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Q9HCX4

- TRPC7_HUMAN

UniProt

Q9HCX4 - TRPC7_HUMAN

Protein

Short transient receptor potential channel 7

Gene

TRPC7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) By similarity. May also be activated by intracellular calcium store depletion.By similarity

    GO - Molecular functioni

    1. calcium channel activity Source: UniProtKB-KW
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. axon guidance Source: Reactome
    2. blood coagulation Source: Reactome
    3. calcium ion transmembrane transport Source: Reactome
    4. ion transmembrane transport Source: Reactome
    5. manganese ion transport Source: Ensembl
    6. platelet activation Source: Reactome
    7. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Calcium channel, Ion channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_162. Elevation of cytosolic Ca2+ levels.
    REACT_169333. TRP channels.
    REACT_2202. Effects of PIP2 hydrolysis.
    REACT_22228. Role of second messengers in netrin-1 signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Short transient receptor potential channel 7
    Short name:
    TrpC7
    Alternative name(s):
    Transient receptor protein 7
    Short name:
    TRP-7
    Short name:
    hTRP7
    Gene namesi
    Name:TRPC7
    Synonyms:TRP7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:20754. TRPC7.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication. Nucleus envelope 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. nuclear envelope Source: UniProtKB-SubCell
    3. perinuclear region of cytoplasm Source: Ensembl
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164742693.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 862862Short transient receptor potential channel 7PRO_0000215324Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei15 – 151Phosphothreonine; by PKG/PRKG11 Publication
    Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity.1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ9HCX4.
    PRIDEiQ9HCX4.

    PTM databases

    PhosphoSiteiQ9HCX4.

    Expressioni

    Gene expression databases

    BgeeiQ9HCX4.
    CleanExiHS_TRPC7.
    GenevestigatoriQ9HCX4.

    Organism-specific databases

    HPAiCAB022592.
    HPA031126.

    Interactioni

    Subunit structurei

    Interacts with MX1 and RNF24. Interacts (via ANK-repeat domains) with PRKG1.3 Publications

    Protein-protein interaction databases

    BioGridi121378. 4 interactions.
    IntActiQ9HCX4. 1 interaction.
    STRINGi9606.ENSP00000265193.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HCX4.
    SMRiQ9HCX4. Positions 45-199.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 351351CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini373 – 38311ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini405 – 46561CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini487 – 53751ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini559 – 58123CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini603 – 65149ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini673 – 862190CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei352 – 37221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei384 – 40421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei466 – 48621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei538 – 55821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei582 – 60221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei652 – 67221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati42 – 7130ANK 1Add
    BLAST
    Repeati77 – 10630ANK 2Add
    BLAST
    Repeati108 – 13427ANK 3Add
    BLAST
    Repeati163 – 19230ANK 4Add
    BLAST

    Sequence similaritiesi

    Contains 4 ANK repeats.Curated

    Keywords - Domaini

    ANK repeat, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG254238.
    HOGENOMiHOG000020590.
    HOVERGENiHBG068337.
    InParanoidiQ9HCX4.
    KOiK04970.
    OMAiGSNTFKN.
    OrthoDBiEOG77HDD1.
    PhylomeDBiQ9HCX4.
    TreeFamiTF313147.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR013555. TRP_dom.
    IPR005463. TRPC7_channel.
    IPR002153. TRPC_channel.
    [Graphical view]
    PANTHERiPTHR10117. PTHR10117. 1 hit.
    PTHR10117:SF9. PTHR10117:SF9. 1 hit.
    PfamiPF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF08344. TRP_2. 1 hit.
    [Graphical view]
    PRINTSiPR01097. TRNSRECEPTRP.
    PR01648. TRPCHANNEL7.
    SMARTiSM00248. ANK. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    TIGRFAMsiTIGR00870. trp. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9HCX4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLRNSTFKNM QRRHTTLREK GRRQAIRGPA YMFNEKGTSL TPEEERFLDS    50
    AEYGNIPVVR KMLEESKTLN FNCVDYMGQN ALQLAVGNEH LEVTELLLKK 100
    ENLARVGDAL LLAISKGYVR IVEAILNHPA FAQGQRLTLS PLEQELRDDD 150
    FYAYDEDGTR FSHDITPIIL AAHCQEYEIV HILLLKGARI ERPHDYFCKC 200
    NECTEKQRKD SFSHSRSRMN AYKGLASAAY LSLSSEDPVL TALELSNELA 250
    RLANIETEFK NDYRKLSMQC KDFVVGVLDL CRDTEEVEAI LNGDVNFQVW 300
    SDHHRPSLSR IKLAIKYEVK KFVAHPNCQQ QLLTMWYENL SGLRQQSIAV 350
    KFLAVFGVSI GLPFLAIAYW IAPCSKLGRT LRSPFMKFVA HAVSFTIFLG 400
    LLVVNASDRF EGVKTLPNET FTDYPKQIFR VKTTQFSWTE MLIMKWVLGM 450
    IWSECKEIWE EGPREYVLHL WNLLDFGMLS IFVASFTARF MAFLKATEAQ 500
    LYVDQHVQDD TLHNVSLPPE VAYFTYARDK WWPSDPQIIS EGLYAIAVVL 550
    SFSRIAYILP ANESFGPLQI SLGRTVKDIF KFMVIFIMVF VAFMIGMFNL 600
    YSYYRGAKYN PAFTTVEESF KTLFWSIFGL SEVISVVLKY DHKFIENIGY 650
    VLYGVYNVTM VVVLLNMLIA MINNSYQEIE EDADVEWKFA RAKLWLSYFD 700
    EGRTLPAPFN LVPSPKSFYY LIMRIKMCLI KLCKSKAKSC ENDLEMGMLN 750
    SKFKKTRYQA GMRNSENLTA NNTLSKPTRY QKIMKRLIKR YVLKAQVDRE 800
    NDEVNEGELK EIKQDISSLR YELLEEKSQA TGELADLIQQ LSEKFGKNLN 850
    KDHLRVNKGK DI 862
    Length:862
    Mass (Da):99,562
    Last modified:March 1, 2001 - v1
    Checksum:iC516E59E80AEF4B0
    GO
    Isoform 2 (identifier: Q9HCX4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         260-375: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:746
    Mass (Da):86,277
    Checksum:iDBF64B392022D797
    GO
    Isoform 3 (identifier: Q9HCX4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         260-320: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:801
    Mass (Da):92,429
    Checksum:i01106D703524DA00
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti412 – 4121G → S in CAD70161. 1 PublicationCurated
    Sequence conflicti486 – 4861F → S in CAD70161. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei260 – 375116Missing in isoform 2. 1 PublicationVSP_043035Add
    BLAST
    Alternative sequencei260 – 32061Missing in isoform 3. 1 PublicationVSP_044897Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ272034 mRNA. Translation: CAC03489.1.
    AY167927 mRNA. Translation: AAO12125.1.
    AJ549088 mRNA. Translation: CAD70161.1.
    AC008661 Genomic DNA. No translation available.
    BC128185 mRNA. Translation: AAI28186.1.
    CCDSiCCDS47267.2. [Q9HCX4-1]
    CCDS54905.1. [Q9HCX4-2]
    CCDS54906.1. [Q9HCX4-3]
    RefSeqiNP_001161048.1. NM_001167576.1. [Q9HCX4-2]
    NP_001161049.1. NM_001167577.1. [Q9HCX4-3]
    NP_065122.1. NM_020389.2. [Q9HCX4-1]
    UniGeneiHs.591263.

    Genome annotation databases

    EnsembliENST00000355180; ENSP00000347312; ENSG00000069018. [Q9HCX4-3]
    ENST00000426057; ENSP00000441628; ENSG00000069018. [Q9HCX4-2]
    ENST00000513104; ENSP00000426070; ENSG00000069018. [Q9HCX4-1]
    GeneIDi57113.
    KEGGihsa:57113.
    UCSCiuc003lbn.2. human. [Q9HCX4-1]
    uc010jei.2. human. [Q9HCX4-2]

    Polymorphism databases

    DMDMi18202960.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ272034 mRNA. Translation: CAC03489.1 .
    AY167927 mRNA. Translation: AAO12125.1 .
    AJ549088 mRNA. Translation: CAD70161.1 .
    AC008661 Genomic DNA. No translation available.
    BC128185 mRNA. Translation: AAI28186.1 .
    CCDSi CCDS47267.2. [Q9HCX4-1 ]
    CCDS54905.1. [Q9HCX4-2 ]
    CCDS54906.1. [Q9HCX4-3 ]
    RefSeqi NP_001161048.1. NM_001167576.1. [Q9HCX4-2 ]
    NP_001161049.1. NM_001167577.1. [Q9HCX4-3 ]
    NP_065122.1. NM_020389.2. [Q9HCX4-1 ]
    UniGenei Hs.591263.

    3D structure databases

    ProteinModelPortali Q9HCX4.
    SMRi Q9HCX4. Positions 45-199.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121378. 4 interactions.
    IntActi Q9HCX4. 1 interaction.
    STRINGi 9606.ENSP00000265193.

    Chemistry

    GuidetoPHARMACOLOGYi 492.

    PTM databases

    PhosphoSitei Q9HCX4.

    Polymorphism databases

    DMDMi 18202960.

    Proteomic databases

    PaxDbi Q9HCX4.
    PRIDEi Q9HCX4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000355180 ; ENSP00000347312 ; ENSG00000069018 . [Q9HCX4-3 ]
    ENST00000426057 ; ENSP00000441628 ; ENSG00000069018 . [Q9HCX4-2 ]
    ENST00000513104 ; ENSP00000426070 ; ENSG00000069018 . [Q9HCX4-1 ]
    GeneIDi 57113.
    KEGGi hsa:57113.
    UCSCi uc003lbn.2. human. [Q9HCX4-1 ]
    uc010jei.2. human. [Q9HCX4-2 ]

    Organism-specific databases

    CTDi 57113.
    GeneCardsi GC05M135549.
    HGNCi HGNC:20754. TRPC7.
    HPAi CAB022592.
    HPA031126.
    neXtProti NX_Q9HCX4.
    PharmGKBi PA164742693.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG254238.
    HOGENOMi HOG000020590.
    HOVERGENi HBG068337.
    InParanoidi Q9HCX4.
    KOi K04970.
    OMAi GSNTFKN.
    OrthoDBi EOG77HDD1.
    PhylomeDBi Q9HCX4.
    TreeFami TF313147.

    Enzyme and pathway databases

    Reactomei REACT_162. Elevation of cytosolic Ca2+ levels.
    REACT_169333. TRP channels.
    REACT_2202. Effects of PIP2 hydrolysis.
    REACT_22228. Role of second messengers in netrin-1 signaling.

    Miscellaneous databases

    GeneWikii TRPC7.
    GenomeRNAii 57113.
    NextBioi 62971.
    PROi Q9HCX4.

    Gene expression databases

    Bgeei Q9HCX4.
    CleanExi HS_TRPC7.
    Genevestigatori Q9HCX4.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR013555. TRP_dom.
    IPR005463. TRPC7_channel.
    IPR002153. TRPC_channel.
    [Graphical view ]
    PANTHERi PTHR10117. PTHR10117. 1 hit.
    PTHR10117:SF9. PTHR10117:SF9. 1 hit.
    Pfami PF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF08344. TRP_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01097. TRNSRECEPTRP.
    PR01648. TRPCHANNEL7.
    SMARTi SM00248. ANK. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    TIGRFAMsi TIGR00870. trp. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Distribution of a novel human capacitative calcium entry channel, htrp7."
      Murphy C.T., Li S., Jordan N.J., Reaves B.J., Wolstenholme A.J., Westwick J.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Localization of TRPC7 and splice variants in human tissues."
      Xu S.-Z., Beech D.J.
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Tissue distribution, alternative splicing and function of human TRPC7."
      Aptel H., Murphy C.T., Li S.W., Chen P.B., Rogers A.T., Franklin I., Westwick J., Reaves B.J., Woodward B., Wolstenholme A.J.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: Brain.
    4. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC."
      Lussier M.P., Cayouette S., Lepage P.K., Bernier C.L., Francoeur N., St-Hilaire M., Pinard M., Boulay G.
      J. Biol. Chem. 280:19393-19400(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MX1.
    7. "RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC."
      Lussier M.P., Lepage P.K., Bousquet S.M., Boulay G.
      Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RNF24.
    8. "Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase Ialpha."
      Yuasa K., Matsuda T., Tsuji A.
      Cell. Signal. 23:1179-1187(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-15 BY PRKG1, INTERACTION WITH PRKG1, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiTRPC7_HUMAN
    AccessioniPrimary (citable) accession number: Q9HCX4
    Secondary accession number(s): A1A4Z4
    , F5H5U9, Q70T26, Q8IWP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3