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Q9HD33 (RM47_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
39S ribosomal protein L47, mitochondrial

Short name=L47mt
Short name=MRP-L47
Alternative name(s):
Nasopharyngeal carcinoma metastasis-related protein 1
Gene names
Name:MRPL47
Synonyms:NCM1
ORF Names:CGI-204
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Mitochondrion.

Sequence similarities

Belongs to the ribosomal protein L47em family.

Sequence caution

The sequence AAG01157.1 differs from that shown. Reason: Chimeric cDNA. Seems to include a portion of the orthologous murine sequence.

The sequence AAO92749.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransit peptide
   Molecular functionRibonucleoprotein
Ribosomal protein
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmitochondrial ribosome

Inferred from electronic annotation. Source: InterPro

mitochondrion

Inferred from direct assay. Source: HPA

   Molecular_functionstructural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9HD33-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9HD33-2)

The sequence of this isoform differs from the canonical sequence as follows:
     34-53: Missing.
Isoform 3 (identifier: Q9HD33-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 25039S ribosomal protein L47, mitochondrialPRO_0000030567

Amino acid modifications

Modified residue1441N6-acetyllysine Ref.7

Natural variations

Alternative sequence1 – 110110Missing in isoform 3.
VSP_035649
Alternative sequence34 – 5320Missing in isoform 2.
VSP_035650
Natural variant101C → G.
Corresponds to variant rs2339844 [ dbSNP | Ensembl ].
VAR_052042
Natural variant2131R → H.
Corresponds to variant rs10513762 [ dbSNP | Ensembl ].
VAR_052043

Experimental info

Sequence conflict2 – 54AAAG → DATY in AAO92749. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 4, 2008. Version 2.
Checksum: 53EE4FF6E6BF5645

FASTA25029,450
        10         20         30         40         50         60 
MAAAGLALLC RRVSSALKSS RSLITPQVPA CTGFFLSLLP KSTPNVTSFH QYRLLHTTLS 

        70         80         90        100        110        120 
RKGLEEFFDD PKNWGQEKVK SGAAWTCQQL RNKSNEDLHK LWYVLLKERN MLLTLEQEAK 

       130        140        150        160        170        180 
RQRLPMPSPE RLDKVVDSMD ALDKVVQERE DALRLLQTGQ ERARPGAWRR DIFGRIIWHK 

       190        200        210        220        230        240 
FKQWVIPWHL NKRYNRKRFF ALPYVDHFLR LEREKRARIK ARKENLERKK AKILLKKFPH 

       250 
LAEAQKSSLV 

« Hide

Isoform 2 [UniParc].

Checksum: 40C145F4E1BFBB05
Show »

FASTA23027,086
Isoform 3 [UniParc].

Checksum: BBA27B6CC4C9D29C
Show »

FASTA14016,991

References

« Hide 'large scale' references
[1]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Lymph.
[4]"Nasopharyngeal carcinoma metastasis-related gene 1."
Zhu L.P., Jin Y.L.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-250 (ISOFORM 1).
[5]"Identification of the human crooked neck gene by comparative gene identification."
Lai C.-H., Chiu J.-Y., Lin W.-C.
Biochim. Biophys. Acta 1517:449-454(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-250 (ISOFORMS 1/2).
[6]"The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-144, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC090425 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78395.1.
CH471052 Genomic DNA. Translation: EAW78396.1.
BC021575 mRNA. Translation: AAH21575.1.
BC032522 mRNA. Translation: AAH32522.1.
AY212270 mRNA. Translation: AAO92749.1. Different initiation.
AF285120 mRNA. Translation: AAG01157.1. Sequence problems.
RefSeqNP_065142.2. NM_020409.2.
NP_817125.1. NM_177988.1.
UniGeneHs.283734.

3D structure databases

ProteinModelPortalQ9HD33.
SMRQ9HD33. Positions 86-152.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121392. 12 interactions.
IntActQ9HD33. 2 interactions.
STRING9606.ENSP00000417602.

PTM databases

PhosphoSiteQ9HD33.

Polymorphism databases

DMDM212276461.

Proteomic databases

PaxDbQ9HD33.
PRIDEQ9HD33.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000259038; ENSP00000259038; ENSG00000136522. [Q9HD33-2]
ENST00000392659; ENSP00000376427; ENSG00000136522. [Q9HD33-3]
ENST00000476781; ENSP00000417602; ENSG00000136522. [Q9HD33-1]
GeneID57129.
KEGGhsa:57129.
UCSCuc003fjz.3. human. [Q9HD33-1]
uc003fkb.3. human. [Q9HD33-2]

Organism-specific databases

CTD57129.
GeneCardsGC03M179306.
HGNCHGNC:16652. MRPL47.
HPAHPA037553.
HPA047779.
MIM611852. gene.
neXtProtNX_Q9HD33.
PharmGKBPA30979.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG116806.
HOGENOMHOG000019703.
HOVERGENHBG050019.
InParanoidQ9HD33.
KOK17428.
OMAAPWTAKQ.
OrthoDBEOG7MD4QR.
PhylomeDBQ9HD33.
TreeFamTF314327.

Gene expression databases

BgeeQ9HD33.
CleanExHS_MRPL47.
GenevestigatorQ9HD33.

Family and domain databases

InterProIPR010729. Ribosomal_L47_mit.
[Graphical view]
PANTHERPTHR21183. PTHR21183. 1 hit.
PfamPF06984. MRP-L47. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi57129.
NextBio63037.
PROQ9HD33.
SOURCESearch...

Entry information

Entry nameRM47_HUMAN
AccessionPrimary (citable) accession number: Q9HD33
Secondary accession number(s): Q6XRG1, Q8N5D1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 4, 2008
Last modified: April 16, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM