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Protein

Bcl-2-like protein 10

Gene

BCL2L10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 10
Short name:
Bcl2-L-10
Alternative name(s):
Anti-apoptotic protein NrH
Apoptosis regulator Bcl-B
Gene namesi
Name:BCL2L10
Synonyms:BCLB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:993. BCL2L10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei173 – 19018HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cytosol Source: HGNC
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: ProtInc
  • mitochondrial outer membrane Source: GO_Central
  • mitochondrion Source: HGNC
  • nuclear membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25304.

Polymorphism and mutation databases

DMDMi23396469.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194Bcl-2-like protein 10PRO_0000143068Add
BLAST

Proteomic databases

PaxDbiQ9HD36.
PRIDEiQ9HD36.

PTM databases

PhosphoSiteiQ9HD36.

Expressioni

Tissue specificityi

Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney.1 Publication

Gene expression databases

BgeeiQ9HD36.
CleanExiHS_BCL2L10.
ExpressionAtlasiQ9HD36. baseline.
GenevisibleiQ9HD36. HS.

Interactioni

Subunit structurei

Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1.2 Publications

Protein-protein interaction databases

BioGridi115334. 6 interactions.
IntActiQ9HD36. 2 interactions.
MINTiMINT-193288.
STRINGi9606.ENSP00000260442.

Structurei

Secondary structure

1
194
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 2017Combined sources
Helixi34 – 4916Combined sources
Helixi51 – 555Combined sources
Turni56 – 594Combined sources
Helixi64 – 7714Combined sources
Helixi84 – 9815Combined sources
Helixi102 – 1054Combined sources
Helixi123 – 14119Combined sources
Helixi144 – 1496Combined sources
Helixi152 – 1609Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4B4SX-ray1.90A2-167[»]
ProteinModelPortaliQ9HD36.
SMRiQ9HD36. Positions 3-165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi76 – 9520BH1Add
BLAST
Motifi146 – 15712BH2Add
BLAST

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46553.
HOGENOMiHOG000059275.
HOVERGENiHBG050646.
InParanoidiQ9HD36.
KOiK18451.
OrthoDBiEOG7Q5HFF.
PhylomeDBiQ9HD36.
TreeFamiTF334762.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HD36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPLRERTE LLLADYLGYC AREPGTPEPA PSTPEAAVLR SAAARLRQIH
60 70 80 90 100
RSFFSAYLGY PGNRFELVAL MADSVLSDSP GPTWGRVVTL VTFAGTLLER
110 120 130 140 150
GPLVTARWKK WGFQPRLKEQ EGDVARDCQR LVALLSSRLM GQHRAWLQAQ
160 170 180 190
GGWDGFCHFF RTPFPLAFWR KQLVQAFLSC LLTTAFIYLW TRLL
Length:194
Mass (Da):21,973
Last modified:September 19, 2002 - v2
Checksum:i86F9F1A39377755F
GO

Sequence cautioni

The sequence AAG00503.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH93826.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH93828.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI04443.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI04444.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAK48715.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421A → V in AAI04444 (PubMed:15489334).Curated
Sequence conflicti45 – 451R → W in AAI04444 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111L → R.
Corresponds to variant rs2231292 [ dbSNP | Ensembl ].
VAR_047113

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285092 mRNA. Translation: AAG00503.1. Different initiation.
AF326964 mRNA. Translation: AAK48715.1. Different initiation.
AJ458330 Genomic DNA. Translation: CAD30221.1.
AC023906 Genomic DNA. No translation available.
BC093826 mRNA. Translation: AAH93826.1. Different initiation.
BC093828 mRNA. Translation: AAH93828.1. Different initiation.
BC104442 mRNA. Translation: AAI04443.1. Different initiation.
BC104443 mRNA. Translation: AAI04444.1. Different initiation.
RefSeqiNP_065129.1. NM_020396.3.
UniGeneiHs.283672.

Genome annotation databases

EnsembliENST00000260442; ENSP00000260442; ENSG00000137875.
GeneIDi10017.
KEGGihsa:10017.
UCSCiuc002abq.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285092 mRNA. Translation: AAG00503.1. Different initiation.
AF326964 mRNA. Translation: AAK48715.1. Different initiation.
AJ458330 Genomic DNA. Translation: CAD30221.1.
AC023906 Genomic DNA. No translation available.
BC093826 mRNA. Translation: AAH93826.1. Different initiation.
BC093828 mRNA. Translation: AAH93828.1. Different initiation.
BC104442 mRNA. Translation: AAI04443.1. Different initiation.
BC104443 mRNA. Translation: AAI04444.1. Different initiation.
RefSeqiNP_065129.1. NM_020396.3.
UniGeneiHs.283672.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4B4SX-ray1.90A2-167[»]
ProteinModelPortaliQ9HD36.
SMRiQ9HD36. Positions 3-165.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115334. 6 interactions.
IntActiQ9HD36. 2 interactions.
MINTiMINT-193288.
STRINGi9606.ENSP00000260442.

Chemistry

BindingDBiQ9HD36.
ChEMBLiCHEMBL5988.

PTM databases

PhosphoSiteiQ9HD36.

Polymorphism and mutation databases

DMDMi23396469.

Proteomic databases

PaxDbiQ9HD36.
PRIDEiQ9HD36.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260442; ENSP00000260442; ENSG00000137875.
GeneIDi10017.
KEGGihsa:10017.
UCSCiuc002abq.3. human.

Organism-specific databases

CTDi10017.
GeneCardsiGC15M052401.
HGNCiHGNC:993. BCL2L10.
MIMi606910. gene.
neXtProtiNX_Q9HD36.
PharmGKBiPA25304.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46553.
HOGENOMiHOG000059275.
HOVERGENiHBG050646.
InParanoidiQ9HD36.
KOiK18451.
OrthoDBiEOG7Q5HFF.
PhylomeDBiQ9HD36.
TreeFamiTF334762.

Miscellaneous databases

GeneWikiiBCL2L10.
GenomeRNAii10017.
NextBioi37845.
PROiQ9HD36.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HD36.
CleanExiHS_BCL2L10.
ExpressionAtlasiQ9HD36. baseline.
GenevisibleiQ9HD36. HS.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway."
    Zhang H., Holzgreve W., De Geyter C.
    Hum. Mol. Genet. 10:2329-2339(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  2. "Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak."
    Ke N., Godzik A., Reed J.C.
    J. Biol. Chem. 276:12481-12484(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH BAX.
    Tissue: Liver.
  3. "NrH, a human homologue of Nr-13 associates with Bcl-Xs and is an inhibitor of apoptosis."
    Aouacheria A., Arnaud E., Venet S., Lalle P., Gouy M., Rigal D., Gillet G.
    Oncogene 20:5846-5855(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH BCLX.
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiB2L10_HUMAN
AccessioniPrimary (citable) accession number: Q9HD36
Secondary accession number(s): Q3SX80, Q52LQ9, Q8TCS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: June 24, 2015
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.