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Q9HD43

- PTPRH_HUMAN

UniProt

Q9HD43 - PTPRH_HUMAN

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Protein

Receptor-type tyrosine-protein phosphatase H

Gene

PTPRH

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of p130cas, focal adhesion kinase and c-Src. Reduces migratory activity of Jurkat cells.4 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Enzyme regulationi

Regulated by reversible dimerization. Dimerization reduces its catalytic activity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1020 – 10201Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. peptidyl-tyrosine dephosphorylation Source: GOC
  3. protein dephosphorylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase H (EC:3.1.3.48)
Short name:
R-PTP-H
Alternative name(s):
Stomach cancer-associated protein tyrosine phosphatase 1
Short name:
SAP-1
Transmembrane-type protein-tyrosine phosphatase type H
Gene namesi
Name:PTPRH
Synonyms:SAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:9672. PTPRH.

Subcellular locationi

Membrane Curated; Single-pass type I membrane protein Curated. Cytoplasm 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 754727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei755 – 77521HelicalSequence AnalysisAdd
BLAST
Topological domaini776 – 1115340CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi986 – 9861D → A: Loss of activity. Acts as a dominant negative mutant. 1 Publication
Mutagenesisi1020 – 10201C → S: Loss of activity. No induction of apoptosis. 2 Publications

Organism-specific databases

PharmGKBiPA34017.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 11151088Receptor-type tyrosine-protein phosphatase HPRO_0000318950Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi468 – 4681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi556 – 5561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi642 – 6421N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9HD43.
PaxDbiQ9HD43.
PRIDEiQ9HD43.

PTM databases

PhosphoSiteiQ9HD43.

Expressioni

Tissue specificityi

Expressed at high levels in the brain, spleen and liver and at lower levels in the heart and stomach. Expressed in pancreatic and colorectal cancer cells, but not in normal pancreas or colon. Expression in hepatocellular carcinoma is related to the differentiation status of the tumor and expression is inversely related to tumor aggressiveness.3 Publications

Inductioni

Induced at the early stage of hepatocellular carcinoma and is suppressed at later stages.1 Publication

Gene expression databases

BgeeiQ9HD43.
CleanExiHS_PTPRH.
GenevestigatoriQ9HD43.

Organism-specific databases

HPAiHPA042300.

Interactioni

Subunit structurei

Homodimer; disulfide-linked (Probable). Interacts with LCK.2 PublicationsCurated

Binary interactionsi

WithEntry#Exp.IntActNotes
GHRP109124EBI-1267176,EBI-286316

Protein-protein interaction databases

BioGridi111758. 4 interactions.
IntActiQ9HD43. 5 interactions.
MINTiMINT-1349530.
STRINGi9606.ENSP00000365528.

Structurei

3D structure databases

ProteinModelPortaliQ9HD43.
SMRiQ9HD43. Positions 28-561, 569-651, 800-1081.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 12190Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini122 – 20988Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini210 – 29990Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini300 – 38788Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini388 – 47790Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini478 – 56386Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini564 – 666103Fibronectin type-III 7PROSITE-ProRule annotationAdd
BLAST
Domaini665 – 74985Fibronectin type-III 8PROSITE-ProRule annotationAdd
BLAST
Domaini820 – 1079260Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Domaini

The extracellular domain mediates homodimerization. One or more cysteines in the extracellular domain is essential for the formation of dimers probably by forming a disulfide bond.
The cytoplasmic domain mediates the interaction with LCK.

Sequence similaritiesi

Contains 8 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000170539.
HOVERGENiHBG108307.
InParanoidiQ9HD43.
OMAiFSVWAEK.
OrthoDBiEOG7PCJFZ.
PhylomeDBiQ9HD43.
TreeFamiTF351926.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
3.90.190.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR028855. R-PTP-H.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PANTHERiPTHR19134:SF254. PTHR19134:SF254. 1 hit.
PfamiPF00041. fn3. 7 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 7 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
SSF52799. SSF52799. 1 hit.
PROSITEiPS50853. FN3. 7 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9HD43-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGAGGGLGV WGNLVLLGLC SWTGARAPAP NPGRNLTVET QTTSSISLSW
60 70 80 90 100
EVPDGLDSQN SNYWVQCTGD GGTTETRNTT ATNVTVDGLG PGSLYTCSVW
110 120 130 140 150
VEKDGVNSSV GTVTTATAPN PVRNLRVEAQ TNSSIALTWE VPDGPDPQNS
160 170 180 190 200
TYGVEYTGDG GRAGTRSTAH TNITVDGLEP GCLYAFSMWV GKNGINSSRE
210 220 230 240 250
TRNATTAHNP VRNLRVEAQT TSSISLSWEV PDGTDPQNST YCVQCTGDGG
260 270 280 290 300
RTETRNTTDT RVTVDGLGPG SLYTCSVWVE KDGVNSSVEI VTSATAPNPV
310 320 330 340 350
RNLTVEAQTN SSIALTWEVP DGPDPQNSTY GVEYTGDGGR AGTRSTAHTN
360 370 380 390 400
ITVDRLEPGC LYVFSVWVGK NGINSSRETR NATTAPNPVR NLHMETQTNS
410 420 430 440 450
SIALCWEVPD GPYPQDYTYW VEYTGDGGGT ETRNTTNTSV TAERLEPGTL
460 470 480 490 500
YTFSVWAEKN GARGSRQNVS ISTVPNAVTS LSKQDWTNST IALRWTAPQG
510 520 530 540 550
PGQSSYSYWV SWVREGMTDP RTQSTSGTDI TLKELEAGSL YHLTVWAERN
560 570 580 590 600
EVRGYNSTLT AATAPNEVTD LQNETQTKNS VMLWWKAPGD PHSQLYVYWV
610 620 630 640 650
QWASKGHPRR GQDPQANWVN QTSRTNETWY KVEALEPGTL YNFTVWAERN
660 670 680 690 700
DVASSTQSLC ASTYPDTVTI TSCVSTSAGY GVNLIWSCPQ GGYEAFELEV
710 720 730 740 750
GGQRGSQDRS SCGEAVSVLG LGPARSYPAT ITTIWDGMKV VSHSVVCHTE
760 770 780 790 800
SAGVIAGAFV GILLFLILVG LLIFFLKRRN KKKQQKPELR DLVFSSPGDI
810 820 830 840 850
PAEDFADHVR KNERDSNCGF ADKYQQLSLV GHSQSQMVAS ASENNAKNRY
860 870 880 890 900
RNVLPYDWSR VPLKPIHEEP GSDYINASFM PGLWSPQEFI ATQGPLPQTV
910 920 930 940 950
GDFWRLVWEQ QSHTLVMLTN CMEAGRVKCE HYWPLDSQPC THGHLRVTLV
960 970 980 990 1000
GEEVMENWTV RELLLLQVEE QKTLSVRQFH YQAWPDHGVP SSPDTLLAFW
1010 1020 1030 1040 1050
RMLRQWLDQT MEGGPPIVHC SAGVGRTGTL IALDVLLRQL QSEGLLGPFS
1060 1070 1080 1090 1100
FVRKMRESRP LMVQTEAQYV FLHQCILRFL QQSAQAPAEK EVPYEDVENL
1110
IYENVAAIQA HKLEV
Length:1,115
Mass (Da):122,352
Last modified:May 18, 2010 - v3
Checksum:iA7A1AB24CFCD3846
GO
Isoform 2 (identifier: Q9HD43-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-261: Missing.

Show »
Length:937
Mass (Da):103,483
Checksum:i5E579E14580244FF
GO
Isoform 3 (identifier: Q9HD43-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-303: Missing.

Show »
Length:937
Mass (Da):103,412
Checksum:iA444EEE28EA7324C
GO

Sequence cautioni

The sequence BAA03645.2 differs from that shown. Reason: Frameshift at positions 213, 244, 264, 287 and 291. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti294 – 2941A → T in BAA03645. (PubMed:8294459)Curated
Sequence conflicti422 – 4221E → G in BAA03645. (PubMed:8294459)Curated
Sequence conflicti951 – 9511G → D in AAI11716. (PubMed:15489334)Curated
Sequence conflicti1109 – 11091Q → K in AAI11716. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti232 – 2321D → N.
Corresponds to variant rs55870162 [ dbSNP | Ensembl ].
VAR_061762
Natural varianti243 – 2431V → I.
Corresponds to variant rs45535035 [ dbSNP | Ensembl ].
VAR_061763
Natural varianti348 – 3481H → Y.1 Publication
Corresponds to variant rs2288515 [ dbSNP | Ensembl ].
VAR_038918
Natural varianti543 – 5431L → F.
Corresponds to variant rs16986309 [ dbSNP | Ensembl ].
VAR_038919
Natural varianti781 – 7811K → N.
Corresponds to variant rs2288523 [ dbSNP | Ensembl ].
VAR_038920
Natural varianti823 – 8231K → E.2 Publications
Corresponds to variant rs890870 [ dbSNP | Ensembl ].
VAR_038921
Natural varianti831 – 8311G → D.
Corresponds to variant rs36092369 [ dbSNP | Ensembl ].
VAR_061764
Natural varianti1076 – 10761I → V.
Corresponds to variant rs2288419 [ dbSNP | Ensembl ].
VAR_038922

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei84 – 261178Missing in isoform 2. 1 PublicationVSP_031318Add
BLAST
Alternative sequencei126 – 303178Missing in isoform 3. CuratedVSP_054222Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D15049 mRNA. Translation: BAA03645.2. Frameshift.
AF275150
, AF275131, AF275132, AF275133, AF275134, AF275135, AF275136, AF275137, AF275138, AF275139, AF275140, AF275141, AF275142, AF275143, AF275144, AF275145, AF275146, AF275147, AF275148, AF275149 Genomic DNA. Translation: AAF91411.1.
AC010327 Genomic DNA. No translation available.
BC111715 mRNA. Translation: AAI11716.1.
BC111716 mRNA. Translation: AAI11717.1.
CCDSiCCDS33110.1. [Q9HD43-1]
CCDS54321.1. [Q9HD43-3]
PIRiA49724.
UniGeneiHs.179770.

Genome annotation databases

EnsembliENST00000263434; ENSP00000263434; ENSG00000080031.
ENST00000376350; ENSP00000365528; ENSG00000080031.
UCSCiuc002qjq.3. human. [Q9HD43-1]

Polymorphism databases

DMDMi296452983.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D15049 mRNA. Translation: BAA03645.2 . Frameshift.
AF275150
, AF275131 , AF275132 , AF275133 , AF275134 , AF275135 , AF275136 , AF275137 , AF275138 , AF275139 , AF275140 , AF275141 , AF275142 , AF275143 , AF275144 , AF275145 , AF275146 , AF275147 , AF275148 , AF275149 Genomic DNA. Translation: AAF91411.1 .
AC010327 Genomic DNA. No translation available.
BC111715 mRNA. Translation: AAI11716.1 .
BC111716 mRNA. Translation: AAI11717.1 .
CCDSi CCDS33110.1. [Q9HD43-1 ]
CCDS54321.1. [Q9HD43-3 ]
PIRi A49724.
UniGenei Hs.179770.

3D structure databases

ProteinModelPortali Q9HD43.
SMRi Q9HD43. Positions 28-561, 569-651, 800-1081.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111758. 4 interactions.
IntActi Q9HD43. 5 interactions.
MINTi MINT-1349530.
STRINGi 9606.ENSP00000365528.

PTM databases

PhosphoSitei Q9HD43.

Polymorphism databases

DMDMi 296452983.

Proteomic databases

MaxQBi Q9HD43.
PaxDbi Q9HD43.
PRIDEi Q9HD43.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263434 ; ENSP00000263434 ; ENSG00000080031 .
ENST00000376350 ; ENSP00000365528 ; ENSG00000080031 .
UCSCi uc002qjq.3. human. [Q9HD43-1 ]

Organism-specific databases

GeneCardsi GC19M055692.
HGNCi HGNC:9672. PTPRH.
HPAi HPA042300.
MIMi 602510. gene.
neXtProti NX_Q9HD43.
PharmGKBi PA34017.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000170539.
HOVERGENi HBG108307.
InParanoidi Q9HD43.
OMAi FSVWAEK.
OrthoDBi EOG7PCJFZ.
PhylomeDBi Q9HD43.
TreeFami TF351926.

Miscellaneous databases

GenomeRNAii 5794.
NextBioi 22560.
PROi Q9HD43.
SOURCEi Search...

Gene expression databases

Bgeei Q9HD43.
CleanExi HS_PTPRH.
Genevestigatori Q9HD43.

Family and domain databases

Gene3Di 2.60.40.10. 7 hits.
3.90.190.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR028855. R-PTP-H.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
PANTHERi PTHR19134:SF254. PTHR19134:SF254. 1 hit.
Pfami PF00041. fn3. 7 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 7 hits.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 4 hits.
SSF52799. SSF52799. 1 hit.
PROSITEi PS50853. FN3. 7 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a human transmembrane-type protein tyrosine phosphatase and its expression in gastrointestinal cancers."
    Matozaki T., Suzuki T., Uchida T., Inazawa J., Ariyama T., Matsuda K., Horita K., Noguchi H., Mizuno H., Sakamoto C., Kasuga M.
    J. Biol. Chem. 269:2075-2081(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT GLU-823.
  2. "Gene for the human transmembrane-type protein tyrosine phosphatase H (PTPRH): genomic structure, fine-mapping and its exclusion as a candidate for Peutz-Jeghers syndrome."
    Marneros A.G., Mehenni H., Reichenberger E., Antonarakis S.E., Krieg T., Olsen B.R.
    Cytogenet. Cell Genet. 92:213-216(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS TYR-348 AND GLU-823.
  5. "Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas."
    Noguchi T., Tsuda M., Takeda H., Takada T., Inagaki K., Yamao T., Fukunaga K., Matozaki T., Kasuga M.
    J. Biol. Chem. 276:15216-15224(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF ASP-986 AND CYS-1020.
  6. "Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1."
    Takada T., Noguchi T., Inagaki K., Hosooka T., Fukunaga K., Yamao T., Ogawa W., Matozaki T., Kasuga M.
    J. Biol. Chem. 277:34359-34366(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF CYS-1020.
  7. "Interaction of SAP-1, a transmembrane-type protein-tyrosine phosphatase, with the tyrosine kinase Lck. Roles in regulation of T cell function."
    Ito T., Okazawa H., Maruyama K., Tomizawa K., Motegi S., Ohnishi H., Kuwano H., Kosugi A., Matozaki T.
    J. Biol. Chem. 278:34854-34863(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DOMAIN, TISSUE SPECIFICITY, INTERACTION WITH LCK.
  8. "Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma."
    Nagano H., Noguchi T., Inagaki K., Yoon S., Matozaki T., Itoh H., Kasuga M., Hayashi Y.
    Oncogene 22:4656-4663(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.
  9. Cited for: FUNCTION, SUBUNIT, ENZYME REGULATION, DOMAIN.

Entry informationi

Entry nameiPTPRH_HUMAN
AccessioniPrimary (citable) accession number: Q9HD43
Secondary accession number(s): C9JCH2
, Q15426, Q2NKN9, Q2NKP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3