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Q9HCY8 (S10AE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein S100-A14
Alternative name(s):
S100 calcium-binding protein A14
Short name=S114
Gene names
Name:S100A14
Synonyms:S100A15
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length104 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasm Ref.1.

Tissue specificity

Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, small intestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes. Ref.1

Sequence similarities

Belongs to the S-100 family.

Contains 2 EF-hand domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 104104Protein S100-A14
PRO_0000144021

Regions

Domain27 – 6135EF-hand 1
Calcium binding33 – 45131; low affinity Potential
Calcium binding72 – 83122; high affinity Potential

Amino acid modifications

Modified residue321Phosphotyrosine Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9HCY8 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 97EF31A46B388E79

FASTA10411,662
        10         20         30         40         50         60 
MGQCRSANAE DAQEFSDVER AIETLIKNFH QYSVEGGKET LTPSELRDLV TQQLPHLMPS 

        70         80         90        100 
NCGLEEKIAN LGSCNDSKLE FRSFWELIGE AAKSVKLERP VRGH 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of the human S100A14 gene encoding a novel member of the S100 family."
Pietas A., Schluns K., Marenholz I., Schafer B.W., Heizmann C.W., Petersen I.
Genomics 79:513-522(2002) [PubMed: 11944983] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
[4]"An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells."
Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A., Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D., Wiley H.S., Qian W.-J.
J. Proteome Res. 8:3852-3861(2009) [PubMed: 19534553] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-32, MASS SPECTROMETRY.
Tissue: Mammary epithelium.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY007220 mRNA. Translation: AAG01893.1.
AF426828 Genomic DNA. Translation: AAM19206.1.
BX470102 Genomic DNA. Translation: CAI14759.1.
BC005019 mRNA. Translation: AAH05019.1.
IPIIPI00010214.
RefSeqNP_065723.1. NM_020672.1.
UniGeneHs.288998.

3D structure databases

ProteinModelPortalQ9HCY8.
SMRQ9HCY8. Positions 12-102.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9HCY8. 1 interaction.
MINTMINT-5002007.
STRINGQ9HCY8.

PTM databases

PhosphoSiteQ9HCY8.

Polymorphism databases

DMDM20178118.

Proteomic databases

PeptideAtlasQ9HCY8.
PRIDEQ9HCY8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000344616; ENSP00000340463; ENSG00000189334.
ENST00000368701; ENSP00000357690; ENSG00000189334.
ENST00000368702; ENSP00000357691; ENSG00000189334.
ENST00000476873; ENSP00000420296; ENSG00000189334.
GeneID57402.
KEGGhsa:57402.
UCSCuc001fce.1. human.

Organism-specific databases

CTD57402.
GeneCardsGC01M153586.
H-InvDBHIX0199952.
HGNCHGNC:18901. S100A14.
HPAHPA027613.
MIM607986. gene.
neXtProtNX_Q9HCY8.
PharmGKBPA134905502.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG21170.
GeneTreeENSGT00530000063972.
HOGENOMHBG716817.
HOVERGENHBG001479.
InParanoidQ9HCY8.
OMAIANLGNC.
OrthoDBEOG4WSWC3.
PhylomeDBQ9HCY8.

Gene expression databases

ArrayExpressQ9HCY8.
BgeeQ9HCY8.
CleanExHS_S100A14.
GenevestigatorQ9HCY8.
GermOnlineENSG00000189334. Homo sapiens.

Family and domain databases

InterProIPR011992. EF-hand-like_dom.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
Gene3DG3DSA:1.10.238.10. EF-Hand_type. 1 hit.
PfamPF01023. S_100. 1 hit.
[Graphical view]
PROSITEPS00018. EF_HAND_1. False negative.
PS50222. EF_HAND_2. False negative.
PS00303. S100_CABP. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio63504.
SOURCESearch...

Entry information

Entry nameS10AE_HUMAN
AccessionPrimary (citable) accession number: Q9HCY8
Secondary accession number(s): Q5RHT0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2001
Last modified: January 25, 2012
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families