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Q9HD20

- AT131_HUMAN

UniProt

Q9HD20 - AT131_HUMAN

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Protein

Manganese-transporting ATPase 13A1

Gene

ATP13A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei533 – 53314-aspartylphosphate intermediateBy similarity
Metal bindingi864 – 8641MagnesiumBy similarity
Metal bindingi868 – 8681MagnesiumBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cation-transporting ATPase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Protein family/group databases

TCDBi3.A.3.10.19. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Manganese-transporting ATPase 13A1 (EC:3.6.3.-)
Gene namesi
Name:ATP13A1
Synonyms:ATP13A, KIAA1825
ORF Names:CGI-152
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:24215. ATP13A1.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 6665CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei67 – 8721HelicalSequence AnalysisAdd
BLAST
Topological domaini88 – 958ExtracellularSequence Analysis
Transmembranei96 – 11621HelicalSequence AnalysisAdd
BLAST
Topological domaini117 – 243127CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence AnalysisAdd
BLAST
Topological domaini265 – 443179ExtracellularSequence AnalysisAdd
BLAST
Transmembranei444 – 46421HelicalSequence AnalysisAdd
BLAST
Topological domaini465 – 989525CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei990 – 101021HelicalSequence AnalysisAdd
BLAST
Topological domaini1011 – 10111ExtracellularSequence Analysis
Transmembranei1012 – 103221HelicalSequence AnalysisAdd
BLAST
Topological domaini1033 – 105119CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei1052 – 107221HelicalSequence AnalysisAdd
BLAST
Topological domaini1073 – 109624ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1097 – 111721HelicalSequence AnalysisAdd
BLAST
Topological domaini1118 – 113215CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei1133 – 115321HelicalSequence AnalysisAdd
BLAST
Topological domaini1154 – 116613ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1167 – 118721HelicalSequence AnalysisAdd
BLAST
Topological domaini1188 – 120417CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134988892.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 12041203Manganese-transporting ATPase 13A1PRO_0000046421Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi420 – 4201N-linked (GlcNAc...)1 Publication
Modified residuei899 – 8991Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9HD20.
PaxDbiQ9HD20.
PeptideAtlasiQ9HD20.
PRIDEiQ9HD20.

PTM databases

PhosphoSiteiQ9HD20.

Expressioni

Gene expression databases

BgeeiQ9HD20.
CleanExiHS_ATP13A1.
ExpressionAtlasiQ9HD20. baseline and differential.
GenevestigatoriQ9HD20.

Organism-specific databases

HPAiHPA031798.
HPA049717.

Interactioni

Protein-protein interaction databases

BioGridi121393. 4 interactions.
IntActiQ9HD20. 1 interaction.
STRINGi9606.ENSP00000349877.

Structurei

3D structure databases

ProteinModelPortaliQ9HD20.
SMRiQ9HD20. Positions 260-881.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi455 – 4606Poly-Ala
Compositional biasi892 – 8976Poly-Arg

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
GeneTreeiENSGT00550000075064.
HOGENOMiHOG000199432.
HOVERGENiHBG050602.
InParanoidiQ9HD20.
KOiK14950.
OMAiIISCPLK.
OrthoDBiEOG7T1R9G.
PhylomeDBiQ9HD20.
TreeFamiTF300725.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR006544. ATPase_P-typ_Cation_typ_V.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PANTHERiPTHR24093:SF82. PTHR24093:SF82. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Note: Experimental confirmation may be lacking for some isoforms.

Isoform A (identifier: Q9HD20-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAAVGNA VPCGARPCGV RPDGQPKPGP QPRALLAAGP ALIANGDELV
60 70 80 90 100
AAVWPYRRLA LLRRLTVLPF AGLLYPAWLG AAAAGCWGWG SSWVQIPEAA
110 120 130 140 150
LLVLATICLA HALTVLSGHW SVHAHCALTC TPEYDPSKAT FVKVVPTPNN
160 170 180 190 200
GSTELVALHR NEGEDGLEVL SFEFQKIKYS YDALEKKQFL PVAFPVGNAF
210 220 230 240 250
SYYQSNRGFQ EDSEIRAAEK KFGSNKAEMV VPDFSELFKE RATAPFFVFQ
260 270 280 290 300
VFCVGLWCLD EYWYYSVFTL SMLVAFEASL VQQQMRNMSE IRKMGNKPHM
310 320 330 340 350
IQVYRSRKWR PIASDEIVPG DIVSIGRSPQ ENLVPCDVLL LRGRCIVDEA
360 370 380 390 400
MLTGESVPQM KEPIEDLSPD RVLDLQADSR LHVIFGGTKV VQHIPPQKAT
410 420 430 440 450
TGLKPVDSGC VAYVLRTGFN TSQGKLLRTI LFGVKRVTAN NLETFIFILF
460 470 480 490 500
LLVFAIAAAA YVWIEGTKDP SRNRYKLFLE CTLILTSVVP PELPIELSLA
510 520 530 540 550
VNTSLIALAK LYMYCTEPFR IPFAGKVEVC CFDKTGTLTS DSLVVRGVAG
560 570 580 590 600
LRDGKEVTPV SSIPVETHRA LASCHSLMQL DDGTLVGDPL EKAMLTAVDW
610 620 630 640 650
TLTKDEKVFP RSIKTQGLKI HQRFHFASAL KRMSVLASYE KLGSTDLCYI
660 670 680 690 700
AAVKGAPETL HSMFSQCPPD YHHIHTEISR EGARVLALGY KELGHLTHQQ
710 720 730 740 750
AREVKREALE CSLKFVGFIV VSCPLKADSK AVIREIQNAS HRVVMITGDN
760 770 780 790 800
PLTACHVAQE LHFIEKAHTL ILQPPSEKGR QCEWRSIDGS IVLPLARGSP
810 820 830 840 850
KALALEYALC LTGDGLAHLQ ATDPQQLLRL IPHVQVFARV APKQKEFVIT
860 870 880 890 900
SLKELGYVTL MCGDGTNDVG ALKHADVGVA LLANAPERVV ERRRRPRDSP
910 920 930 940 950
TLSNSGIRAT SRTAKQRSGL PPSEEQPTSQ RDRLSQVLRD LEDESTPIVK
960 970 980 990 1000
LGDASIAAPF TSKLSSIQCI CHVIKQGRCT LVTTLQMFKI LALNALILAY
1010 1020 1030 1040 1050
SQSVLYLEGV KFSDFQATLQ GLLLAGCFLF ISRSKPLKTL SRERPLPNIF
1060 1070 1080 1090 1100
NLYTILTVML QFFVHFLSLV YLYREAQARS PEKQEQFVDL YKEFEPSLVN
1110 1120 1130 1140 1150
STVYIMAMAM QMATFAINYK GPPFMESLPE NKPLVWSLAV SLLAIIGLLL
1160 1170 1180 1190 1200
GSSPDFNSQF GLVDIPVEFK LVIAQVLLLD FCLALLADRV LQFFLGTPKL

KVPS
Length:1,204
Mass (Da):132,955
Last modified:October 18, 2001 - v2
Checksum:i9DE335C025FBBA89
GO
Isoform B (identifier: Q9HD20-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.
     119-132: HWSVHAHCALTCTP → MEKWEELNSHQPGE

Show »
Length:1,086
Mass (Da):121,110
Checksum:i0D0D62BF402E68D0
GO
Isoform C (identifier: Q9HD20-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-860: Missing.

Show »
Length:344
Mass (Da):38,207
Checksum:iE988B4A90EC2DE3D
GO

Sequence cautioni

The sequence AAH69211.1 differs from that shown. Reason: Frameshift at position 846. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti364 – 3641I → T in BAD18759. (PubMed:14702039)Curated
Sequence conflicti501 – 5011V → D in BAD18759. (PubMed:14702039)Curated
Sequence conflicti1150 – 11501L → P in BAD18759. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 860860Missing in isoform C. 1 PublicationVSP_000433Add
BLAST
Alternative sequencei1 – 118118Missing in isoform B. 1 PublicationVSP_000434Add
BLAST
Alternative sequencei119 – 13214HWSVH…LTCTP → MEKWEELNSHQPGE in isoform B. 1 PublicationVSP_000435Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288687 mRNA. Translation: AAG01173.1.
AK026044 mRNA. Translation: BAB15334.1.
AK056420 mRNA. Translation: BAG51704.1.
AK095287 mRNA. Translation: BAG53019.1.
AK172778 mRNA. Translation: BAD18759.1.
AB058728 mRNA. Translation: BAB47454.1.
CH471106 Genomic DNA. Translation: EAW84849.1.
CH471106 Genomic DNA. Translation: EAW84850.1.
BC009302 mRNA. Translation: AAH09302.2.
BC069211 mRNA. Translation: AAH69211.1. Frameshift.
CCDSiCCDS32970.2. [Q9HD20-1]
RefSeqiNP_065143.2. NM_020410.2. [Q9HD20-1]
UniGeneiHs.501794.

Genome annotation databases

EnsembliENST00000291503; ENSP00000291503; ENSG00000105726. [Q9HD20-2]
ENST00000357324; ENSP00000349877; ENSG00000105726. [Q9HD20-1]
GeneIDi57130.
KEGGihsa:57130.
UCSCiuc002nne.3. human. [Q9HD20-3]
uc002nnf.4. human. [Q9HD20-2]
uc002nnh.4. human. [Q9HD20-1]

Polymorphism databases

DMDMi18202961.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288687 mRNA. Translation: AAG01173.1 .
AK026044 mRNA. Translation: BAB15334.1 .
AK056420 mRNA. Translation: BAG51704.1 .
AK095287 mRNA. Translation: BAG53019.1 .
AK172778 mRNA. Translation: BAD18759.1 .
AB058728 mRNA. Translation: BAB47454.1 .
CH471106 Genomic DNA. Translation: EAW84849.1 .
CH471106 Genomic DNA. Translation: EAW84850.1 .
BC009302 mRNA. Translation: AAH09302.2 .
BC069211 mRNA. Translation: AAH69211.1 . Frameshift.
CCDSi CCDS32970.2. [Q9HD20-1 ]
RefSeqi NP_065143.2. NM_020410.2. [Q9HD20-1 ]
UniGenei Hs.501794.

3D structure databases

ProteinModelPortali Q9HD20.
SMRi Q9HD20. Positions 260-881.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121393. 4 interactions.
IntActi Q9HD20. 1 interaction.
STRINGi 9606.ENSP00000349877.

Protein family/group databases

TCDBi 3.A.3.10.19. the p-type atpase (p-atpase) superfamily.

PTM databases

PhosphoSitei Q9HD20.

Polymorphism databases

DMDMi 18202961.

Proteomic databases

MaxQBi Q9HD20.
PaxDbi Q9HD20.
PeptideAtlasi Q9HD20.
PRIDEi Q9HD20.

Protocols and materials databases

DNASUi 57130.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000291503 ; ENSP00000291503 ; ENSG00000105726 . [Q9HD20-2 ]
ENST00000357324 ; ENSP00000349877 ; ENSG00000105726 . [Q9HD20-1 ]
GeneIDi 57130.
KEGGi hsa:57130.
UCSCi uc002nne.3. human. [Q9HD20-3 ]
uc002nnf.4. human. [Q9HD20-2 ]
uc002nnh.4. human. [Q9HD20-1 ]

Organism-specific databases

CTDi 57130.
GeneCardsi GC19M019758.
HGNCi HGNC:24215. ATP13A1.
HPAi HPA031798.
HPA049717.
neXtProti NX_Q9HD20.
PharmGKBi PA134988892.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0474.
GeneTreei ENSGT00550000075064.
HOGENOMi HOG000199432.
HOVERGENi HBG050602.
InParanoidi Q9HD20.
KOi K14950.
OMAi IISCPLK.
OrthoDBi EOG7T1R9G.
PhylomeDBi Q9HD20.
TreeFami TF300725.

Miscellaneous databases

ChiTaRSi ATP13A1. human.
GenomeRNAii 57130.
NextBioi 63043.
PROi Q9HD20.

Gene expression databases

Bgeei Q9HD20.
CleanExi HS_ATP13A1.
ExpressionAtlasi Q9HD20. baseline and differential.
Genevestigatori Q9HD20.

Family and domain databases

Gene3Di 2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProi IPR006544. ATPase_P-typ_Cation_typ_V.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
PANTHERi PTHR24093:SF82. PTHR24093:SF82. 1 hit.
Pfami PF00122. E1-E2_ATPase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SUPFAMi SSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human genes by comparative proteomics."
    Chou M.C.-H., Lin W.-C.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND C).
    Tissue: Hepatoma and Kidney epithelium.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1204 (ISOFORM A).
    Tissue: Brain.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 844-1204.
    Tissue: Brain and Kidney.
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-420.
    Tissue: Plasma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-899, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: FUNCTION, SUBCELLULAR LOCATION, MISCELLANEOUS.

Entry informationi

Entry nameiAT131_HUMAN
AccessioniPrimary (citable) accession number: Q9HD20
Secondary accession number(s): B3KPJ2
, B3KTA7, Q6NT90, Q6ZMG7, Q9H6C6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: October 29, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Depletion of ATP13A1 with siRNAs leads to induction of the unfolded protein response (UPR) and increased activity of glucosylceramide synthase (GlcCer).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3