2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM