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Q9HCU4

- CELR2_HUMAN

UniProt

Q9HCU4 - CELR2_HUMAN

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Protein

Cadherin EGF LAG seven-pass G-type receptor 2

Gene
CELSR2, CDHF10, EGFL2, KIAA0279, MEGF3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor that may have an important role in cell/cell signaling during nervous system formation.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

  1. cerebrospinal fluid secretion Source: Ensembl
  2. cilium assembly Source: Ensembl
  3. cilium movement Source: Ensembl
  4. dendrite morphogenesis Source: BHF-UCL
  5. G-protein coupled receptor signaling pathway Source: UniProtKB
  6. homophilic cell adhesion Source: BHF-UCL
  7. neural plate anterior/posterior regionalization Source: BHF-UCL
  8. neuron migration Source: Ensembl
  9. neuropeptide signaling pathway Source: InterPro
  10. regulation of cell-cell adhesion Source: BHF-UCL
  11. regulation of protein localization Source: Ensembl
  12. regulation of transcription, DNA-templated Source: BHF-UCL
  13. ventricular system development Source: Ensembl
  14. Wnt signaling pathway Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Calcium

Enzyme and pathway databases

SignaLinkiQ9HCU4.

Protein family/group databases

MEROPSiS63.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin EGF LAG seven-pass G-type receptor 2
Alternative name(s):
Cadherin family member 10
Epidermal growth factor-like protein 2
Short name:
EGF-like protein 2
Flamingo homolog 3
Multiple epidermal growth factor-like domains protein 3
Short name:
Multiple EGF-like domains protein 3
Gene namesi
Name:CELSR2
Synonyms:CDHF10, EGFL2, KIAA0279, MEGF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:3231. CELSR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 23802349Extracellular Reviewed predictionAdd
BLAST
Transmembranei2381 – 240121Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini2402 – 241615Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei2417 – 243721Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini2438 – 24381Extracellular Reviewed prediction
Transmembranei2439 – 245921Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini2460 – 248021Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei2481 – 250121Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini2502 – 251918Extracellular Reviewed predictionAdd
BLAST
Transmembranei2520 – 254021Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini2541 – 256020Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei2561 – 258121Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini2582 – 259110Extracellular Reviewed prediction
Transmembranei2592 – 261221Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini2613 – 2923311Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. integral component of membrane Source: UniProtKB
  3. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26394.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131 Reviewed predictionAdd
BLAST
Chaini32 – 29232892Cadherin EGF LAG seven-pass G-type receptor 2PRO_0000012916Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi486 – 4861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi557 – 5571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi701 – 7011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1036 – 10361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1076 – 10761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1182 – 11821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1212 – 12121N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1232 ↔ 1243 By similarity
Disulfide bondi1237 ↔ 1274 By similarity
Disulfide bondi1276 ↔ 1285 By similarity
Disulfide bondi1292 ↔ 1303 By similarity
Disulfide bondi1297 ↔ 1312 By similarity
Disulfide bondi1314 ↔ 1323 By similarity
Disulfide bondi1332 ↔ 1343 By similarity
Disulfide bondi1337 ↔ 1353 By similarity
Disulfide bondi1355 ↔ 1365 By similarity
Glycosylationi1501 – 15011N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1545 ↔ 1571 By similarity
Glycosylationi1565 – 15651N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1578 ↔ 1589 By similarity
Disulfide bondi1583 ↔ 1598 By similarity
Modified residuei1591 – 15911(3R)-3-hydroxyasparagine Reviewed prediction
Disulfide bondi1600 ↔ 1609 By similarity
Glycosylationi1741 – 17411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1761 ↔ 1791 By similarity
Disulfide bondi1797 ↔ 1808 By similarity
Disulfide bondi1802 ↔ 1817 By similarity
Modified residuei1810 – 18101(3R)-3-hydroxyasparagine Reviewed prediction
Disulfide bondi1819 ↔ 1828 By similarity
Glycosylationi1827 – 18271N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1832 ↔ 1843 By similarity
Disulfide bondi1837 ↔ 1855 By similarity
Disulfide bondi1857 ↔ 1866 By similarity
Disulfide bondi1887 ↔ 1899 By similarity
Disulfide bondi1889 ↔ 1906 By similarity
Glycosylationi1900 – 19001N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1908 ↔ 1921 By similarity
Disulfide bondi1924 ↔ 1936 By similarity
Disulfide bondi1926 ↔ 1943 By similarity
Disulfide bondi1945 ↔ 1954 By similarity
Disulfide bondi1957 ↔ 1969 By similarity
Glycosylationi2024 – 20241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2043 – 20431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2061 – 20611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2323 – 23231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2345 – 23451N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiQ9HCU4.
PaxDbiQ9HCU4.
PRIDEiQ9HCU4.

PTM databases

PhosphoSiteiQ9HCU4.

Expressioni

Tissue specificityi

Highest expression in brain and testis.

Gene expression databases

BgeeiQ9HCU4.
CleanExiHS_CELSR2.
GenevestigatoriQ9HCU4.

Organism-specific databases

HPAiHPA013952.

Interactioni

Protein-protein interaction databases

BioGridi108272. 2 interactions.
IntActiQ9HCU4. 7 interactions.
MINTiMINT-1395407.
STRINGi9606.ENSP00000271332.

Structurei

3D structure databases

ProteinModelPortaliQ9HCU4.
SMRiQ9HCU4. Positions 152-1089, 1228-1367, 1376-1700, 1795-1970, 1977-2356.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini182 – 289108Cadherin 1Add
BLAST
Domaini290 – 399110Cadherin 2Add
BLAST
Domaini400 – 505106Cadherin 3Add
BLAST
Domaini506 – 610105Cadherin 4Add
BLAST
Domaini611 – 712102Cadherin 5Add
BLAST
Domaini713 – 815103Cadherin 6Add
BLAST
Domaini816 – 921106Cadherin 7Add
BLAST
Domaini922 – 1023102Cadherin 8Add
BLAST
Domaini1028 – 1146119Cadherin 9Add
BLAST
Domaini1228 – 128659EGF-like 1; calcium-bindingAdd
BLAST
Domaini1288 – 132437EGF-like 2; calcium-bindingAdd
BLAST
Domaini1328 – 136639EGF-like 3; calcium-bindingAdd
BLAST
Domaini1367 – 1571205Laminin G-like 1Add
BLAST
Domaini1574 – 161037EGF-like 4; calcium-bindingAdd
BLAST
Domaini1614 – 1791178Laminin G-like 2Add
BLAST
Domaini1793 – 182836EGF-like 5; calcium-bindingAdd
BLAST
Domaini1829 – 186739EGF-like 6; calcium-bindingAdd
BLAST
Domaini1883 – 192240EGF-like 7; calcium-bindingAdd
BLAST
Domaini1924 – 197148Laminin EGF-likeAdd
BLAST
Domaini2316 – 236853GPSAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2743 – 275210Poly-Glu

Sequence similaritiesi

Contains 9 cadherin domains.
Contains 7 EGF-like domains.
Contains 1 GPS domain.

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000231346.
HOVERGENiHBG050887.
InParanoidiQ9HCU4.
KOiK04601.
OMAiCKLAQAP.
OrthoDBiEOG7BP81K.
PhylomeDBiQ9HCU4.
TreeFamiTF323983.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
2.60.40.60. 9 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR002049. EGF_laminin.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 8 hits.
PF12003. DUF3497. 1 hit.
PF00008. EGF. 1 hit.
PF01825. GPS. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTiSM00112. CA. 9 hits.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 1 hit.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
SM00208. TNFR. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 9 hits.
SSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS00232. CADHERIN_1. 7 hits.
PS50268. CADHERIN_2. 9 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 2 hits.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HCU4-1 [UniParc]FASTAAdd to Basket

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MRSPATGVPL PTPPPPLLLL LLLLLPPPLL GDQVGPCRSL GSRGRGSSGA     50
CAPMGWLCPS SASNLWLYTS RCRDAGTELT GHLVPHHDGL RVWCPESEAH 100
IPLPPAPEGC PWSCRLLGIG GHLSPQGKLT LPEEHPCLKA PRLRCQSCKL 150
AQAPGLRAGE RSPEESLGGR RKRNVNTAPQ FQPPSYQATV PENQPAGTPV 200
ASLRAIDPDE GEAGRLEYTM DALFDSRSNQ FFSLDPVTGA VTTAEELDRE 250
TKSTHVFRVT AQDHGMPRRS ALATLTILVT DTNDHDPVFE QQEYKESLRE 300
NLEVGYEVLT VRATDGDAPP NANILYRLLE GSGGSPSEVF EIDPRSGVIR 350
TRGPVDREEV ESYQLTVEAS DQGRDPGPRS TTAAVFLSVE DDNDNAPQFS 400
EKRYVVQVRE DVTPGAPVLR VTASDRDKGS NAVVHYSIMS GNARGQFYLD 450
AQTGALDVVS PLDYETTKEY TLRVRAQDGG RPPLSNVSGL VTVQVLDIND 500
NAPIFVSTPF QATVLESVPL GYLVLHVQAI DADAGDNARL EYRLAGVGHD 550
FPFTINNGTG WISVAAELDR EEVDFYSFGV EARDHGTPAL TASASVSVTV 600
LDVNDNNPTF TQPEYTVRLN EDAAVGTSVV TVSAVDRDAH SVITYQITSG 650
NTRNRFSITS QSGGGLVSLA LPLDYKLERQ YVLAVTASDG TRQDTAQIVV 700
NVTDANTHRP VFQSSHYTVN VNEDRPAGTT VVLISATDED TGENARITYF 750
MEDSIPQFRI DADTGAVTTQ AELDYEDQVS YTLAITARDN GIPQKSDTTY 800
LEILVNDVND NAPQFLRDSY QGSVYEDVPP FTSVLQISAT DRDSGLNGRV 850
FYTFQGGDDG DGDFIVESTS GIVRTLRRLD RENVAQYVLR AYAVDKGMPP 900
ARTPMEVTVT VLDVNDNPPV FEQDEFDVFV EENSPIGLAV ARVTATDPDE 950
GTNAQIMYQI VEGNIPEVFQ LDIFSGELTA LVDLDYEDRP EYVLVIQATS 1000
APLVSRATVH VRLLDRNDNP PVLGNFEILF NNYVTNRSSS FPGGAIGRVP 1050
AHDPDISDSL TYSFERGNEL SLVLLNASTG ELKLSRALDN NRPLEAIMSV 1100
LVSDGVHSVT AQCALRVTII TDEMLTHSIT LRLEDMSPER FLSPLLGLFI 1150
QAVAATLATP PDHVVVFNVQ RDTDAPGGHI LNVSLSVGQP PGPGGGPPFL 1200
PSEDLQERLY LNRSLLTAIS AQRVLPFDDN ICLREPCENY MRCVSVLRFD 1250
SSAPFIASSS VLFRPIHPVG GLRCRCPPGF TGDYCETEVD LCYSRPCGPH 1300
GRCRSREGGY TCLCRDGYTG EHCEVSARSG RCTPGVCKNG GTCVNLLVGG 1350
FKCDCPSGDF EKPYCQVTTR SFPAHSFITF RGLRQRFHFT LALSFATKER 1400
DGLLLYNGRF NEKHDFVALE VIQEQVQLTF SAGESTTTVS PFVPGGVSDG 1450
QWHTVQLKYY NKPLLGQTGL PQGPSEQKVA VVTVDGCDTG VALRFGSVLG 1500
NYSCAAQGTQ GGSKKSLDLT GPLLLGGVPD LPESFPVRMR QFVGCMRNLQ 1550
VDSRHIDMAD FIANNGTVPG CPAKKNVCDS NTCHNGGTCV NQWDAFSCEC 1600
PLGFGGKSCA QEMANPQHFL GSSLVAWHGL SLPISQPWYL SLMFRTRQAD 1650
GVLLQAITRG RSTITLQLRE GHVMLSVEGT GLQASSLRLE PGRANDGDWH 1700
HAQLALGASG GPGHAILSFD YGQQRAEGNL GPRLHGLHLS NITVGGIPGP 1750
AGGVARGFRG CLQGVRVSDT PEGVNSLDPS HGESINVEQG CSLPDPCDSN 1800
PCPANSYCSN DWDSYSCSCD PGYYGDNCTN VCDLNPCEHQ SVCTRKPSAP 1850
HGYTCECPPN YLGPYCETRI DQPCPRGWWG HPTCGPCNCD VSKGFDPDCN 1900
KTSGECHCKE NHYRPPGSPT CLLCDCYPTG SLSRVCDPED GQCPCKPGVI 1950
GRQCDRCDNP FAEVTTNGCE VNYDSCPRAI EAGIWWPRTR FGLPAAAPCP 2000
KGSFGTAVRH CDEHRGWLPP NLFNCTSITF SELKGFAERL QRNESGLDSG 2050
RSQQLALLLR NATQHTAGYF GSDVKVAYQL ATRLLAHEST QRGFGLSATQ 2100
DVHFTENLLR VGSALLDTAN KRHWELIQQT EGGTAWLLQH YEAYASALAQ 2150
NMRHTYLSPF TIVTPNIVIS VVRLDKGNFA GAKLPRYEAL RGEQPPDLET 2200
TVILPESVFR ETPPVVRPAG PGEAQEPEEL ARRQRRHPEL SQGEAVASVI 2250
IYRTLAGLLP HNYDPDKRSL RVPKRPIINT PVVSISVHDD EELLPRALDK 2300
PVTVQFRLLE TEERTKPICV FWNHSILVSG TGGWSARGCE VVFRNESHVS 2350
CQCNHMTSFA VLMDVSRREN GEILPLKTLT YVALGVTLAA LLLTFFFLTL 2400
LRILRSNQHG IRRNLTAALG LAQLVFLLGI NQADLPFACT VIAILLHFLY 2450
LCTFSWALLE ALHLYRALTE VRDVNTGPMR FYYMLGWGVP AFITGLAVGL 2500
DPEGYGNPDF CWLSIYDTLI WSFAGPVAFA VSMSVFLYIL AARASCAAQR 2550
QGFEKKGPVS GLQPSFAVLL LLSATWLLAL LSVNSDTLLF HYLFATCNCI 2600
QGPFIFLSYV VLSKEVRKAL KLACSRKPSP DPALTTKSTL TSSYNCPSPY 2650
ADGRLYQPYG DSAGSLHSTS RSGKSQPSYI PFLLREESAL NPGQGPPGLG 2700
DPGSLFLEGQ DQQHDPDTDS DSDLSLEDDQ SGSYASTHSS DSEEEEEEEE 2750
EEAAFPGEQG WDSLLGPGAE RLPLHSTPKD GGPGPGKAPW PGDFGTTAKE 2800
SSGNGAPEER LRENGDALSR EGSLGPLPGS SAQPHKGILK KKCLPTISEK 2850
SSLLRLPLEQ CTGSSRGSSA SEGSRGGPPP RPPPRQSLQE QLNGVMPIAM 2900
SIKAGTVDED SSGSEFLFFN FLH 2923
Length:2,923
Mass (Da):317,453
Last modified:March 1, 2001 - v1
Checksum:i382757D315158ED8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1066 – 10661R → Q.
Corresponds to variant rs12083590 [ dbSNP | Ensembl ].
VAR_049474
Natural varianti1639 – 16391Y → H.1 Publication
Corresponds to variant rs653635 [ dbSNP | Ensembl ].
VAR_024481
Natural varianti1992 – 19921G → R.
Corresponds to variant rs12567377 [ dbSNP | Ensembl ].
VAR_049475
Natural varianti2387 – 23871T → A.
Corresponds to variant rs17035649 [ dbSNP | Ensembl ].
VAR_049476

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF234887 mRNA. Translation: AAG00080.1.
AB065955 Genomic DNA. Translation: BAC06168.1.
AL390252 Genomic DNA. Translation: CAI13170.1.
D87469 mRNA. Translation: BAA13407.2.
CCDSiCCDS796.1.
RefSeqiNP_001399.1. NM_001408.2.
UniGeneiHs.57652.

Genome annotation databases

EnsembliENST00000271332; ENSP00000271332; ENSG00000143126.
GeneIDi1952.
KEGGihsa:1952.
UCSCiuc001dxa.4. human.

Polymorphism databases

DMDMi22095550.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF234887 mRNA. Translation: AAG00080.1 .
AB065955 Genomic DNA. Translation: BAC06168.1 .
AL390252 Genomic DNA. Translation: CAI13170.1 .
D87469 mRNA. Translation: BAA13407.2 .
CCDSi CCDS796.1.
RefSeqi NP_001399.1. NM_001408.2.
UniGenei Hs.57652.

3D structure databases

ProteinModelPortali Q9HCU4.
SMRi Q9HCU4. Positions 152-1089, 1228-1367, 1376-1700, 1795-1970, 1977-2356.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108272. 2 interactions.
IntActi Q9HCU4. 7 interactions.
MINTi MINT-1395407.
STRINGi 9606.ENSP00000271332.

Protein family/group databases

MEROPSi S63.009.
GPCRDBi Search...

PTM databases

PhosphoSitei Q9HCU4.

Polymorphism databases

DMDMi 22095550.

Proteomic databases

MaxQBi Q9HCU4.
PaxDbi Q9HCU4.
PRIDEi Q9HCU4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000271332 ; ENSP00000271332 ; ENSG00000143126 .
GeneIDi 1952.
KEGGi hsa:1952.
UCSCi uc001dxa.4. human.

Organism-specific databases

CTDi 1952.
GeneCardsi GC01P109792.
HGNCi HGNC:3231. CELSR2.
HPAi HPA013952.
MIMi 604265. gene.
neXtProti NX_Q9HCU4.
PharmGKBi PA26394.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000231346.
HOVERGENi HBG050887.
InParanoidi Q9HCU4.
KOi K04601.
OMAi CKLAQAP.
OrthoDBi EOG7BP81K.
PhylomeDBi Q9HCU4.
TreeFami TF323983.

Enzyme and pathway databases

SignaLinki Q9HCU4.

Miscellaneous databases

ChiTaRSi CELSR2. human.
GeneWikii CELSR2.
GenomeRNAii 1952.
NextBioi 7911.
PROi Q9HCU4.
SOURCEi Search...

Gene expression databases

Bgeei Q9HCU4.
CleanExi HS_CELSR2.
Genevestigatori Q9HCU4.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
2.60.40.60. 9 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR022624. DUF3497.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR002049. EGF_laminin.
IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF00028. Cadherin. 8 hits.
PF12003. DUF3497. 1 hit.
PF00008. EGF. 1 hit.
PF01825. GPS. 1 hit.
PF00053. Laminin_EGF. 1 hit.
PF02210. Laminin_G_2. 2 hits.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
PR00249. GPCRSECRETIN.
SMARTi SM00112. CA. 9 hits.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 1 hit.
SM00180. EGF_Lam. 1 hit.
SM00303. GPS. 1 hit.
SM00008. HormR. 1 hit.
SM00282. LamG. 2 hits.
SM00208. TNFR. 1 hit.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 9 hits.
SSF49899. SSF49899. 2 hits.
SSF57184. SSF57184. 2 hits.
PROSITEi PS00010. ASX_HYDROXYL. 2 hits.
PS00232. CADHERIN_1. 7 hits.
PS50268. CADHERIN_2. 9 hits.
PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01248. EGF_LAM_1. 1 hit.
PS50027. EGF_LAM_2. 2 hits.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
PS50025. LAM_G_DOMAIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human homologue of flamingo, EGFL2, encodes a brain-expressed large cadherin-like protein with epidermal growth factor-like domains, and maps to chromosome 1p13.3-p21.1."
    Vincent J.B., Skaug J., Scherer S.W.
    DNA Res. 7:233-235(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-2923, VARIANT HIS-1639.
    Tissue: Brain.
  5. Ohara O., Nagase T., Kikuno R., Nomura N.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiCELR2_HUMAN
AccessioniPrimary (citable) accession number: Q9HCU4
Secondary accession number(s): Q5T2Y7, Q92566
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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