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Q9HCU4 (CELR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cadherin EGF LAG seven-pass G-type receptor 2
Alternative name(s):
Cadherin family member 10
Epidermal growth factor-like protein 2
Short name=EGF-like protein 2
Flamingo homolog 3
Multiple epidermal growth factor-like domains protein 3
Short name=Multiple EGF-like domains protein 3
Gene names
Name:CELSR2
Synonyms:CDHF10, EGFL2, KIAA0279, MEGF3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2923 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor that may have an important role in cell/cell signaling during nervous system formation.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Highest expression in brain and testis.

Post-translational modification

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Contains 9 cadherin domains.

Contains 7 EGF-like domains.

Contains 1 GPS domain.

Contains 1 laminin EGF-like domain.

Contains 2 laminin G-like domains.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainEGF-like domain
Laminin EGF-like domain
Repeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
   Molecular functionDevelopmental protein
G-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Hydroxylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Non-traceable author statement Ref.1. Source: UniProtKB

Wnt signaling pathway

Inferred from sequence or structural similarity. Source: BHF-UCL

cerebrospinal fluid secretion

Inferred from electronic annotation. Source: Ensembl

cilium assembly

Inferred from electronic annotation. Source: Ensembl

cilium movement

Inferred from electronic annotation. Source: Ensembl

dendrite morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

homophilic cell adhesion

Inferred from sequence or structural similarity. Source: BHF-UCL

neural plate anterior/posterior regionalization

Inferred from sequence or structural similarity. Source: BHF-UCL

neuron migration

Inferred from electronic annotation. Source: Ensembl

neuropeptide signaling pathway

Inferred from electronic annotation. Source: InterPro

regulation of cell-cell adhesion

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of protein localization

Inferred from electronic annotation. Source: Ensembl

regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: BHF-UCL

ventricular system development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from sequence or structural similarity. Source: BHF-UCL

integral component of membrane

Non-traceable author statement Ref.1. Source: UniProtKB

plasma membrane

Inferred from sequence or structural similarity. Source: BHF-UCL

   Molecular_functionG-protein coupled receptor activity

Non-traceable author statement Ref.1. Source: UniProtKB

calcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Chain32 – 29232892Cadherin EGF LAG seven-pass G-type receptor 2
PRO_0000012916

Regions

Topological domain32 – 23802349Extracellular Potential
Transmembrane2381 – 240121Helical; Name=1; Potential
Topological domain2402 – 241615Cytoplasmic Potential
Transmembrane2417 – 243721Helical; Name=2; Potential
Topological domain24381Extracellular Potential
Transmembrane2439 – 245921Helical; Name=3; Potential
Topological domain2460 – 248021Cytoplasmic Potential
Transmembrane2481 – 250121Helical; Name=4; Potential
Topological domain2502 – 251918Extracellular Potential
Transmembrane2520 – 254021Helical; Name=5; Potential
Topological domain2541 – 256020Cytoplasmic Potential
Transmembrane2561 – 258121Helical; Name=6; Potential
Topological domain2582 – 259110Extracellular Potential
Transmembrane2592 – 261221Helical; Name=7; Potential
Topological domain2613 – 2923311Cytoplasmic Potential
Domain182 – 289108Cadherin 1
Domain290 – 399110Cadherin 2
Domain400 – 505106Cadherin 3
Domain506 – 610105Cadherin 4
Domain611 – 712102Cadherin 5
Domain713 – 815103Cadherin 6
Domain816 – 921106Cadherin 7
Domain922 – 1023102Cadherin 8
Domain1028 – 1146119Cadherin 9
Domain1228 – 128659EGF-like 1; calcium-binding
Domain1288 – 132437EGF-like 2; calcium-binding
Domain1328 – 136639EGF-like 3; calcium-binding
Domain1367 – 1571205Laminin G-like 1
Domain1574 – 161037EGF-like 4; calcium-binding
Domain1614 – 1791178Laminin G-like 2
Domain1793 – 182836EGF-like 5; calcium-binding
Domain1829 – 186739EGF-like 6; calcium-binding
Domain1883 – 192240EGF-like 7; calcium-binding
Domain1924 – 197148Laminin EGF-like
Domain2316 – 236853GPS
Compositional bias2743 – 275210Poly-Glu

Amino acid modifications

Modified residue15911(3R)-3-hydroxyasparagine Potential
Modified residue18101(3R)-3-hydroxyasparagine Potential
Glycosylation4861N-linked (GlcNAc...) Potential
Glycosylation5571N-linked (GlcNAc...) Potential
Glycosylation7011N-linked (GlcNAc...) Potential
Glycosylation10361N-linked (GlcNAc...) Potential
Glycosylation10761N-linked (GlcNAc...) Potential
Glycosylation11821N-linked (GlcNAc...) Potential
Glycosylation12121N-linked (GlcNAc...) Potential
Glycosylation15011N-linked (GlcNAc...) Potential
Glycosylation15651N-linked (GlcNAc...) Potential
Glycosylation17411N-linked (GlcNAc...) Potential
Glycosylation18271N-linked (GlcNAc...) Potential
Glycosylation19001N-linked (GlcNAc...) Potential
Glycosylation20241N-linked (GlcNAc...) Potential
Glycosylation20431N-linked (GlcNAc...) Potential
Glycosylation20611N-linked (GlcNAc...) Potential
Glycosylation23231N-linked (GlcNAc...) Potential
Glycosylation23451N-linked (GlcNAc...) Potential
Disulfide bond1232 ↔ 1243 By similarity
Disulfide bond1237 ↔ 1274 By similarity
Disulfide bond1276 ↔ 1285 By similarity
Disulfide bond1292 ↔ 1303 By similarity
Disulfide bond1297 ↔ 1312 By similarity
Disulfide bond1314 ↔ 1323 By similarity
Disulfide bond1332 ↔ 1343 By similarity
Disulfide bond1337 ↔ 1353 By similarity
Disulfide bond1355 ↔ 1365 By similarity
Disulfide bond1545 ↔ 1571 By similarity
Disulfide bond1578 ↔ 1589 By similarity
Disulfide bond1583 ↔ 1598 By similarity
Disulfide bond1600 ↔ 1609 By similarity
Disulfide bond1761 ↔ 1791 By similarity
Disulfide bond1797 ↔ 1808 By similarity
Disulfide bond1802 ↔ 1817 By similarity
Disulfide bond1819 ↔ 1828 By similarity
Disulfide bond1832 ↔ 1843 By similarity
Disulfide bond1837 ↔ 1855 By similarity
Disulfide bond1857 ↔ 1866 By similarity
Disulfide bond1887 ↔ 1899 By similarity
Disulfide bond1889 ↔ 1906 By similarity
Disulfide bond1908 ↔ 1921 By similarity
Disulfide bond1924 ↔ 1936 By similarity
Disulfide bond1926 ↔ 1943 By similarity
Disulfide bond1945 ↔ 1954 By similarity
Disulfide bond1957 ↔ 1969 By similarity

Natural variations

Natural variant10661R → Q.
Corresponds to variant rs12083590 [ dbSNP | Ensembl ].
VAR_049474
Natural variant16391Y → H. Ref.4
Corresponds to variant rs653635 [ dbSNP | Ensembl ].
VAR_024481
Natural variant19921G → R.
Corresponds to variant rs12567377 [ dbSNP | Ensembl ].
VAR_049475
Natural variant23871T → A.
Corresponds to variant rs17035649 [ dbSNP | Ensembl ].
VAR_049476

Sequences

Sequence LengthMass (Da)Tools
Q9HCU4 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 382757D315158ED8

FASTA2,923317,453
        10         20         30         40         50         60 
MRSPATGVPL PTPPPPLLLL LLLLLPPPLL GDQVGPCRSL GSRGRGSSGA CAPMGWLCPS 

        70         80         90        100        110        120 
SASNLWLYTS RCRDAGTELT GHLVPHHDGL RVWCPESEAH IPLPPAPEGC PWSCRLLGIG 

       130        140        150        160        170        180 
GHLSPQGKLT LPEEHPCLKA PRLRCQSCKL AQAPGLRAGE RSPEESLGGR RKRNVNTAPQ 

       190        200        210        220        230        240 
FQPPSYQATV PENQPAGTPV ASLRAIDPDE GEAGRLEYTM DALFDSRSNQ FFSLDPVTGA 

       250        260        270        280        290        300 
VTTAEELDRE TKSTHVFRVT AQDHGMPRRS ALATLTILVT DTNDHDPVFE QQEYKESLRE 

       310        320        330        340        350        360 
NLEVGYEVLT VRATDGDAPP NANILYRLLE GSGGSPSEVF EIDPRSGVIR TRGPVDREEV 

       370        380        390        400        410        420 
ESYQLTVEAS DQGRDPGPRS TTAAVFLSVE DDNDNAPQFS EKRYVVQVRE DVTPGAPVLR 

       430        440        450        460        470        480 
VTASDRDKGS NAVVHYSIMS GNARGQFYLD AQTGALDVVS PLDYETTKEY TLRVRAQDGG 

       490        500        510        520        530        540 
RPPLSNVSGL VTVQVLDIND NAPIFVSTPF QATVLESVPL GYLVLHVQAI DADAGDNARL 

       550        560        570        580        590        600 
EYRLAGVGHD FPFTINNGTG WISVAAELDR EEVDFYSFGV EARDHGTPAL TASASVSVTV 

       610        620        630        640        650        660 
LDVNDNNPTF TQPEYTVRLN EDAAVGTSVV TVSAVDRDAH SVITYQITSG NTRNRFSITS 

       670        680        690        700        710        720 
QSGGGLVSLA LPLDYKLERQ YVLAVTASDG TRQDTAQIVV NVTDANTHRP VFQSSHYTVN 

       730        740        750        760        770        780 
VNEDRPAGTT VVLISATDED TGENARITYF MEDSIPQFRI DADTGAVTTQ AELDYEDQVS 

       790        800        810        820        830        840 
YTLAITARDN GIPQKSDTTY LEILVNDVND NAPQFLRDSY QGSVYEDVPP FTSVLQISAT 

       850        860        870        880        890        900 
DRDSGLNGRV FYTFQGGDDG DGDFIVESTS GIVRTLRRLD RENVAQYVLR AYAVDKGMPP 

       910        920        930        940        950        960 
ARTPMEVTVT VLDVNDNPPV FEQDEFDVFV EENSPIGLAV ARVTATDPDE GTNAQIMYQI 

       970        980        990       1000       1010       1020 
VEGNIPEVFQ LDIFSGELTA LVDLDYEDRP EYVLVIQATS APLVSRATVH VRLLDRNDNP 

      1030       1040       1050       1060       1070       1080 
PVLGNFEILF NNYVTNRSSS FPGGAIGRVP AHDPDISDSL TYSFERGNEL SLVLLNASTG 

      1090       1100       1110       1120       1130       1140 
ELKLSRALDN NRPLEAIMSV LVSDGVHSVT AQCALRVTII TDEMLTHSIT LRLEDMSPER 

      1150       1160       1170       1180       1190       1200 
FLSPLLGLFI QAVAATLATP PDHVVVFNVQ RDTDAPGGHI LNVSLSVGQP PGPGGGPPFL 

      1210       1220       1230       1240       1250       1260 
PSEDLQERLY LNRSLLTAIS AQRVLPFDDN ICLREPCENY MRCVSVLRFD SSAPFIASSS 

      1270       1280       1290       1300       1310       1320 
VLFRPIHPVG GLRCRCPPGF TGDYCETEVD LCYSRPCGPH GRCRSREGGY TCLCRDGYTG 

      1330       1340       1350       1360       1370       1380 
EHCEVSARSG RCTPGVCKNG GTCVNLLVGG FKCDCPSGDF EKPYCQVTTR SFPAHSFITF 

      1390       1400       1410       1420       1430       1440 
RGLRQRFHFT LALSFATKER DGLLLYNGRF NEKHDFVALE VIQEQVQLTF SAGESTTTVS 

      1450       1460       1470       1480       1490       1500 
PFVPGGVSDG QWHTVQLKYY NKPLLGQTGL PQGPSEQKVA VVTVDGCDTG VALRFGSVLG 

      1510       1520       1530       1540       1550       1560 
NYSCAAQGTQ GGSKKSLDLT GPLLLGGVPD LPESFPVRMR QFVGCMRNLQ VDSRHIDMAD 

      1570       1580       1590       1600       1610       1620 
FIANNGTVPG CPAKKNVCDS NTCHNGGTCV NQWDAFSCEC PLGFGGKSCA QEMANPQHFL 

      1630       1640       1650       1660       1670       1680 
GSSLVAWHGL SLPISQPWYL SLMFRTRQAD GVLLQAITRG RSTITLQLRE GHVMLSVEGT 

      1690       1700       1710       1720       1730       1740 
GLQASSLRLE PGRANDGDWH HAQLALGASG GPGHAILSFD YGQQRAEGNL GPRLHGLHLS 

      1750       1760       1770       1780       1790       1800 
NITVGGIPGP AGGVARGFRG CLQGVRVSDT PEGVNSLDPS HGESINVEQG CSLPDPCDSN 

      1810       1820       1830       1840       1850       1860 
PCPANSYCSN DWDSYSCSCD PGYYGDNCTN VCDLNPCEHQ SVCTRKPSAP HGYTCECPPN 

      1870       1880       1890       1900       1910       1920 
YLGPYCETRI DQPCPRGWWG HPTCGPCNCD VSKGFDPDCN KTSGECHCKE NHYRPPGSPT 

      1930       1940       1950       1960       1970       1980 
CLLCDCYPTG SLSRVCDPED GQCPCKPGVI GRQCDRCDNP FAEVTTNGCE VNYDSCPRAI 

      1990       2000       2010       2020       2030       2040 
EAGIWWPRTR FGLPAAAPCP KGSFGTAVRH CDEHRGWLPP NLFNCTSITF SELKGFAERL 

      2050       2060       2070       2080       2090       2100 
QRNESGLDSG RSQQLALLLR NATQHTAGYF GSDVKVAYQL ATRLLAHEST QRGFGLSATQ 

      2110       2120       2130       2140       2150       2160 
DVHFTENLLR VGSALLDTAN KRHWELIQQT EGGTAWLLQH YEAYASALAQ NMRHTYLSPF 

      2170       2180       2190       2200       2210       2220 
TIVTPNIVIS VVRLDKGNFA GAKLPRYEAL RGEQPPDLET TVILPESVFR ETPPVVRPAG 

      2230       2240       2250       2260       2270       2280 
PGEAQEPEEL ARRQRRHPEL SQGEAVASVI IYRTLAGLLP HNYDPDKRSL RVPKRPIINT 

      2290       2300       2310       2320       2330       2340 
PVVSISVHDD EELLPRALDK PVTVQFRLLE TEERTKPICV FWNHSILVSG TGGWSARGCE 

      2350       2360       2370       2380       2390       2400 
VVFRNESHVS CQCNHMTSFA VLMDVSRREN GEILPLKTLT YVALGVTLAA LLLTFFFLTL 

      2410       2420       2430       2440       2450       2460 
LRILRSNQHG IRRNLTAALG LAQLVFLLGI NQADLPFACT VIAILLHFLY LCTFSWALLE 

      2470       2480       2490       2500       2510       2520 
ALHLYRALTE VRDVNTGPMR FYYMLGWGVP AFITGLAVGL DPEGYGNPDF CWLSIYDTLI 

      2530       2540       2550       2560       2570       2580 
WSFAGPVAFA VSMSVFLYIL AARASCAAQR QGFEKKGPVS GLQPSFAVLL LLSATWLLAL 

      2590       2600       2610       2620       2630       2640 
LSVNSDTLLF HYLFATCNCI QGPFIFLSYV VLSKEVRKAL KLACSRKPSP DPALTTKSTL 

      2650       2660       2670       2680       2690       2700 
TSSYNCPSPY ADGRLYQPYG DSAGSLHSTS RSGKSQPSYI PFLLREESAL NPGQGPPGLG 

      2710       2720       2730       2740       2750       2760 
DPGSLFLEGQ DQQHDPDTDS DSDLSLEDDQ SGSYASTHSS DSEEEEEEEE EEAAFPGEQG 

      2770       2780       2790       2800       2810       2820 
WDSLLGPGAE RLPLHSTPKD GGPGPGKAPW PGDFGTTAKE SSGNGAPEER LRENGDALSR 

      2830       2840       2850       2860       2870       2880 
EGSLGPLPGS SAQPHKGILK KKCLPTISEK SSLLRLPLEQ CTGSSRGSSA SEGSRGGPPP 

      2890       2900       2910       2920 
RPPPRQSLQE QLNGVMPIAM SIKAGTVDED SSGSEFLFFN FLH 

« Hide

References

« Hide 'large scale' references
[1]"The human homologue of flamingo, EGFL2, encodes a brain-expressed large cadherin-like protein with epidermal growth factor-like domains, and maps to chromosome 1p13.3-p21.1."
Vincent J.B., Skaug J., Scherer S.W.
DNA Res. 7:233-235(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-2923, VARIANT HIS-1639.
Tissue: Brain.
[5]Ohara O., Nagase T., Kikuno R., Nomura N.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF234887 mRNA. Translation: AAG00080.1.
AB065955 Genomic DNA. Translation: BAC06168.1.
AL390252 Genomic DNA. Translation: CAI13170.1.
D87469 mRNA. Translation: BAA13407.2.
RefSeqNP_001399.1. NM_001408.2.
UniGeneHs.57652.

3D structure databases

ProteinModelPortalQ9HCU4.
SMRQ9HCU4. Positions 152-1124, 1228-1368, 1370-1770, 1795-1970, 1977-2356.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108272. 2 interactions.
IntActQ9HCU4. 7 interactions.
MINTMINT-1395407.
STRING9606.ENSP00000271332.

Protein family/group databases

MEROPSS63.009.
GPCRDBSearch...

PTM databases

PhosphoSiteQ9HCU4.

Polymorphism databases

DMDM22095550.

Proteomic databases

PaxDbQ9HCU4.
PRIDEQ9HCU4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000271332; ENSP00000271332; ENSG00000143126.
GeneID1952.
KEGGhsa:1952.
UCSCuc001dxa.4. human.

Organism-specific databases

CTD1952.
GeneCardsGC01P109792.
HGNCHGNC:3231. CELSR2.
HPAHPA013952.
MIM604265. gene.
neXtProtNX_Q9HCU4.
PharmGKBPA26394.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000231346.
HOVERGENHBG050887.
InParanoidQ9HCU4.
KOK04601.
OMACKLAQAP.
OrthoDBEOG7BP81K.
PhylomeDBQ9HCU4.
TreeFamTF323983.

Enzyme and pathway databases

SignaLinkQ9HCU4.

Gene expression databases

BgeeQ9HCU4.
CleanExHS_CELSR2.
GenevestigatorQ9HCU4.

Family and domain databases

Gene3D2.60.120.200. 2 hits.
2.60.40.60. 9 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR002049. EGF_laminin.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 8 hits.
PF12003. DUF3497. 1 hit.
PF00008. EGF. 1 hit.
PF01825. GPS. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSPR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTSM00112. CA. 9 hits.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 1 hit.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
SM00208. TNFR. 1 hit.
[Graphical view]
SUPFAMSSF49313. SSF49313. 9 hits.
SSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 2 hits.
PROSITEPS00010. ASX_HYDROXYL. 2 hits.
PS00232. CADHERIN_1. 7 hits.
PS50268. CADHERIN_2. 9 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 2 hits.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCELSR2. human.
GeneWikiCELSR2.
GenomeRNAi1952.
NextBio7911.
PROQ9HCU4.
SOURCESearch...

Entry information

Entry nameCELR2_HUMAN
AccessionPrimary (citable) accession number: Q9HCU4
Secondary accession number(s): Q5T2Y7, Q92566
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries