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Q9HD36

- B2L10_HUMAN

UniProt

Q9HD36 - B2L10_HUMAN

Protein

Bcl-2-like protein 10

Gene

BCL2L10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (19 Sep 2002)
      Previous versions | rss
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    Functioni

    Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.1 Publication

    GO - Molecular functioni

    1. protein binding Source: HGNC
    2. protein heterodimerization activity Source: RefGenome
    3. protein homodimerization activity Source: RefGenome

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: ProtInc
    2. extrinsic apoptotic signaling pathway in absence of ligand Source: RefGenome
    3. female gamete generation Source: ProtInc
    4. intrinsic apoptotic signaling pathway in response to DNA damage Source: RefGenome
    5. negative regulation of apoptotic process Source: HGNC
    6. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    7. negative regulation of intrinsic apoptotic signaling pathway Source: RefGenome
    8. positive regulation of apoptotic process Source: Ensembl
    9. spermatogenesis Source: ProtInc

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bcl-2-like protein 10
    Short name:
    Bcl2-L-10
    Alternative name(s):
    Anti-apoptotic protein NrH
    Apoptosis regulator Bcl-B
    Gene namesi
    Name:BCL2L10
    Synonyms:BCLB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:993. BCL2L10.

    Subcellular locationi

    Mitochondrion 1 Publication. Nucleus membrane 1 Publication

    GO - Cellular componenti

    1. cytosol Source: HGNC
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: ProtInc
    4. mitochondrial outer membrane Source: RefGenome
    5. mitochondrion Source: HGNC
    6. nuclear membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25304.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 194194Bcl-2-like protein 10PRO_0000143068Add
    BLAST

    Proteomic databases

    PaxDbiQ9HD36.
    PRIDEiQ9HD36.

    PTM databases

    PhosphoSiteiQ9HD36.

    Expressioni

    Tissue specificityi

    Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney.1 Publication

    Gene expression databases

    ArrayExpressiQ9HD36.
    BgeeiQ9HD36.
    CleanExiHS_BCL2L10.
    GenevestigatoriQ9HD36.

    Organism-specific databases

    HPAiHPA042222.

    Interactioni

    Subunit structurei

    Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1.2 Publications

    Protein-protein interaction databases

    BioGridi115334. 5 interactions.
    IntActiQ9HD36. 1 interaction.
    MINTiMINT-193288.
    STRINGi9606.ENSP00000260442.

    Structurei

    Secondary structure

    1
    194
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 2017
    Helixi34 – 4916
    Helixi51 – 555
    Turni56 – 594
    Helixi64 – 7714
    Helixi84 – 9815
    Helixi102 – 1054
    Helixi123 – 14119
    Helixi144 – 1496
    Helixi152 – 1609

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4B4SX-ray1.90A2-167[»]
    ProteinModelPortaliQ9HD36.
    SMRiQ9HD36. Positions 3-165.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei173 – 19018HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi76 – 9520BH1Add
    BLAST
    Motifi146 – 15712BH2Add
    BLAST

    Sequence similaritiesi

    Belongs to the Bcl-2 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46553.
    HOGENOMiHOG000059275.
    HOVERGENiHBG050646.
    InParanoidiQ9HD36.
    OrthoDBiEOG7Q5HFF.
    PhylomeDBiQ9HD36.
    TreeFamiTF334762.

    Family and domain databases

    InterProiIPR002475. Bcl2-like.
    IPR020717. Bcl2_BH1_motif_CS.
    IPR020726. Bcl2_BH2_motif_CS.
    IPR026298. Blc2_fam.
    [Graphical view]
    PANTHERiPTHR11256. PTHR11256. 1 hit.
    PfamiPF00452. Bcl-2. 1 hit.
    [Graphical view]
    PROSITEiPS50062. BCL2_FAMILY. 1 hit.
    PS01080. BH1. 1 hit.
    PS01258. BH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9HD36-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADPLRERTE LLLADYLGYC AREPGTPEPA PSTPEAAVLR SAAARLRQIH    50
    RSFFSAYLGY PGNRFELVAL MADSVLSDSP GPTWGRVVTL VTFAGTLLER 100
    GPLVTARWKK WGFQPRLKEQ EGDVARDCQR LVALLSSRLM GQHRAWLQAQ 150
    GGWDGFCHFF RTPFPLAFWR KQLVQAFLSC LLTTAFIYLW TRLL 194
    Length:194
    Mass (Da):21,973
    Last modified:September 19, 2002 - v2
    Checksum:i86F9F1A39377755F
    GO

    Sequence cautioni

    The sequence AAG00503.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH93826.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH93828.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAI04443.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAI04444.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAK48715.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421A → V in AAI04444. (PubMed:15489334)Curated
    Sequence conflicti45 – 451R → W in AAI04444. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111L → R.
    Corresponds to variant rs2231292 [ dbSNP | Ensembl ].
    VAR_047113

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF285092 mRNA. Translation: AAG00503.1. Different initiation.
    AF326964 mRNA. Translation: AAK48715.1. Different initiation.
    AJ458330 Genomic DNA. Translation: CAD30221.1.
    AC023906 Genomic DNA. No translation available.
    BC093826 mRNA. Translation: AAH93826.1. Different initiation.
    BC093828 mRNA. Translation: AAH93828.1. Different initiation.
    BC104442 mRNA. Translation: AAI04443.1. Different initiation.
    BC104443 mRNA. Translation: AAI04444.1. Different initiation.
    RefSeqiNP_065129.1. NM_020396.2.
    UniGeneiHs.283672.

    Genome annotation databases

    EnsembliENST00000260442; ENSP00000260442; ENSG00000137875.
    GeneIDi10017.
    KEGGihsa:10017.
    UCSCiuc002abq.3. human.

    Polymorphism databases

    DMDMi23396469.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF285092 mRNA. Translation: AAG00503.1 . Different initiation.
    AF326964 mRNA. Translation: AAK48715.1 . Different initiation.
    AJ458330 Genomic DNA. Translation: CAD30221.1 .
    AC023906 Genomic DNA. No translation available.
    BC093826 mRNA. Translation: AAH93826.1 . Different initiation.
    BC093828 mRNA. Translation: AAH93828.1 . Different initiation.
    BC104442 mRNA. Translation: AAI04443.1 . Different initiation.
    BC104443 mRNA. Translation: AAI04444.1 . Different initiation.
    RefSeqi NP_065129.1. NM_020396.2.
    UniGenei Hs.283672.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4B4S X-ray 1.90 A 2-167 [» ]
    ProteinModelPortali Q9HD36.
    SMRi Q9HD36. Positions 3-165.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115334. 5 interactions.
    IntActi Q9HD36. 1 interaction.
    MINTi MINT-193288.
    STRINGi 9606.ENSP00000260442.

    Chemistry

    BindingDBi Q9HD36.
    ChEMBLi CHEMBL5988.

    PTM databases

    PhosphoSitei Q9HD36.

    Polymorphism databases

    DMDMi 23396469.

    Proteomic databases

    PaxDbi Q9HD36.
    PRIDEi Q9HD36.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000260442 ; ENSP00000260442 ; ENSG00000137875 .
    GeneIDi 10017.
    KEGGi hsa:10017.
    UCSCi uc002abq.3. human.

    Organism-specific databases

    CTDi 10017.
    GeneCardsi GC15M052401.
    HGNCi HGNC:993. BCL2L10.
    HPAi HPA042222.
    MIMi 606910. gene.
    neXtProti NX_Q9HD36.
    PharmGKBi PA25304.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46553.
    HOGENOMi HOG000059275.
    HOVERGENi HBG050646.
    InParanoidi Q9HD36.
    OrthoDBi EOG7Q5HFF.
    PhylomeDBi Q9HD36.
    TreeFami TF334762.

    Miscellaneous databases

    GeneWikii BCL2L10.
    GenomeRNAii 10017.
    NextBioi 37845.
    PROi Q9HD36.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HD36.
    Bgeei Q9HD36.
    CleanExi HS_BCL2L10.
    Genevestigatori Q9HD36.

    Family and domain databases

    InterProi IPR002475. Bcl2-like.
    IPR020717. Bcl2_BH1_motif_CS.
    IPR020726. Bcl2_BH2_motif_CS.
    IPR026298. Blc2_fam.
    [Graphical view ]
    PANTHERi PTHR11256. PTHR11256. 1 hit.
    Pfami PF00452. Bcl-2. 1 hit.
    [Graphical view ]
    PROSITEi PS50062. BCL2_FAMILY. 1 hit.
    PS01080. BH1. 1 hit.
    PS01258. BH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway."
      Zhang H., Holzgreve W., De Geyter C.
      Hum. Mol. Genet. 10:2329-2339(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.
    2. "Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak."
      Ke N., Godzik A., Reed J.C.
      J. Biol. Chem. 276:12481-12484(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH BAX.
      Tissue: Liver.
    3. "NrH, a human homologue of Nr-13 associates with Bcl-Xs and is an inhibitor of apoptosis."
      Aouacheria A., Arnaud E., Venet S., Lalle P., Gouy M., Rigal D., Gillet G.
      Oncogene 20:5846-5855(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH BCLX.
    4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiB2L10_HUMAN
    AccessioniPrimary (citable) accession number: Q9HD36
    Secondary accession number(s): Q3SX80, Q52LQ9, Q8TCS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: September 19, 2002
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3