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Protein

39S ribosomal protein L47, mitochondrial

Gene

MRPL47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L47, mitochondrial
Short name:
L47mt
Short name:
MRP-L47
Alternative name(s):
Nasopharyngeal carcinoma metastasis-related protein 1
Gene namesi
Name:MRPL47
Synonyms:NCM1
ORF Names:CGI-204
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:16652. MRPL47.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30979.

Polymorphism and mutation databases

BioMutaiMRPL47.
DMDMi212276461.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 25039S ribosomal protein L47, mitochondrialPRO_0000030567
Transit peptidei1 – ?MitochondrionSequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei144 – 1441N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9HD33.
PaxDbiQ9HD33.
PRIDEiQ9HD33.

PTM databases

PhosphoSiteiQ9HD33.

Expressioni

Gene expression databases

BgeeiQ9HD33.
CleanExiHS_MRPL47.
GenevisibleiQ9HD33. HS.

Organism-specific databases

HPAiHPA037553.
HPA047779.

Interactioni

Protein-protein interaction databases

BioGridi121392. 59 interactions.
IntActiQ9HD33. 2 interactions.
STRINGi9606.ENSP00000417602.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40Y1-250[»]
3J9Melectron microscopy3.50Y1-250[»]
ProteinModelPortaliQ9HD33.
SMRiQ9HD33. Positions 63-238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L47em family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG116806.
GeneTreeiENSGT00390000002837.
HOGENOMiHOG000019703.
HOVERGENiHBG050019.
InParanoidiQ9HD33.
KOiK17428.
OMAiMEHECND.
OrthoDBiEOG7MD4QR.
PhylomeDBiQ9HD33.
TreeFamiTF314327.

Family and domain databases

InterProiIPR010729. Ribosomal_L47_mit.
[Graphical view]
PANTHERiPTHR21183. PTHR21183. 1 hit.
PfamiPF06984. MRP-L47. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HD33-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAGLALLC RRVSSALKSS RSLITPQVPA CTGFFLSLLP KSTPNVTSFH
60 70 80 90 100
QYRLLHTTLS RKGLEEFFDD PKNWGQEKVK SGAAWTCQQL RNKSNEDLHK
110 120 130 140 150
LWYVLLKERN MLLTLEQEAK RQRLPMPSPE RLDKVVDSMD ALDKVVQERE
160 170 180 190 200
DALRLLQTGQ ERARPGAWRR DIFGRIIWHK FKQWVIPWHL NKRYNRKRFF
210 220 230 240 250
ALPYVDHFLR LEREKRARIK ARKENLERKK AKILLKKFPH LAEAQKSSLV
Length:250
Mass (Da):29,450
Last modified:November 4, 2008 - v2
Checksum:i53EE4FF6E6BF5645
GO
Isoform 2 (identifier: Q9HD33-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-53: Missing.

Show »
Length:230
Mass (Da):27,086
Checksum:i40C145F4E1BFBB05
GO
Isoform 3 (identifier: Q9HD33-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Show »
Length:140
Mass (Da):16,991
Checksum:iBBA27B6CC4C9D29C
GO

Sequence cautioni

The sequence AAG01157.1 differs from that shown.Chimeric cDNA. Seems to include a portion of the orthologous murine sequence.Curated
The sequence AAO92749.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 54AAAG → DATY in AAO92749 (Ref. 4) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101C → G.
Corresponds to variant rs2339844 [ dbSNP | Ensembl ].
VAR_052042
Natural varianti213 – 2131R → H.
Corresponds to variant rs10513762 [ dbSNP | Ensembl ].
VAR_052043

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 110110Missing in isoform 3. 1 PublicationVSP_035649Add
BLAST
Alternative sequencei34 – 5320Missing in isoform 2. 1 PublicationVSP_035650Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090425 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78395.1.
CH471052 Genomic DNA. Translation: EAW78396.1.
BC021575 mRNA. Translation: AAH21575.1.
BC032522 mRNA. Translation: AAH32522.1.
AY212270 mRNA. Translation: AAO92749.1. Different initiation.
AF285120 mRNA. Translation: AAG01157.1. Sequence problems.
CCDSiCCDS3232.1. [Q9HD33-1]
CCDS3233.1. [Q9HD33-3]
RefSeqiNP_065142.2. NM_020409.2. [Q9HD33-1]
NP_817125.1. NM_177988.1. [Q9HD33-3]
UniGeneiHs.283734.

Genome annotation databases

EnsembliENST00000259038; ENSP00000259038; ENSG00000136522. [Q9HD33-2]
ENST00000392659; ENSP00000376427; ENSG00000136522. [Q9HD33-3]
ENST00000476781; ENSP00000417602; ENSG00000136522.
GeneIDi57129.
KEGGihsa:57129.
UCSCiuc003fjz.3. human. [Q9HD33-1]
uc003fkb.3. human. [Q9HD33-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090425 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78395.1.
CH471052 Genomic DNA. Translation: EAW78396.1.
BC021575 mRNA. Translation: AAH21575.1.
BC032522 mRNA. Translation: AAH32522.1.
AY212270 mRNA. Translation: AAO92749.1. Different initiation.
AF285120 mRNA. Translation: AAG01157.1. Sequence problems.
CCDSiCCDS3232.1. [Q9HD33-1]
CCDS3233.1. [Q9HD33-3]
RefSeqiNP_065142.2. NM_020409.2. [Q9HD33-1]
NP_817125.1. NM_177988.1. [Q9HD33-3]
UniGeneiHs.283734.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40Y1-250[»]
3J9Melectron microscopy3.50Y1-250[»]
ProteinModelPortaliQ9HD33.
SMRiQ9HD33. Positions 63-238.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121392. 59 interactions.
IntActiQ9HD33. 2 interactions.
STRINGi9606.ENSP00000417602.

PTM databases

PhosphoSiteiQ9HD33.

Polymorphism and mutation databases

BioMutaiMRPL47.
DMDMi212276461.

Proteomic databases

MaxQBiQ9HD33.
PaxDbiQ9HD33.
PRIDEiQ9HD33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259038; ENSP00000259038; ENSG00000136522. [Q9HD33-2]
ENST00000392659; ENSP00000376427; ENSG00000136522. [Q9HD33-3]
ENST00000476781; ENSP00000417602; ENSG00000136522.
GeneIDi57129.
KEGGihsa:57129.
UCSCiuc003fjz.3. human. [Q9HD33-1]
uc003fkb.3. human. [Q9HD33-2]

Organism-specific databases

CTDi57129.
GeneCardsiGC03M179306.
HGNCiHGNC:16652. MRPL47.
HPAiHPA037553.
HPA047779.
MIMi611852. gene.
neXtProtiNX_Q9HD33.
PharmGKBiPA30979.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG116806.
GeneTreeiENSGT00390000002837.
HOGENOMiHOG000019703.
HOVERGENiHBG050019.
InParanoidiQ9HD33.
KOiK17428.
OMAiMEHECND.
OrthoDBiEOG7MD4QR.
PhylomeDBiQ9HD33.
TreeFamiTF314327.

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Miscellaneous databases

GenomeRNAii57129.
NextBioi63037.
PROiQ9HD33.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HD33.
CleanExiHS_MRPL47.
GenevisibleiQ9HD33. HS.

Family and domain databases

InterProiIPR010729. Ribosomal_L47_mit.
[Graphical view]
PANTHERiPTHR21183. PTHR21183. 1 hit.
PfamiPF06984. MRP-L47. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Lymph.
  4. "Nasopharyngeal carcinoma metastasis-related gene 1."
    Zhu L.P., Jin Y.L.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-250 (ISOFORM 1).
  5. "Identification of the human crooked neck gene by comparative gene identification."
    Lai C.-H., Chiu J.-Y., Lin W.-C.
    Biochim. Biophys. Acta 1517:449-454(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-250 (ISOFORMS 1/2).
  6. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-144, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM47_HUMAN
AccessioniPrimary (citable) accession number: Q9HD33
Secondary accession number(s): Q6XRG1, Q8N5D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 4, 2008
Last modified: July 22, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.