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Q9HD36

- B2L10_HUMAN

UniProt

Q9HD36 - B2L10_HUMAN

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Protein

Bcl-2-like protein 10

Gene
BCL2L10, BCLB
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.1 Publication

GO - Molecular functioni

  1. protein binding Source: HGNC
  2. protein heterodimerization activity Source: RefGenome
  3. protein homodimerization activity Source: RefGenome

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: ProtInc
  2. extrinsic apoptotic signaling pathway in absence of ligand Source: RefGenome
  3. female gamete generation Source: ProtInc
  4. intrinsic apoptotic signaling pathway in response to DNA damage Source: RefGenome
  5. negative regulation of apoptotic process Source: HGNC
  6. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  7. negative regulation of intrinsic apoptotic signaling pathway Source: RefGenome
  8. positive regulation of apoptotic process Source: Ensembl
  9. spermatogenesis Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 10
Short name:
Bcl2-L-10
Alternative name(s):
Anti-apoptotic protein NrH
Apoptosis regulator Bcl-B
Gene namesi
Name:BCL2L10
Synonyms:BCLB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:993. BCL2L10.

Subcellular locationi

Mitochondrion. Nucleus membrane 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei173 – 19018Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytosol Source: HGNC
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: ProtInc
  4. mitochondrial outer membrane Source: RefGenome
  5. mitochondrion Source: HGNC
  6. nuclear membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25304.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194Bcl-2-like protein 10PRO_0000143068Add
BLAST

Proteomic databases

PaxDbiQ9HD36.
PRIDEiQ9HD36.

PTM databases

PhosphoSiteiQ9HD36.

Expressioni

Tissue specificityi

Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney.1 Publication

Gene expression databases

ArrayExpressiQ9HD36.
BgeeiQ9HD36.
CleanExiHS_BCL2L10.
GenevestigatoriQ9HD36.

Organism-specific databases

HPAiHPA042222.

Interactioni

Subunit structurei

Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1.2 Publications

Protein-protein interaction databases

BioGridi115334. 5 interactions.
IntActiQ9HD36. 1 interaction.
MINTiMINT-193288.
STRINGi9606.ENSP00000260442.

Structurei

Secondary structure

1
194
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 2017
Helixi34 – 4916
Helixi51 – 555
Turni56 – 594
Helixi64 – 7714
Helixi84 – 9815
Helixi102 – 1054
Helixi123 – 14119
Helixi144 – 1496
Helixi152 – 1609

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4B4SX-ray1.90A2-167[»]
ProteinModelPortaliQ9HD36.
SMRiQ9HD36. Positions 3-165.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi76 – 9520BH1Add
BLAST
Motifi146 – 15712BH2Add
BLAST

Sequence similaritiesi

Belongs to the Bcl-2 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46553.
HOGENOMiHOG000059275.
HOVERGENiHBG050646.
InParanoidiQ9HD36.
OrthoDBiEOG7Q5HFF.
PhylomeDBiQ9HD36.
TreeFamiTF334762.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HD36-1 [UniParc]FASTAAdd to Basket

« Hide

MADPLRERTE LLLADYLGYC AREPGTPEPA PSTPEAAVLR SAAARLRQIH    50
RSFFSAYLGY PGNRFELVAL MADSVLSDSP GPTWGRVVTL VTFAGTLLER 100
GPLVTARWKK WGFQPRLKEQ EGDVARDCQR LVALLSSRLM GQHRAWLQAQ 150
GGWDGFCHFF RTPFPLAFWR KQLVQAFLSC LLTTAFIYLW TRLL 194
Length:194
Mass (Da):21,973
Last modified:September 19, 2002 - v2
Checksum:i86F9F1A39377755F
GO

Sequence cautioni

The sequence AAG00503.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH93826.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH93828.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAI04443.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAI04444.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAK48715.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111L → R.
Corresponds to variant rs2231292 [ dbSNP | Ensembl ].
VAR_047113

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421A → V in AAI04444. 1 Publication
Sequence conflicti45 – 451R → W in AAI04444. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF285092 mRNA. Translation: AAG00503.1. Different initiation.
AF326964 mRNA. Translation: AAK48715.1. Different initiation.
AJ458330 Genomic DNA. Translation: CAD30221.1.
AC023906 Genomic DNA. No translation available.
BC093826 mRNA. Translation: AAH93826.1. Different initiation.
BC093828 mRNA. Translation: AAH93828.1. Different initiation.
BC104442 mRNA. Translation: AAI04443.1. Different initiation.
BC104443 mRNA. Translation: AAI04444.1. Different initiation.
RefSeqiNP_065129.1. NM_020396.2.
UniGeneiHs.283672.

Genome annotation databases

EnsembliENST00000260442; ENSP00000260442; ENSG00000137875.
GeneIDi10017.
KEGGihsa:10017.
UCSCiuc002abq.3. human.

Polymorphism databases

DMDMi23396469.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF285092 mRNA. Translation: AAG00503.1 . Different initiation.
AF326964 mRNA. Translation: AAK48715.1 . Different initiation.
AJ458330 Genomic DNA. Translation: CAD30221.1 .
AC023906 Genomic DNA. No translation available.
BC093826 mRNA. Translation: AAH93826.1 . Different initiation.
BC093828 mRNA. Translation: AAH93828.1 . Different initiation.
BC104442 mRNA. Translation: AAI04443.1 . Different initiation.
BC104443 mRNA. Translation: AAI04444.1 . Different initiation.
RefSeqi NP_065129.1. NM_020396.2.
UniGenei Hs.283672.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4B4S X-ray 1.90 A 2-167 [» ]
ProteinModelPortali Q9HD36.
SMRi Q9HD36. Positions 3-165.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115334. 5 interactions.
IntActi Q9HD36. 1 interaction.
MINTi MINT-193288.
STRINGi 9606.ENSP00000260442.

Chemistry

BindingDBi Q9HD36.
ChEMBLi CHEMBL5988.

PTM databases

PhosphoSitei Q9HD36.

Polymorphism databases

DMDMi 23396469.

Proteomic databases

PaxDbi Q9HD36.
PRIDEi Q9HD36.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000260442 ; ENSP00000260442 ; ENSG00000137875 .
GeneIDi 10017.
KEGGi hsa:10017.
UCSCi uc002abq.3. human.

Organism-specific databases

CTDi 10017.
GeneCardsi GC15M052401.
HGNCi HGNC:993. BCL2L10.
HPAi HPA042222.
MIMi 606910. gene.
neXtProti NX_Q9HD36.
PharmGKBi PA25304.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46553.
HOGENOMi HOG000059275.
HOVERGENi HBG050646.
InParanoidi Q9HD36.
OrthoDBi EOG7Q5HFF.
PhylomeDBi Q9HD36.
TreeFami TF334762.

Miscellaneous databases

GeneWikii BCL2L10.
GenomeRNAii 10017.
NextBioi 37845.
PROi Q9HD36.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9HD36.
Bgeei Q9HD36.
CleanExi HS_BCL2L10.
Genevestigatori Q9HD36.

Family and domain databases

InterProi IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR026298. Blc2_fam.
[Graphical view ]
PANTHERi PTHR11256. PTHR11256. 1 hit.
Pfami PF00452. Bcl-2. 1 hit.
[Graphical view ]
PROSITEi PS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway."
    Zhang H., Holzgreve W., De Geyter C.
    Hum. Mol. Genet. 10:2329-2339(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  2. "Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak."
    Ke N., Godzik A., Reed J.C.
    J. Biol. Chem. 276:12481-12484(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH BAX.
    Tissue: Liver.
  3. "NrH, a human homologue of Nr-13 associates with Bcl-Xs and is an inhibitor of apoptosis."
    Aouacheria A., Arnaud E., Venet S., Lalle P., Gouy M., Rigal D., Gillet G.
    Oncogene 20:5846-5855(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH BCLX.
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiB2L10_HUMAN
AccessioniPrimary (citable) accession number: Q9HD36
Secondary accession number(s): Q3SX80, Q52LQ9, Q8TCS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: June 11, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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