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Protein

Zinc finger protein 334

Gene

ZNF334

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri237 – 25923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri461 – 48323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri544 – 56623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri572 – 59423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri600 – 62223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri628 – 65023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri656 – 67823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 334
Gene namesi
Name:ZNF334
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15806. ZNF334.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38040.

Polymorphism and mutation databases

BioMutaiZNF334.
DMDMi20141040.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 680680Zinc finger protein 334PRO_0000047537Add
BLAST

Proteomic databases

EPDiQ9HCZ1.
PaxDbiQ9HCZ1.
PeptideAtlasiQ9HCZ1.
PRIDEiQ9HCZ1.

PTM databases

iPTMnetiQ9HCZ1.
PhosphoSiteiQ9HCZ1.

Expressioni

Gene expression databases

BgeeiQ9HCZ1.
CleanExiHS_ZNF334.
ExpressionAtlasiQ9HCZ1. baseline and differential.
GenevisibleiQ9HCZ1. HS.

Organism-specific databases

HPAiHPA050022.

Interactioni

Protein-protein interaction databases

BioGridi120835. 1 interaction.
IntActiQ9HCZ1. 2 interactions.
STRINGi9606.ENSP00000255129.

Structurei

3D structure databases

ProteinModelPortaliQ9HCZ1.
SMRiQ9HCZ1. Positions 10-52, 168-678.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 8172KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri237 – 25923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri461 – 48323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri544 – 56623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri572 – 59423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri600 – 62223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri628 – 65023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri656 – 67823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129694.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9HCZ1.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9HCZ1.
TreeFamiTF337898.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HCZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMKKFQIPV SFQDLTVNFT QEEWQQLDPA QRLLYRDVML ENYSNLVSVG
60 70 80 90 100
YHVSKPDVIF KLEQGEEPWI VEEFSNQNYP DIDDALEKNK EIQDKHLTQT
110 120 130 140 150
VFFSNKTLIT ERENVFGKTL NLGMNSVPSR KMPYKCNPGG NSLKTNSEVI
160 170 180 190 200
VAKKSKENRK IPDGYSGFGK HEKSHLGMKK YRYNPMRKAS NQNENLILHQ
210 220 230 240 250
NIQILKQPFD YNKCGKTFFK RAILITQKGR QTERKPNECN ECRKTFSKRS
260 270 280 290 300
TLIVHQRIHT GEKPYVCSDC RKTFRVKTSL TRHRRIHTGE RPYECSECRK
310 320 330 340 350
TFIDKSALIV HQKIHGGEKS YECNECGKTF FRKSALAEHF RSHTGEKPYE
360 370 380 390 400
CKECGNAFSK KSYLVVHQRT HRGEKPNECK ECGKTFFCQS ALTAHQRIHT
410 420 430 440 450
GEKPYECSEC EKTFFCQSAL NVHRRSHTGE KPYECSQCGK FLCTKSALIA
460 470 480 490 500
HQITHRGKKS YECNECGKFF CHKSTLTIHQ RTHTGEKHGV FNKCGRISIV
510 520 530 540 550
KSNCSQCKRM NTKENLYECS EHGHAVSKNS HLIVHQRTIW ERPYECNECG
560 570 580 590 600
RTYCRKSALT HHQRTHTGQR PYECNECGKT FCQKFSFVEH QRTHTGEKPY
610 620 630 640 650
ECNECGKSFC HKSAFRVHRR IHTGEKPYEC NQCGKTYRRL WTLTEHQKIH
660 670 680
TGEKPYECNK CEKTFRHKSN FLLHQKSHKE
Length:680
Mass (Da):79,649
Last modified:January 23, 2002 - v2
Checksum:i77DB5086B9261DC6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti118 – 1181K → E in BAA91630 (PubMed:14702039).Curated
Sequence conflicti426 – 4261S → G in BAA91630 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti547 – 5471N → S.
Corresponds to variant rs3764690 [ dbSNP | Ensembl ].
VAR_052813

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001331 mRNA. Translation: BAA91630.1.
AL034424, AL354745 Genomic DNA. Translation: CAI42502.1.
AL354745, AL034424 Genomic DNA. Translation: CAI12459.1.
BC024177 mRNA. Translation: AAH24177.1.
CCDSiCCDS33480.1.
RefSeqiNP_060572.3. NM_018102.4.
XP_006723880.1. XM_006723817.2.
XP_011527198.1. XM_011528896.1.
UniGeneiHs.147041.

Genome annotation databases

EnsembliENST00000347606; ENSP00000255129; ENSG00000198185.
GeneIDi55713.
KEGGihsa:55713.
UCSCiuc002xsc.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001331 mRNA. Translation: BAA91630.1.
AL034424, AL354745 Genomic DNA. Translation: CAI42502.1.
AL354745, AL034424 Genomic DNA. Translation: CAI12459.1.
BC024177 mRNA. Translation: AAH24177.1.
CCDSiCCDS33480.1.
RefSeqiNP_060572.3. NM_018102.4.
XP_006723880.1. XM_006723817.2.
XP_011527198.1. XM_011528896.1.
UniGeneiHs.147041.

3D structure databases

ProteinModelPortaliQ9HCZ1.
SMRiQ9HCZ1. Positions 10-52, 168-678.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120835. 1 interaction.
IntActiQ9HCZ1. 2 interactions.
STRINGi9606.ENSP00000255129.

PTM databases

iPTMnetiQ9HCZ1.
PhosphoSiteiQ9HCZ1.

Polymorphism and mutation databases

BioMutaiZNF334.
DMDMi20141040.

Proteomic databases

EPDiQ9HCZ1.
PaxDbiQ9HCZ1.
PeptideAtlasiQ9HCZ1.
PRIDEiQ9HCZ1.

Protocols and materials databases

DNASUi55713.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347606; ENSP00000255129; ENSG00000198185.
GeneIDi55713.
KEGGihsa:55713.
UCSCiuc002xsc.5. human.

Organism-specific databases

CTDi55713.
GeneCardsiZNF334.
HGNCiHGNC:15806. ZNF334.
HPAiHPA050022.
neXtProtiNX_Q9HCZ1.
PharmGKBiPA38040.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129694.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9HCZ1.
KOiK09228.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9HCZ1.
TreeFamiTF337898.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF334. human.
GenomeRNAii55713.
PROiQ9HCZ1.

Gene expression databases

BgeeiQ9HCZ1.
CleanExiHS_ZNF334.
ExpressionAtlasiQ9HCZ1. baseline and differential.
GenevisibleiQ9HCZ1. HS.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 14 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZN334_HUMAN
AccessioniPrimary (citable) accession number: Q9HCZ1
Secondary accession number(s): Q5T6U2, Q9NVW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: July 6, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.