Q9HD36 (B2L10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bcl-2-like protein 10
Short name=Bcl2-L-10

Alternative name(s):
Anti-apoptotic protein NrH
Apoptosis regulator Bcl-B

Gene names

Name:	BCL2L10
Synonyms:	BCLB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK. Ref.2
Subunit structure	Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1. Ref.2 Ref.3
Subcellular location	Mitochondrion. Nucleus membrane Ref.3.
Tissue specificity	Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney. Ref.3
Sequence similarities	Belongs to the Bcl-2 family.
Sequence caution	The sequence AAG00503.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH93826.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH93828.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI04443.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI04444.1 differs from that shown. Reason: Erroneous initiation. The sequence AAK48715.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Membrane Mitochondrion Nucleus
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of cysteine-type endopeptidase activity involved in apoptotic process Traceable author statement PubMed 9829980. Source: ProtInc female gamete generation Traceable author statement PubMed 9878060. Source: ProtInc negative regulation of apoptotic process Inferred from direct assay Ref.2. Source: HGNC spermatogenesis Traceable author statement PubMed 9878060. Source: ProtInc
Cellular_component	cytosol Inferred from direct assay Ref.2. Source: HGNC integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane Traceable author statement PubMed 9878060. Source: ProtInc mitochondrion Inferred from direct assay Ref.2. Source: HGNC nuclear membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 194

194

Bcl-2-like protein 10

PRO_0000143068

Regions

Transmembrane

173 – 190

18

Helical; Potential

Motif

76 – 95

20

BH1

Motif

146 – 157

12

BH2

Natural variations

Natural variant

11

1

L → R.
Corresponds to variant rs2231292 [ dbSNP | Ensembl ].

VAR_047113

Experimental info

Sequence conflict

42

1

A → V in AAI04444. Ref.5

Sequence conflict

45

1

R → W in AAI04444. Ref.5

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

194

Helix Strand Turn

Details...

Helix

4 – 20

17

Helix

34 – 49

16

Helix

51 – 55

5

Turn

56 – 59

4

Helix

64 – 77

14

Helix

84 – 98

15

Helix

102 – 105

4

Helix

123 – 141

19

Helix

144 – 149

6

Helix

152 – 160

9

Sequences

	Sequence		Length	Mass (Da)
	Q9HD36 [UniParc]. Last modified September 19, 2002. Version 2. Checksum: 86F9F1A39377755F	FASTA	194	21,973
	10 20 30 40 50 60 MADPLRERTE LLLADYLGYC AREPGTPEPA PSTPEAAVLR SAAARLRQIH RSFFSAYLGY 70 80 90 100 110 120 PGNRFELVAL MADSVLSDSP GPTWGRVVTL VTFAGTLLER GPLVTARWKK WGFQPRLKEQ 130 140 150 160 170 180 EGDVARDCQR LVALLSSRLM GQHRAWLQAQ GGWDGFCHFF RTPFPLAFWR KQLVQAFLSC 190 LLTTAFIYLW TRLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway." Zhang H., Holzgreve W., De Geyter C. Hum. Mol. Genet. 10:2329-2339(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.
[2]	"Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak." Ke N., Godzik A., Reed J.C. J. Biol. Chem. 276:12481-12484(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH BAX. Tissue: Liver.
[3]	"NrH, a human homologue of Nr-13 associates with Bcl-Xs and is an inhibitor of apoptosis." Aouacheria A., Arnaud E., Venet S., Lalle P., Gouy M., Rigal D., Gillet G. Oncogene 20:5846-5855(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH BCLX.
[4]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF285092 mRNA. Translation: AAG00503.1. Different initiation.
AF326964 mRNA. Translation: AAK48715.1. Different initiation.
AJ458330 Genomic DNA. Translation: CAD30221.1.
AC023906 Genomic DNA. No translation available.
BC093826 mRNA. Translation: AAH93826.1. Different initiation.
BC093828 mRNA. Translation: AAH93828.1. Different initiation.
BC104442 mRNA. Translation: AAI04443.1. Different initiation.
BC104443 mRNA. Translation: AAI04444.1. Different initiation.

IPI

IPI00216614.

RefSeq

NP_065129.1. NM_020396.2.

UniGene

Hs.283672.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4B4S	X-ray	1.90	A	2-167	[»]

ProteinModelPortal

Q9HD36.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9HD36. 1 interaction.

MINT

MINT-193288.

STRING

9606.ENSP00000260442.

PTM databases

PhosphoSite

Q9HD36.

Polymorphism databases

DMDM

23396469.

Proteomic databases

PaxDb

Q9HD36.

PRIDE

Q9HD36.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000260442; ENSP00000260442; ENSG00000137875.

GeneID

10017.

KEGG

hsa:10017.

UCSC

uc002abq.3. human.

Organism-specific databases

CTD

10017.

GeneCards

GC15M052401.

HGNC

HGNC:993. BCL2L10.

HPA

HPA042222.

MIM

606910. gene.

neXtProt

NX_Q9HD36.

PharmGKB

PA25304.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG46553.

HOGENOM

HOG000059275.

HOVERGEN

HBG050646.

InParanoid

Q9HD36.

OrthoDB

EOG4NVZMR.

Gene expression databases

ArrayExpress

Q9HD36.

Bgee

Q9HD36.

CleanEx

HS_BCL2L10.

Genevestigator

Q9HD36.

GermOnline

ENSG00000137875. Homo sapiens.

Family and domain databases

InterPro

IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR026312. BCL2L10.
IPR026298. Blc2_fam.
[Graphical view]

PANTHER

PTHR11256. PTHR11256. 1 hit.
PTHR11256:SF5. PTHR11256:SF5. 1 hit.

Pfam

PF00452. Bcl-2. 1 hit.
[Graphical view]

PROSITE

PS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

Q9HD36.

ChEMBL

CHEMBL5988.

GenomeRNAi

10017.

NextBio

37845.

SOURCE

Search...

Entry information

Entry name

B2L10_HUMAN

Accession

Primary (citable) accession number: Q9HD36
Secondary accession number(s): Q3SX80, Q52LQ9, Q8TCS9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	September 19, 2002
Last modified:	May 1, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.