Q9HCU4 (CELR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cadherin EGF LAG seven-pass G-type receptor 2

Alternative name(s):
Cadherin family member 10
Epidermal growth factor-like protein 2
Short name=EGF-like protein 2
Flamingo homolog 3
Multiple epidermal growth factor-like domains protein 3
Short name=Multiple EGF-like domains protein 3

Gene names

Name:	CELSR2
Synonyms:	CDHF10, EGFL2, KIAA0279, MEGF3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2923 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor that may have an important role in cell/cell signaling during nervous system formation.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Highest expression in brain and testis.
Post-translational modification	The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 9 cadherin domains. Contains 7 EGF-like domains. Contains 1 GPS domain. Contains 1 laminin EGF-like domain. Contains 2 laminin G-like domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	EGF-like domain Laminin EGF-like domain Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Developmental protein G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Hydroxylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway Inferred from sequence or structural similarity. Source: BHF-UCL dendrite morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL homophilic cell adhesion Inferred from sequence or structural similarity. Source: BHF-UCL neural plate anterior/posterior regionalization Inferred from sequence or structural similarity. Source: BHF-UCL neuron migration Inferred from electronic annotation. Source: Compara neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro regulation of cell-cell adhesion Inferred from sequence or structural similarity. Source: BHF-UCL regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: BHF-UCL ventricular system development Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: BHF-UCL integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB plasma membrane Inferred from sequence or structural similarity. Source: BHF-UCL
Molecular_function	G-protein coupled receptor activity Non-traceable author statement Ref.1. Source: UniProtKB calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	Potential
	Chain	32 – 2923	2892	Cadherin EGF LAG seven-pass G-type receptor 2		PRO_0000012916
Regions
	Topological domain	32 – 2380	2349	Extracellular Potential
	Transmembrane	2381 – 2401	21	Helical; Name=1; Potential
	Topological domain	2402 – 2416	15	Cytoplasmic Potential
	Transmembrane	2417 – 2437	21	Helical; Name=2; Potential
	Topological domain	2438	1	Extracellular Potential
	Transmembrane	2439 – 2459	21	Helical; Name=3; Potential
	Topological domain	2460 – 2480	21	Cytoplasmic Potential
	Transmembrane	2481 – 2501	21	Helical; Name=4; Potential
	Topological domain	2502 – 2519	18	Extracellular Potential
	Transmembrane	2520 – 2540	21	Helical; Name=5; Potential
	Topological domain	2541 – 2560	20	Cytoplasmic Potential
	Transmembrane	2561 – 2581	21	Helical; Name=6; Potential
	Topological domain	2582 – 2591	10	Extracellular Potential
	Transmembrane	2592 – 2612	21	Helical; Name=7; Potential
	Topological domain	2613 – 2923	311	Cytoplasmic Potential
	Domain	182 – 289	108	Cadherin 1
	Domain	290 – 399	110	Cadherin 2
	Domain	400 – 505	106	Cadherin 3
	Domain	506 – 610	105	Cadherin 4
	Domain	611 – 712	102	Cadherin 5
	Domain	713 – 815	103	Cadherin 6
	Domain	816 – 921	106	Cadherin 7
	Domain	922 – 1023	102	Cadherin 8
	Domain	1028 – 1146	119	Cadherin 9
	Domain	1228 – 1286	59	EGF-like 1; calcium-binding
	Domain	1288 – 1324	37	EGF-like 2; calcium-binding
	Domain	1328 – 1366	39	EGF-like 3; calcium-binding
	Domain	1367 – 1571	205	Laminin G-like 1
	Domain	1574 – 1610	37	EGF-like 4; calcium-binding
	Domain	1614 – 1791	178	Laminin G-like 2
	Domain	1793 – 1828	36	EGF-like 5; calcium-binding
	Domain	1829 – 1867	39	EGF-like 6; calcium-binding
	Domain	1883 – 1922	40	EGF-like 7; calcium-binding
	Domain	1924 – 1971	48	Laminin EGF-like
	Domain	2316 – 2368	53	GPS
	Compositional bias	2743 – 2752	10	Poly-Glu
Amino acid modifications
	Modified residue	1591	1	(3R)-3-hydroxyasparagine Potential
	Modified residue	1810	1	(3R)-3-hydroxyasparagine Potential
	Glycosylation	486	1	N-linked (GlcNAc...) Potential
	Glycosylation	557	1	N-linked (GlcNAc...) Potential
	Glycosylation	701	1	N-linked (GlcNAc...) Potential
	Glycosylation	1036	1	N-linked (GlcNAc...) Potential
	Glycosylation	1076	1	N-linked (GlcNAc...) Potential
	Glycosylation	1182	1	N-linked (GlcNAc...) Potential
	Glycosylation	1212	1	N-linked (GlcNAc...) Potential
	Glycosylation	1501	1	N-linked (GlcNAc...) Potential
	Glycosylation	1565	1	N-linked (GlcNAc...) Potential
	Glycosylation	1741	1	N-linked (GlcNAc...) Potential
	Glycosylation	1827	1	N-linked (GlcNAc...) Potential
	Glycosylation	1900	1	N-linked (GlcNAc...) Potential
	Glycosylation	2024	1	N-linked (GlcNAc...) Potential
	Glycosylation	2043	1	N-linked (GlcNAc...) Potential
	Glycosylation	2061	1	N-linked (GlcNAc...) Potential
	Glycosylation	2323	1	N-linked (GlcNAc...) Potential
	Glycosylation	2345	1	N-linked (GlcNAc...) Potential
	Disulfide bond	1232 ↔ 1243		By similarity
	Disulfide bond	1237 ↔ 1274		By similarity
	Disulfide bond	1276 ↔ 1285		By similarity
	Disulfide bond	1292 ↔ 1303		By similarity
	Disulfide bond	1297 ↔ 1312		By similarity
	Disulfide bond	1314 ↔ 1323		By similarity
	Disulfide bond	1332 ↔ 1343		By similarity
	Disulfide bond	1337 ↔ 1353		By similarity
	Disulfide bond	1355 ↔ 1365		By similarity
	Disulfide bond	1545 ↔ 1571		By similarity
	Disulfide bond	1578 ↔ 1589		By similarity
	Disulfide bond	1583 ↔ 1598		By similarity
	Disulfide bond	1600 ↔ 1609		By similarity
	Disulfide bond	1761 ↔ 1791		By similarity
	Disulfide bond	1797 ↔ 1808		By similarity
	Disulfide bond	1802 ↔ 1817		By similarity
	Disulfide bond	1819 ↔ 1828		By similarity
	Disulfide bond	1832 ↔ 1843		By similarity
	Disulfide bond	1837 ↔ 1855		By similarity
	Disulfide bond	1857 ↔ 1866		By similarity
	Disulfide bond	1887 ↔ 1899		By similarity
	Disulfide bond	1889 ↔ 1906		By similarity
	Disulfide bond	1908 ↔ 1921		By similarity
	Disulfide bond	1924 ↔ 1936		By similarity
	Disulfide bond	1926 ↔ 1943		By similarity
	Disulfide bond	1945 ↔ 1954		By similarity
	Disulfide bond	1957 ↔ 1969		By similarity
Natural variations
	Natural variant	1066	1	R → Q. Corresponds to variant rs12083590 [ dbSNP | Ensembl ].		VAR_049474
	Natural variant	1639	1	Y → H. Ref.4 Corresponds to variant rs653635 [ dbSNP | Ensembl ].		VAR_024481
	Natural variant	1992	1	G → R. Corresponds to variant rs12567377 [ dbSNP | Ensembl ].		VAR_049475
	Natural variant	2387	1	T → A. Corresponds to variant rs17035649 [ dbSNP | Ensembl ].		VAR_049476

Sequences

	Sequence		Length	Mass (Da)
	Q9HCU4 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 382757D315158ED8	FASTA	2,923	317,453
	10 20 30 40 50 60 MRSPATGVPL PTPPPPLLLL LLLLLPPPLL GDQVGPCRSL GSRGRGSSGA CAPMGWLCPS 70 80 90 100 110 120 SASNLWLYTS RCRDAGTELT GHLVPHHDGL RVWCPESEAH IPLPPAPEGC PWSCRLLGIG 130 140 150 160 170 180 GHLSPQGKLT LPEEHPCLKA PRLRCQSCKL AQAPGLRAGE RSPEESLGGR RKRNVNTAPQ 190 200 210 220 230 240 FQPPSYQATV PENQPAGTPV ASLRAIDPDE GEAGRLEYTM DALFDSRSNQ FFSLDPVTGA 250 260 270 280 290 300 VTTAEELDRE TKSTHVFRVT AQDHGMPRRS ALATLTILVT DTNDHDPVFE QQEYKESLRE 310 320 330 340 350 360 NLEVGYEVLT VRATDGDAPP NANILYRLLE GSGGSPSEVF EIDPRSGVIR TRGPVDREEV 370 380 390 400 410 420 ESYQLTVEAS DQGRDPGPRS TTAAVFLSVE DDNDNAPQFS EKRYVVQVRE DVTPGAPVLR 430 440 450 460 470 480 VTASDRDKGS NAVVHYSIMS GNARGQFYLD AQTGALDVVS PLDYETTKEY TLRVRAQDGG 490 500 510 520 530 540 RPPLSNVSGL VTVQVLDIND NAPIFVSTPF QATVLESVPL GYLVLHVQAI DADAGDNARL 550 560 570 580 590 600 EYRLAGVGHD FPFTINNGTG WISVAAELDR EEVDFYSFGV EARDHGTPAL TASASVSVTV 610 620 630 640 650 660 LDVNDNNPTF TQPEYTVRLN EDAAVGTSVV TVSAVDRDAH SVITYQITSG NTRNRFSITS 670 680 690 700 710 720 QSGGGLVSLA LPLDYKLERQ YVLAVTASDG TRQDTAQIVV NVTDANTHRP VFQSSHYTVN 730 740 750 760 770 780 VNEDRPAGTT VVLISATDED TGENARITYF MEDSIPQFRI DADTGAVTTQ AELDYEDQVS 790 800 810 820 830 840 YTLAITARDN GIPQKSDTTY LEILVNDVND NAPQFLRDSY QGSVYEDVPP FTSVLQISAT 850 860 870 880 890 900 DRDSGLNGRV FYTFQGGDDG DGDFIVESTS GIVRTLRRLD RENVAQYVLR AYAVDKGMPP 910 920 930 940 950 960 ARTPMEVTVT VLDVNDNPPV FEQDEFDVFV EENSPIGLAV ARVTATDPDE GTNAQIMYQI 970 980 990 1000 1010 1020 VEGNIPEVFQ LDIFSGELTA LVDLDYEDRP EYVLVIQATS APLVSRATVH VRLLDRNDNP 1030 1040 1050 1060 1070 1080 PVLGNFEILF NNYVTNRSSS FPGGAIGRVP AHDPDISDSL TYSFERGNEL SLVLLNASTG 1090 1100 1110 1120 1130 1140 ELKLSRALDN NRPLEAIMSV LVSDGVHSVT AQCALRVTII TDEMLTHSIT LRLEDMSPER 1150 1160 1170 1180 1190 1200 FLSPLLGLFI QAVAATLATP PDHVVVFNVQ RDTDAPGGHI LNVSLSVGQP PGPGGGPPFL 1210 1220 1230 1240 1250 1260 PSEDLQERLY LNRSLLTAIS AQRVLPFDDN ICLREPCENY MRCVSVLRFD SSAPFIASSS 1270 1280 1290 1300 1310 1320 VLFRPIHPVG GLRCRCPPGF TGDYCETEVD LCYSRPCGPH GRCRSREGGY TCLCRDGYTG 1330 1340 1350 1360 1370 1380 EHCEVSARSG RCTPGVCKNG GTCVNLLVGG FKCDCPSGDF EKPYCQVTTR SFPAHSFITF 1390 1400 1410 1420 1430 1440 RGLRQRFHFT LALSFATKER DGLLLYNGRF NEKHDFVALE VIQEQVQLTF SAGESTTTVS 1450 1460 1470 1480 1490 1500 PFVPGGVSDG QWHTVQLKYY NKPLLGQTGL PQGPSEQKVA VVTVDGCDTG VALRFGSVLG 1510 1520 1530 1540 1550 1560 NYSCAAQGTQ GGSKKSLDLT GPLLLGGVPD LPESFPVRMR QFVGCMRNLQ VDSRHIDMAD 1570 1580 1590 1600 1610 1620 FIANNGTVPG CPAKKNVCDS NTCHNGGTCV NQWDAFSCEC PLGFGGKSCA QEMANPQHFL 1630 1640 1650 1660 1670 1680 GSSLVAWHGL SLPISQPWYL SLMFRTRQAD GVLLQAITRG RSTITLQLRE GHVMLSVEGT 1690 1700 1710 1720 1730 1740 GLQASSLRLE PGRANDGDWH HAQLALGASG GPGHAILSFD YGQQRAEGNL GPRLHGLHLS 1750 1760 1770 1780 1790 1800 NITVGGIPGP AGGVARGFRG CLQGVRVSDT PEGVNSLDPS HGESINVEQG CSLPDPCDSN 1810 1820 1830 1840 1850 1860 PCPANSYCSN DWDSYSCSCD PGYYGDNCTN VCDLNPCEHQ SVCTRKPSAP HGYTCECPPN 1870 1880 1890 1900 1910 1920 YLGPYCETRI DQPCPRGWWG HPTCGPCNCD VSKGFDPDCN KTSGECHCKE NHYRPPGSPT 1930 1940 1950 1960 1970 1980 CLLCDCYPTG SLSRVCDPED GQCPCKPGVI GRQCDRCDNP FAEVTTNGCE VNYDSCPRAI 1990 2000 2010 2020 2030 2040 EAGIWWPRTR FGLPAAAPCP KGSFGTAVRH CDEHRGWLPP NLFNCTSITF SELKGFAERL 2050 2060 2070 2080 2090 2100 QRNESGLDSG RSQQLALLLR NATQHTAGYF GSDVKVAYQL ATRLLAHEST QRGFGLSATQ 2110 2120 2130 2140 2150 2160 DVHFTENLLR VGSALLDTAN KRHWELIQQT EGGTAWLLQH YEAYASALAQ NMRHTYLSPF 2170 2180 2190 2200 2210 2220 TIVTPNIVIS VVRLDKGNFA GAKLPRYEAL RGEQPPDLET TVILPESVFR ETPPVVRPAG 2230 2240 2250 2260 2270 2280 PGEAQEPEEL ARRQRRHPEL SQGEAVASVI IYRTLAGLLP HNYDPDKRSL RVPKRPIINT 2290 2300 2310 2320 2330 2340 PVVSISVHDD EELLPRALDK PVTVQFRLLE TEERTKPICV FWNHSILVSG TGGWSARGCE 2350 2360 2370 2380 2390 2400 VVFRNESHVS CQCNHMTSFA VLMDVSRREN GEILPLKTLT YVALGVTLAA LLLTFFFLTL 2410 2420 2430 2440 2450 2460 LRILRSNQHG IRRNLTAALG LAQLVFLLGI NQADLPFACT VIAILLHFLY LCTFSWALLE 2470 2480 2490 2500 2510 2520 ALHLYRALTE VRDVNTGPMR FYYMLGWGVP AFITGLAVGL DPEGYGNPDF CWLSIYDTLI 2530 2540 2550 2560 2570 2580 WSFAGPVAFA VSMSVFLYIL AARASCAAQR QGFEKKGPVS GLQPSFAVLL LLSATWLLAL 2590 2600 2610 2620 2630 2640 LSVNSDTLLF HYLFATCNCI QGPFIFLSYV VLSKEVRKAL KLACSRKPSP DPALTTKSTL 2650 2660 2670 2680 2690 2700 TSSYNCPSPY ADGRLYQPYG DSAGSLHSTS RSGKSQPSYI PFLLREESAL NPGQGPPGLG 2710 2720 2730 2740 2750 2760 DPGSLFLEGQ DQQHDPDTDS DSDLSLEDDQ SGSYASTHSS DSEEEEEEEE EEAAFPGEQG 2770 2780 2790 2800 2810 2820 WDSLLGPGAE RLPLHSTPKD GGPGPGKAPW PGDFGTTAKE SSGNGAPEER LRENGDALSR 2830 2840 2850 2860 2870 2880 EGSLGPLPGS SAQPHKGILK KKCLPTISEK SSLLRLPLEQ CTGSSRGSSA SEGSRGGPPP 2890 2900 2910 2920 RPPPRQSLQE QLNGVMPIAM SIKAGTVDED SSGSEFLFFN FLH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human homologue of flamingo, EGFL2, encodes a brain-expressed large cadherin-like protein with epidermal growth factor-like domains, and maps to chromosome 1p13.3-p21.1." Vincent J.B., Skaug J., Scherer S.W. DNA Res. 7:233-235(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N. DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-2923, VARIANT HIS-1639. Tissue: Brain.
[5]	Ohara O., Nagase T., Kikuno R., Nomura N. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF234887 mRNA. Translation: AAG00080.1. AB065955 Genomic DNA. Translation: BAC06168.1. AL390252 Genomic DNA. Translation: CAI13170.1. D87469 mRNA. Translation: BAA13407.2.
IPI	IPI00015346.
RefSeq	NP_001399.1. NM_001408.2.
UniGene	Hs.57652.
3D structure databases
ProteinModelPortal	Q9HCU4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9HCU4. 6 interactions.
MINT	MINT-1395407.
STRING	9606.ENSP00000271332.
Protein family/group databases
MEROPS	I63.002.
GPCRDB	Search...
PTM databases
PhosphoSite	Q9HCU4.
Polymorphism databases
DMDM	22095550.
Proteomic databases
PaxDb	Q9HCU4.
PRIDE	Q9HCU4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000271332; ENSP00000271332; ENSG00000143126.
GeneID	1952.
KEGG	hsa:1952.
UCSC	uc001dxa.4. human.
Organism-specific databases
CTD	1952.
GeneCards	GC01P109792.
HGNC	HGNC:3231. CELSR2.
HPA	HPA013952.
MIM	604265. gene.
neXtProt	NX_Q9HCU4.
PharmGKB	PA26394.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000231346.
HOVERGEN	HBG050887.
InParanoid	Q9HCU4.
KO	K04601.
OMA	YILRAYA.
OrthoDB	EOG4KKZ23.
Enzyme and pathway databases
SignaLink	Q9HCU4.
Gene expression databases
Bgee	Q9HCU4.
CleanEx	HS_CELSR2.
Genevestigator	Q9HCU4.
GermOnline	ENSG00000143126. Homo sapiens.
Family and domain databases
Gene3D	2.60.120.200. 2 hits. 2.60.40.60. 9 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR022624. DUF3497. IPR000742. EG-like_dom. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR002049. EGF_laminin. IPR017981. GPCR_2-like. IPR001879. GPCR_2_extracellular_dom. IPR000832. GPCR_2_secretin-like. IPR000203. GPS_dom. IPR001791. Laminin_G. IPR001368. TNFR/NGFR_Cys_rich_reg. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. PF00028. Cadherin. 8 hits. PF12003. DUF3497. 1 hit. PF00008. EGF. 1 hit. PF01825. GPS. 1 hit. PF00053. Laminin_EGF. 1 hit. PF02210. Laminin_G_2. 2 hits. [Graphical view]
PRINTS	PR00205. CADHERIN. PR00249. GPCRSECRETIN.
SMART	SM00112. CA. 9 hits. SM00181. EGF. 5 hits. SM00179. EGF_CA. 1 hit. SM00180. EGF_Lam. 1 hit. SM00303. GPS. 1 hit. SM00008. HormR. 1 hit. SM00282. LamG. 2 hits. SM00208. TNFR. 1 hit. [Graphical view]
SUPFAM	SSF49313. Cadherin. 9 hits. SSF49899. ConA_like_lec_gl. 2 hits.
PROSITE	PS00010. ASX_HYDROXYL. 2 hits. PS00232. CADHERIN_1. 7 hits. PS50268. CADHERIN_2. 9 hits. PS00022. EGF_1. 6 hits. PS01186. EGF_2. 4 hits. PS50026. EGF_3. 6 hits. PS01248. EGF_LAM_1. 1 hit. PS50027. EGF_LAM_2. 2 hits. PS00649. G_PROTEIN_RECEP_F2_1. False negative. PS00650. G_PROTEIN_RECEP_F2_2. False negative. PS50227. G_PROTEIN_RECEP_F2_3. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. PS50221. GPS. 1 hit. PS50025. LAM_G_DOMAIN. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CELSR2. human.
GenomeRNAi	1952.
NextBio	7911.
SOURCE	Search...

Entry information

Entry name

CELR2_HUMAN

Accession

Primary (citable) accession number: Q9HCU4
Secondary accession number(s): Q5T2Y7, Q92566

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 2, 2002
Last sequence update:	March 1, 2001
Last modified:	May 29, 2013
This is version 123 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.