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Q9HCX4

- TRPC7_HUMAN

UniProt

Q9HCX4 - TRPC7_HUMAN

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Protein
Short transient receptor potential channel 7
Gene
TRPC7, TRP7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) By similarity. May also be activated by intracellular calcium store depletion.

GO - Molecular functioni

  1. calcium channel activity Source: UniProtKB-KW
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. axon guidance Source: Reactome
  2. blood coagulation Source: Reactome
  3. calcium ion transmembrane transport Source: Reactome
  4. ion transmembrane transport Source: Reactome
  5. manganese ion transport Source: Ensembl
  6. platelet activation Source: Reactome
  7. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_162. Elevation of cytosolic Ca2+ levels.
REACT_169333. TRP channels.
REACT_2202. Effects of PIP2 hydrolysis.
REACT_22228. Role of second messengers in netrin-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 7
Short name:
TrpC7
Alternative name(s):
Transient receptor protein 7
Short name:
TRP-7
Short name:
hTRP7
Gene namesi
Name:TRPC7
Synonyms:TRP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:20754. TRPC7.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Nucleus envelope 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 351351Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei352 – 37221Helical; Reviewed prediction
Add
BLAST
Topological domaini373 – 38311Extracellular Reviewed prediction
Add
BLAST
Transmembranei384 – 40421Helical; Reviewed prediction
Add
BLAST
Topological domaini405 – 46561Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei466 – 48621Helical; Reviewed prediction
Add
BLAST
Topological domaini487 – 53751Extracellular Reviewed prediction
Add
BLAST
Transmembranei538 – 55821Helical; Reviewed prediction
Add
BLAST
Topological domaini559 – 58123Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei582 – 60221Helical; Reviewed prediction
Add
BLAST
Topological domaini603 – 65149Extracellular Reviewed prediction
Add
BLAST
Transmembranei652 – 67221Helical; Reviewed prediction
Add
BLAST
Topological domaini673 – 862190Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nuclear envelope Source: UniProtKB-SubCell
  3. perinuclear region of cytoplasm Source: Ensembl
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164742693.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Short transient receptor potential channel 7
PRO_0000215324Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151Phosphothreonine; by PKG/PRKG11 Publication
Glycosylationi514 – 5141N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9HCX4.
PRIDEiQ9HCX4.

PTM databases

PhosphoSiteiQ9HCX4.

Expressioni

Gene expression databases

BgeeiQ9HCX4.
CleanExiHS_TRPC7.
GenevestigatoriQ9HCX4.

Organism-specific databases

HPAiCAB022592.
HPA031126.

Interactioni

Subunit structurei

Interacts with MX1 and RNF24. Interacts (via ANK-repeat domains) with PRKG1.3 Publications

Protein-protein interaction databases

BioGridi121378. 4 interactions.
IntActiQ9HCX4. 1 interaction.
STRINGi9606.ENSP00000265193.

Structurei

3D structure databases

ProteinModelPortaliQ9HCX4.
SMRiQ9HCX4. Positions 45-199.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati42 – 7130ANK 1
Add
BLAST
Repeati77 – 10630ANK 2
Add
BLAST
Repeati108 – 13427ANK 3
Add
BLAST
Repeati163 – 19230ANK 4
Add
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG254238.
HOGENOMiHOG000020590.
HOVERGENiHBG068337.
InParanoidiQ9HCX4.
KOiK04970.
OMAiGSNTFKN.
OrthoDBiEOG77HDD1.
PhylomeDBiQ9HCX4.
TreeFamiTF313147.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005463. TRPC7_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF9. PTHR10117:SF9. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01648. TRPCHANNEL7.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9HCX4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLRNSTFKNM QRRHTTLREK GRRQAIRGPA YMFNEKGTSL TPEEERFLDS    50
AEYGNIPVVR KMLEESKTLN FNCVDYMGQN ALQLAVGNEH LEVTELLLKK 100
ENLARVGDAL LLAISKGYVR IVEAILNHPA FAQGQRLTLS PLEQELRDDD 150
FYAYDEDGTR FSHDITPIIL AAHCQEYEIV HILLLKGARI ERPHDYFCKC 200
NECTEKQRKD SFSHSRSRMN AYKGLASAAY LSLSSEDPVL TALELSNELA 250
RLANIETEFK NDYRKLSMQC KDFVVGVLDL CRDTEEVEAI LNGDVNFQVW 300
SDHHRPSLSR IKLAIKYEVK KFVAHPNCQQ QLLTMWYENL SGLRQQSIAV 350
KFLAVFGVSI GLPFLAIAYW IAPCSKLGRT LRSPFMKFVA HAVSFTIFLG 400
LLVVNASDRF EGVKTLPNET FTDYPKQIFR VKTTQFSWTE MLIMKWVLGM 450
IWSECKEIWE EGPREYVLHL WNLLDFGMLS IFVASFTARF MAFLKATEAQ 500
LYVDQHVQDD TLHNVSLPPE VAYFTYARDK WWPSDPQIIS EGLYAIAVVL 550
SFSRIAYILP ANESFGPLQI SLGRTVKDIF KFMVIFIMVF VAFMIGMFNL 600
YSYYRGAKYN PAFTTVEESF KTLFWSIFGL SEVISVVLKY DHKFIENIGY 650
VLYGVYNVTM VVVLLNMLIA MINNSYQEIE EDADVEWKFA RAKLWLSYFD 700
EGRTLPAPFN LVPSPKSFYY LIMRIKMCLI KLCKSKAKSC ENDLEMGMLN 750
SKFKKTRYQA GMRNSENLTA NNTLSKPTRY QKIMKRLIKR YVLKAQVDRE 800
NDEVNEGELK EIKQDISSLR YELLEEKSQA TGELADLIQQ LSEKFGKNLN 850
KDHLRVNKGK DI 862
Length:862
Mass (Da):99,562
Last modified:March 1, 2001 - v1
Checksum:iC516E59E80AEF4B0
GO
Isoform 2 (identifier: Q9HCX4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-375: Missing.

Note: No experimental confirmation available.

Show »
Length:746
Mass (Da):86,277
Checksum:iDBF64B392022D797
GO
Isoform 3 (identifier: Q9HCX4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-320: Missing.

Note: No experimental confirmation available.

Show »
Length:801
Mass (Da):92,429
Checksum:i01106D703524DA00
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei260 – 375116Missing in isoform 2.
VSP_043035Add
BLAST
Alternative sequencei260 – 32061Missing in isoform 3.
VSP_044897Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti412 – 4121G → S in CAD70161. 1 Publication
Sequence conflicti486 – 4861F → S in CAD70161. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ272034 mRNA. Translation: CAC03489.1.
AY167927 mRNA. Translation: AAO12125.1.
AJ549088 mRNA. Translation: CAD70161.1.
AC008661 Genomic DNA. No translation available.
BC128185 mRNA. Translation: AAI28186.1.
CCDSiCCDS47267.2. [Q9HCX4-1]
CCDS54905.1. [Q9HCX4-2]
CCDS54906.1. [Q9HCX4-3]
RefSeqiNP_001161048.1. NM_001167576.1. [Q9HCX4-2]
NP_001161049.1. NM_001167577.1. [Q9HCX4-3]
NP_065122.1. NM_020389.2. [Q9HCX4-1]
UniGeneiHs.591263.

Genome annotation databases

EnsembliENST00000355180; ENSP00000347312; ENSG00000069018. [Q9HCX4-3]
ENST00000426057; ENSP00000441628; ENSG00000069018. [Q9HCX4-2]
ENST00000513104; ENSP00000426070; ENSG00000069018. [Q9HCX4-1]
GeneIDi57113.
KEGGihsa:57113.
UCSCiuc003lbn.2. human. [Q9HCX4-1]
uc010jei.2. human. [Q9HCX4-2]

Polymorphism databases

DMDMi18202960.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ272034 mRNA. Translation: CAC03489.1 .
AY167927 mRNA. Translation: AAO12125.1 .
AJ549088 mRNA. Translation: CAD70161.1 .
AC008661 Genomic DNA. No translation available.
BC128185 mRNA. Translation: AAI28186.1 .
CCDSi CCDS47267.2. [Q9HCX4-1 ]
CCDS54905.1. [Q9HCX4-2 ]
CCDS54906.1. [Q9HCX4-3 ]
RefSeqi NP_001161048.1. NM_001167576.1. [Q9HCX4-2 ]
NP_001161049.1. NM_001167577.1. [Q9HCX4-3 ]
NP_065122.1. NM_020389.2. [Q9HCX4-1 ]
UniGenei Hs.591263.

3D structure databases

ProteinModelPortali Q9HCX4.
SMRi Q9HCX4. Positions 45-199.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121378. 4 interactions.
IntActi Q9HCX4. 1 interaction.
STRINGi 9606.ENSP00000265193.

Chemistry

GuidetoPHARMACOLOGYi 492.

PTM databases

PhosphoSitei Q9HCX4.

Polymorphism databases

DMDMi 18202960.

Proteomic databases

PaxDbi Q9HCX4.
PRIDEi Q9HCX4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355180 ; ENSP00000347312 ; ENSG00000069018 . [Q9HCX4-3 ]
ENST00000426057 ; ENSP00000441628 ; ENSG00000069018 . [Q9HCX4-2 ]
ENST00000513104 ; ENSP00000426070 ; ENSG00000069018 . [Q9HCX4-1 ]
GeneIDi 57113.
KEGGi hsa:57113.
UCSCi uc003lbn.2. human. [Q9HCX4-1 ]
uc010jei.2. human. [Q9HCX4-2 ]

Organism-specific databases

CTDi 57113.
GeneCardsi GC05M135549.
HGNCi HGNC:20754. TRPC7.
HPAi CAB022592.
HPA031126.
neXtProti NX_Q9HCX4.
PharmGKBi PA164742693.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG254238.
HOGENOMi HOG000020590.
HOVERGENi HBG068337.
InParanoidi Q9HCX4.
KOi K04970.
OMAi GSNTFKN.
OrthoDBi EOG77HDD1.
PhylomeDBi Q9HCX4.
TreeFami TF313147.

Enzyme and pathway databases

Reactomei REACT_162. Elevation of cytosolic Ca2+ levels.
REACT_169333. TRP channels.
REACT_2202. Effects of PIP2 hydrolysis.
REACT_22228. Role of second messengers in netrin-1 signaling.

Miscellaneous databases

GeneWikii TRPC7.
GenomeRNAii 57113.
NextBioi 62971.
PROi Q9HCX4.

Gene expression databases

Bgeei Q9HCX4.
CleanExi HS_TRPC7.
Genevestigatori Q9HCX4.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005463. TRPC7_channel.
IPR002153. TRPC_channel.
[Graphical view ]
PANTHERi PTHR10117. PTHR10117. 1 hit.
PTHR10117:SF9. PTHR10117:SF9. 1 hit.
Pfami PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view ]
PRINTSi PR01097. TRNSRECEPTRP.
PR01648. TRPCHANNEL7.
SMARTi SM00248. ANK. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
TIGRFAMsi TIGR00870. trp. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Distribution of a novel human capacitative calcium entry channel, htrp7."
    Murphy C.T., Li S., Jordan N.J., Reaves B.J., Wolstenholme A.J., Westwick J.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Localization of TRPC7 and splice variants in human tissues."
    Xu S.-Z., Beech D.J.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Tissue distribution, alternative splicing and function of human TRPC7."
    Aptel H., Murphy C.T., Li S.W., Chen P.B., Rogers A.T., Franklin I., Westwick J., Reaves B.J., Woodward B., Wolstenholme A.J.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Brain.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC."
    Lussier M.P., Cayouette S., Lepage P.K., Bernier C.L., Francoeur N., St-Hilaire M., Pinard M., Boulay G.
    J. Biol. Chem. 280:19393-19400(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MX1.
  7. "RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC."
    Lussier M.P., Lepage P.K., Bousquet S.M., Boulay G.
    Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RNF24.
  8. "Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase Ialpha."
    Yuasa K., Matsuda T., Tsuji A.
    Cell. Signal. 23:1179-1187(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-15 BY PRKG1, INTERACTION WITH PRKG1, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTRPC7_HUMAN
AccessioniPrimary (citable) accession number: Q9HCX4
Secondary accession number(s): A1A4Z4
, F5H5U9, Q70T26, Q8IWP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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