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Protein

Short transient receptor potential channel 7

Gene

TRPC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.By similarity

Caution

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-114508 Effects of PIP2 hydrolysis
R-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-3295583 TRP channels
R-HSA-418890 Role of second messengers in netrin-1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 7
Short name:
TrpC7
Alternative name(s):
Transient receptor protein 7
Short name:
TRP-7
Short name:
hTRP7
Gene namesi
Name:TRPC7
Synonyms:TRP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000069018.17
HGNCiHGNC:20754 TRPC7
neXtProtiNX_Q9HCX4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 351CytoplasmicSequence analysisAdd BLAST351
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Topological domaini373 – 383ExtracellularSequence analysisAdd BLAST11
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Topological domaini405 – 465CytoplasmicSequence analysisAdd BLAST61
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Topological domaini487 – 537ExtracellularSequence analysisAdd BLAST51
Transmembranei538 – 558HelicalSequence analysisAdd BLAST21
Topological domaini559 – 581CytoplasmicSequence analysisAdd BLAST23
Transmembranei582 – 602HelicalSequence analysisAdd BLAST21
Topological domaini603 – 651ExtracellularSequence analysisAdd BLAST49
Transmembranei652 – 672HelicalSequence analysisAdd BLAST21
Topological domaini673 – 862CytoplasmicSequence analysisAdd BLAST190

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57113
OpenTargetsiENSG00000069018
PharmGKBiPA164742693

Polymorphism and mutation databases

BioMutaiTRPC7
DMDMi18202960

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153241 – 862Short transient receptor potential channel 7Add BLAST862

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15Phosphothreonine; by PKG/PRKG11 Publication1
Glycosylationi514N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9HCX4
PeptideAtlasiQ9HCX4
PRIDEiQ9HCX4

PTM databases

iPTMnetiQ9HCX4
PhosphoSitePlusiQ9HCX4

Expressioni

Gene expression databases

BgeeiENSG00000069018
CleanExiHS_TRPC7
ExpressionAtlasiQ9HCX4 baseline and differential
GenevisibleiQ9HCX4 HS

Organism-specific databases

HPAiCAB022592
HPA031126

Interactioni

Subunit structurei

Interacts with MX1 and RNF24. Interacts (via ANK-repeat domains) with PRKG1.3 Publications

Protein-protein interaction databases

BioGridi1213784 interactors.
CORUMiQ9HCX4
IntActiQ9HCX4 1 interactor.
STRINGi9606.ENSP00000426070

Structurei

3D structure databases

ProteinModelPortaliQ9HCX4
SMRiQ9HCX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati42 – 71ANK 1Add BLAST30
Repeati77 – 106ANK 2Add BLAST30
Repeati108 – 134ANK 3Add BLAST27
Repeati163 – 192ANK 4Add BLAST30

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
GeneTreeiENSGT00760000119180
HOGENOMiHOG000020590
HOVERGENiHBG068337
InParanoidiQ9HCX4
KOiK04970
OMAiSEQCKQY
OrthoDBiEOG091G01FB
PhylomeDBiQ9HCX4
TreeFamiTF313147

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.201 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR013555 TRP_dom
IPR005463 TRPC7_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF9 PTHR10117:SF9, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01648 TRPCHANNEL7
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HCX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRNSTFKNM QRRHTTLREK GRRQAIRGPA YMFNEKGTSL TPEEERFLDS
60 70 80 90 100
AEYGNIPVVR KMLEESKTLN FNCVDYMGQN ALQLAVGNEH LEVTELLLKK
110 120 130 140 150
ENLARVGDAL LLAISKGYVR IVEAILNHPA FAQGQRLTLS PLEQELRDDD
160 170 180 190 200
FYAYDEDGTR FSHDITPIIL AAHCQEYEIV HILLLKGARI ERPHDYFCKC
210 220 230 240 250
NECTEKQRKD SFSHSRSRMN AYKGLASAAY LSLSSEDPVL TALELSNELA
260 270 280 290 300
RLANIETEFK NDYRKLSMQC KDFVVGVLDL CRDTEEVEAI LNGDVNFQVW
310 320 330 340 350
SDHHRPSLSR IKLAIKYEVK KFVAHPNCQQ QLLTMWYENL SGLRQQSIAV
360 370 380 390 400
KFLAVFGVSI GLPFLAIAYW IAPCSKLGRT LRSPFMKFVA HAVSFTIFLG
410 420 430 440 450
LLVVNASDRF EGVKTLPNET FTDYPKQIFR VKTTQFSWTE MLIMKWVLGM
460 470 480 490 500
IWSECKEIWE EGPREYVLHL WNLLDFGMLS IFVASFTARF MAFLKATEAQ
510 520 530 540 550
LYVDQHVQDD TLHNVSLPPE VAYFTYARDK WWPSDPQIIS EGLYAIAVVL
560 570 580 590 600
SFSRIAYILP ANESFGPLQI SLGRTVKDIF KFMVIFIMVF VAFMIGMFNL
610 620 630 640 650
YSYYRGAKYN PAFTTVEESF KTLFWSIFGL SEVISVVLKY DHKFIENIGY
660 670 680 690 700
VLYGVYNVTM VVVLLNMLIA MINNSYQEIE EDADVEWKFA RAKLWLSYFD
710 720 730 740 750
EGRTLPAPFN LVPSPKSFYY LIMRIKMCLI KLCKSKAKSC ENDLEMGMLN
760 770 780 790 800
SKFKKTRYQA GMRNSENLTA NNTLSKPTRY QKIMKRLIKR YVLKAQVDRE
810 820 830 840 850
NDEVNEGELK EIKQDISSLR YELLEEKSQA TGELADLIQQ LSEKFGKNLN
860
KDHLRVNKGK DI
Length:862
Mass (Da):99,562
Last modified:March 1, 2001 - v1
Checksum:iC516E59E80AEF4B0
GO
Isoform 2 (identifier: Q9HCX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-375: Missing.

Note: No experimental confirmation available.
Show »
Length:746
Mass (Da):86,277
Checksum:iDBF64B392022D797
GO
Isoform 3 (identifier: Q9HCX4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-320: Missing.

Note: No experimental confirmation available.
Show »
Length:801
Mass (Da):92,429
Checksum:i01106D703524DA00
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti412G → S in CAD70161 (Ref. 3) Curated1
Sequence conflicti486F → S in CAD70161 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043035260 – 375Missing in isoform 2. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_044897260 – 320Missing in isoform 3. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272034 mRNA Translation: CAC03489.1
AY167927 mRNA Translation: AAO12125.1
AJ549088 mRNA Translation: CAD70161.1
AC008661 Genomic DNA No translation available.
BC128185 mRNA Translation: AAI28186.1
CCDSiCCDS47267.2 [Q9HCX4-1]
CCDS54905.1 [Q9HCX4-2]
CCDS54906.1 [Q9HCX4-3]
RefSeqiNP_001161048.1, NM_001167576.1 [Q9HCX4-2]
NP_001161049.1, NM_001167577.1 [Q9HCX4-3]
NP_065122.1, NM_020389.2 [Q9HCX4-1]
UniGeneiHs.591263

Genome annotation databases

EnsembliENST00000352189; ENSP00000330322; ENSG00000069018 [Q9HCX4-2]
ENST00000378459; ENSP00000367720; ENSG00000069018 [Q9HCX4-3]
ENST00000513104; ENSP00000426070; ENSG00000069018 [Q9HCX4-1]
GeneIDi57113
KEGGihsa:57113
UCSCiuc003lbn.3 human [Q9HCX4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTRPC7_HUMAN
AccessioniPrimary (citable) accession number: Q9HCX4
Secondary accession number(s): A1A4Z4
, F5H5U9, Q70T26, Q8IWP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: February 28, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome