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Q9HCX4 (TRPC7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Short transient receptor potential channel 7

Short name=TrpC7
Alternative name(s):
Transient receptor protein 7
Short name=TRP-7
Short name=hTRP7
Gene names
Name:TRPC7
Synonyms:TRP7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length862 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) By similarity. May also be activated by intracellular calcium store depletion.

Subunit structure

Interacts with MX1 and RNF24. Interacts (via ANK-repeat domains) with PRKG1. Ref.6 Ref.7 Ref.8

Subcellular location

Cell membrane; Multi-pass membrane protein. Nucleus envelope Ref.8.

Post-translational modification

Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity.

Sequence similarities

Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily. [View classification]

Contains 4 ANK repeats.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9HCX4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9HCX4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     260-375: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9HCX4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     260-320: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 862862Short transient receptor potential channel 7
PRO_0000215324

Regions

Topological domain1 – 351351Cytoplasmic Potential
Transmembrane352 – 37221Helical; Potential
Topological domain373 – 38311Extracellular Potential
Transmembrane384 – 40421Helical; Potential
Topological domain405 – 46561Cytoplasmic Potential
Transmembrane466 – 48621Helical; Potential
Topological domain487 – 53751Extracellular Potential
Transmembrane538 – 55821Helical; Potential
Topological domain559 – 58123Cytoplasmic Potential
Transmembrane582 – 60221Helical; Potential
Topological domain603 – 65149Extracellular Potential
Transmembrane652 – 67221Helical; Potential
Topological domain673 – 862190Cytoplasmic Potential
Repeat42 – 7130ANK 1
Repeat77 – 10630ANK 2
Repeat108 – 13427ANK 3
Repeat163 – 19230ANK 4

Amino acid modifications

Modified residue151Phosphothreonine; by PKG/PRKG1 Ref.8
Glycosylation5141N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence260 – 375116Missing in isoform 2.
VSP_043035
Alternative sequence260 – 32061Missing in isoform 3.
VSP_044897

Experimental info

Sequence conflict4121G → S in CAD70161. Ref.3
Sequence conflict4861F → S in CAD70161. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: C516E59E80AEF4B0

FASTA86299,562
        10         20         30         40         50         60 
MLRNSTFKNM QRRHTTLREK GRRQAIRGPA YMFNEKGTSL TPEEERFLDS AEYGNIPVVR 

        70         80         90        100        110        120 
KMLEESKTLN FNCVDYMGQN ALQLAVGNEH LEVTELLLKK ENLARVGDAL LLAISKGYVR 

       130        140        150        160        170        180 
IVEAILNHPA FAQGQRLTLS PLEQELRDDD FYAYDEDGTR FSHDITPIIL AAHCQEYEIV 

       190        200        210        220        230        240 
HILLLKGARI ERPHDYFCKC NECTEKQRKD SFSHSRSRMN AYKGLASAAY LSLSSEDPVL 

       250        260        270        280        290        300 
TALELSNELA RLANIETEFK NDYRKLSMQC KDFVVGVLDL CRDTEEVEAI LNGDVNFQVW 

       310        320        330        340        350        360 
SDHHRPSLSR IKLAIKYEVK KFVAHPNCQQ QLLTMWYENL SGLRQQSIAV KFLAVFGVSI 

       370        380        390        400        410        420 
GLPFLAIAYW IAPCSKLGRT LRSPFMKFVA HAVSFTIFLG LLVVNASDRF EGVKTLPNET 

       430        440        450        460        470        480 
FTDYPKQIFR VKTTQFSWTE MLIMKWVLGM IWSECKEIWE EGPREYVLHL WNLLDFGMLS 

       490        500        510        520        530        540 
IFVASFTARF MAFLKATEAQ LYVDQHVQDD TLHNVSLPPE VAYFTYARDK WWPSDPQIIS 

       550        560        570        580        590        600 
EGLYAIAVVL SFSRIAYILP ANESFGPLQI SLGRTVKDIF KFMVIFIMVF VAFMIGMFNL 

       610        620        630        640        650        660 
YSYYRGAKYN PAFTTVEESF KTLFWSIFGL SEVISVVLKY DHKFIENIGY VLYGVYNVTM 

       670        680        690        700        710        720 
VVVLLNMLIA MINNSYQEIE EDADVEWKFA RAKLWLSYFD EGRTLPAPFN LVPSPKSFYY 

       730        740        750        760        770        780 
LIMRIKMCLI KLCKSKAKSC ENDLEMGMLN SKFKKTRYQA GMRNSENLTA NNTLSKPTRY 

       790        800        810        820        830        840 
QKIMKRLIKR YVLKAQVDRE NDEVNEGELK EIKQDISSLR YELLEEKSQA TGELADLIQQ 

       850        860 
LSEKFGKNLN KDHLRVNKGK DI 

« Hide

Isoform 2 [UniParc].

Checksum: DBF64B392022D797
Show »

FASTA74686,277
Isoform 3 [UniParc].

Checksum: 01106D703524DA00
Show »

FASTA80192,429

References

« Hide 'large scale' references
[1]"Distribution of a novel human capacitative calcium entry channel, htrp7."
Murphy C.T., Li S., Jordan N.J., Reaves B.J., Wolstenholme A.J., Westwick J.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"Localization of TRPC7 and splice variants in human tissues."
Xu S.-Z., Beech D.J.
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]"Tissue distribution, alternative splicing and function of human TRPC7."
Aptel H., Murphy C.T., Li S.W., Chen P.B., Rogers A.T., Franklin I., Westwick J., Reaves B.J., Woodward B., Wolstenholme A.J.
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
Tissue: Brain.
[4]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]"MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC."
Lussier M.P., Cayouette S., Lepage P.K., Bernier C.L., Francoeur N., St-Hilaire M., Pinard M., Boulay G.
J. Biol. Chem. 280:19393-19400(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MX1.
[7]"RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC."
Lussier M.P., Lepage P.K., Bousquet S.M., Boulay G.
Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RNF24.
[8]"Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase Ialpha."
Yuasa K., Matsuda T., Tsuji A.
Cell. Signal. 23:1179-1187(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT THR-15 BY PRKG1, INTERACTION WITH PRKG1, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ272034 mRNA. Translation: CAC03489.1.
AY167927 mRNA. Translation: AAO12125.1.
AJ549088 mRNA. Translation: CAD70161.1.
AC008661 Genomic DNA. No translation available.
BC128185 mRNA. Translation: AAI28186.1.
RefSeqNP_001161048.1. NM_001167576.1.
NP_001161049.1. NM_001167577.1.
NP_065122.1. NM_020389.2.
UniGeneHs.591263.

3D structure databases

ProteinModelPortalQ9HCX4.
SMRQ9HCX4. Positions 22-199.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121378. 4 interactions.
IntActQ9HCX4. 1 interaction.
STRING9606.ENSP00000265193.

Chemistry

GuidetoPHARMACOLOGY492.

PTM databases

PhosphoSiteQ9HCX4.

Polymorphism databases

DMDM18202960.

Proteomic databases

PaxDbQ9HCX4.
PRIDEQ9HCX4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000355180; ENSP00000347312; ENSG00000069018. [Q9HCX4-3]
ENST00000426057; ENSP00000441628; ENSG00000069018. [Q9HCX4-2]
ENST00000513104; ENSP00000426070; ENSG00000069018. [Q9HCX4-1]
GeneID57113.
KEGGhsa:57113.
UCSCuc003lbn.2. human. [Q9HCX4-1]
uc010jei.2. human. [Q9HCX4-2]

Organism-specific databases

CTD57113.
GeneCardsGC05M135549.
HGNCHGNC:20754. TRPC7.
HPACAB022592.
HPA031126.
neXtProtNX_Q9HCX4.
PharmGKBPA164742693.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG254238.
HOGENOMHOG000020590.
HOVERGENHBG068337.
InParanoidQ9HCX4.
KOK04970.
OMAFKKTRYQ.
OrthoDBEOG77HDD1.
PhylomeDBQ9HCX4.
TreeFamTF313147.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.
REACT_111102. Signal Transduction.
REACT_15518. Transmembrane transport of small molecules.
REACT_604. Hemostasis.

Gene expression databases

BgeeQ9HCX4.
CleanExHS_TRPC7.
GenevestigatorQ9HCX4.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005463. TRPC7_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF9. PTHR10117:SF9. 1 hit.
PfamPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSPR01097. TRNSRECEPTRP.
PR01648. TRPCHANNEL7.
SMARTSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
TIGRFAMsTIGR00870. trp. 1 hit.
ProtoNetSearch...

Other

GeneWikiTRPC7.
GenomeRNAi57113.
NextBio62971.
PROQ9HCX4.

Entry information

Entry nameTRPC7_HUMAN
AccessionPrimary (citable) accession number: Q9HCX4
Secondary accession number(s): A1A4Z4 expand/collapse secondary AC list , F5H5U9, Q70T26, Q8IWP7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM