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Q9HD36 (B2L10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bcl-2-like protein 10

Short name=Bcl2-L-10
Alternative name(s):
Anti-apoptotic protein NrH
Apoptosis regulator Bcl-B
Gene names
Name:BCL2L10
Synonyms:BCLB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK. Ref.2

Subunit structure

Binds to Bcl-2, Bcl-X and BAX. Interacts with APAF1. Ref.2 Ref.3

Subcellular location

Mitochondrion. Nucleus membrane Ref.3.

Tissue specificity

Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney. Ref.3

Sequence similarities

Belongs to the Bcl-2 family.

Sequence caution

The sequence AAG00503.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH93826.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH93828.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAI04443.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAI04444.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAK48715.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentMembrane
Mitochondrion
Nucleus
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process

Traceable author statement PubMed 9829980. Source: ProtInc

extrinsic apoptotic signaling pathway in absence of ligand

Inferred from Biological aspect of Ancestor. Source: RefGenome

female gamete generation

Traceable author statement PubMed 9878060. Source: ProtInc

intrinsic apoptotic signaling pathway in response to DNA damage

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of apoptotic process

Inferred from direct assay Ref.2. Source: HGNC

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Inferred from electronic annotation. Source: Ensembl

negative regulation of intrinsic apoptotic signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

spermatogenesis

Traceable author statement PubMed 9878060. Source: ProtInc

   Cellular_componentcytosol

Inferred from direct assay Ref.2. Source: HGNC

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Traceable author statement PubMed 9878060. Source: ProtInc

mitochondrial outer membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

mitochondrion

Inferred from direct assay Ref.2. Source: HGNC

nuclear membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein binding

Inferred from physical interaction Ref.2. Source: HGNC

protein heterodimerization activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

protein homodimerization activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 194194Bcl-2-like protein 10
PRO_0000143068

Regions

Transmembrane173 – 19018Helical; Potential
Motif76 – 9520BH1
Motif146 – 15712BH2

Natural variations

Natural variant111L → R.
Corresponds to variant rs2231292 [ dbSNP | Ensembl ].
VAR_047113

Experimental info

Sequence conflict421A → V in AAI04444. Ref.5
Sequence conflict451R → W in AAI04444. Ref.5

Secondary structure

.................... 194
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9HD36 [UniParc].

Last modified September 19, 2002. Version 2.
Checksum: 86F9F1A39377755F

FASTA19421,973
        10         20         30         40         50         60 
MADPLRERTE LLLADYLGYC AREPGTPEPA PSTPEAAVLR SAAARLRQIH RSFFSAYLGY 

        70         80         90        100        110        120 
PGNRFELVAL MADSVLSDSP GPTWGRVVTL VTFAGTLLER GPLVTARWKK WGFQPRLKEQ 

       130        140        150        160        170        180 
EGDVARDCQR LVALLSSRLM GQHRAWLQAQ GGWDGFCHFF RTPFPLAFWR KQLVQAFLSC 

       190 
LLTTAFIYLW TRLL 

« Hide

References

« Hide 'large scale' references
[1]"Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway."
Zhang H., Holzgreve W., De Geyter C.
Hum. Mol. Genet. 10:2329-2339(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.
[2]"Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak."
Ke N., Godzik A., Reed J.C.
J. Biol. Chem. 276:12481-12484(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH BAX.
Tissue: Liver.
[3]"NrH, a human homologue of Nr-13 associates with Bcl-Xs and is an inhibitor of apoptosis."
Aouacheria A., Arnaud E., Venet S., Lalle P., Gouy M., Rigal D., Gillet G.
Oncogene 20:5846-5855(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH BCLX.
[4]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF285092 mRNA. Translation: AAG00503.1. Different initiation.
AF326964 mRNA. Translation: AAK48715.1. Different initiation.
AJ458330 Genomic DNA. Translation: CAD30221.1.
AC023906 Genomic DNA. No translation available.
BC093826 mRNA. Translation: AAH93826.1. Different initiation.
BC093828 mRNA. Translation: AAH93828.1. Different initiation.
BC104442 mRNA. Translation: AAI04443.1. Different initiation.
BC104443 mRNA. Translation: AAI04444.1. Different initiation.
RefSeqNP_065129.1. NM_020396.2.
UniGeneHs.283672.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4B4SX-ray1.90A2-167[»]
ProteinModelPortalQ9HD36.
SMRQ9HD36. Positions 3-165.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115334. 5 interactions.
IntActQ9HD36. 1 interaction.
MINTMINT-193288.
STRING9606.ENSP00000260442.

Chemistry

BindingDBQ9HD36.
ChEMBLCHEMBL5988.

PTM databases

PhosphoSiteQ9HD36.

Polymorphism databases

DMDM23396469.

Proteomic databases

PaxDbQ9HD36.
PRIDEQ9HD36.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000260442; ENSP00000260442; ENSG00000137875.
GeneID10017.
KEGGhsa:10017.
UCSCuc002abq.3. human.

Organism-specific databases

CTD10017.
GeneCardsGC15M052401.
HGNCHGNC:993. BCL2L10.
HPAHPA042222.
MIM606910. gene.
neXtProtNX_Q9HD36.
PharmGKBPA25304.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46553.
HOGENOMHOG000059275.
HOVERGENHBG050646.
InParanoidQ9HD36.
OrthoDBEOG7Q5HFF.
PhylomeDBQ9HD36.
TreeFamTF334762.

Gene expression databases

ArrayExpressQ9HD36.
BgeeQ9HD36.
CleanExHS_BCL2L10.
GenevestigatorQ9HD36.

Family and domain databases

InterProIPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERPTHR11256. PTHR11256. 1 hit.
PfamPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiBCL2L10.
GenomeRNAi10017.
NextBio37845.
PROQ9HD36.
SOURCESearch...

Entry information

Entry nameB2L10_HUMAN
AccessionPrimary (citable) accession number: Q9HD36
Secondary accession number(s): Q3SX80, Q52LQ9, Q8TCS9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: June 11, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM