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Protein

Transmembrane 9 superfamily member 3

Gene

TM9SF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000077147-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 9 superfamily member 3
Alternative name(s):
EP70-P-iso
SM-11044-binding protein
Gene namesi
Name:TM9SF3
Synonyms:SMBP
ORF Names:UNQ245/PRO282
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:21529. TM9SF3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Transmembranei360 – 380HelicalSequence analysisAdd BLAST21
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Transmembranei449 – 469HelicalSequence analysisAdd BLAST21
Transmembranei482 – 502HelicalSequence analysisAdd BLAST21
Transmembranei519 – 539HelicalSequence analysisAdd BLAST21
Transmembranei551 – 571HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56889.
OpenTargetsiENSG00000077147.
PharmGKBiPA144596264.

Polymorphism and mutation databases

BioMutaiTM9SF3.
DMDMi13878808.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000003436929 – 589Transmembrane 9 superfamily member 3Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi174N-linked (GlcNAc...)2 Publications1
Glycosylationi419N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9HD45.
MaxQBiQ9HD45.
PaxDbiQ9HD45.
PeptideAtlasiQ9HD45.
PRIDEiQ9HD45.

PTM databases

iPTMnetiQ9HD45.
PhosphoSitePlusiQ9HD45.
SwissPalmiQ9HD45.

Expressioni

Gene expression databases

BgeeiENSG00000077147.
CleanExiHS_TM9SF3.
ExpressionAtlasiQ9HD45. baseline and differential.
GenevisibleiQ9HD45. HS.

Organism-specific databases

HPAiHPA039609.

Interactioni

Protein-protein interaction databases

BioGridi121219. 10 interactors.
IntActiQ9HD45. 17 interactors.
MINTiMINT-5005017.
STRINGi9606.ENSP00000360184.

Structurei

3D structure databases

ProteinModelPortaliQ9HD45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1277. Eukaryota.
ENOG410XSVB. LUCA.
GeneTreeiENSGT00530000062897.
HOGENOMiHOG000216680.
HOVERGENiHBG054197.
InParanoidiQ9HD45.
KOiK17087.
OMAiPGSHINF.
OrthoDBiEOG091G03BV.
PhylomeDBiQ9HD45.
TreeFamiTF314271.

Family and domain databases

InterProiIPR004240. EMP70.
[Graphical view]
PANTHERiPTHR10766. PTHR10766. 1 hit.
PfamiPF02990. EMP70. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HD45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLPGALGV AAAAALWLLL LLLPRTRADE HEHTYQDKEE VVLWMNTVGP
60 70 80 90 100
YHNRQETYKY FSLPFCVGSK KSISHYHETL GEALQGVELE FSGLDIKFKD
110 120 130 140 150
DVMPATYCEI DLDKEKRDAF VYAIKNHYWY QMYIDDLPIW GIVGEADENG
160 170 180 190 200
EDYYLWTYKK LEIGFNGNRI VDVNLTSEGK VKLVPNTKIQ MSYSVKWKKS
210 220 230 240 250
DVKFEDRFDK YLDPSFFQHR IHWFSIFNSF MMVIFLVGLV SMILMRTLRK
260 270 280 290 300
DYARYSKEEE MDDMDRDLGD EYGWKQVHGD VFRPSSHPLI FSSLIGSGCQ
310 320 330 340 350
IFAVSLIVII VAMIEDLYTE RGSMLSTAIF VYAATSPVNG YFGGSLYARQ
360 370 380 390 400
GGRRWIKQMF IGAFLIPAMV CGTAFFINFI AIYYHASRAI PFGTMVAVCC
410 420 430 440 450
ICFFVILPLN LVGTILGRNL SGQPNFPCRV NAVPRPIPEK KWFMEPAVIV
460 470 480 490 500
CLGGILPFGS IFIEMYFIFT SFWAYKIYYV YGFMMLVLVI LCIVTVCVTI
510 520 530 540 550
VCTYFLLNAE DYRWQWTSFL SAASTAIYVY MYSFYYYFFK TKMYGLFQTS
560 570 580
FYFGYMAVFS TALGIMCGAI GYMGTSAFVR KIYTNVKID
Length:589
Mass (Da):67,888
Last modified:April 27, 2001 - v2
Checksum:iE673D547A35BC4A7
GO

Sequence cautioni

The sequence AAF67014 differs from that shown. Reason: Frameshift at positions 184, 198, 370 and 446.Curated
The sequence AAQ89178 differs from that shown. Reason: Frameshift at position 70.Curated
The sequence BAA91362 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15Missing in AAF67014 (Ref. 2) Curated1
Sequence conflicti191M → I in AAF98159 (Ref. 1) Curated1
Sequence conflicti210 – 218KYLDPSFFQ → NILIVLFS in AAF67014 (Ref. 2) Curated9
Sequence conflicti232M → T in BAA91362 (PubMed:14702039).Curated1
Sequence conflicti398V → R in AAQ89178 (PubMed:12975309).Curated1
Sequence conflicti547F → S in BAA91362 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF269150 mRNA. Translation: AAF98159.1.
AF160213 mRNA. Translation: AAF67014.1. Frameshift.
AL138765 Genomic DNA. Translation: CAI13584.1.
CH471066 Genomic DNA. Translation: EAW49972.1.
CH471066 Genomic DNA. Translation: EAW49974.1.
BC136788 mRNA. Translation: AAI36789.1.
BC136789 mRNA. Translation: AAI36790.1.
AF116347 mRNA. Translation: AAF21983.1.
AY358819 mRNA. Translation: AAQ89178.1. Frameshift.
AK000756 mRNA. Translation: BAA91362.1. Different initiation.
CCDSiCCDS7450.1.
RefSeqiNP_064508.3. NM_020123.3.
UniGeneiHs.500674.

Genome annotation databases

EnsembliENST00000371142; ENSP00000360184; ENSG00000077147.
GeneIDi56889.
KEGGihsa:56889.
UCSCiuc001kmm.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF269150 mRNA. Translation: AAF98159.1.
AF160213 mRNA. Translation: AAF67014.1. Frameshift.
AL138765 Genomic DNA. Translation: CAI13584.1.
CH471066 Genomic DNA. Translation: EAW49972.1.
CH471066 Genomic DNA. Translation: EAW49974.1.
BC136788 mRNA. Translation: AAI36789.1.
BC136789 mRNA. Translation: AAI36790.1.
AF116347 mRNA. Translation: AAF21983.1.
AY358819 mRNA. Translation: AAQ89178.1. Frameshift.
AK000756 mRNA. Translation: BAA91362.1. Different initiation.
CCDSiCCDS7450.1.
RefSeqiNP_064508.3. NM_020123.3.
UniGeneiHs.500674.

3D structure databases

ProteinModelPortaliQ9HD45.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121219. 10 interactors.
IntActiQ9HD45. 17 interactors.
MINTiMINT-5005017.
STRINGi9606.ENSP00000360184.

PTM databases

iPTMnetiQ9HD45.
PhosphoSitePlusiQ9HD45.
SwissPalmiQ9HD45.

Polymorphism and mutation databases

BioMutaiTM9SF3.
DMDMi13878808.

Proteomic databases

EPDiQ9HD45.
MaxQBiQ9HD45.
PaxDbiQ9HD45.
PeptideAtlasiQ9HD45.
PRIDEiQ9HD45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371142; ENSP00000360184; ENSG00000077147.
GeneIDi56889.
KEGGihsa:56889.
UCSCiuc001kmm.5. human.

Organism-specific databases

CTDi56889.
DisGeNETi56889.
GeneCardsiTM9SF3.
H-InvDBHIX0009076.
HGNCiHGNC:21529. TM9SF3.
HPAiHPA039609.
neXtProtiNX_Q9HD45.
OpenTargetsiENSG00000077147.
PharmGKBiPA144596264.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1277. Eukaryota.
ENOG410XSVB. LUCA.
GeneTreeiENSGT00530000062897.
HOGENOMiHOG000216680.
HOVERGENiHBG054197.
InParanoidiQ9HD45.
KOiK17087.
OMAiPGSHINF.
OrthoDBiEOG091G03BV.
PhylomeDBiQ9HD45.
TreeFamiTF314271.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000077147-MONOMER.

Miscellaneous databases

ChiTaRSiTM9SF3. human.
GenomeRNAii56889.
PROiQ9HD45.

Gene expression databases

BgeeiENSG00000077147.
CleanExiHS_TM9SF3.
ExpressionAtlasiQ9HD45. baseline and differential.
GenevisibleiQ9HD45. HS.

Family and domain databases

InterProiIPR004240. EMP70.
[Graphical view]
PANTHERiPTHR10766. PTHR10766. 1 hit.
PfamiPF02990. EMP70. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM9S3_HUMAN
AccessioniPrimary (citable) accession number: Q9HD45
Secondary accession number(s): Q5TB57
, Q6UWE7, Q9NWL8, Q9P0G9, Q9UHW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.