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Protein

Zinc finger protein 334

Gene

ZNF334

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri237 – 259C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 287C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri293 – 315C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 343C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri461 – 483C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri544 – 566C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 594C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri600 – 622C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri628 – 650C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri656 – 678C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 334
Gene namesi
Name:ZNF334
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000198185.11
HGNCiHGNC:15806 ZNF334
neXtProtiNX_Q9HCZ1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55713
OpenTargetsiENSG00000198185
PharmGKBiPA38040

Polymorphism and mutation databases

BioMutaiZNF334
DMDMi20141040

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475371 – 680Zinc finger protein 334Add BLAST680

Proteomic databases

EPDiQ9HCZ1
MaxQBiQ9HCZ1
PaxDbiQ9HCZ1
PeptideAtlasiQ9HCZ1
PRIDEiQ9HCZ1
ProteomicsDBi81808

PTM databases

iPTMnetiQ9HCZ1
PhosphoSitePlusiQ9HCZ1

Expressioni

Gene expression databases

BgeeiENSG00000198185
CleanExiHS_ZNF334
ExpressionAtlasiQ9HCZ1 baseline and differential
GenevisibleiQ9HCZ1 HS

Organism-specific databases

HPAiHPA050022

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-748965,EBI-748961

Protein-protein interaction databases

BioGridi120835, 1 interactor
IntActiQ9HCZ1, 2 interactors
STRINGi9606.ENSP00000255129

Structurei

3D structure databases

ProteinModelPortaliQ9HCZ1
SMRiQ9HCZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 81KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri237 – 259C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 287C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri293 – 315C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 343C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri461 – 483C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri544 – 566C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 594C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri600 – 622C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri628 – 650C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri656 – 678C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140826
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9HCZ1
KOiK09228
PhylomeDBiQ9HCZ1
TreeFamiTF337898

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

Sequencei

Sequence statusi: Complete.

Q9HCZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMKKFQIPV SFQDLTVNFT QEEWQQLDPA QRLLYRDVML ENYSNLVSVG
60 70 80 90 100
YHVSKPDVIF KLEQGEEPWI VEEFSNQNYP DIDDALEKNK EIQDKHLTQT
110 120 130 140 150
VFFSNKTLIT ERENVFGKTL NLGMNSVPSR KMPYKCNPGG NSLKTNSEVI
160 170 180 190 200
VAKKSKENRK IPDGYSGFGK HEKSHLGMKK YRYNPMRKAS NQNENLILHQ
210 220 230 240 250
NIQILKQPFD YNKCGKTFFK RAILITQKGR QTERKPNECN ECRKTFSKRS
260 270 280 290 300
TLIVHQRIHT GEKPYVCSDC RKTFRVKTSL TRHRRIHTGE RPYECSECRK
310 320 330 340 350
TFIDKSALIV HQKIHGGEKS YECNECGKTF FRKSALAEHF RSHTGEKPYE
360 370 380 390 400
CKECGNAFSK KSYLVVHQRT HRGEKPNECK ECGKTFFCQS ALTAHQRIHT
410 420 430 440 450
GEKPYECSEC EKTFFCQSAL NVHRRSHTGE KPYECSQCGK FLCTKSALIA
460 470 480 490 500
HQITHRGKKS YECNECGKFF CHKSTLTIHQ RTHTGEKHGV FNKCGRISIV
510 520 530 540 550
KSNCSQCKRM NTKENLYECS EHGHAVSKNS HLIVHQRTIW ERPYECNECG
560 570 580 590 600
RTYCRKSALT HHQRTHTGQR PYECNECGKT FCQKFSFVEH QRTHTGEKPY
610 620 630 640 650
ECNECGKSFC HKSAFRVHRR IHTGEKPYEC NQCGKTYRRL WTLTEHQKIH
660 670 680
TGEKPYECNK CEKTFRHKSN FLLHQKSHKE
Length:680
Mass (Da):79,649
Last modified:January 23, 2002 - v2
Checksum:i77DB5086B9261DC6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118K → E in BAA91630 (PubMed:14702039).Curated1
Sequence conflicti426S → G in BAA91630 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052813547N → S. Corresponds to variant dbSNP:rs3764690Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001331 mRNA Translation: BAA91630.1
AL034424 Genomic DNA No translation available.
AL354745 Genomic DNA No translation available.
BC024177 mRNA Translation: AAH24177.1
CCDSiCCDS33480.1
RefSeqiNP_060572.3, NM_018102.4
XP_016883425.1, XM_017027936.1
XP_016883427.1, XM_017027938.1
UniGeneiHs.147041

Genome annotation databases

EnsembliENST00000347606; ENSP00000255129; ENSG00000198185
GeneIDi55713
KEGGihsa:55713
UCSCiuc002xsc.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN334_HUMAN
AccessioniPrimary (citable) accession number: Q9HCZ1
Secondary accession number(s): Q5T6U2, Q9NVW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: June 20, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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