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Protein

Transmembrane 9 superfamily member 3

Gene

TM9SF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 9 superfamily member 3
Alternative name(s):
EP70-P-iso
SM-11044-binding protein
Gene namesi
Name:TM9SF3
Synonyms:SMBP
ORF Names:UNQ245/PRO282
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:21529. TM9SF3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei224 – 24421HelicalSequence analysisAdd
BLAST
Transmembranei294 – 31421HelicalSequence analysisAdd
BLAST
Transmembranei328 – 34821HelicalSequence analysisAdd
BLAST
Transmembranei360 – 38021HelicalSequence analysisAdd
BLAST
Transmembranei389 – 40921HelicalSequence analysisAdd
BLAST
Transmembranei449 – 46921HelicalSequence analysisAdd
BLAST
Transmembranei482 – 50221HelicalSequence analysisAdd
BLAST
Transmembranei519 – 53921HelicalSequence analysisAdd
BLAST
Transmembranei551 – 57121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596264.

Polymorphism and mutation databases

BioMutaiTM9SF3.
DMDMi13878808.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 589561Transmembrane 9 superfamily member 3PRO_0000034369Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi174 – 1741N-linked (GlcNAc...)2 Publications
Glycosylationi419 – 4191N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9HD45.
MaxQBiQ9HD45.
PaxDbiQ9HD45.
PeptideAtlasiQ9HD45.
PRIDEiQ9HD45.

PTM databases

iPTMnetiQ9HD45.
PhosphoSiteiQ9HD45.
SwissPalmiQ9HD45.

Expressioni

Gene expression databases

BgeeiQ9HD45.
CleanExiHS_TM9SF3.
ExpressionAtlasiQ9HD45. baseline and differential.
GenevisibleiQ9HD45. HS.

Organism-specific databases

HPAiHPA039609.

Interactioni

Protein-protein interaction databases

BioGridi121219. 9 interactions.
IntActiQ9HD45. 9 interactions.
MINTiMINT-5005017.
STRINGi9606.ENSP00000360184.

Structurei

3D structure databases

ProteinModelPortaliQ9HD45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1277. Eukaryota.
ENOG410XSVB. LUCA.
GeneTreeiENSGT00530000062897.
HOGENOMiHOG000216680.
HOVERGENiHBG054197.
InParanoidiQ9HD45.
KOiK17087.
OMAiMVEDLYT.
OrthoDBiEOG7PZRWX.
PhylomeDBiQ9HD45.
TreeFamiTF314271.

Family and domain databases

InterProiIPR004240. EMP70.
[Graphical view]
PANTHERiPTHR10766. PTHR10766. 1 hit.
PfamiPF02990. EMP70. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HD45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLPGALGV AAAAALWLLL LLLPRTRADE HEHTYQDKEE VVLWMNTVGP
60 70 80 90 100
YHNRQETYKY FSLPFCVGSK KSISHYHETL GEALQGVELE FSGLDIKFKD
110 120 130 140 150
DVMPATYCEI DLDKEKRDAF VYAIKNHYWY QMYIDDLPIW GIVGEADENG
160 170 180 190 200
EDYYLWTYKK LEIGFNGNRI VDVNLTSEGK VKLVPNTKIQ MSYSVKWKKS
210 220 230 240 250
DVKFEDRFDK YLDPSFFQHR IHWFSIFNSF MMVIFLVGLV SMILMRTLRK
260 270 280 290 300
DYARYSKEEE MDDMDRDLGD EYGWKQVHGD VFRPSSHPLI FSSLIGSGCQ
310 320 330 340 350
IFAVSLIVII VAMIEDLYTE RGSMLSTAIF VYAATSPVNG YFGGSLYARQ
360 370 380 390 400
GGRRWIKQMF IGAFLIPAMV CGTAFFINFI AIYYHASRAI PFGTMVAVCC
410 420 430 440 450
ICFFVILPLN LVGTILGRNL SGQPNFPCRV NAVPRPIPEK KWFMEPAVIV
460 470 480 490 500
CLGGILPFGS IFIEMYFIFT SFWAYKIYYV YGFMMLVLVI LCIVTVCVTI
510 520 530 540 550
VCTYFLLNAE DYRWQWTSFL SAASTAIYVY MYSFYYYFFK TKMYGLFQTS
560 570 580
FYFGYMAVFS TALGIMCGAI GYMGTSAFVR KIYTNVKID
Length:589
Mass (Da):67,888
Last modified:April 27, 2001 - v2
Checksum:iE673D547A35BC4A7
GO

Sequence cautioni

The sequence AAF67014.1 differs from that shown. Reason: Frameshift at positions 184, 198, 370 and 446. Curated
The sequence AAQ89178.1 differs from that shown. Reason: Frameshift at position 70. Curated
The sequence BAA91362.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151Missing in AAF67014 (Ref. 2) Curated
Sequence conflicti191 – 1911M → I in AAF98159 (Ref. 1) Curated
Sequence conflicti210 – 2189KYLDPSFFQ → NILIVLFS in AAF67014 (Ref. 2) Curated
Sequence conflicti232 – 2321M → T in BAA91362 (PubMed:14702039).Curated
Sequence conflicti398 – 3981V → R in AAQ89178 (PubMed:12975309).Curated
Sequence conflicti547 – 5471F → S in BAA91362 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF269150 mRNA. Translation: AAF98159.1.
AF160213 mRNA. Translation: AAF67014.1. Frameshift.
AL138765 Genomic DNA. Translation: CAI13584.1.
CH471066 Genomic DNA. Translation: EAW49972.1.
CH471066 Genomic DNA. Translation: EAW49974.1.
BC136788 mRNA. Translation: AAI36789.1.
BC136789 mRNA. Translation: AAI36790.1.
AF116347 mRNA. Translation: AAF21983.1.
AY358819 mRNA. Translation: AAQ89178.1. Frameshift.
AK000756 mRNA. Translation: BAA91362.1. Different initiation.
CCDSiCCDS7450.1.
RefSeqiNP_064508.3. NM_020123.3.
UniGeneiHs.500674.

Genome annotation databases

EnsembliENST00000371142; ENSP00000360184; ENSG00000077147.
GeneIDi56889.
KEGGihsa:56889.
UCSCiuc001kmm.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF269150 mRNA. Translation: AAF98159.1.
AF160213 mRNA. Translation: AAF67014.1. Frameshift.
AL138765 Genomic DNA. Translation: CAI13584.1.
CH471066 Genomic DNA. Translation: EAW49972.1.
CH471066 Genomic DNA. Translation: EAW49974.1.
BC136788 mRNA. Translation: AAI36789.1.
BC136789 mRNA. Translation: AAI36790.1.
AF116347 mRNA. Translation: AAF21983.1.
AY358819 mRNA. Translation: AAQ89178.1. Frameshift.
AK000756 mRNA. Translation: BAA91362.1. Different initiation.
CCDSiCCDS7450.1.
RefSeqiNP_064508.3. NM_020123.3.
UniGeneiHs.500674.

3D structure databases

ProteinModelPortaliQ9HD45.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121219. 9 interactions.
IntActiQ9HD45. 9 interactions.
MINTiMINT-5005017.
STRINGi9606.ENSP00000360184.

PTM databases

iPTMnetiQ9HD45.
PhosphoSiteiQ9HD45.
SwissPalmiQ9HD45.

Polymorphism and mutation databases

BioMutaiTM9SF3.
DMDMi13878808.

Proteomic databases

EPDiQ9HD45.
MaxQBiQ9HD45.
PaxDbiQ9HD45.
PeptideAtlasiQ9HD45.
PRIDEiQ9HD45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371142; ENSP00000360184; ENSG00000077147.
GeneIDi56889.
KEGGihsa:56889.
UCSCiuc001kmm.5. human.

Organism-specific databases

CTDi56889.
GeneCardsiTM9SF3.
H-InvDBHIX0009076.
HGNCiHGNC:21529. TM9SF3.
HPAiHPA039609.
neXtProtiNX_Q9HD45.
PharmGKBiPA144596264.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1277. Eukaryota.
ENOG410XSVB. LUCA.
GeneTreeiENSGT00530000062897.
HOGENOMiHOG000216680.
HOVERGENiHBG054197.
InParanoidiQ9HD45.
KOiK17087.
OMAiMVEDLYT.
OrthoDBiEOG7PZRWX.
PhylomeDBiQ9HD45.
TreeFamiTF314271.

Miscellaneous databases

ChiTaRSiTM9SF3. human.
GenomeRNAii56889.
PROiQ9HD45.

Gene expression databases

BgeeiQ9HD45.
CleanExiHS_TM9SF3.
ExpressionAtlasiQ9HD45. baseline and differential.
GenevisibleiQ9HD45. HS.

Family and domain databases

InterProiIPR004240. EMP70.
[Graphical view]
PANTHERiPTHR10766. PTHR10766. 1 hit.
PfamiPF02990. EMP70. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Evolution of the TM9 super family of membrane spanning proteins."
    Warner S.J., Lomax M.I.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Gu Y., Peng Y., Li Y., Fu S., Gu J., Gu W., Jiang C., Yu Y., Han Z., Wang Y., Chen Z., Fu G.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adrenal gland.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The iodocyanopindolol and SM-11044 binding protein (SMBP) belongs to the emerging family of MP70 multispanning membrane proteins."
    Sugasawa T., Lenzen G., Simon S., Hidaka J., Cahen A., Guillaume J.L., Camoin L., Nahmias C., Strosberg A.D.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-589.
    Tissue: Skeletal muscle.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 39-589.
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 128-589.
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-174.
    Tissue: Liver.
  10. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-174.
    Tissue: Leukemic T-cell.
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTM9S3_HUMAN
AccessioniPrimary (citable) accession number: Q9HD45
Secondary accession number(s): Q5TB57
, Q6UWE7, Q9NWL8, Q9P0G9, Q9UHW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: June 8, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.