true
2001-06-20
2024-01-24
179
TRPC7_HUMAN
Distribution of a novel human capacitative calcium entry channel, htrp7.
Murphy C.T.
Li S.
Jordan N.J.
Reaves B.J.
Wolstenholme A.J.
Westwick J.
2000-02
EMBL/GenBank/DDBJ
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
Brain
Localization of TRPC7 and splice variants in human tissues.
Xu S.-Z.
Beech D.J.
2002-10
EMBL/GenBank/DDBJ
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
Tissue distribution, alternative splicing and function of human TRPC7.
Aptel H.
Murphy C.T.
Li S.W.
Chen P.B.
Rogers A.T.
Franklin I.
Westwick J.
Reaves B.J.
Woodward B.
Wolstenholme A.J.
2003-03
EMBL/GenBank/DDBJ
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
The DNA sequence and comparative analysis of human chromosome 5.
Schmutz J.
Martin J.
Terry A.
Couronne O.
Grimwood J.
Lowry S.
Gordon L.A.
Scott D.
Xie G.
Huang W.
Hellsten U.
Tran-Gyamfi M.
She X.
Prabhakar S.
Aerts A.
Altherr M.
Bajorek E.
Black S.
Branscomb E.
Caoile C.
Challacombe J.F.
Chan Y.M.
Denys M.
Detter J.C.
Escobar J.
Flowers D.
Fotopulos D.
Glavina T.
Gomez M.
Gonzales E.
Goodstein D.
Grigoriev I.
Groza M.
Hammon N.
Hawkins T.
Haydu L.
Israni S.
Jett J.
Kadner K.
Kimball H.
Kobayashi A.
Lopez F.
Lou Y.
Martinez D.
Medina C.
Morgan J.
Nandkeshwar R.
Noonan J.P.
Pitluck S.
Pollard M.
Predki P.
Priest J.
Ramirez L.
Retterer J.
Rodriguez A.
Rogers S.
Salamov A.
Salazar A.
Thayer N.
Tice H.
Tsai M.
Ustaszewska A.
Vo N.
Wheeler J.
Wu K.
Yang J.
Dickson M.
Cheng J.-F.
Eichler E.E.
Olsen A.
Pennacchio L.A.
Rokhsar D.S.
Richardson P.
Lucas S.M.
Myers R.M.
Rubin E.M.
doi:10.1038/nature02919
2004
Nature
431
268-274
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team
doi:10.1101/gr.2596504
2004
Genome Res.
14
2121-2127
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.
Lussier M.P.
Cayouette S.
Lepage P.K.
Bernier C.L.
Francoeur N.
St-Hilaire M.
Pinard M.
Boulay G.
doi:10.1074/jbc.m500391200
2005
J. Biol. Chem.
280
19393-19400
INTERACTION WITH MX1
RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC.
Lussier M.P.
Lepage P.K.
Bousquet S.M.
Boulay G.
doi:10.1016/j.ceca.2007.07.009
2008
Cell Calcium
43
432-443
INTERACTION WITH RNF24
Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase Ialpha.
Yuasa K.
Matsuda T.
Tsuji A.
doi:10.1016/j.cellsig.2011.03.005
2011
Cell. Signal.
23
1179-1187
PHOSPHORYLATION AT THR-15 BY PRKG1
INTERACTION WITH PRKG1
SUBCELLULAR LOCATION
5
1
1 site, No reported glycans
1 site
339 antibodies from 35 providers
human
TRPC7
Not detected
Eukaryota
Effects of PIP2 hydrolysis
Elevation of cytosolic Ca2+ levels
TRP channels
Role of second messengers in netrin-1 signaling
9 hits in 1143 CRISPR screens
human
Tchem
Protein
Expressed in buccal mucosa cell and 39 other cell types or tissues
baseline and differential
Ankyrin repeat-containing domain
Ankyrin_rpt
Ankyrin_rpt-contain_sf
Ion_trans_dom
TRP_dom
TRPC7_channel
TRPC_channel
trp
SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 7
TRANSIENT RECEPTOR POTENTIAL CHANNEL
Ank_2
Ion_trans
TRP_2
TRNSRECEPTRP
TRPCHANNEL7
ANK
TRP_2
Ankyrin repeat
HS
Short transient receptor potential channel 7
TrpC7
Transient receptor protein 7
TRP-7
hTRP7
TRPC7
TRP7
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.
Interacts with MX1 and RNF24. Interacts (via ANK-repeat domains) with PRKG1.
Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity.
Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily.
Short transient receptor potential channel 7
99562
1
862
Cytoplasmic
351
Helical
352
372
Extracellular
373
383
Helical
384
404
Cytoplasmic
405
465
Helical
466
486
Extracellular
487
537
Helical
538
558
Cytoplasmic
559
581
Helical
582
602
Extracellular
603
651
Helical
652
672
Cytoplasmic
673
ANK 1
42
71
ANK 2
77
106
ANK 3
108
134
ANK 4
163
192
Disordered
21
Phosphothreonine; by PKG/PRKG1
15
N-linked (GlcNAc...) asparagine
514
In isoform 2.
260
375
In isoform 3.
320
S
412
S
2001-03-01
1
99562
0d974916f4a95bcc4a5c53e92c6ef74d
1
MLRNSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILNHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNFQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKATEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKSCENDLEMGMLNSKFKKTRYQAGMRNSENLTANNTLSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRVNKGKDI
2
MLRNSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILNHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKATEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKSCENDLEMGMLNSKFKKTRYQAGMRNSENLTANNTLSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRVNKGKDI
3
MLRNSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILNHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKATEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKSCENDLEMGMLNSKFKKTRYQAGMRNSENLTANNTLSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRVNKGKDI
true
true
true
true
true
true
true
true
true
true