Reviewed, UniProtKB/Swiss-Prot Q9HD20 (AT131_HUMAN)

Names and origin

Protein names

Recommended name:
    Probable cation-transporting ATPase 13A1
    EC=3.6.3.-

Gene names

Name:	ATP13A1
Synonyms:	ATP13A, KIAA1825
ORF Names:	CGI-152

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1204 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	ATP + H2O = ADP + phosphate.
Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type V subfamily.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro cation transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform A (identifier: Q9HD20-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q9HD20-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.
     119-132: HWSVHAHCALTCTP → MEKWEELNSHQPGE

Isoform C (identifier: Q9HD20-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-860: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1204	1204	Probable cation-transporting ATPase 13A1		PRO_0000046421
Regions
	Topological domain	1 – 66	66	Cytoplasmic Potential
	Transmembrane	67 – 87	21	Potential
	Topological domain	88 – 95	8	Extracellular Potential
	Transmembrane	96 – 116	21	Potential
	Topological domain	117 – 243	127	Cytoplasmic Potential
	Transmembrane	244 – 264	21	Potential
	Topological domain	265 – 443	179	Extracellular Potential
	Transmembrane	444 – 464	21	Potential
	Topological domain	465 – 989	525	Cytoplasmic Potential
	Transmembrane	990 – 1010	21	Potential
	Topological domain	1011	1	Extracellular Potential
	Transmembrane	1012 – 1032	21	Potential
	Topological domain	1033 – 1051	19	Cytoplasmic Potential
	Transmembrane	1052 – 1072	21	Potential
	Topological domain	1073 – 1096	24	Extracellular Potential
	Transmembrane	1097 – 1117	21	Potential
	Topological domain	1118 – 1132	15	Cytoplasmic Potential
	Transmembrane	1133 – 1153	21	Potential
	Topological domain	1154 – 1166	13	Extracellular Potential
	Transmembrane	1167 – 1187	21	Potential
	Topological domain	1188 – 1204	17	Cytoplasmic Potential
	Compositional bias	455 – 460	6	Poly-Ala
	Compositional bias	892 – 897	6	Poly-Arg
Sites
	Active site	533	1	4-aspartylphosphate intermediate By similarity
	Metal binding	864	1	Magnesium By similarity
	Metal binding	868	1	Magnesium By similarity
Amino acid modifications
	Modified residue	899	1	Phosphoserine Ref.7 Ref.8 Ref.10
	Modified residue	901	1	Phosphothreonine Ref.8
	Modified residue	935	1	Phosphoserine Ref.9
	Glycosylation	287	1	N-linked (GlcNAc...) Potential
	Glycosylation	420	1	N-linked (GlcNAc...) Ref.6
Natural variations
	Alternative sequence	1 – 860	860	Missing in isoform C.		VSP_000433
	Alternative sequence	1 – 118	118	Missing in isoform B.		VSP_000434
	Alternative sequence	119 – 132	14	HWSVH…LTCTP → MEKWEELNSHQPGE in isoform B.		VSP_000435

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified October 18, 2001. Version 2. Checksum: 9DE335C025FBBA89	FASTA	1,204	132,955
	10 20 30 40 50 60 MAAAAAVGNA VPCGARPCGV RPDGQPKPGP QPRALLAAGP ALIANGDELV AAVWPYRRLA 70 80 90 100 110 120 LLRRLTVLPF AGLLYPAWLG AAAAGCWGWG SSWVQIPEAA LLVLATICLA HALTVLSGHW 130 140 150 160 170 180 SVHAHCALTC TPEYDPSKAT FVKVVPTPNN GSTELVALHR NEGEDGLEVL SFEFQKIKYS 190 200 210 220 230 240 YDALEKKQFL PVAFPVGNAF SYYQSNRGFQ EDSEIRAAEK KFGSNKAEMV VPDFSELFKE 250 260 270 280 290 300 RATAPFFVFQ VFCVGLWCLD EYWYYSVFTL SMLVAFEASL VQQQMRNMSE IRKMGNKPHM 310 320 330 340 350 360 IQVYRSRKWR PIASDEIVPG DIVSIGRSPQ ENLVPCDVLL LRGRCIVDEA MLTGESVPQM 370 380 390 400 410 420 KEPIEDLSPD RVLDLQADSR LHVIFGGTKV VQHIPPQKAT TGLKPVDSGC VAYVLRTGFN 430 440 450 460 470 480 TSQGKLLRTI LFGVKRVTAN NLETFIFILF LLVFAIAAAA YVWIEGTKDP SRNRYKLFLE 490 500 510 520 530 540 CTLILTSVVP PELPIELSLA VNTSLIALAK LYMYCTEPFR IPFAGKVEVC CFDKTGTLTS 550 560 570 580 590 600 DSLVVRGVAG LRDGKEVTPV SSIPVETHRA LASCHSLMQL DDGTLVGDPL EKAMLTAVDW 610 620 630 640 650 660 TLTKDEKVFP RSIKTQGLKI HQRFHFASAL KRMSVLASYE KLGSTDLCYI AAVKGAPETL 670 680 690 700 710 720 HSMFSQCPPD YHHIHTEISR EGARVLALGY KELGHLTHQQ AREVKREALE CSLKFVGFIV 730 740 750 760 770 780 VSCPLKADSK AVIREIQNAS HRVVMITGDN PLTACHVAQE LHFIEKAHTL ILQPPSEKGR 790 800 810 820 830 840 QCEWRSIDGS IVLPLARGSP KALALEYALC LTGDGLAHLQ ATDPQQLLRL IPHVQVFARV 850 860 870 880 890 900 APKQKEFVIT SLKELGYVTL MCGDGTNDVG ALKHADVGVA LLANAPERVV ERRRRPRDSP 910 920 930 940 950 960 TLSNSGIRAT SRTAKQRSGL PPSEEQPTSQ RDRLSQVLRD LEDESTPIVK LGDASIAAPF 970 980 990 1000 1010 1020 TSKLSSIQCI CHVIKQGRCT LVTTLQMFKI LALNALILAY SQSVLYLEGV KFSDFQATLQ 1030 1040 1050 1060 1070 1080 GLLLAGCFLF ISRSKPLKTL SRERPLPNIF NLYTILTVML QFFVHFLSLV YLYREAQARS 1090 1100 1110 1120 1130 1140 PEKQEQFVDL YKEFEPSLVN STVYIMAMAM QMATFAINYK GPPFMESLPE NKPLVWSLAV 1150 1160 1170 1180 1190 1200 SLLAIIGLLL GSSPDFNSQF GLVDIPVEFK LVIAQVLLLD FCLALLADRV LQFFLGTPKL KVPS
	Isoform B. Checksum: 0D0D62BF402E68D0	FASTA	1,086	121,110
	10 20 30 40 50 60 MEKWEELNSH QPGEEYDPSK ATFVKVVPTP NNGSTELVAL HRNEGEDGLE VLSFEFQKIK 70 80 90 100 110 120 YSYDALEKKQ FLPVAFPVGN AFSYYQSNRG FQEDSEIRAA EKKFGSNKAE MVVPDFSELF 130 140 150 160 170 180 KERATAPFFV FQVFCVGLWC LDEYWYYSVF TLSMLVAFEA SLVQQQMRNM SEIRKMGNKP 190 200 210 220 230 240 HMIQVYRSRK WRPIASDEIV PGDIVSIGRS PQENLVPCDV LLLRGRCIVD EAMLTGESVP 250 260 270 280 290 300 QMKEPIEDLS PDRVLDLQAD SRLHVIFGGT KVVQHIPPQK ATTGLKPVDS GCVAYVLRTG 310 320 330 340 350 360 FNTSQGKLLR TILFGVKRVT ANNLETFIFI LFLLVFAIAA AAYVWIEGTK DPSRNRYKLF 370 380 390 400 410 420 LECTLILTSV VPPELPIELS LAVNTSLIAL AKLYMYCTEP FRIPFAGKVE VCCFDKTGTL 430 440 450 460 470 480 TSDSLVVRGV AGLRDGKEVT PVSSIPVETH RALASCHSLM QLDDGTLVGD PLEKAMLTAV 490 500 510 520 530 540 DWTLTKDEKV FPRSIKTQGL KIHQRFHFAS ALKRMSVLAS YEKLGSTDLC YIAAVKGAPE 550 560 570 580 590 600 TLHSMFSQCP PDYHHIHTEI SREGARVLAL GYKELGHLTH QQAREVKREA LECSLKFVGF 610 620 630 640 650 660 IVVSCPLKAD SKAVIREIQN ASHRVVMITG DNPLTACHVA QELHFIEKAH TLILQPPSEK 670 680 690 700 710 720 GRQCEWRSID GSIVLPLARG SPKALALEYA LCLTGDGLAH LQATDPQQLL RLIPHVQVFA 730 740 750 760 770 780 RVAPKQKEFV ITSLKELGYV TLMCGDGTND VGALKHADVG VALLANAPER VVERRRRPRD 790 800 810 820 830 840 SPTLSNSGIR ATSRTAKQRS GLPPSEEQPT SQRDRLSQVL RDLEDESTPI VKLGDASIAA 850 860 870 880 890 900 PFTSKLSSIQ CICHVIKQGR CTLVTTLQMF KILALNALIL AYSQSVLYLE GVKFSDFQAT 910 920 930 940 950 960 LQGLLLAGCF LFISRSKPLK TLSRERPLPN IFNLYTILTV MLQFFVHFLS LVYLYREAQA 970 980 990 1000 1010 1020 RSPEKQEQFV DLYKEFEPSL VNSTVYIMAM AMQMATFAIN YKGPPFMESL PENKPLVWSL 1030 1040 1050 1060 1070 1080 AVSLLAIIGL LLGSSPDFNS QFGLVDIPVE FKLVIAQVLL LDFCLALLAD RVLQFFLGTP KLKVPS
	Isoform C. Checksum: E988B4A90EC2DE3D	FASTA	344	38,207
	10 20 30 40 50 60 MCGDGTNDVG ALKHADVGVA LLANAPERVV ERRRRPRDSP TLSNSGIRAT SRTAKQRSGL 70 80 90 100 110 120 PPSEEQPTSQ RDRLSQVLRD LEDESTPIVK LGDASIAAPF TSKLSSIQCI CHVIKQGRCT 130 140 150 160 170 180 LVTTLQMFKI LALNALILAY SQSVLYLEGV KFSDFQATLQ GLLLAGCFLF ISRSKPLKTL 190 200 210 220 230 240 SRERPLPNIF NLYTILTVML QFFVHFLSLV YLYREAQARS PEKQEQFVDL YKEFEPSLVN 250 260 270 280 290 300 STVYIMAMAM QMATFAINYK GPPFMESLPE NKPLVWSLAV SLLAIIGLLL GSSPDFNSQF 310 320 330 340 GLVDIPVEFK LVIAQVLLLD FCLALLADRV LQFFLGTPKL KVPS

References

[1]	"Identification of novel human genes by comparative proteomics." Chou M.C.-H., Lin W.-C. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND C). Tissue: Kidney epithelium.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed: 11347906] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1204 (ISOFORM A). Tissue: Brain.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 844-1204. Tissue: Brain.
[6]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-420, MASS SPECTROMETRY. Tissue: Plasma.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-899, MASS SPECTROMETRY. Tissue: Epithelium.
[8]	"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis." Wang B., Malik R., Nigg E.A., Korner R. Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-899 AND THR-901, MASS SPECTROMETRY.
[9]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-935, MASS SPECTROMETRY.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-899, MASS SPECTROMETRY.
[11]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[12]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-899, MASS SPECTROMETRY. Tissue: T-cell.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF288687 mRNA. Translation: AAG01173.1. AK026044 mRNA. Translation: BAB15334.1. AK056420 mRNA. Translation: BAG51704.1. AK095287 mRNA. Translation: BAG53019.1. AB058728 mRNA. Translation: BAB47454.1. CH471106 Genomic DNA. Translation: EAW84849.1. CH471106 Genomic DNA. Translation: EAW84850.1. BC009302 mRNA. Translation: AAH09302.2.
IPI	IPI00034277. IPI00218353. IPI00218354.
RefSeq	NP_065143.2.
UniGene	Hs.501794
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9HD20.
PTM databases
PhosphoSite	Q9HD20.
Proteomic databases
PeptideAtlas	Q9HD20.
PRIDE	Q9HD20.
Genome annotation databases
Ensembl	ENST00000357324; ENSP00000349877; ENSG00000105726; Homo sapiens. [Genome view]
GeneID	57130.
KEGG	hsa:57130.
UCSC	uc002nne.1. human. uc002nng.1. human. uc002nnh.2. human.
Organism-specific databases
CTD	57130.
GeneCards	GC19M019620.
HGNC	HGNC:24215. ATP13A1.
PharmGKB	PA134988892.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9HD20.
HOVERGEN	Q9HD20.
OMA	YVYCTEP
OrthoDB	EOG905VKM
Gene expression databases
ArrayExpress	Q9HD20.
Bgee	Q9HD20.
CleanEx	HS_ATP13A1.
Genevestigator	Q9HD20.
GermOnline	ENSG00000105726. Homo sapiens.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-reg. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR006544. ATPase_P-typ_unknown-pump-sp. IPR005834. Dehalogen-like_hydro. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 2 hits. [Graphical view]
PRINTS	PR00119. CATATPASE.
TIGRFAMs	TIGR01494. ATPase_P-type. 3 hits. TIGR01657. P-ATPase-V. 1 hit.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	63043.

Entry information

Entry name

AT131_HUMAN

Accession

Primary (citable) accession number: Q9HD20
Secondary accession number(s): B3KPJ2, B3KTA7, Q9H6C6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	October 18, 2001
Last modified:	November 24, 2009
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.