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Protein

Short transient receptor potential channel 7

Gene

TRPC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000069018-MONOMER.
ReactomeiR-HSA-114508. Effects of PIP2 hydrolysis.
R-HSA-139853. Elevation of cytosolic Ca2+ levels.
R-HSA-3295583. TRP channels.
R-HSA-418890. Role of second messengers in netrin-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 7
Short name:
TrpC7
Alternative name(s):
Transient receptor protein 7
Short name:
TRP-7
Short name:
hTRP7
Gene namesi
Name:TRPC7
Synonyms:TRP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:20754. TRPC7.

Subcellular locationi

  • Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
  • Nucleus envelope 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 351CytoplasmicSequence analysisAdd BLAST351
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Topological domaini373 – 383ExtracellularSequence analysisAdd BLAST11
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Topological domaini405 – 465CytoplasmicSequence analysisAdd BLAST61
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Topological domaini487 – 537ExtracellularSequence analysisAdd BLAST51
Transmembranei538 – 558HelicalSequence analysisAdd BLAST21
Topological domaini559 – 581CytoplasmicSequence analysisAdd BLAST23
Transmembranei582 – 602HelicalSequence analysisAdd BLAST21
Topological domaini603 – 651ExtracellularSequence analysisAdd BLAST49
Transmembranei652 – 672HelicalSequence analysisAdd BLAST21
Topological domaini673 – 862CytoplasmicSequence analysisAdd BLAST190

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57113.
OpenTargetsiENSG00000069018.
PharmGKBiPA164742693.

Polymorphism and mutation databases

BioMutaiTRPC7.
DMDMi18202960.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153241 – 862Short transient receptor potential channel 7Add BLAST862

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15Phosphothreonine; by PKG/PRKG11 Publication1
Glycosylationi514N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9HCX4.
PeptideAtlasiQ9HCX4.
PRIDEiQ9HCX4.

PTM databases

iPTMnetiQ9HCX4.
PhosphoSitePlusiQ9HCX4.

Expressioni

Gene expression databases

BgeeiENSG00000069018.
CleanExiHS_TRPC7.
ExpressionAtlasiQ9HCX4. baseline and differential.
GenevisibleiQ9HCX4. HS.

Organism-specific databases

HPAiCAB022592.
HPA031126.

Interactioni

Subunit structurei

Interacts with MX1 and RNF24. Interacts (via ANK-repeat domains) with PRKG1.3 Publications

Protein-protein interaction databases

BioGridi121378. 4 interactors.
IntActiQ9HCX4. 1 interactor.
STRINGi9606.ENSP00000426070.

Structurei

3D structure databases

ProteinModelPortaliQ9HCX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati42 – 71ANK 1Add BLAST30
Repeati77 – 106ANK 2Add BLAST30
Repeati108 – 134ANK 3Add BLAST27
Repeati163 – 192ANK 4Add BLAST30

Sequence similaritiesi

Contains 4 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000020590.
HOVERGENiHBG068337.
InParanoidiQ9HCX4.
KOiK04970.
OMAiGSNTFKN.
OrthoDBiEOG091G01FB.
PhylomeDBiQ9HCX4.
TreeFamiTF313147.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005463. TRPC7_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF9. PTHR10117:SF9. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01648. TRPCHANNEL7.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HCX4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRNSTFKNM QRRHTTLREK GRRQAIRGPA YMFNEKGTSL TPEEERFLDS
60 70 80 90 100
AEYGNIPVVR KMLEESKTLN FNCVDYMGQN ALQLAVGNEH LEVTELLLKK
110 120 130 140 150
ENLARVGDAL LLAISKGYVR IVEAILNHPA FAQGQRLTLS PLEQELRDDD
160 170 180 190 200
FYAYDEDGTR FSHDITPIIL AAHCQEYEIV HILLLKGARI ERPHDYFCKC
210 220 230 240 250
NECTEKQRKD SFSHSRSRMN AYKGLASAAY LSLSSEDPVL TALELSNELA
260 270 280 290 300
RLANIETEFK NDYRKLSMQC KDFVVGVLDL CRDTEEVEAI LNGDVNFQVW
310 320 330 340 350
SDHHRPSLSR IKLAIKYEVK KFVAHPNCQQ QLLTMWYENL SGLRQQSIAV
360 370 380 390 400
KFLAVFGVSI GLPFLAIAYW IAPCSKLGRT LRSPFMKFVA HAVSFTIFLG
410 420 430 440 450
LLVVNASDRF EGVKTLPNET FTDYPKQIFR VKTTQFSWTE MLIMKWVLGM
460 470 480 490 500
IWSECKEIWE EGPREYVLHL WNLLDFGMLS IFVASFTARF MAFLKATEAQ
510 520 530 540 550
LYVDQHVQDD TLHNVSLPPE VAYFTYARDK WWPSDPQIIS EGLYAIAVVL
560 570 580 590 600
SFSRIAYILP ANESFGPLQI SLGRTVKDIF KFMVIFIMVF VAFMIGMFNL
610 620 630 640 650
YSYYRGAKYN PAFTTVEESF KTLFWSIFGL SEVISVVLKY DHKFIENIGY
660 670 680 690 700
VLYGVYNVTM VVVLLNMLIA MINNSYQEIE EDADVEWKFA RAKLWLSYFD
710 720 730 740 750
EGRTLPAPFN LVPSPKSFYY LIMRIKMCLI KLCKSKAKSC ENDLEMGMLN
760 770 780 790 800
SKFKKTRYQA GMRNSENLTA NNTLSKPTRY QKIMKRLIKR YVLKAQVDRE
810 820 830 840 850
NDEVNEGELK EIKQDISSLR YELLEEKSQA TGELADLIQQ LSEKFGKNLN
860
KDHLRVNKGK DI
Length:862
Mass (Da):99,562
Last modified:March 1, 2001 - v1
Checksum:iC516E59E80AEF4B0
GO
Isoform 2 (identifier: Q9HCX4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-375: Missing.

Note: No experimental confirmation available.
Show »
Length:746
Mass (Da):86,277
Checksum:iDBF64B392022D797
GO
Isoform 3 (identifier: Q9HCX4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     260-320: Missing.

Note: No experimental confirmation available.
Show »
Length:801
Mass (Da):92,429
Checksum:i01106D703524DA00
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti412G → S in CAD70161 (Ref. 3) Curated1
Sequence conflicti486F → S in CAD70161 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043035260 – 375Missing in isoform 2. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_044897260 – 320Missing in isoform 3. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272034 mRNA. Translation: CAC03489.1.
AY167927 mRNA. Translation: AAO12125.1.
AJ549088 mRNA. Translation: CAD70161.1.
AC008661 Genomic DNA. No translation available.
BC128185 mRNA. Translation: AAI28186.1.
CCDSiCCDS47267.2. [Q9HCX4-1]
CCDS54905.1. [Q9HCX4-2]
CCDS54906.1. [Q9HCX4-3]
RefSeqiNP_001161048.1. NM_001167576.1. [Q9HCX4-2]
NP_001161049.1. NM_001167577.1. [Q9HCX4-3]
NP_065122.1. NM_020389.2. [Q9HCX4-1]
UniGeneiHs.591263.

Genome annotation databases

EnsembliENST00000352189; ENSP00000330322; ENSG00000069018. [Q9HCX4-2]
ENST00000378459; ENSP00000367720; ENSG00000069018. [Q9HCX4-3]
ENST00000513104; ENSP00000426070; ENSG00000069018. [Q9HCX4-1]
GeneIDi57113.
KEGGihsa:57113.
UCSCiuc003lbn.3. human. [Q9HCX4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272034 mRNA. Translation: CAC03489.1.
AY167927 mRNA. Translation: AAO12125.1.
AJ549088 mRNA. Translation: CAD70161.1.
AC008661 Genomic DNA. No translation available.
BC128185 mRNA. Translation: AAI28186.1.
CCDSiCCDS47267.2. [Q9HCX4-1]
CCDS54905.1. [Q9HCX4-2]
CCDS54906.1. [Q9HCX4-3]
RefSeqiNP_001161048.1. NM_001167576.1. [Q9HCX4-2]
NP_001161049.1. NM_001167577.1. [Q9HCX4-3]
NP_065122.1. NM_020389.2. [Q9HCX4-1]
UniGeneiHs.591263.

3D structure databases

ProteinModelPortaliQ9HCX4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121378. 4 interactors.
IntActiQ9HCX4. 1 interactor.
STRINGi9606.ENSP00000426070.

PTM databases

iPTMnetiQ9HCX4.
PhosphoSitePlusiQ9HCX4.

Polymorphism and mutation databases

BioMutaiTRPC7.
DMDMi18202960.

Proteomic databases

PaxDbiQ9HCX4.
PeptideAtlasiQ9HCX4.
PRIDEiQ9HCX4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000352189; ENSP00000330322; ENSG00000069018. [Q9HCX4-2]
ENST00000378459; ENSP00000367720; ENSG00000069018. [Q9HCX4-3]
ENST00000513104; ENSP00000426070; ENSG00000069018. [Q9HCX4-1]
GeneIDi57113.
KEGGihsa:57113.
UCSCiuc003lbn.3. human. [Q9HCX4-1]

Organism-specific databases

CTDi57113.
DisGeNETi57113.
GeneCardsiTRPC7.
HGNCiHGNC:20754. TRPC7.
HPAiCAB022592.
HPA031126.
neXtProtiNX_Q9HCX4.
OpenTargetsiENSG00000069018.
PharmGKBiPA164742693.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000020590.
HOVERGENiHBG068337.
InParanoidiQ9HCX4.
KOiK04970.
OMAiGSNTFKN.
OrthoDBiEOG091G01FB.
PhylomeDBiQ9HCX4.
TreeFamiTF313147.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000069018-MONOMER.
ReactomeiR-HSA-114508. Effects of PIP2 hydrolysis.
R-HSA-139853. Elevation of cytosolic Ca2+ levels.
R-HSA-3295583. TRP channels.
R-HSA-418890. Role of second messengers in netrin-1 signaling.

Miscellaneous databases

ChiTaRSiTRPC7. human.
GeneWikiiTRPC7.
GenomeRNAii57113.
PROiQ9HCX4.

Gene expression databases

BgeeiENSG00000069018.
CleanExiHS_TRPC7.
ExpressionAtlasiQ9HCX4. baseline and differential.
GenevisibleiQ9HCX4. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005463. TRPC7_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF9. PTHR10117:SF9. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01648. TRPCHANNEL7.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPC7_HUMAN
AccessioniPrimary (citable) accession number: Q9HCX4
Secondary accession number(s): A1A4Z4
, F5H5U9, Q70T26, Q8IWP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.