Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Breast cancer metastasis-suppressor 1

Gene

BRMS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.3 Publications

GO - Molecular functioni

  • histone deacetylase activity Source: Reactome
  • histone deacetylase binding Source: GO_Central
  • NF-kappaB binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • histone deacetylation Source: GO_Central
  • negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • positive regulation of anoikis Source: UniProtKB
  • positive regulation of protein deacetylation Source: UniProtKB
  • regulation of apoptotic process Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionRepressor
Biological processApoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214815. HDACs deacetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Breast cancer metastasis-suppressor 1
Gene namesi
Name:BRMS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:17262. BRMS1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
  • Sin3-type complex Source: GO_Central

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi25855.
OpenTargetsiENSG00000174744.
PharmGKBiPA164741342.

Polymorphism and mutation databases

BioMutaiBRMS1.
DMDMi18202959.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000649881 – 246Breast cancer metastasis-suppressor 1Add BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki184Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki242Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9HCU9.
MaxQBiQ9HCU9.
PaxDbiQ9HCU9.
PeptideAtlasiQ9HCU9.
PRIDEiQ9HCU9.

PTM databases

iPTMnetiQ9HCU9.
PhosphoSitePlusiQ9HCU9.

Expressioni

Tissue specificityi

Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.1 Publication

Gene expression databases

BgeeiENSG00000174744.
CleanExiHS_BRMS1.
ExpressionAtlasiQ9HCU9. baseline and differential.
GenevisibleiQ9HCU9. HS.

Organism-specific databases

HPAiCAB010824.
HPA019637.

Interactioni

Subunit structurei

Homohexamer (Potential). Interacts with SNX6, HDAC1 and RELA. Interacts with ARID4A. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, SUDS3, ARID4A, HDAC1 and HDAC2. Interacts with SPOP; this recruits the protein to a ubiquitin ligase complex containing SPOP and CUL3.Curated5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • histone deacetylase binding Source: GO_Central
  • NF-kappaB binding Source: UniProtKB

Protein-protein interaction databases

BioGridi117379. 64 interactors.
DIPiDIP-24250N.
IntActiQ9HCU9. 36 interactors.
MINTiMINT-1389009.
STRINGi9606.ENSP00000396052.

Structurei

Secondary structure

1246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi55 – 93Combined sources39

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XUSX-ray1.91A/B51-98[»]
4AUVX-ray2.00A/B/C/D/E/F/G/H51-84[»]
ProteinModelPortaliQ9HCU9.
SMRiQ9HCU9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HCU9.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili51 – 981 PublicationAdd BLAST48

Domaini

Contains an N-terminal anti-parallel coiled coil formed by two BRMS1 chains; this region can form homohexamers.

Sequence similaritiesi

Belongs to the BRMS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4466. Eukaryota.
ENOG410Y9N9. LUCA.
GeneTreeiENSGT00530000063177.
HOGENOMiHOG000007483.
HOVERGENiHBG050734.
InParanoidiQ9HCU9.
KOiK19196.
PhylomeDBiQ9HCU9.

Family and domain databases

InterProiView protein in InterPro
IPR013907. Sds3.
PfamiView protein in Pfam
PF08598. Sds3. 1 hit.
SMARTiView protein in SMART
SM01401. Sds3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9HCU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVQPPSKDT EEMEAEGDSA AEMNGEEEES EEERSGSQTE SEEESSEMDD
60 70 80 90 100
EDYERRRSEC VSEMLDLEKQ FSELKEKLFR ERLSQLRLRL EEVGAERAPE
110 120 130 140 150
YTEPLGGLQR SLKIRIQVAG IYKGFCLDVI RNKYECELQG AKQHLESEKL
160 170 180 190 200
LLYDTLQGEL QERIQRLEED RQSLDLSSEW WDDKLHARGS SRSWDSLPPS
210 220 230 240
KRKKAPLVSG PYIVYMLQEI DILEDWTAIK KARAAVSPQK RKSDGP
Length:246
Mass (Da):28,461
Last modified:March 1, 2001 - v1
Checksum:i89FB59FB96ECD4DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159141 mRNA. Translation: AAG00075.1.
AF281036 Genomic DNA. Translation: AAK69131.1.
CR457173 mRNA. Translation: CAG33454.1.
AK313773 mRNA. Translation: BAG36511.1.
BC009834 mRNA. Translation: AAH09834.1.
CCDSiCCDS8135.1.
RefSeqiNP_056214.1. NM_015399.3.
UniGeneiHs.100426.

Genome annotation databases

EnsembliENST00000359957; ENSP00000353042; ENSG00000174744.
GeneIDi25855.
KEGGihsa:25855.
UCSCiuc001ohp.2. human.

Similar proteinsi

Entry informationi

Entry nameiBRMS1_HUMAN
AccessioniPrimary (citable) accession number: Q9HCU9
Secondary accession number(s): Q6IAI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: August 30, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families