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Protein

Protein S100-A14

Gene

S100A14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.3 Publications

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • chemokine receptor binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • calcium ion homeostasis Source: UniProtKB
  • defense response to bacterium Source: UniProtKB
  • positive regulation of granulocyte chemotaxis Source: UniProtKB
  • positive regulation of monocyte chemotaxis Source: UniProtKB
  • response to lipopolysaccharide Source: UniProtKB
  • toll-like receptor 4 signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135289-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A14
Alternative name(s):
S100 calcium-binding protein A14
Short name:
S114
Gene namesi
Name:S100A14
Synonyms:S100A15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18901. S100A14.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: HPA
  • cytoplasm Source: HPA
  • extracellular exosome Source: UniProtKB
  • microtubule cytoskeleton Source: HPA
  • nucleoplasm Source: HPA
  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi57402.
OpenTargetsiENSG00000189334.
PharmGKBiPA134905502.

Polymorphism and mutation databases

BioMutaiS100A14.
DMDMi20178118.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440211 – 104Protein S100-A14Add BLAST104

Proteomic databases

EPDiQ9HCY8.
MaxQBiQ9HCY8.
PaxDbiQ9HCY8.
PeptideAtlasiQ9HCY8.
PRIDEiQ9HCY8.
TopDownProteomicsiQ9HCY8.

PTM databases

iPTMnetiQ9HCY8.
PhosphoSitePlusiQ9HCY8.
SwissPalmiQ9HCY8.

Expressioni

Tissue specificityi

Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, small intestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000189334.
CleanExiHS_S100A14.
GenevisibleiQ9HCY8. HS.

Organism-specific databases

HPAiHPA027613.

Interactioni

Subunit structurei

Homodimer. Interacts with AGER.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA6P433603EBI-751842,EBI-1045155
S100A16Q96FQ66EBI-751842,EBI-751850

GO - Molecular functioni

  • chemokine receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121504. 20 interactors.
IntActiQ9HCY8. 10 interactors.
MINTiMINT-5002007.
STRINGi9606.ENSP00000340463.

Structurei

Secondary structure

1104
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 11Combined sources4
Helixi19 – 32Combined sources14
Turni34 – 39Combined sources6
Helixi43 – 53Combined sources11
Turni55 – 57Combined sources3
Helixi60 – 62Combined sources3
Helixi65 – 71Combined sources7
Helixi81 – 94Combined sources14
Beta strandi98 – 100Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M0RNMR-A/B1-104[»]
ProteinModelPortaliQ9HCY8.
SMRiQ9HCY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 61EF-handAdd BLAST35

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 1 EF-hand domain.Curated

Phylogenomic databases

eggNOGiENOG410IZKB. Eukaryota.
ENOG4111EF5. LUCA.
GeneTreeiENSGT00530000063972.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiQ9HCY8.
OMAiNLGNCND.
OrthoDBiEOG091G0YGX.
PhylomeDBiQ9HCY8.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR013787. S100_Ca-bd_sub.
IPR028493. S100A14.
[Graphical view]
PANTHERiPTHR11639:SF4. PTHR11639:SF4. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HCY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQCRSANAE DAQEFSDVER AIETLIKNFH QYSVEGGKET LTPSELRDLV
60 70 80 90 100
TQQLPHLMPS NCGLEEKIAN LGSCNDSKLE FRSFWELIGE AAKSVKLERP

VRGH
Length:104
Mass (Da):11,662
Last modified:March 1, 2001 - v1
Checksum:i97EF31A46B388E79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007220 mRNA. Translation: AAG01893.1.
AF426828 Genomic DNA. Translation: AAM19206.1.
BX470102 Genomic DNA. Translation: CAI14759.1.
BC005019 mRNA. Translation: AAH05019.1.
CCDSiCCDS1046.1.
RefSeqiNP_065723.1. NM_020672.2.
XP_005245419.1. XM_005245362.1.
XP_016857364.1. XM_017001875.1.
UniGeneiHs.288998.

Genome annotation databases

EnsembliENST00000344616; ENSP00000340463; ENSG00000189334.
ENST00000368701; ENSP00000357690; ENSG00000189334.
ENST00000368702; ENSP00000357691; ENSG00000189334.
ENST00000476873; ENSP00000420296; ENSG00000189334.
GeneIDi57402.
KEGGihsa:57402.
UCSCiuc001fce.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007220 mRNA. Translation: AAG01893.1.
AF426828 Genomic DNA. Translation: AAM19206.1.
BX470102 Genomic DNA. Translation: CAI14759.1.
BC005019 mRNA. Translation: AAH05019.1.
CCDSiCCDS1046.1.
RefSeqiNP_065723.1. NM_020672.2.
XP_005245419.1. XM_005245362.1.
XP_016857364.1. XM_017001875.1.
UniGeneiHs.288998.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M0RNMR-A/B1-104[»]
ProteinModelPortaliQ9HCY8.
SMRiQ9HCY8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121504. 20 interactors.
IntActiQ9HCY8. 10 interactors.
MINTiMINT-5002007.
STRINGi9606.ENSP00000340463.

PTM databases

iPTMnetiQ9HCY8.
PhosphoSitePlusiQ9HCY8.
SwissPalmiQ9HCY8.

Polymorphism and mutation databases

BioMutaiS100A14.
DMDMi20178118.

Proteomic databases

EPDiQ9HCY8.
MaxQBiQ9HCY8.
PaxDbiQ9HCY8.
PeptideAtlasiQ9HCY8.
PRIDEiQ9HCY8.
TopDownProteomicsiQ9HCY8.

Protocols and materials databases

DNASUi57402.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344616; ENSP00000340463; ENSG00000189334.
ENST00000368701; ENSP00000357690; ENSG00000189334.
ENST00000368702; ENSP00000357691; ENSG00000189334.
ENST00000476873; ENSP00000420296; ENSG00000189334.
GeneIDi57402.
KEGGihsa:57402.
UCSCiuc001fce.4. human.

Organism-specific databases

CTDi57402.
DisGeNETi57402.
GeneCardsiS100A14.
HGNCiHGNC:18901. S100A14.
HPAiHPA027613.
MIMi607986. gene.
neXtProtiNX_Q9HCY8.
OpenTargetsiENSG00000189334.
PharmGKBiPA134905502.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZKB. Eukaryota.
ENOG4111EF5. LUCA.
GeneTreeiENSGT00530000063972.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiQ9HCY8.
OMAiNLGNCND.
OrthoDBiEOG091G0YGX.
PhylomeDBiQ9HCY8.
TreeFamiTF332727.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135289-MONOMER.

Miscellaneous databases

ChiTaRSiS100A14. human.
GenomeRNAii57402.
PROiQ9HCY8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000189334.
CleanExiHS_S100A14.
GenevisibleiQ9HCY8. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR013787. S100_Ca-bd_sub.
IPR028493. S100A14.
[Graphical view]
PANTHERiPTHR11639:SF4. PTHR11639:SF4. 1 hit.
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS10AE_HUMAN
AccessioniPrimary (citable) accession number: Q9HCY8
Secondary accession number(s): Q5RHT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Part of the residues that are essential for calcium binding are not conserved, resulting in loss of calcium binding at physiological calcium concentrations.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.