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Q9HCY8 (S10AE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein S100-A14
Alternative name(s):
S100 calcium-binding protein A14
Short name=S114
Gene names
Name:S100A14
Synonyms:S100A15
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length104 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. Ref.5 Ref.6 Ref.7

Subunit structure

Homodimer. Interacts with AGER. Ref.5 Ref.8

Subcellular location

Cytoplasm Ref.1.

Tissue specificity

Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, small intestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes. Ref.1

Sequence similarities

Belongs to the S-100 family.

Contains 1 EF-hand domain.

Caution

Part of the residues that are essential for calcium binding are not conserved, resulting in loss of calcium binding at physiological calcium concentrations (Ref.8).

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 104104Protein S100-A14
PRO_0000144021

Regions

Domain27 – 6135EF-hand

Secondary structure

................... 104
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9HCY8 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 97EF31A46B388E79

FASTA10411,662
        10         20         30         40         50         60 
MGQCRSANAE DAQEFSDVER AIETLIKNFH QYSVEGGKET LTPSELRDLV TQQLPHLMPS 

        70         80         90        100 
NCGLEEKIAN LGSCNDSKLE FRSFWELIGE AAKSVKLERP VRGH 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of the human S100A14 gene encoding a novel member of the S100 family."
Pietas A., Schluns K., Marenholz I., Schafer B.W., Heizmann C.W., Petersen I.
Genomics 79:513-522(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE)."
Jin Q., Chen H., Luo A., Ding F., Liu Z.
PLoS ONE 6:E19375-E19375(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH AGER.
[6]"Involvement of S100A14 protein in cell invasion by affecting expression and function of matrix metalloproteinase (MMP)-2 via p53-dependent transcriptional regulation."
Chen H., Yuan Y., Zhang C., Luo A., Ding F., Ma J., Yang S., Tian Y., Tong T., Zhan Q., Liu Z.
J. Biol. Chem. 287:17109-17119(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest."
Sapkota D., Costea D.E., Blo M., Bruland O., Lorens J.B., Vasstrand E.N., Ibrahim S.O.
Oral Oncol. 48:219-225(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[8]"Solution structure and dynamics of human S100A14."
Bertini I., Borsi V., Cerofolini L., Das Gupta S., Fragai M., Luchinat C.
J. Biol. Inorg. Chem. 18:183-194(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR, ABSENCE OF CALCIUM BINDING, SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY007220 mRNA. Translation: AAG01893.1.
AF426828 Genomic DNA. Translation: AAM19206.1.
BX470102 Genomic DNA. Translation: CAI14759.1.
BC005019 mRNA. Translation: AAH05019.1.
RefSeqNP_065723.1. NM_020672.2.
XP_005245419.1. XM_005245362.1.
UniGeneHs.288998.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2M0RNMR-A/B1-104[»]
ProteinModelPortalQ9HCY8.
SMRQ9HCY8. Positions 1-104.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121504. 5 interactions.
IntActQ9HCY8. 3 interactions.
MINTMINT-5002007.
STRING9606.ENSP00000340463.

PTM databases

PhosphoSiteQ9HCY8.

Polymorphism databases

DMDM20178118.

Proteomic databases

PaxDbQ9HCY8.
PeptideAtlasQ9HCY8.
PRIDEQ9HCY8.

Protocols and materials databases

DNASU57402.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000344616; ENSP00000340463; ENSG00000189334.
ENST00000368701; ENSP00000357690; ENSG00000189334.
ENST00000368702; ENSP00000357691; ENSG00000189334.
ENST00000476873; ENSP00000420296; ENSG00000189334.
GeneID57402.
KEGGhsa:57402.
UCSCuc001fce.3. human.

Organism-specific databases

CTD57402.
GeneCardsGC01M153586.
HGNCHGNC:18901. S100A14.
HPAHPA027613.
MIM607986. gene.
neXtProtNX_Q9HCY8.
PharmGKBPA134905502.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46731.
HOGENOMHOG000246968.
HOVERGENHBG001479.
InParanoidQ9HCY8.
OMAIANLGNC.
OrthoDBEOG715Q6C.
PhylomeDBQ9HCY8.
TreeFamTF332727.

Gene expression databases

BgeeQ9HCY8.
CleanExHS_S100A14.
GenevestigatorQ9HCY8.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR013787. S100_Ca-bd_sub.
IPR028493. S100A14.
[Graphical view]
PANTHERPTHR11639:SF4. PTHR11639:SF4. 1 hit.
PfamPF01023. S_100. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSS100A14. human.
GenomeRNAi57402.
NextBio63504.
PROQ9HCY8.
SOURCESearch...

Entry information

Entry nameS10AE_HUMAN
AccessionPrimary (citable) accession number: Q9HCY8
Secondary accession number(s): Q5RHT0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM