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Q9HD33

- RM47_HUMAN

UniProt

Q9HD33 - RM47_HUMAN

Protein

39S ribosomal protein L47, mitochondrial

Gene

MRPL47

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (04 Nov 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L47, mitochondrial
    Short name:
    L47mt
    Short name:
    MRP-L47
    Alternative name(s):
    Nasopharyngeal carcinoma metastasis-related protein 1
    Gene namesi
    Name:MRPL47
    Synonyms:NCM1
    ORF Names:CGI-204
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:16652. MRPL47.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial ribosome Source: InterPro
    2. mitochondrion Source: HPA

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30979.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 25039S ribosomal protein L47, mitochondrialPRO_0000030567
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei144 – 1441N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9HD33.
    PaxDbiQ9HD33.
    PRIDEiQ9HD33.

    PTM databases

    PhosphoSiteiQ9HD33.

    Expressioni

    Gene expression databases

    BgeeiQ9HD33.
    CleanExiHS_MRPL47.
    GenevestigatoriQ9HD33.

    Organism-specific databases

    HPAiHPA037553.
    HPA047779.

    Interactioni

    Protein-protein interaction databases

    BioGridi121392. 12 interactions.
    IntActiQ9HD33. 2 interactions.
    STRINGi9606.ENSP00000417602.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HD33.
    SMRiQ9HD33. Positions 84-159.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L47em family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG116806.
    HOGENOMiHOG000019703.
    HOVERGENiHBG050019.
    InParanoidiQ9HD33.
    KOiK17428.
    OMAiAPWTAKQ.
    OrthoDBiEOG7MD4QR.
    PhylomeDBiQ9HD33.
    TreeFamiTF314327.

    Family and domain databases

    InterProiIPR010729. Ribosomal_L47_mit.
    [Graphical view]
    PANTHERiPTHR21183. PTHR21183. 1 hit.
    PfamiPF06984. MRP-L47. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HD33-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAGLALLC RRVSSALKSS RSLITPQVPA CTGFFLSLLP KSTPNVTSFH    50
    QYRLLHTTLS RKGLEEFFDD PKNWGQEKVK SGAAWTCQQL RNKSNEDLHK 100
    LWYVLLKERN MLLTLEQEAK RQRLPMPSPE RLDKVVDSMD ALDKVVQERE 150
    DALRLLQTGQ ERARPGAWRR DIFGRIIWHK FKQWVIPWHL NKRYNRKRFF 200
    ALPYVDHFLR LEREKRARIK ARKENLERKK AKILLKKFPH LAEAQKSSLV 250
    Length:250
    Mass (Da):29,450
    Last modified:November 4, 2008 - v2
    Checksum:i53EE4FF6E6BF5645
    GO
    Isoform 2 (identifier: Q9HD33-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         34-53: Missing.

    Show »
    Length:230
    Mass (Da):27,086
    Checksum:i40C145F4E1BFBB05
    GO
    Isoform 3 (identifier: Q9HD33-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-110: Missing.

    Show »
    Length:140
    Mass (Da):16,991
    Checksum:iBBA27B6CC4C9D29C
    GO

    Sequence cautioni

    The sequence AAG01157.1 differs from that shown. Reason: Chimeric cDNA. Seems to include a portion of the orthologous murine sequence.
    The sequence AAO92749.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 54AAAG → DATY in AAO92749. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101C → G.
    Corresponds to variant rs2339844 [ dbSNP | Ensembl ].
    VAR_052042
    Natural varianti213 – 2131R → H.
    Corresponds to variant rs10513762 [ dbSNP | Ensembl ].
    VAR_052043

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 110110Missing in isoform 3. 1 PublicationVSP_035649Add
    BLAST
    Alternative sequencei34 – 5320Missing in isoform 2. 1 PublicationVSP_035650Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC090425 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78395.1.
    CH471052 Genomic DNA. Translation: EAW78396.1.
    BC021575 mRNA. Translation: AAH21575.1.
    BC032522 mRNA. Translation: AAH32522.1.
    AY212270 mRNA. Translation: AAO92749.1. Different initiation.
    AF285120 mRNA. Translation: AAG01157.1. Sequence problems.
    CCDSiCCDS3232.1. [Q9HD33-1]
    CCDS3233.1. [Q9HD33-3]
    RefSeqiNP_065142.2. NM_020409.2. [Q9HD33-1]
    NP_817125.1. NM_177988.1. [Q9HD33-3]
    UniGeneiHs.283734.

    Genome annotation databases

    EnsembliENST00000259038; ENSP00000259038; ENSG00000136522. [Q9HD33-2]
    ENST00000392659; ENSP00000376427; ENSG00000136522. [Q9HD33-3]
    ENST00000476781; ENSP00000417602; ENSG00000136522. [Q9HD33-1]
    GeneIDi57129.
    KEGGihsa:57129.
    UCSCiuc003fjz.3. human. [Q9HD33-1]
    uc003fkb.3. human. [Q9HD33-2]

    Polymorphism databases

    DMDMi212276461.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC090425 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78395.1 .
    CH471052 Genomic DNA. Translation: EAW78396.1 .
    BC021575 mRNA. Translation: AAH21575.1 .
    BC032522 mRNA. Translation: AAH32522.1 .
    AY212270 mRNA. Translation: AAO92749.1 . Different initiation.
    AF285120 mRNA. Translation: AAG01157.1 . Sequence problems.
    CCDSi CCDS3232.1. [Q9HD33-1 ]
    CCDS3233.1. [Q9HD33-3 ]
    RefSeqi NP_065142.2. NM_020409.2. [Q9HD33-1 ]
    NP_817125.1. NM_177988.1. [Q9HD33-3 ]
    UniGenei Hs.283734.

    3D structure databases

    ProteinModelPortali Q9HD33.
    SMRi Q9HD33. Positions 84-159.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121392. 12 interactions.
    IntActi Q9HD33. 2 interactions.
    STRINGi 9606.ENSP00000417602.

    PTM databases

    PhosphoSitei Q9HD33.

    Polymorphism databases

    DMDMi 212276461.

    Proteomic databases

    MaxQBi Q9HD33.
    PaxDbi Q9HD33.
    PRIDEi Q9HD33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259038 ; ENSP00000259038 ; ENSG00000136522 . [Q9HD33-2 ]
    ENST00000392659 ; ENSP00000376427 ; ENSG00000136522 . [Q9HD33-3 ]
    ENST00000476781 ; ENSP00000417602 ; ENSG00000136522 . [Q9HD33-1 ]
    GeneIDi 57129.
    KEGGi hsa:57129.
    UCSCi uc003fjz.3. human. [Q9HD33-1 ]
    uc003fkb.3. human. [Q9HD33-2 ]

    Organism-specific databases

    CTDi 57129.
    GeneCardsi GC03M179306.
    HGNCi HGNC:16652. MRPL47.
    HPAi HPA037553.
    HPA047779.
    MIMi 611852. gene.
    neXtProti NX_Q9HD33.
    PharmGKBi PA30979.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG116806.
    HOGENOMi HOG000019703.
    HOVERGENi HBG050019.
    InParanoidi Q9HD33.
    KOi K17428.
    OMAi APWTAKQ.
    OrthoDBi EOG7MD4QR.
    PhylomeDBi Q9HD33.
    TreeFami TF314327.

    Miscellaneous databases

    GenomeRNAii 57129.
    NextBioi 63037.
    PROi Q9HD33.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9HD33.
    CleanExi HS_MRPL47.
    Genevestigatori Q9HD33.

    Family and domain databases

    InterProi IPR010729. Ribosomal_L47_mit.
    [Graphical view ]
    PANTHERi PTHR21183. PTHR21183. 1 hit.
    Pfami PF06984. MRP-L47. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Lymph.
    4. "Nasopharyngeal carcinoma metastasis-related gene 1."
      Zhu L.P., Jin Y.L.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-250 (ISOFORM 1).
    5. "Identification of the human crooked neck gene by comparative gene identification."
      Lai C.-H., Chiu J.-Y., Lin W.-C.
      Biochim. Biophys. Acta 1517:449-454(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-250 (ISOFORMS 1/2).
    6. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-144, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM47_HUMAN
    AccessioniPrimary (citable) accession number: Q9HD33
    Secondary accession number(s): Q6XRG1, Q8N5D1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: November 4, 2008
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3