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Protein

Breast cancer metastasis-suppressor 1

Gene

BRMS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.3 Publications

GO - Molecular functioni

  • histone deacetylase activity Source: Reactome
  • histone deacetylase binding Source: GO_Central
  • NF-kappaB binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • histone deacetylation Source: GO_Central
  • negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: GO_Central
  • positive regulation of anoikis Source: UniProtKB
  • positive regulation of protein deacetylation Source: UniProtKB
  • regulation of apoptotic process Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionRepressor
Biological processApoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214815 HDACs deacetylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
Breast cancer metastasis-suppressor 1
Gene namesi
Name:BRMS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000174744.13
HGNCiHGNC:17262 BRMS1
MIMi606259 gene
neXtProtiNX_Q9HCU9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi25855
OpenTargetsiENSG00000174744
PharmGKBiPA164741342

Polymorphism and mutation databases

BioMutaiBRMS1
DMDMi18202959

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000649881 – 246Breast cancer metastasis-suppressor 1Add BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki184Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki242Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9HCU9
MaxQBiQ9HCU9
PaxDbiQ9HCU9
PeptideAtlasiQ9HCU9
PRIDEiQ9HCU9

PTM databases

iPTMnetiQ9HCU9
PhosphoSitePlusiQ9HCU9

Expressioni

Tissue specificityi

Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.1 Publication

Gene expression databases

BgeeiENSG00000174744
CleanExiHS_BRMS1
ExpressionAtlasiQ9HCU9 baseline and differential
GenevisibleiQ9HCU9 HS

Organism-specific databases

HPAiCAB010824
HPA019637

Interactioni

Subunit structurei

Homohexamer (Potential). Interacts with SNX6, HDAC1 and RELA. Interacts with ARID4A. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, SUDS3, ARID4A, HDAC1 and HDAC2. Interacts with SPOP; this recruits the protein to a ubiquitin ligase complex containing SPOP and CUL3.Curated5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • histone deacetylase binding Source: GO_Central
  • NF-kappaB binding Source: UniProtKB

Protein-protein interaction databases

BioGridi11737964 interactors.
CORUMiQ9HCU9
DIPiDIP-24250N
IntActiQ9HCU9 36 interactors.
MINTiQ9HCU9
STRINGi9606.ENSP00000396052

Structurei

Secondary structure

1246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi55 – 93Combined sources39

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XUSX-ray1.91A/B51-98[»]
4AUVX-ray2.00A/B/C/D/E/F/G/H51-84[»]
ProteinModelPortaliQ9HCU9
SMRiQ9HCU9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HCU9

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili51 – 981 PublicationAdd BLAST48

Domaini

Contains an N-terminal anti-parallel coiled coil formed by two BRMS1 chains; this region can form homohexamers.

Sequence similaritiesi

Belongs to the BRMS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4466 Eukaryota
ENOG410Y9N9 LUCA
GeneTreeiENSGT00910000144178
HOGENOMiHOG000007483
HOVERGENiHBG050734
InParanoidiQ9HCU9
KOiK19196
PhylomeDBiQ9HCU9

Family and domain databases

InterProiView protein in InterPro
IPR013907 Sds3
PANTHERiPTHR21964 PTHR21964, 1 hit
PfamiView protein in Pfam
PF08598 Sds3, 1 hit
SMARTiView protein in SMART
SM01401 Sds3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9HCU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVQPPSKDT EEMEAEGDSA AEMNGEEEES EEERSGSQTE SEEESSEMDD
60 70 80 90 100
EDYERRRSEC VSEMLDLEKQ FSELKEKLFR ERLSQLRLRL EEVGAERAPE
110 120 130 140 150
YTEPLGGLQR SLKIRIQVAG IYKGFCLDVI RNKYECELQG AKQHLESEKL
160 170 180 190 200
LLYDTLQGEL QERIQRLEED RQSLDLSSEW WDDKLHARGS SRSWDSLPPS
210 220 230 240
KRKKAPLVSG PYIVYMLQEI DILEDWTAIK KARAAVSPQK RKSDGP
Length:246
Mass (Da):28,461
Last modified:March 1, 2001 - v1
Checksum:i89FB59FB96ECD4DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159141 mRNA Translation: AAG00075.1
AF281036 Genomic DNA Translation: AAK69131.1
CR457173 mRNA Translation: CAG33454.1
AK313773 mRNA Translation: BAG36511.1
BC009834 mRNA Translation: AAH09834.1
CCDSiCCDS8135.1
RefSeqiNP_056214.1, NM_015399.3
UniGeneiHs.100426

Genome annotation databases

EnsembliENST00000359957; ENSP00000353042; ENSG00000174744
GeneIDi25855
KEGGihsa:25855
UCSCiuc001ohp.2 human

Similar proteinsi

Entry informationi

Entry nameiBRMS1_HUMAN
AccessioniPrimary (citable) accession number: Q9HCU9
Secondary accession number(s): Q6IAI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome