Q9HD33 (RM47_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
39S ribosomal protein L47, mitochondrial
Short name=L47mt
Short name=MRP-L47

Alternative name(s):
Nasopharyngeal carcinoma metastasis-related protein 1

Gene names

Name:	MRPL47
Synonyms:	NCM1
ORF Names:	CGI-204

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the ribosomal protein L47em family.
Sequence caution	The sequence AAG01157.1 differs from that shown. Reason: Chimeric cDNA. Seems to include a portion of the orthologous murine sequence. The sequence AAO92749.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrial ribosome Inferred from electronic annotation. Source: InterPro
Molecular_function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9HD33-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9HD33-2)

The sequence of this isoform differs from the canonical sequence as follows:
     34-53: Missing.

Isoform 3 (identifier: Q9HD33-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 250		39S ribosomal protein L47, mitochondrial		PRO_0000030567
Amino acid modifications
	Modified residue	144	1	N6-acetyllysine Ref.7
Natural variations
	Alternative sequence	1 – 110	110	Missing in isoform 3.		VSP_035649
	Alternative sequence	34 – 53	20	Missing in isoform 2.		VSP_035650
	Natural variant	10	1	C → G. Corresponds to variant rs2339844 [ dbSNP | Ensembl ].		VAR_052042
	Natural variant	213	1	R → H. Corresponds to variant rs10513762 [ dbSNP | Ensembl ].		VAR_052043
Experimental info
	Sequence conflict	2 – 5	4	AAAG → DATY in AAO92749. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 4, 2008. Version 2. Checksum: 53EE4FF6E6BF5645	FASTA	250	29,450
	10 20 30 40 50 60 MAAAGLALLC RRVSSALKSS RSLITPQVPA CTGFFLSLLP KSTPNVTSFH QYRLLHTTLS 70 80 90 100 110 120 RKGLEEFFDD PKNWGQEKVK SGAAWTCQQL RNKSNEDLHK LWYVLLKERN MLLTLEQEAK 130 140 150 160 170 180 RQRLPMPSPE RLDKVVDSMD ALDKVVQERE DALRLLQTGQ ERARPGAWRR DIFGRIIWHK 190 200 210 220 230 240 FKQWVIPWHL NKRYNRKRFF ALPYVDHFLR LEREKRARIK ARKENLERKK AKILLKKFPH 250 LAEAQKSSLV
	Isoform 2 [UniParc]. Checksum: 40C145F4E1BFBB05	FASTA	230	27,086
	10 20 30 40 50 60 MAAAGLALLC RRVSSALKSS RSLITPQVPA CTGLLHTTLS RKGLEEFFDD PKNWGQEKVK 70 80 90 100 110 120 SGAAWTCQQL RNKSNEDLHK LWYVLLKERN MLLTLEQEAK RQRLPMPSPE RLDKVVDSMD 130 140 150 160 170 180 ALDKVVQERE DALRLLQTGQ ERARPGAWRR DIFGRIIWHK FKQWVIPWHL NKRYNRKRFF 190 200 210 220 230 ALPYVDHFLR LEREKRARIK ARKENLERKK AKILLKKFPH LAEAQKSSLV
	Isoform 3 [UniParc]. Checksum: BBA27B6CC4C9D29C	FASTA	140	16,991
	10 20 30 40 50 60 MLLTLEQEAK RQRLPMPSPE RLDKVVDSMD ALDKVVQERE DALRLLQTGQ ERARPGAWRR 70 80 90 100 110 120 DIFGRIIWHK FKQWVIPWHL NKRYNRKRFF ALPYVDHFLR LEREKRARIK ARKENLERKK 130 140 AKILLKKFPH LAEAQKSSLV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Lymph.
[4]	"Nasopharyngeal carcinoma metastasis-related gene 1." Zhu L.P., Jin Y.L. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-250 (ISOFORM 1).
[5]	"Identification of the human crooked neck gene by comparative gene identification." Lai C.-H., Chiu J.-Y., Lin W.-C. Biochim. Biophys. Acta 1517:449-454(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-250 (ISOFORMS 1/2).
[6]	"The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L. J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[7]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-144, MASS SPECTROMETRY.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC090425 Genomic DNA. No translation available. CH471052 Genomic DNA. Translation: EAW78395.1. CH471052 Genomic DNA. Translation: EAW78396.1. BC021575 mRNA. Translation: AAH21575.1. BC032522 mRNA. Translation: AAH32522.1. AY212270 mRNA. Translation: AAO92749.1. Different initiation. AF285120 mRNA. Translation: AAG01157.1. Sequence problems.
IPI	IPI00030820. IPI00375687. IPI00794978.
RefSeq	NP_065142.2. NM_020409.2. NP_817125.1. NM_177988.1.
UniGene	Hs.283734.
3D structure databases
ProteinModelPortal	Q9HD33.
SMR	Q9HD33. Positions 86-149.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9HD33. 1 interaction.
STRING	9606.ENSP00000417602.
PTM databases
PhosphoSite	Q9HD33.
Polymorphism databases
DMDM	212276461.
Proteomic databases
PaxDb	Q9HD33.
PRIDE	Q9HD33.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000259038; ENSP00000259038; ENSG00000136522. ENST00000392659; ENSP00000376427; ENSG00000136522. ENST00000476781; ENSP00000417602; ENSG00000136522.
GeneID	57129.
KEGG	hsa:57129.
UCSC	uc003fjz.3. human. uc003fkb.3. human.
Organism-specific databases
CTD	57129.
GeneCards	GC03M179306.
HGNC	HGNC:16652. MRPL47.
HPA	HPA037553.
MIM	611852. gene.
neXtProt	NX_Q9HD33.
PharmGKB	PA30979.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG116806.
HOGENOM	HOG000019703.
HOVERGEN	HBG050019.
InParanoid	Q9HD33.
OMA	KSGAPWT.
OrthoDB	EOG4ZKJNC.
PhylomeDB	Q9HD33.
Gene expression databases
Bgee	Q9HD33.
CleanEx	HS_MRPL47.
Genevestigator	Q9HD33.
GermOnline	ENSG00000136522. Homo sapiens.
Family and domain databases
InterPro	IPR010729. Ribosomal_L47_mit. [Graphical view]
PANTHER	PTHR21183. PTHR21183. 1 hit.
Pfam	PF06984. MRP-L47. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	57129.
NextBio	63037.
SOURCE	Search...

Entry information

Entry name

RM47_HUMAN

Accession

Primary (citable) accession number: Q9HD33
Secondary accession number(s): Q6XRG1, Q8N5D1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	November 4, 2008
Last modified:	May 1, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.