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Reviewed, UniProtKB/Swiss-Prot Q9HD20 (AT131_HUMAN)

Last modified November 24, 2009. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Probable cation-transporting ATPase 13A1
    EC=3.6.3.-
Gene names
Name: ATP13A1
Synonyms: ATP13A, KIAA1825
ORF Names: CGI-152
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1204 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

ATP + H2O = ADP + phosphate.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cation transport ATPase (P-type) family. Type V subfamily.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.
Isoform A (identifier: Q9HD20-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: Q9HD20-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.
     119-132: HWSVHAHCALTCTP → MEKWEELNSHQPGE
Isoform C (identifier: Q9HD20-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-860: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12041204Probable cation-transporting ATPase 13A1
PRO_0000046421

Regions

Topological domain1 – 6666Cytoplasmic Potential
Transmembrane67 – 8721 Potential
Topological domain88 – 958Extracellular Potential
Transmembrane96 – 11621 Potential
Topological domain117 – 243127Cytoplasmic Potential
Transmembrane244 – 26421 Potential
Topological domain265 – 443179Extracellular Potential
Transmembrane444 – 46421 Potential
Topological domain465 – 989525Cytoplasmic Potential
Transmembrane990 – 101021 Potential
Topological domain10111Extracellular Potential
Transmembrane1012 – 103221 Potential
Topological domain1033 – 105119Cytoplasmic Potential
Transmembrane1052 – 107221 Potential
Topological domain1073 – 109624Extracellular Potential
Transmembrane1097 – 111721 Potential
Topological domain1118 – 113215Cytoplasmic Potential
Transmembrane1133 – 115321 Potential
Topological domain1154 – 116613Extracellular Potential
Transmembrane1167 – 118721 Potential
Topological domain1188 – 120417Cytoplasmic Potential
Compositional bias455 – 4606Poly-Ala
Compositional bias892 – 8976Poly-Arg

Sites

Active site53314-aspartylphosphate intermediate By similarity
Metal binding8641Magnesium By similarity
Metal binding8681Magnesium By similarity

Amino acid modifications

Modified residue8991Phosphoserine Ref.7 Ref.8 Ref.10
Modified residue9011Phosphothreonine Ref.8
Modified residue9351Phosphoserine Ref.9
Glycosylation2871N-linked (GlcNAc...) Potential
Glycosylation4201N-linked (GlcNAc...) Ref.6

Natural variations

Alternative sequence1 – 860860Missing in isoform C.
VSP_000433
Alternative sequence1 – 118118Missing in isoform B.
VSP_000434
Alternative sequence119 – 13214HWSVH…LTCTP → MEKWEELNSHQPGE in isoform B.
VSP_000435

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified October 18, 2001. Version 2.
Checksum: 9DE335C025FBBA89

FASTA1,204132,955
        10         20         30         40         50         60 
MAAAAAVGNA VPCGARPCGV RPDGQPKPGP QPRALLAAGP ALIANGDELV AAVWPYRRLA 

        70         80         90        100        110        120 
LLRRLTVLPF AGLLYPAWLG AAAAGCWGWG SSWVQIPEAA LLVLATICLA HALTVLSGHW 

       130        140        150        160        170        180 
SVHAHCALTC TPEYDPSKAT FVKVVPTPNN GSTELVALHR NEGEDGLEVL SFEFQKIKYS 

       190        200        210        220        230        240 
YDALEKKQFL PVAFPVGNAF SYYQSNRGFQ EDSEIRAAEK KFGSNKAEMV VPDFSELFKE 

       250        260        270        280        290        300 
RATAPFFVFQ VFCVGLWCLD EYWYYSVFTL SMLVAFEASL VQQQMRNMSE IRKMGNKPHM 

       310        320        330        340        350        360 
IQVYRSRKWR PIASDEIVPG DIVSIGRSPQ ENLVPCDVLL LRGRCIVDEA MLTGESVPQM 

       370        380        390        400        410        420 
KEPIEDLSPD RVLDLQADSR LHVIFGGTKV VQHIPPQKAT TGLKPVDSGC VAYVLRTGFN 

       430        440        450        460        470        480 
TSQGKLLRTI LFGVKRVTAN NLETFIFILF LLVFAIAAAA YVWIEGTKDP SRNRYKLFLE 

       490        500        510        520        530        540 
CTLILTSVVP PELPIELSLA VNTSLIALAK LYMYCTEPFR IPFAGKVEVC CFDKTGTLTS 

       550        560        570        580        590        600 
DSLVVRGVAG LRDGKEVTPV SSIPVETHRA LASCHSLMQL DDGTLVGDPL EKAMLTAVDW 

       610        620        630        640        650        660 
TLTKDEKVFP RSIKTQGLKI HQRFHFASAL KRMSVLASYE KLGSTDLCYI AAVKGAPETL 

       670        680        690        700        710        720 
HSMFSQCPPD YHHIHTEISR EGARVLALGY KELGHLTHQQ AREVKREALE CSLKFVGFIV 

       730        740        750        760        770        780 
VSCPLKADSK AVIREIQNAS HRVVMITGDN PLTACHVAQE LHFIEKAHTL ILQPPSEKGR 

       790        800        810        820        830        840 
QCEWRSIDGS IVLPLARGSP KALALEYALC LTGDGLAHLQ ATDPQQLLRL IPHVQVFARV 

       850        860        870        880        890        900 
APKQKEFVIT SLKELGYVTL MCGDGTNDVG ALKHADVGVA LLANAPERVV ERRRRPRDSP 

       910        920        930        940        950        960 
TLSNSGIRAT SRTAKQRSGL PPSEEQPTSQ RDRLSQVLRD LEDESTPIVK LGDASIAAPF 

       970        980        990       1000       1010       1020 
TSKLSSIQCI CHVIKQGRCT LVTTLQMFKI LALNALILAY SQSVLYLEGV KFSDFQATLQ 

      1030       1040       1050       1060       1070       1080 
GLLLAGCFLF ISRSKPLKTL SRERPLPNIF NLYTILTVML QFFVHFLSLV YLYREAQARS 

      1090       1100       1110       1120       1130       1140 
PEKQEQFVDL YKEFEPSLVN STVYIMAMAM QMATFAINYK GPPFMESLPE NKPLVWSLAV 

      1150       1160       1170       1180       1190       1200 
SLLAIIGLLL GSSPDFNSQF GLVDIPVEFK LVIAQVLLLD FCLALLADRV LQFFLGTPKL 


KVPS 

« Hide

Isoform B.

Checksum: 0D0D62BF402E68D0
Show »

FASTA1,086121,110
Isoform C.

Checksum: E988B4A90EC2DE3D
Show »

FASTA34438,207

References

[1]"Identification of novel human genes by comparative proteomics."
Chou M.C.-H., Lin W.-C.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND C).
Tissue: Kidney epithelium.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
DNA Res. 8:85-95(2001) [PubMed: 11347906] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1204 (ISOFORM A).
Tissue: Brain.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 844-1204.
Tissue: Brain.
[6]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-420, MASS SPECTROMETRY.
Tissue: Plasma.
[7]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed: 17081983] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-899, MASS SPECTROMETRY.
Tissue: Epithelium.
[8]"Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis."
Wang B., Malik R., Nigg E.A., Korner R.
Anal. Chem. 80:9526-9533(2008) [PubMed: 19007248] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-899 AND THR-901, MASS SPECTROMETRY.
[9]"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.
Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-935, MASS SPECTROMETRY.
[10]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-899, MASS SPECTROMETRY.
[11]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[12]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-899, MASS SPECTROMETRY.
Tissue: T-cell.

Cross-references

Sequence databases

AF288687 mRNA. Translation: AAG01173.1.
AK026044 mRNA. Translation: BAB15334.1.
AK056420 mRNA. Translation: BAG51704.1.
AK095287 mRNA. Translation: BAG53019.1.
AB058728 mRNA. Translation: BAB47454.1.
CH471106 Genomic DNA. Translation: EAW84849.1.
CH471106 Genomic DNA. Translation: EAW84850.1.
BC009302 mRNA. Translation: AAH09302.2.
IPIIPI00034277.
IPI00218353.
IPI00218354.
RefSeqNP_065143.2.
UniGeneHs.501794

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ9HD20.

PTM databases

PhosphoSiteQ9HD20.

Proteomic databases

PeptideAtlasQ9HD20.
PRIDEQ9HD20.

Genome annotation databases

EnsemblENST00000357324; ENSP00000349877; ENSG00000105726; Homo sapiens. [Genome view]
GeneID57130.
KEGGhsa:57130.
UCSCuc002nne.1. human.
uc002nng.1. human.
uc002nnh.2. human.

Organism-specific databases

CTD57130.
GeneCardsGC19M019620.
HGNCHGNC:24215. ATP13A1.
PharmGKBPA134988892.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9HD20.
HOVERGENQ9HD20.
OMAYVYCTEP
OrthoDBEOG905VKM

Gene expression databases

ArrayExpressQ9HD20.
BgeeQ9HD20.
CleanExHS_ATP13A1.
GenevestigatorQ9HD20.
GermOnlineENSG00000105726. Homo sapiens.

Family and domain databases

InterProIPR008250. ATPase_P-typ_ATPase-assoc-reg.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR006544. ATPase_P-typ_unknown-pump-sp.
IPR005834. Dehalogen-like_hydro.
[Graphical view]
PANTHERPTHR11939. ATPase_P. 1 hit.
PfamPF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 2 hits.
[Graphical view]
PRINTSPR00119. CATATPASE.
TIGRFAMsTIGR01494. ATPase_P-type. 3 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio63043.

Entry information

Entry nameAT131_HUMAN
AccessionPrimary (citable) accession number: Q9HD20
Secondary accession number(s): B3KPJ2, B3KTA7, Q9H6C6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: November 24, 2009
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents