Q9HD23 (MRS2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Magnesium transporter MRS2 homolog, mitochondrial

Alternative name(s):
MRS2-like protein

Gene names

Name:	MRS2
Synonyms:	HPT, MRS2L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	443 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Magnesium transporter that may mediate the influx of magnesium into the mitochondrial matrix. Ref.1
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity Ref.1.
Miscellaneous	Has the ability to complement a deletion of MRS2 in S.cerevisiae and partly restore mitochondrial magnesium concentrations.
Sequence similarities	Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. [View classification]
Sequence caution	The sequence CAI17109.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transit peptide Transmembrane Transmembrane helix
Ligand	Magnesium
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	magnesium ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9HD23-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9HD23-2)

The sequence of this isoform differs from the canonical sequence as follows:
     408-408: M → V
     409-443: Missing.

Isoform 3 (identifier: Q9HD23-3)

The sequence of this isoform differs from the canonical sequence as follows:
     101-117: ERKKTELYQELGLQARD → VFESCDNSRVSSDIRLS
     118-443: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 49	49	Mitochondrion Potential
	Chain	50 – 443	394	Magnesium transporter MRS2 homolog, mitochondrial		PRO_0000042837
Regions
	Topological domain	50 – 339	290	Mitochondrial matrix Potential
	Transmembrane	340 – 360	21	Helical; Potential
	Topological domain	361 – 372	12	Mitochondrial intermembrane Potential
	Transmembrane	373 – 393	21	Helical; Potential
	Topological domain	394 – 443	50	Mitochondrial matrix Potential
Natural variations
	Alternative sequence	101 – 117	17	ERKKT…LQARD → VFESCDNSRVSSDIRLS in isoform 3.		VSP_016207
	Alternative sequence	118 – 443	326	Missing in isoform 3.		VSP_016208
	Alternative sequence	408	1	M → V in isoform 2.		VSP_016209
	Alternative sequence	409 – 443	35	Missing in isoform 2.		VSP_016210
	Natural variant	35	1	P → S. Corresponds to variant rs2295651 [ dbSNP | Ensembl ].		VAR_023782
	Natural variant	412	1	P → S. Corresponds to variant rs35261004 [ dbSNP | Ensembl ].		VAR_061129

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 396EEFB64A8BB14F	FASTA	443	50,318
	10 20 30 40 50 60 MECLRSLPCL LPRAMRLPRR TLCALALDVT SVGPPVAACG RRANLIGRSR AAQLCGPDRL 70 80 90 100 110 120 RVAGEVHRFR TSDVSQATLA SVAPVFTVTK FDKQGNVTSF ERKKTELYQE LGLQARDLRF 130 140 150 160 170 180 QHVMSITVRN NRIIMRMEYL KAVITPECLL ILDYRNLNLE QWLFRELPSQ LSGEGQLVTY 190 200 210 220 230 240 PLPFEFRAIE ALLQYWINTL QGKLSILQPL ILETLDALVD PKHSSVDRSK LHILLQNGKS 250 260 270 280 290 300 LSELETDIKI FKESILEILD EEELLEELCV SKWSDPQVFE KSSAGIDHAE EMELLLENYY 310 320 330 340 350 360 RLADDLSNAA RELRVLIDDS QSIIFINLDS HRNVMMRLNL QLTMGTFSLS LFGLMGVAFG 370 380 390 400 410 420 MNLESSLEED HRIFWLITGI MFMGSGLIWR RLLSFLGRQL EAPLPPMMAS LPKKTLLADR 430 440 SMELKNSLRL DGLGSGRSIL TNR
	Isoform 2 [UniParc]. Checksum: 5BC6550A6444D27E	FASTA	408	46,491
	10 20 30 40 50 60 MECLRSLPCL LPRAMRLPRR TLCALALDVT SVGPPVAACG RRANLIGRSR AAQLCGPDRL 70 80 90 100 110 120 RVAGEVHRFR TSDVSQATLA SVAPVFTVTK FDKQGNVTSF ERKKTELYQE LGLQARDLRF 130 140 150 160 170 180 QHVMSITVRN NRIIMRMEYL KAVITPECLL ILDYRNLNLE QWLFRELPSQ LSGEGQLVTY 190 200 210 220 230 240 PLPFEFRAIE ALLQYWINTL QGKLSILQPL ILETLDALVD PKHSSVDRSK LHILLQNGKS 250 260 270 280 290 300 LSELETDIKI FKESILEILD EEELLEELCV SKWSDPQVFE KSSAGIDHAE EMELLLENYY 310 320 330 340 350 360 RLADDLSNAA RELRVLIDDS QSIIFINLDS HRNVMMRLNL QLTMGTFSLS LFGLMGVAFG 370 380 390 400 MNLESSLEED HRIFWLITGI MFMGSGLIWR RLLSFLGRQL EAPLPPMV
	Isoform 3 [UniParc]. Checksum: 27AAD2D247E889C2	FASTA	117	12,691
	10 20 30 40 50 60 MECLRSLPCL LPRAMRLPRR TLCALALDVT SVGPPVAACG RRANLIGRSR AAQLCGPDRL 70 80 90 100 110 RVAGEVHRFR TSDVSQATLA SVAPVFTVTK FDKQGNVTSF VFESCDNSRV SSDIRLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter." Zsurka G., Gregan J., Schweyen R.J. Genomics 72:158-168(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 241-278, FUNCTION, SUBCELLULAR LOCATION.
[2]	"Putative mammalian magnesium transporters." Bosma T.J., MacDiarmid C.W., Gardner R.C. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Lung and Lymph.
[7]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF293076 mRNA. Translation: AAK38615.1. AF293078 Genomic DNA. Translation: AAK38617.1. AF288288 mRNA. Translation: AAG01170.1. AK054587 mRNA. Translation: BAG51394.1. AK291058 mRNA. Translation: BAF83747.1. AL359713 Genomic DNA. Translation: CAI17107.1. AL359713 Genomic DNA. Translation: CAI17108.1. AL359713 Genomic DNA. Translation: CAI17109.1. Sequence problems. CH471087 Genomic DNA. Translation: EAW55445.1. CH471087 Genomic DNA. Translation: EAW55446.1. BC001028 mRNA. Translation: AAH01028.2. BC069009 mRNA. Translation: AAH69009.1.
IPI	IPI00031487. IPI00646426. IPI00941475.
RefSeq	NP_065713.1. NM_020662.2.
UniGene	Hs.741269.
3D structure databases
ProteinModelPortal	Q9HD23.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9HD23. 1 interaction.
STRING	9606.ENSP00000367637.
PTM databases
PhosphoSite	Q9HD23.
Polymorphism databases
DMDM	74752816.
Proteomic databases
PaxDb	Q9HD23.
PRIDE	Q9HD23.
Protocols and materials databases
DNASU	57380.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000274747; ENSP00000274747; ENSG00000124532. ENST00000378353; ENSP00000367604; ENSG00000124532. ENST00000378386; ENSP00000367637; ENSG00000124532.
GeneID	57380.
KEGG	hsa:57380.
UCSC	uc003nea.3. human. uc003neb.3. human.
Organism-specific databases
CTD	57380.
GeneCards	GC06P024403.
HGNC	HGNC:13785. MRS2.
neXtProt	NX_Q9HD23.
PharmGKB	PA162396189.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG284534.
HOGENOM	HOG000013083.
HOVERGEN	HBG103267.
InParanoid	Q9HD23.
KO	K16075.
OrthoDB	EOG4B8JDF.
PhylomeDB	Q9HD23.
Gene expression databases
ArrayExpress	Q9HD23.
Bgee	Q9HD23.
CleanEx	HS_MRS2.
Genevestigator	Q9HD23.
GermOnline	ENSG00000124532. Homo sapiens.
Family and domain databases
InterPro	IPR026573. MRS2/LPE10. [Graphical view]
PANTHER	PTHR13890. PTHR13890. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	MRS2. human.
GenomeRNAi	57380.
NextBio	63482.

Entry information

Entry name

MRS2_HUMAN

Accession

Primary (citable) accession number: Q9HD23
Secondary accession number(s): A8K4U3 , B3KNN2, Q5T3Y1, Q6NTG4, Q96KF8, Q9BVP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.