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Q9HD23 (MRS2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Magnesium transporter MRS2 homolog, mitochondrial
Alternative name(s):
MRS2-like protein
Gene names
Name:MRS2
Synonyms:HPT, MRS2L
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Magnesium transporter that may mediate the influx of magnesium into the mitochondrial matrix. Ref.1

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity Ref.1.

Miscellaneous

Has the ability to complement a deletion of MRS2 in S.cerevisiae and partly restore mitochondrial magnesium concentrations.

Sequence similarities

Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. [View classification]

Sequence caution

The sequence CAI17109.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9HD23-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9HD23-2)

The sequence of this isoform differs from the canonical sequence as follows:
     408-408: M → V
     409-443: Missing.
Isoform 3 (identifier: Q9HD23-3)

The sequence of this isoform differs from the canonical sequence as follows:
     101-117: ERKKTELYQELGLQARD → VFESCDNSRVSSDIRLS
     118-443: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q9HD23-4)

The sequence of this isoform differs from the canonical sequence as follows:
     139-159: YLKAVITPECLLILDYRNLNL → KYSLLLESVASILQNSVSFMERQT
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4949Mitochondrion Potential
Chain50 – 443394Magnesium transporter MRS2 homolog, mitochondrial
PRO_0000042837

Regions

Topological domain50 – 339290Mitochondrial matrix Potential
Transmembrane340 – 36021Helical; Potential
Topological domain361 – 37212Mitochondrial intermembrane Potential
Transmembrane373 – 39321Helical; Potential
Topological domain394 – 44350Mitochondrial matrix Potential

Natural variations

Alternative sequence101 – 11717ERKKT…LQARD → VFESCDNSRVSSDIRLS in isoform 3.
VSP_016207
Alternative sequence118 – 443326Missing in isoform 3.
VSP_016208
Alternative sequence139 – 15921YLKAV…RNLNL → KYSLLLESVASILQNSVSFM ERQT in isoform 4.
VSP_055287
Alternative sequence4081M → V in isoform 2.
VSP_016209
Alternative sequence409 – 44335Missing in isoform 2.
VSP_016210
Natural variant351P → S.
Corresponds to variant rs2295651 [ dbSNP | Ensembl ].
VAR_023782
Natural variant4121P → S.
Corresponds to variant rs35261004 [ dbSNP | Ensembl ].
VAR_061129

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 396EEFB64A8BB14F

FASTA44350,318
        10         20         30         40         50         60 
MECLRSLPCL LPRAMRLPRR TLCALALDVT SVGPPVAACG RRANLIGRSR AAQLCGPDRL 

        70         80         90        100        110        120 
RVAGEVHRFR TSDVSQATLA SVAPVFTVTK FDKQGNVTSF ERKKTELYQE LGLQARDLRF 

       130        140        150        160        170        180 
QHVMSITVRN NRIIMRMEYL KAVITPECLL ILDYRNLNLE QWLFRELPSQ LSGEGQLVTY 

       190        200        210        220        230        240 
PLPFEFRAIE ALLQYWINTL QGKLSILQPL ILETLDALVD PKHSSVDRSK LHILLQNGKS 

       250        260        270        280        290        300 
LSELETDIKI FKESILEILD EEELLEELCV SKWSDPQVFE KSSAGIDHAE EMELLLENYY 

       310        320        330        340        350        360 
RLADDLSNAA RELRVLIDDS QSIIFINLDS HRNVMMRLNL QLTMGTFSLS LFGLMGVAFG 

       370        380        390        400        410        420 
MNLESSLEED HRIFWLITGI MFMGSGLIWR RLLSFLGRQL EAPLPPMMAS LPKKTLLADR 

       430        440 
SMELKNSLRL DGLGSGRSIL TNR 

« Hide

Isoform 2 [UniParc].

Checksum: 5BC6550A6444D27E
Show »

FASTA40846,491
Isoform 3 [UniParc].

Checksum: 27AAD2D247E889C2
Show »

FASTA11712,691
Isoform 4 [UniParc].

Checksum: 5E2C71D8F6A34181
Show »

FASTA44650,584

References

« Hide 'large scale' references
[1]"The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter."
Zsurka G., Gregan J., Schweyen R.J.
Genomics 72:158-168(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 241-278, FUNCTION, SUBCELLULAR LOCATION.
[2]"Putative mammalian magnesium transporters."
Bosma T.J., MacDiarmid C.W., Gardner R.C.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Lung and Lymph.
[7]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF293076 mRNA. Translation: AAK38615.1.
AF293078 Genomic DNA. Translation: AAK38617.1.
AF288288 mRNA. Translation: AAG01170.1.
AK054587 mRNA. Translation: BAG51394.1.
AK291058 mRNA. Translation: BAF83747.1.
AK298849 mRNA. Translation: BAG60974.1.
AL359713 Genomic DNA. Translation: CAI17107.1.
AL359713 Genomic DNA. Translation: CAI17108.1.
AL359713 Genomic DNA. Translation: CAI17109.1. Sequence problems.
CH471087 Genomic DNA. Translation: EAW55445.1.
CH471087 Genomic DNA. Translation: EAW55446.1.
BC001028 mRNA. Translation: AAH01028.2.
BC069009 mRNA. Translation: AAH69009.1.
CCDSCCDS4552.1. [Q9HD23-1]
RefSeqNP_001273193.1. NM_001286264.1.
NP_001273194.1. NM_001286265.1. [Q9HD23-2]
NP_001273195.1. NM_001286266.1.
NP_065713.1. NM_020662.3. [Q9HD23-1]
UniGeneHs.658612.
Hs.732395.

3D structure databases

ProteinModelPortalQ9HD23.
SMRQ9HD23. Positions 80-332.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121498. 3 interactions.
IntActQ9HD23. 1 interaction.
STRING9606.ENSP00000367637.

PTM databases

PhosphoSiteQ9HD23.

Polymorphism databases

DMDM74752816.

Proteomic databases

MaxQBQ9HD23.
PaxDbQ9HD23.
PRIDEQ9HD23.

Protocols and materials databases

DNASU57380.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000274747; ENSP00000274747; ENSG00000124532. [Q9HD23-3]
ENST00000378353; ENSP00000367604; ENSG00000124532. [Q9HD23-2]
ENST00000378386; ENSP00000367637; ENSG00000124532. [Q9HD23-1]
ENST00000443868; ENSP00000399585; ENSG00000124532.
GeneID57380.
KEGGhsa:57380.
UCSCuc003nea.3. human. [Q9HD23-2]
uc003neb.3. human. [Q9HD23-1]

Organism-specific databases

CTD57380.
GeneCardsGC06P024403.
HGNCHGNC:13785. MRS2.
HPAHPA017642.
neXtProtNX_Q9HD23.
PharmGKBPA162396189.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG284534.
HOGENOMHOG000013083.
HOVERGENHBG103267.
InParanoidQ9HD23.
KOK16075.
OrthoDBEOG7F7W8Z.
PhylomeDBQ9HD23.
TreeFamTF328433.

Gene expression databases

ArrayExpressQ9HD23.
BgeeQ9HD23.
CleanExHS_MRS2.
GenevestigatorQ9HD23.

Family and domain databases

InterProIPR026573. MRS2/LPE10.
[Graphical view]
PANTHERPTHR13890. PTHR13890. 1 hit.
ProtoNetSearch...

Other

ChiTaRSMRS2. human.
GeneWikiMRS2L.
GenomeRNAi57380.
NextBio63482.
PROQ9HD23.

Entry information

Entry nameMRS2_HUMAN
AccessionPrimary (citable) accession number: Q9HD23
Secondary accession number(s): A8K4U3 expand/collapse secondary AC list , B3KNN2, B4DQL2, Q5T3Y1, Q6NTG4, Q96KF8, Q9BVP1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM