Q9HCY8 (S10AE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein S100-A14

Alternative name(s):
S100 calcium-binding protein A14
Short name=S114

Gene names

Name:	S100A14
Synonyms:	S100A15

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	104 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm Ref.1.
Tissue specificity	Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, small intestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes. Ref.1
Sequence similarities	Belongs to the S-100 family. Contains 2 EF-hand domains.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Calcium
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	calcium ion homeostasis Non-traceable author statement. Source: UniProtKB defense response to bacterium Inferred from expression pattern. Source: UniProtKB positive regulation of granulocyte chemotaxis Inferred from direct assay. Source: UniProtKB positive regulation of monocyte chemotaxis Inferred from direct assay. Source: UniProtKB response to lipopolysaccharide Inferred from expression pattern. Source: UniProtKB toll-like receptor 4 signaling pathway Inferred from direct assay. Source: UniProtKB
Cellular component	cell junction Inferred from direct assay. Source: HPA microtubule cytoskeleton Inferred from direct assay. Source: HPA perinuclear region of cytoplasm Inferred from direct assay Ref.1. Source: UniProtKB plasma membrane Inferred from direct assay. Source: HPA
Molecular function	calcium ion binding Non-traceable author statement. Source: UniProtKB chemokine receptor binding Inferred from mutant phenotype. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 104	104	Protein S100-A14		PRO_0000144021
Regions
	Domain	27 – 61	35	EF-hand 1
	Calcium binding	33 – 45	13	1; low affinity Potential
	Calcium binding	72 – 83	12	2; high affinity Potential
Amino acid modifications
	Modified residue	32	1	Phosphotyrosine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q9HCY8 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 97EF31A46B388E79	FASTA	104	11,662
	10 20 30 40 50 60 MGQCRSANAE DAQEFSDVER AIETLIKNFH QYSVEGGKET LTPSELRDLV TQQLPHLMPS 70 80 90 100 NCGLEEKIAN LGSCNDSKLE FRSFWELIGE AAKSVKLERP VRGH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of the human S100A14 gene encoding a novel member of the S100 family." Pietas A., Schluns K., Marenholz I., Schafer B.W., Heizmann C.W., Petersen I. Genomics 79:513-522(2002) [PubMed: 11944983] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
[4]	"An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells." Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A., Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D., Wiley H.S., Qian W.-J. J. Proteome Res. 8:3852-3861(2009) [PubMed: 19534553] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-32, MASS SPECTROMETRY. Tissue: Mammary epithelium.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY007220 mRNA. Translation: AAG01893.1. AF426828 Genomic DNA. Translation: AAM19206.1. BX470102 Genomic DNA. Translation: CAI14759.1. BC005019 mRNA. Translation: AAH05019.1.
IPI	IPI00010214.
RefSeq	NP_065723.1. NM_020672.1.
UniGene	Hs.288998.
3D structure databases
ProteinModelPortal	Q9HCY8.
SMR	Q9HCY8. Positions 12-102.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9HCY8. 1 interaction.
MINT	MINT-5002007.
STRING	Q9HCY8.
PTM databases
PhosphoSite	Q9HCY8.
Polymorphism databases
DMDM	20178118.
Proteomic databases
PeptideAtlas	Q9HCY8.
PRIDE	Q9HCY8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000344616; ENSP00000340463; ENSG00000189334. ENST00000368701; ENSP00000357690; ENSG00000189334. ENST00000368702; ENSP00000357691; ENSG00000189334. ENST00000476873; ENSP00000420296; ENSG00000189334.
GeneID	57402.
KEGG	hsa:57402.
UCSC	uc001fce.1. human.
Organism-specific databases
CTD	57402.
GeneCards	GC01M153586.
H-InvDB	HIX0199952.
HGNC	HGNC:18901. S100A14.
HPA	HPA027613.
MIM	607986. gene.
neXtProt	NX_Q9HCY8.
PharmGKB	PA134905502.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21170.
GeneTree	ENSGT00530000063972.
HOGENOM	HBG716817.
HOVERGEN	HBG001479.
InParanoid	Q9HCY8.
OMA	IANLGNC.
OrthoDB	EOG4WSWC3.
PhylomeDB	Q9HCY8.
Gene expression databases
ArrayExpress	Q9HCY8.
Bgee	Q9HCY8.
CleanEx	HS_S100A14.
Genevestigator	Q9HCY8.
GermOnline	ENSG00000189334. Homo sapiens.
Family and domain databases
InterPro	IPR011992. EF-hand-like_dom. IPR013787. S100_Ca-bd_sub. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit.
Pfam	PF01023. S_100. 1 hit. [Graphical view]
PROSITE	PS00018. EF_HAND_1. False negative. PS50222. EF_HAND_2. False negative. PS00303. S100_CABP. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	63504.
SOURCE	Search...

Entry information

Entry name

S10AE_HUMAN

Accession

Primary (citable) accession number: Q9HCY8
Secondary accession number(s): Q5RHT0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.