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Q9HCU4

- CELR2_HUMAN

UniProt

Q9HCU4 - CELR2_HUMAN

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Protein

Cadherin EGF LAG seven-pass G-type receptor 2

Gene

CELSR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor that may have an important role in cell/cell signaling during nervous system formation.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

  1. cerebrospinal fluid secretion Source: Ensembl
  2. cilium assembly Source: Ensembl
  3. cilium movement Source: Ensembl
  4. dendrite morphogenesis Source: BHF-UCL
  5. G-protein coupled receptor signaling pathway Source: UniProtKB
  6. homophilic cell adhesion Source: BHF-UCL
  7. neural plate anterior/posterior regionalization Source: BHF-UCL
  8. neuron migration Source: Ensembl
  9. neuropeptide signaling pathway Source: InterPro
  10. regulation of cell-cell adhesion Source: BHF-UCL
  11. regulation of protein localization Source: Ensembl
  12. regulation of transcription, DNA-templated Source: BHF-UCL
  13. ventricular system development Source: Ensembl
  14. Wnt signaling pathway Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Calcium

Enzyme and pathway databases

SignaLinkiQ9HCU4.

Protein family/group databases

MEROPSiS63.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin EGF LAG seven-pass G-type receptor 2
Alternative name(s):
Cadherin family member 10
Epidermal growth factor-like protein 2
Short name:
EGF-like protein 2
Flamingo homolog 3
Multiple epidermal growth factor-like domains protein 3
Short name:
Multiple EGF-like domains protein 3
Gene namesi
Name:CELSR2
Synonyms:CDHF10, EGFL2, KIAA0279, MEGF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:3231. CELSR2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. integral component of membrane Source: UniProtKB
  3. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26394.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 29232892Cadherin EGF LAG seven-pass G-type receptor 2PRO_0000012916Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi557 – 5571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi701 – 7011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1036 – 10361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1076 – 10761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1182 – 11821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1212 – 12121N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1232 ↔ 1243By similarity
Disulfide bondi1237 ↔ 1274By similarity
Disulfide bondi1276 ↔ 1285By similarity
Disulfide bondi1292 ↔ 1303By similarity
Disulfide bondi1297 ↔ 1312By similarity
Disulfide bondi1314 ↔ 1323By similarity
Disulfide bondi1332 ↔ 1343By similarity
Disulfide bondi1337 ↔ 1353By similarity
Disulfide bondi1355 ↔ 1365By similarity
Glycosylationi1501 – 15011N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1545 ↔ 1571By similarity
Glycosylationi1565 – 15651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1578 ↔ 1589By similarity
Disulfide bondi1583 ↔ 1598By similarity
Modified residuei1591 – 15911(3R)-3-hydroxyasparagineSequence Analysis
Disulfide bondi1600 ↔ 1609By similarity
Glycosylationi1741 – 17411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1761 ↔ 1791By similarity
Disulfide bondi1797 ↔ 1808By similarity
Disulfide bondi1802 ↔ 1817By similarity
Modified residuei1810 – 18101(3R)-3-hydroxyasparagineSequence Analysis
Disulfide bondi1819 ↔ 1828By similarity
Glycosylationi1827 – 18271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1832 ↔ 1843By similarity
Disulfide bondi1837 ↔ 1855By similarity
Disulfide bondi1857 ↔ 1866By similarity
Disulfide bondi1887 ↔ 1899By similarity
Disulfide bondi1889 ↔ 1906By similarity
Glycosylationi1900 – 19001N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1908 ↔ 1921By similarity
Disulfide bondi1924 ↔ 1936By similarity
Disulfide bondi1926 ↔ 1943By similarity
Disulfide bondi1945 ↔ 1954By similarity
Disulfide bondi1957 ↔ 1969By similarity
Glycosylationi2024 – 20241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2043 – 20431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2061 – 20611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2323 – 23231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2345 – 23451N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiQ9HCU4.
PaxDbiQ9HCU4.
PRIDEiQ9HCU4.

PTM databases

PhosphoSiteiQ9HCU4.

Expressioni

Tissue specificityi

Highest expression in brain and testis.

Gene expression databases

BgeeiQ9HCU4.
CleanExiHS_CELSR2.
GenevestigatoriQ9HCU4.

Organism-specific databases

HPAiHPA013952.

Interactioni

Protein-protein interaction databases

BioGridi108272. 10 interactions.
IntActiQ9HCU4. 7 interactions.
MINTiMINT-1395407.
STRINGi9606.ENSP00000271332.

Structurei

3D structure databases

ProteinModelPortaliQ9HCU4.
SMRiQ9HCU4. Positions 152-1089, 1228-1368, 1376-1700, 1791-1970, 1977-2356.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 23802349ExtracellularSequence AnalysisAdd
BLAST
Topological domaini2402 – 241615CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini2438 – 24381ExtracellularSequence Analysis
Topological domaini2460 – 248021CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini2502 – 251918ExtracellularSequence AnalysisAdd
BLAST
Topological domaini2541 – 256020CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini2582 – 259110ExtracellularSequence Analysis
Topological domaini2613 – 2923311CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2381 – 240121Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei2417 – 243721Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei2439 – 245921Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei2481 – 250121Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei2520 – 254021Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei2561 – 258121Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei2592 – 261221Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini182 – 289108Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini290 – 399110Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini400 – 505106Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini506 – 610105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini611 – 712102Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini713 – 815103Cadherin 6PROSITE-ProRule annotationAdd
BLAST
Domaini816 – 921106Cadherin 7PROSITE-ProRule annotationAdd
BLAST
Domaini922 – 1023102Cadherin 8PROSITE-ProRule annotationAdd
BLAST
Domaini1028 – 1146119Cadherin 9PROSITE-ProRule annotationAdd
BLAST
Domaini1228 – 128659EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1288 – 132437EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1328 – 136639EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1367 – 1571205Laminin G-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini1574 – 161037EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1614 – 1791178Laminin G-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini1793 – 182836EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1829 – 186739EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1883 – 192240EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1924 – 197148Laminin EGF-likePROSITE-ProRule annotationAdd
BLAST
Domaini2316 – 236853GPSPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2743 – 275210Poly-Glu

Sequence similaritiesi

Contains 9 cadherin domains.PROSITE-ProRule annotation
Contains 7 EGF-like domains.PROSITE-ProRule annotation
Contains 1 GPS domain.PROSITE-ProRule annotation
Contains 1 laminin EGF-like domain.PROSITE-ProRule annotation
Contains 2 laminin G-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000231346.
HOVERGENiHBG050887.
InParanoidiQ9HCU4.
KOiK04601.
OMAiCKLAQAP.
OrthoDBiEOG7BP81K.
PhylomeDBiQ9HCU4.
TreeFamiTF323983.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
2.60.40.60. 9 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR002049. EGF_laminin.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 8 hits.
PF12003. DUF3497. 1 hit.
PF00008. EGF. 1 hit.
PF01825. GPS. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTiSM00112. CA. 9 hits.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 1 hit.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
SM00208. TNFR. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 9 hits.
SSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS00232. CADHERIN_1. 7 hits.
PS50268. CADHERIN_2. 9 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 2 hits.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HCU4-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MRSPATGVPL PTPPPPLLLL LLLLLPPPLL GDQVGPCRSL GSRGRGSSGA
60 70 80 90 100
CAPMGWLCPS SASNLWLYTS RCRDAGTELT GHLVPHHDGL RVWCPESEAH
110 120 130 140 150
IPLPPAPEGC PWSCRLLGIG GHLSPQGKLT LPEEHPCLKA PRLRCQSCKL
160 170 180 190 200
AQAPGLRAGE RSPEESLGGR RKRNVNTAPQ FQPPSYQATV PENQPAGTPV
210 220 230 240 250
ASLRAIDPDE GEAGRLEYTM DALFDSRSNQ FFSLDPVTGA VTTAEELDRE
260 270 280 290 300
TKSTHVFRVT AQDHGMPRRS ALATLTILVT DTNDHDPVFE QQEYKESLRE
310 320 330 340 350
NLEVGYEVLT VRATDGDAPP NANILYRLLE GSGGSPSEVF EIDPRSGVIR
360 370 380 390 400
TRGPVDREEV ESYQLTVEAS DQGRDPGPRS TTAAVFLSVE DDNDNAPQFS
410 420 430 440 450
EKRYVVQVRE DVTPGAPVLR VTASDRDKGS NAVVHYSIMS GNARGQFYLD
460 470 480 490 500
AQTGALDVVS PLDYETTKEY TLRVRAQDGG RPPLSNVSGL VTVQVLDIND
510 520 530 540 550
NAPIFVSTPF QATVLESVPL GYLVLHVQAI DADAGDNARL EYRLAGVGHD
560 570 580 590 600
FPFTINNGTG WISVAAELDR EEVDFYSFGV EARDHGTPAL TASASVSVTV
610 620 630 640 650
LDVNDNNPTF TQPEYTVRLN EDAAVGTSVV TVSAVDRDAH SVITYQITSG
660 670 680 690 700
NTRNRFSITS QSGGGLVSLA LPLDYKLERQ YVLAVTASDG TRQDTAQIVV
710 720 730 740 750
NVTDANTHRP VFQSSHYTVN VNEDRPAGTT VVLISATDED TGENARITYF
760 770 780 790 800
MEDSIPQFRI DADTGAVTTQ AELDYEDQVS YTLAITARDN GIPQKSDTTY
810 820 830 840 850
LEILVNDVND NAPQFLRDSY QGSVYEDVPP FTSVLQISAT DRDSGLNGRV
860 870 880 890 900
FYTFQGGDDG DGDFIVESTS GIVRTLRRLD RENVAQYVLR AYAVDKGMPP
910 920 930 940 950
ARTPMEVTVT VLDVNDNPPV FEQDEFDVFV EENSPIGLAV ARVTATDPDE
960 970 980 990 1000
GTNAQIMYQI VEGNIPEVFQ LDIFSGELTA LVDLDYEDRP EYVLVIQATS
1010 1020 1030 1040 1050
APLVSRATVH VRLLDRNDNP PVLGNFEILF NNYVTNRSSS FPGGAIGRVP
1060 1070 1080 1090 1100
AHDPDISDSL TYSFERGNEL SLVLLNASTG ELKLSRALDN NRPLEAIMSV
1110 1120 1130 1140 1150
LVSDGVHSVT AQCALRVTII TDEMLTHSIT LRLEDMSPER FLSPLLGLFI
1160 1170 1180 1190 1200
QAVAATLATP PDHVVVFNVQ RDTDAPGGHI LNVSLSVGQP PGPGGGPPFL
1210 1220 1230 1240 1250
PSEDLQERLY LNRSLLTAIS AQRVLPFDDN ICLREPCENY MRCVSVLRFD
1260 1270 1280 1290 1300
SSAPFIASSS VLFRPIHPVG GLRCRCPPGF TGDYCETEVD LCYSRPCGPH
1310 1320 1330 1340 1350
GRCRSREGGY TCLCRDGYTG EHCEVSARSG RCTPGVCKNG GTCVNLLVGG
1360 1370 1380 1390 1400
FKCDCPSGDF EKPYCQVTTR SFPAHSFITF RGLRQRFHFT LALSFATKER
1410 1420 1430 1440 1450
DGLLLYNGRF NEKHDFVALE VIQEQVQLTF SAGESTTTVS PFVPGGVSDG
1460 1470 1480 1490 1500
QWHTVQLKYY NKPLLGQTGL PQGPSEQKVA VVTVDGCDTG VALRFGSVLG
1510 1520 1530 1540 1550
NYSCAAQGTQ GGSKKSLDLT GPLLLGGVPD LPESFPVRMR QFVGCMRNLQ
1560 1570 1580 1590 1600
VDSRHIDMAD FIANNGTVPG CPAKKNVCDS NTCHNGGTCV NQWDAFSCEC
1610 1620 1630 1640 1650
PLGFGGKSCA QEMANPQHFL GSSLVAWHGL SLPISQPWYL SLMFRTRQAD
1660 1670 1680 1690 1700
GVLLQAITRG RSTITLQLRE GHVMLSVEGT GLQASSLRLE PGRANDGDWH
1710 1720 1730 1740 1750
HAQLALGASG GPGHAILSFD YGQQRAEGNL GPRLHGLHLS NITVGGIPGP
1760 1770 1780 1790 1800
AGGVARGFRG CLQGVRVSDT PEGVNSLDPS HGESINVEQG CSLPDPCDSN
1810 1820 1830 1840 1850
PCPANSYCSN DWDSYSCSCD PGYYGDNCTN VCDLNPCEHQ SVCTRKPSAP
1860 1870 1880 1890 1900
HGYTCECPPN YLGPYCETRI DQPCPRGWWG HPTCGPCNCD VSKGFDPDCN
1910 1920 1930 1940 1950
KTSGECHCKE NHYRPPGSPT CLLCDCYPTG SLSRVCDPED GQCPCKPGVI
1960 1970 1980 1990 2000
GRQCDRCDNP FAEVTTNGCE VNYDSCPRAI EAGIWWPRTR FGLPAAAPCP
2010 2020 2030 2040 2050
KGSFGTAVRH CDEHRGWLPP NLFNCTSITF SELKGFAERL QRNESGLDSG
2060 2070 2080 2090 2100
RSQQLALLLR NATQHTAGYF GSDVKVAYQL ATRLLAHEST QRGFGLSATQ
2110 2120 2130 2140 2150
DVHFTENLLR VGSALLDTAN KRHWELIQQT EGGTAWLLQH YEAYASALAQ
2160 2170 2180 2190 2200
NMRHTYLSPF TIVTPNIVIS VVRLDKGNFA GAKLPRYEAL RGEQPPDLET
2210 2220 2230 2240 2250
TVILPESVFR ETPPVVRPAG PGEAQEPEEL ARRQRRHPEL SQGEAVASVI
2260 2270 2280 2290 2300
IYRTLAGLLP HNYDPDKRSL RVPKRPIINT PVVSISVHDD EELLPRALDK
2310 2320 2330 2340 2350
PVTVQFRLLE TEERTKPICV FWNHSILVSG TGGWSARGCE VVFRNESHVS
2360 2370 2380 2390 2400
CQCNHMTSFA VLMDVSRREN GEILPLKTLT YVALGVTLAA LLLTFFFLTL
2410 2420 2430 2440 2450
LRILRSNQHG IRRNLTAALG LAQLVFLLGI NQADLPFACT VIAILLHFLY
2460 2470 2480 2490 2500
LCTFSWALLE ALHLYRALTE VRDVNTGPMR FYYMLGWGVP AFITGLAVGL
2510 2520 2530 2540 2550
DPEGYGNPDF CWLSIYDTLI WSFAGPVAFA VSMSVFLYIL AARASCAAQR
2560 2570 2580 2590 2600
QGFEKKGPVS GLQPSFAVLL LLSATWLLAL LSVNSDTLLF HYLFATCNCI
2610 2620 2630 2640 2650
QGPFIFLSYV VLSKEVRKAL KLACSRKPSP DPALTTKSTL TSSYNCPSPY
2660 2670 2680 2690 2700
ADGRLYQPYG DSAGSLHSTS RSGKSQPSYI PFLLREESAL NPGQGPPGLG
2710 2720 2730 2740 2750
DPGSLFLEGQ DQQHDPDTDS DSDLSLEDDQ SGSYASTHSS DSEEEEEEEE
2760 2770 2780 2790 2800
EEAAFPGEQG WDSLLGPGAE RLPLHSTPKD GGPGPGKAPW PGDFGTTAKE
2810 2820 2830 2840 2850
SSGNGAPEER LRENGDALSR EGSLGPLPGS SAQPHKGILK KKCLPTISEK
2860 2870 2880 2890 2900
SSLLRLPLEQ CTGSSRGSSA SEGSRGGPPP RPPPRQSLQE QLNGVMPIAM
2910 2920
SIKAGTVDED SSGSEFLFFN FLH
Length:2,923
Mass (Da):317,453
Last modified:March 1, 2001 - v1
Checksum:i382757D315158ED8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1066 – 10661R → Q.
Corresponds to variant rs12083590 [ dbSNP | Ensembl ].
VAR_049474
Natural varianti1639 – 16391Y → H.1 Publication
Corresponds to variant rs653635 [ dbSNP | Ensembl ].
VAR_024481
Natural varianti1992 – 19921G → R.
Corresponds to variant rs12567377 [ dbSNP | Ensembl ].
VAR_049475
Natural varianti2387 – 23871T → A.
Corresponds to variant rs17035649 [ dbSNP | Ensembl ].
VAR_049476

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF234887 mRNA. Translation: AAG00080.1.
AB065955 Genomic DNA. Translation: BAC06168.1.
AL390252 Genomic DNA. Translation: CAI13170.1.
D87469 mRNA. Translation: BAA13407.2.
CCDSiCCDS796.1.
RefSeqiNP_001399.1. NM_001408.2.
UniGeneiHs.57652.

Genome annotation databases

EnsembliENST00000271332; ENSP00000271332; ENSG00000143126.
GeneIDi1952.
KEGGihsa:1952.
UCSCiuc001dxa.4. human.

Polymorphism databases

DMDMi22095550.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF234887 mRNA. Translation: AAG00080.1 .
AB065955 Genomic DNA. Translation: BAC06168.1 .
AL390252 Genomic DNA. Translation: CAI13170.1 .
D87469 mRNA. Translation: BAA13407.2 .
CCDSi CCDS796.1.
RefSeqi NP_001399.1. NM_001408.2.
UniGenei Hs.57652.

3D structure databases

ProteinModelPortali Q9HCU4.
SMRi Q9HCU4. Positions 152-1089, 1228-1368, 1376-1700, 1791-1970, 1977-2356.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108272. 10 interactions.
IntActi Q9HCU4. 7 interactions.
MINTi MINT-1395407.
STRINGi 9606.ENSP00000271332.

Protein family/group databases

MEROPSi S63.009.
GPCRDBi Search...

PTM databases

PhosphoSitei Q9HCU4.

Polymorphism databases

DMDMi 22095550.

Proteomic databases

MaxQBi Q9HCU4.
PaxDbi Q9HCU4.
PRIDEi Q9HCU4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000271332 ; ENSP00000271332 ; ENSG00000143126 .
GeneIDi 1952.
KEGGi hsa:1952.
UCSCi uc001dxa.4. human.

Organism-specific databases

CTDi 1952.
GeneCardsi GC01P109792.
HGNCi HGNC:3231. CELSR2.
HPAi HPA013952.
MIMi 604265. gene.
neXtProti NX_Q9HCU4.
PharmGKBi PA26394.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00760000118805.
HOGENOMi HOG000231346.
HOVERGENi HBG050887.
InParanoidi Q9HCU4.
KOi K04601.
OMAi CKLAQAP.
OrthoDBi EOG7BP81K.
PhylomeDBi Q9HCU4.
TreeFami TF323983.

Enzyme and pathway databases

SignaLinki Q9HCU4.

Miscellaneous databases

ChiTaRSi CELSR2. human.
GeneWikii CELSR2.
GenomeRNAii 1952.
NextBioi 7911.
PROi Q9HCU4.
SOURCEi Search...

Gene expression databases

Bgeei Q9HCU4.
CleanExi HS_CELSR2.
Genevestigatori Q9HCU4.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
2.60.40.60. 9 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR002049. EGF_laminin.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 8 hits.
PF12003. DUF3497. 1 hit.
PF00008. EGF. 1 hit.
PF01825. GPS. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTi SM00112. CA. 9 hits.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 1 hit.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
SM00208. TNFR. 1 hit.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 9 hits.
SSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 2 hits.
PS00232. CADHERIN_1. 7 hits.
PS50268. CADHERIN_2. 9 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 2 hits.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human homologue of flamingo, EGFL2, encodes a brain-expressed large cadherin-like protein with epidermal growth factor-like domains, and maps to chromosome 1p13.3-p21.1."
    Vincent J.B., Skaug J., Scherer S.W.
    DNA Res. 7:233-235(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-2923, VARIANT HIS-1639.
    Tissue: Brain.
  5. Ohara O., Nagase T., Kikuno R., Nomura N.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiCELR2_HUMAN
AccessioniPrimary (citable) accession number: Q9HCU4
Secondary accession number(s): Q5T2Y7, Q92566
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

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