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Protein

Bcl-2-like protein 10

Gene

BCL2L10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.1 Publication

GO - Molecular functioni

  • caspase binding Source: ParkinsonsUK-UCL
  • protein heterodimerization activity Source: GO_Central
  • protein homodimerization activity Source: GO_Central

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: ProtInc
  • extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
  • female gamete generation Source: ProtInc
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
  • negative regulation of apoptotic process Source: HGNC
  • negative regulation of intrinsic apoptotic signaling pathway Source: GO_Central
  • spermatogenesis Source: ProtInc

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 10
Short name:
Bcl2-L-10
Alternative name(s):
Anti-apoptotic protein NrH
Apoptosis regulator Bcl-B
Gene namesi
Name:BCL2L10
Synonyms:BCLB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000137875.4
HGNCiHGNC:993 BCL2L10
MIMi606910 gene
neXtProtiNX_Q9HD36

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei173 – 190HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10017
PharmGKBiPA25304

Chemistry databases

ChEMBLiCHEMBL5988

Polymorphism and mutation databases

DMDMi23396469

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001430681 – 194Bcl-2-like protein 10Add BLAST194

Proteomic databases

PaxDbiQ9HD36
PeptideAtlasiQ9HD36
PRIDEiQ9HD36

PTM databases

iPTMnetiQ9HD36
PhosphoSitePlusiQ9HD36

Expressioni

Tissue specificityi

Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney.1 Publication

Gene expression databases

BgeeiENSG00000137875
CleanExiHS_BCL2L10
ExpressionAtlasiQ9HD36 baseline and differential
GenevisibleiQ9HD36 HS

Interactioni

Subunit structurei

Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • caspase binding Source: ParkinsonsUK-UCL
  • protein heterodimerization activity Source: GO_Central
  • protein homodimerization activity Source: GO_Central

Protein-protein interaction databases

BioGridi115334, 8 interactors
IntActiQ9HD36, 5 interactors
MINTiQ9HD36
STRINGi9606.ENSP00000260442

Chemistry databases

BindingDBiQ9HD36

Structurei

Secondary structure

1194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 20Combined sources17
Helixi34 – 49Combined sources16
Helixi51 – 55Combined sources5
Turni56 – 59Combined sources4
Helixi64 – 77Combined sources14
Helixi84 – 98Combined sources15
Helixi102 – 105Combined sources4
Helixi123 – 141Combined sources19
Helixi144 – 149Combined sources6
Helixi152 – 160Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B4SX-ray1.90A2-167[»]
ProteinModelPortaliQ9HD36
SMRiQ9HD36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi76 – 95BH1Add BLAST20
Motifi146 – 157BH2Add BLAST12

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2PB Eukaryota
ENOG4112AS5 LUCA
HOGENOMiHOG000059275
HOVERGENiHBG050646
InParanoidiQ9HD36
KOiK18451
PhylomeDBiQ9HD36
TreeFamiTF334762

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR002475 Bcl2-like
IPR020717 Bcl2_BH1_motif_CS
IPR020726 Bcl2_BH2_motif_CS
IPR036834 Blc2-like_sf
IPR026298 Blc2_fam
PANTHERiPTHR11256 PTHR11256, 1 hit
PfamiView protein in Pfam
PF00452 Bcl-2, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit
PS01080 BH1, 1 hit
PS01258 BH2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HD36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPLRERTE LLLADYLGYC AREPGTPEPA PSTPEAAVLR SAAARLRQIH
60 70 80 90 100
RSFFSAYLGY PGNRFELVAL MADSVLSDSP GPTWGRVVTL VTFAGTLLER
110 120 130 140 150
GPLVTARWKK WGFQPRLKEQ EGDVARDCQR LVALLSSRLM GQHRAWLQAQ
160 170 180 190
GGWDGFCHFF RTPFPLAFWR KQLVQAFLSC LLTTAFIYLW TRLL
Length:194
Mass (Da):21,973
Last modified:September 19, 2002 - v2
Checksum:i86F9F1A39377755F
GO

Sequence cautioni

The sequence AAG00503 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH93826 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH93828 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI04443 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI04444 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAK48715 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42A → V in AAI04444 (PubMed:15489334).Curated1
Sequence conflicti45R → W in AAI04444 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04711311L → R. Corresponds to variant dbSNP:rs2231292Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285092 mRNA Translation: AAG00503.1 Different initiation.
AF326964 mRNA Translation: AAK48715.1 Different initiation.
AJ458330 Genomic DNA Translation: CAD30221.1
AC023906 Genomic DNA No translation available.
BC093826 mRNA Translation: AAH93826.1 Different initiation.
BC093828 mRNA Translation: AAH93828.1 Different initiation.
BC104442 mRNA Translation: AAI04443.1 Different initiation.
BC104443 mRNA Translation: AAI04444.1 Different initiation.
RefSeqiNP_001293097.1, NM_001306168.1
NP_065129.1, NM_020396.3
UniGeneiHs.283672

Genome annotation databases

EnsembliENST00000260442; ENSP00000260442; ENSG00000137875
GeneIDi10017
KEGGihsa:10017
UCSCiuc002abq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiB2L10_HUMAN
AccessioniPrimary (citable) accession number: Q9HD36
Secondary accession number(s): Q3SX80, Q52LQ9, Q8TCS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: February 28, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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