Q9HD40 (SPCS_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
O-phosphoseryl-tRNA(Sec) selenium transferase
EC=2.9.1.2

Alternative name(s):
Liver-pancreas antigen
Short name=LP
SLA-p35
SLA/LP autoantigen
Selenocysteine synthase
Short name=Sec synthase
Selenocysteinyl-tRNA(Sec) synthase
Sep-tRNA:Sec-tRNA synthase
Short name=SepSecS
Soluble liver antigen
Short name=SLA
UGA suppressor tRNA-associated protein
tRNA(Ser/Sec)-associated antigenic protein

Gene names

Name:	SEPSECS
Synonyms:	TRNP48

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. Ref.11
Catalytic activity	O-phospho-L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate.
Cofactor	Pyridoxal phosphate. Ref.11 Ref.12
Pathway	Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2.
Subunit structure	Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer. Ref.12
Subcellular location	Cytoplasm.
Tissue specificity	Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells.
Involvement in disease	Pontocerebellar hypoplasia 2D (PCH2D) [MIM:613811]: A disorder characterized by postnatal onset of progressive atrophy of the cerebrum and cerebellum, microcephaly, profound mental retardation, spasticity, and variable seizures. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13
Miscellaneous	Possible diagnostic marker for autoimmune hepatitis (AIH).
Sequence similarities	Belongs to the SepSecS family.
Sequence caution	The sequence AAD33963.2 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS. The sequence AAH23539.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS. The sequence CAB62209.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAB89517.1 differs from that shown. Reason: Frameshift at position 39.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Disease	Disease mutation
Ligand	Pyridoxal phosphate RNA-binding Selenium tRNA-binding
Molecular function	Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	selenocysteine incorporation Inferred from sequence or structural similarity. Source: HGNC selenocysteinyl-tRNA(Sec) biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: HGNC nucleus Inferred from sequence or structural similarity. Source: HGNC
Molecular_function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro tRNA binding Inferred from sequence or structural similarity. Source: HGNC transferase activity, transferring selenium-containing groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
gag	P04591	3	EBI-6163446,EBI-6163428	From a different organism.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9HD40-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9HD40-2)

The sequence of this isoform differs from the canonical sequence as follows:
     39-47: GKCPENGWD → VHSWHWTIR
     48-501: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

Isoform 3 (identifier: Q9HD40-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MNRESFAAGERLVSPAYVRQGCEARRSHEHLIRLLLEK → MQCDDLGSLQPPPPGFTPFACLSLPSSWDYRRPPPHP

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 501

501

O-phosphoseryl-tRNA(Sec) selenium transferase

PRO_0000219875

Regions

Region

1 – 44

44

Tetramerization

Region

96 – 106

11

Phosphate loop (P-loop)

Region

474 – 493

20

SLA/LP epitope

Sites

Binding site

75

1

PLP By similarity

Binding site

97

1

Substrate

Binding site

98

1

Substrate

Binding site

105

1

Substrate

Binding site

271

1

tRNA variable arm

Binding site

313

1

Substrate

Binding site

398

1

tRNA discriminator base

Binding site

463

1

tRNA acceptor arm

Site

74

1

May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate

Amino acid modifications

Modified residue

284

1

N6-(pyridoxal phosphate)lysine

Natural variations

Alternative sequence

1 – 38

38

MNRES…LLLEK → MQCDDLGSLQPPPPGFTPFA CLSLPSSWDYRRPPPHP in isoform 3.

VSP_038080

Alternative sequence

39 – 47

9

GKCPENGWD → VHSWHWTIR in isoform 2.

VSP_038078

Alternative sequence

48 – 501

454

Missing in isoform 2.

VSP_038079

Natural variant

239

1

A → T in PCH2D; abrogates enzyme activity. Ref.13

VAR_065585

Natural variant

334

1

Y → C in PCH2D; abrogates enzyme activity. Ref.13

VAR_065586

Experimental info

Mutagenesis

75

1

R → A: Inactive in vivo. Ref.12

Mutagenesis

97

1

R → A: Indistinguishable from wild-type. Ref.12

Mutagenesis

97

1

R → Q: Indistinguishable from wild-type. Ref.12

Mutagenesis

105

1

Q → A: Inactive in vivo. Ref.12

Mutagenesis

173

1

K → A: Indistinguishable from wild-type. Ref.12

Mutagenesis

173

1

K → M: Indistinguishable from wild-type. Ref.12

Mutagenesis

284

1

K → A: Loss of activity. Ref.11

Mutagenesis

313

1

R → A: Inactive in vivo. Ref.12

Sequence conflict

98

1

S → P in AAG00491. Ref.8

Sequence conflict

264

1

H → R in BAF85165. Ref.1

Sequence conflict

398

1

R → K in AAD33963. Ref.6

Sequence conflict

398

1

R → K in CAB89517. Ref.6

Sequence conflict

452

1

K → N in AAD33963. Ref.6

Sequence conflict

452

1

K → N in CAB89517. Ref.6

Sequence conflict

467

1

K → R in AAG00491. Ref.8

Secondary structure

1

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501

Helix Strand Turn

Details...

Helix

26 – 38

13

Helix

48 – 59

12

Helix

63 – 65

3

Helix

82 – 87

6

Turn

88 – 90

3

Helix

109 – 128

20

Beta strand

136 – 142

7

Helix

144 – 158

15

Beta strand

164 – 168

5

Helix

173 – 181

9

Beta strand

185 – 189

5

Beta strand

191 – 194

4

Beta strand

197 – 200

4

Helix

202 – 212

11

Helix

214 – 216

3

Beta strand

217 – 223

7

Helix

235 – 245

11

Beta strand

249 – 252

4

Helix

260 – 272

13

Beta strand

277 – 281

5

Helix

282 – 286

5

Beta strand

293 – 298

6

Helix

300 – 308

9

Helix

317 – 357

41

Turn

358 – 360

3

Beta strand

370 – 376

7

Turn

382 – 384

3

Helix

387 – 397

11

Beta strand

404 – 406

3

Beta strand

412 – 414

3

Beta strand

417 – 421

5

Turn

422 – 425

4

Beta strand

433 – 437

5

Helix

444 – 462

19

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 29, 2005. Version 2. Checksum: 7136FB390B18760B	FASTA	501	55,726
	10 20 30 40 50 60 MNRESFAAGE RLVSPAYVRQ GCEARRSHEH LIRLLLEKGK CPENGWDEST LELFLHELAI 70 80 90 100 110 120 MDSNNFLGNC GVGEREGRVA SALVARRHYR FIHGIGRSGD ISAVQPKAAG SSLLNKITNS 130 140 150 160 170 180 LVLDIIKLAG VHTVANCFVV PMATGMSLTL CFLTLRHKRP KAKYIIWPRI DQKSCFKSMI 190 200 210 220 230 240 TAGFEPVVIE NVLEGDELRT DLKAVEAKVQ ELGPDCILCI HSTTSCFAPR VPDRLEELAV 250 260 270 280 290 300 ICANYDIPHI VNNAYGVQSS KCMHLIQQGA RVGRIDAFVQ SLDKNFMVPV GGAIIAGFND 310 320 330 340 350 360 SFIQEISKMY PGRASASPSL DVLITLLSLG SNGYKKLLKE RKEMFSYLSN QIKKLSEAYN 370 380 390 400 410 420 ERLLHTPHNP ISLAMTLKTL DEHRDKAVTQ LGSMLFTRQV SGARVVPLGS MQTVSGYTFR 430 440 450 460 470 480 GFMSHTNNYP CAYLNAASAI GMKMQDVDLF IKRLDRCLKA VRKERSKESD DNYDKTEDVD 490 500 IEEMALKLDN VLLDTYQDAS S
	Isoform 2 [UniParc]. Checksum: 958F3F91D272149B	FASTA	47	5,627
	10 20 30 40 MNRESFAAGE RLVSPAYVRQ GCEARRSHEH LIRLLLEKVH SWHWTIR
	Isoform 3 [UniParc]. Checksum: 82AE23050D9C2011	FASTA	500	55,411
	10 20 30 40 50 60 MQCDDLGSLQ PPPPGFTPFA CLSLPSSWDY RRPPPHPGKC PENGWDESTL ELFLHELAIM 70 80 90 100 110 120 DSNNFLGNCG VGEREGRVAS ALVARRHYRF IHGIGRSGDI SAVQPKAAGS SLLNKITNSL 130 140 150 160 170 180 VLDIIKLAGV HTVANCFVVP MATGMSLTLC FLTLRHKRPK AKYIIWPRID QKSCFKSMIT 190 200 210 220 230 240 AGFEPVVIEN VLEGDELRTD LKAVEAKVQE LGPDCILCIH STTSCFAPRV PDRLEELAVI 250 260 270 280 290 300 CANYDIPHIV NNAYGVQSSK CMHLIQQGAR VGRIDAFVQS LDKNFMVPVG GAIIAGFNDS 310 320 330 340 350 360 FIQEISKMYP GRASASPSLD VLITLLSLGS NGYKKLLKER KEMFSYLSNQ IKKLSEAYNE 370 380 390 400 410 420 RLLHTPHNPI SLAMTLKTLD EHRDKAVTQL GSMLFTRQVS GARVVPLGSM QTVSGYTFRG 430 440 450 460 470 480 FMSHTNNYPC AYLNAASAIG MKMQDVDLFI KRLDRCLKAV RKERSKESDD NYDKTEDVDI 490 500 EEMALKLDNV LLDTYQDASS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Endometrium.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Brain and Muscle.
[6]	"Identification of target antigen for SLA/LP autoantibodies in autoimmune hepatitis." Wies I., Brunner S., Henninger J., Herkel J., Kanzler S., Meyer zum Bueschenfelde K.-H., Lohse A.W. Lancet 355:1510-1515(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-501 (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 29-501 (ISOFORM 2). Tissue: Liver and T-cell lymphoma.
[7]	"Isolation and characterization of cDNA encoding the antigenic protein of the human tRNP(Ser)Sec complex recognized by autoantibodies from patients withtype-1 autoimmune hepatitis." Costa M., Rodriguez-Sanchez J.L., Czaja A.J., Gelpi C. Clin. Exp. Immunol. 121:364-374(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 61-501 (ISOFORM 1). Tissue: Liver.
[8]	"Coding sequence of the human SLA/LP autoantigen." Seelig H.-P., Wiemann C., Plaikner M., Schranz P., Seelig R., Renz M. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 61-501 (ISOFORM 1). Tissue: Liver.
[9]	"Soluble liver antigen: isolation of a 35-kd recombinant protein (SLA-p35) specifically recognizing sera from patients with autoimmune hepatitis." Volkmann M., Martin L., Baeurle A., Heid H., Strassburg C.P., Trautwein C., Fiehn W., Manns M.P. Hepatology 33:591-596(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 208-501.
[10]	"Fine specificity of autoantibodies to soluble liver antigen and liver/pancreas." Herkel J., Heidrich B., Nieraad N., Wies I., Rother M., Lohse A.W. Hepatology 35:403-408(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 434-493, SLA/LP EPITOPE MAPPING.
[11]	"RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea." Yuan J., Palioura S., Salazar J.C., Su D., O'Donoghue P., Hohn M.J., Cardoso A.M., Whitman W.B., Soell D. Proc. Natl. Acad. Sci. U.S.A. 103:18923-18927(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, COFACTOR, MUTAGENESIS OF LYS-284.
[12]	"The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation." Palioura S., Sherrer R.L., Steitz T.A., Soll D., Simonovic M. Science 325:321-325(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) IN COMPLEX WITH TRNA AND PYRIDOXAL PHOSPHATE, SUBUNIT, SUBSTRATE-BINDING SITES, COFACTOR, MUTAGENESIS OF ARG-75; ARG-97; GLN-105; LYS-173 AND ARG-313.
[13]	"Mutations disrupting selenocysteine formation cause progressive cerebello-cerebral atrophy." Agamy O., Ben Zeev B., Lev D., Marcus B., Fine D., Su D., Narkis G., Ofir R., Hoffmann C., Leshinsky-Silver E., Flusser H., Sivan S., Soll D., Lerman-Sagie T., Birk O.S. Am. J. Hum. Genet. 87:538-544(2010) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS PCH2D THR-239 AND CYS-334, CHARACTERIZATION OF VARIANTS PCH2D THR-239 AND CYS-334.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK292476 mRNA. Translation: BAF85165.1.
BX648976 mRNA. No translation available.
AC007073 Genomic DNA. No translation available.
AC104662 Genomic DNA. No translation available.
CH471069 Genomic DNA. Translation: EAW92832.1.
BC023539 mRNA. Translation: AAH23539.1. Sequence problems.
BC117202 mRNA. Translation: AAI17203.1.
AF146396 mRNA. Translation: AAD33963.2. Sequence problems.
AJ277541 mRNA. Translation: CAB89517.1. Frameshift.
AJ238617 mRNA. Translation: CAB62209.1. Different initiation.
AF282065 mRNA. Translation: AAG00491.1.

IPI

IPI00155389.
IPI00302283.
IPI00930339.

RefSeq

NP_058651.3. NM_016955.3.

UniGene

Hs.253305.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3HL2	X-ray	2.81	A/B/C/D	1-501	[»]

ProteinModelPortal

Q9HD40.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9HD40. 1 interaction.

STRING

9606.ENSP00000305956.

PTM databases

PhosphoSite

Q9HD40.

Polymorphism databases

DMDM

62287911.

Proteomic databases

PaxDb

Q9HD40.

PRIDE

Q9HD40.

Protocols and materials databases

DNASU

51091.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000302922; ENSP00000305956; ENSG00000109618.
ENST00000382103; ENSP00000371535; ENSG00000109618.
ENST00000514585; ENSP00000421880; ENSG00000109618.

GeneID

51091.

KEGG

hsa:51091.

UCSC

uc003grg.3. human.
uc003gri.3. human.

Organism-specific databases

CTD

51091.

GeneCards

GC04M025121.

HGNC

HGNC:30605. SEPSECS.

MIM

613009. gene.
613811. phenotype.

neXtProt

NX_Q9HD40.

Orphanet

2524. Pontocerebellar hypoplasia type 2.
247198. Progressive cerebello-cerebral atrophy.

PharmGKB

PA162402915.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0076.

HOGENOM

HOG000254245.

HOVERGEN

HBG061363.

InParanoid

Q9HD40.

KO

K03341.

OMA

IPHVVNN.

OrthoDB

EOG4JQ3XB.

Enzyme and pathway databases

UniPathway

UPA00906; UER00898.

Gene expression databases

ArrayExpress

Q9HD40.

Bgee

Q9HD40.

CleanEx

HS_SEPSECS.

Genevestigator

Q9HD40.

GermOnline

ENSG00000109618. Homo sapiens.

Family and domain databases

Gene3D

3.40.640.10. 1 hit.

InterPro

IPR019793. Peroxidases_heam-ligand_BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR019872. Sec-tRNA_Se_transferase.
IPR008829. SLA/LP_auto_ag.
[Graphical view]

PANTHER

PTHR12944. PTHR12944. 1 hit.

Pfam

PF05889. SLA_LP_auto_ag. 1 hit.
[Graphical view]

PIRSF

PIRSF017689. SepSecS. 1 hit.

SUPFAM

SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.

TIGRFAMs

TIGR03531. selenium_SpcS. 1 hit.

ProtoNet

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Other

DrugBank

DB00114. Pyridoxal Phosphate.

EvolutionaryTrace

Q9HD40.

GenomeRNAi

51091.

NextBio

53771.

SOURCE

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Entry information

Entry name

SPCS_HUMAN

Accession

Primary (citable) accession number: Q9HD40
Secondary accession number(s): A8K8W1 , Q0D2P3, Q17RT1, Q9NXZ5, Q9UGM9, Q9Y353

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	March 29, 2005
Last modified:	May 1, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.