ID   FGF22_HUMAN             Reviewed;         170 AA.
AC   Q9HCT0; B2RPH4;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-JAN-2012, entry version 89.
DE   RecName: Full=Fibroblast growth factor 22;
DE            Short=FGF-22;
DE   Flags: Precursor;
GN   Name=FGF22; ORFNames=UNQ2500/PRO5800;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Placenta;
RX   MEDLINE=21240339; PubMed=11342227; DOI=10.1016/S0167-4781(00)00302-X;
RA   Nakatake Y., Hoshikawa M., Asaki T., Kassai Y., Itoh N.;
RT   "Identification of a novel fibroblast growth factor, FGF-22,
RT   preferentially expressed in the inner root sheath of the hair
RT   follicle.";
RL   Biochim. Biophys. Acta 1517:460-463(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG   NIEHS SNPs program;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   INTERACTION WITH FGFBP1.
RX   PubMed=15806171; DOI=10.1038/sj.onc.1208560;
RA   Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A.,
RA   Werner S.;
RT   "The fibroblast growth factor binding protein is a novel interaction
RT   partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity:
RT   implications for epithelial repair.";
RL   Oncogene 24:5269-5277(2005).
RN   [7]
RP   INTERACTION WITH FGFR1 AND FGFR2, AND FUNCTION IN STIMULATION OF CELL
RP   PROLIFERATION.
RX   PubMed=16597617; DOI=10.1074/jbc.M601252200;
RA   Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M.,
RA   Ornitz D.M.;
RT   "Receptor specificity of the fibroblast growth factor family. The
RT   complete mammalian FGF family.";
RL   J. Biol. Chem. 281:15694-15700(2006).
RN   [8]
RP   REVIEW.
RX   PubMed=20094046; DOI=10.1038/nrc2780;
RA   Turner N., Grose R.;
RT   "Fibroblast growth factor signalling: from development to cancer.";
RL   Nat. Rev. Cancer 10:116-129(2010).
CC   -!- FUNCTION: Plays a role in the fasting response, glucose
CC       homeostasis, lipolysis and lipogenesis. Can stimulate cell
CC       proliferation (in vitro). May be involved in hair development.
CC   -!- SUBUNIT: Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC   -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC       URL="http://egp.gs.washington.edu/data/fgf22/";
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DR   EMBL; AB021925; BAB13479.1; -; mRNA.
DR   EMBL; AY359084; AAQ89955.1; -; mRNA.
DR   EMBL; AY426986; AAQ93357.1; -; Genomic_DNA.
DR   EMBL; CH471242; EAW61175.1; -; Genomic_DNA.
DR   EMBL; BC137444; AAI37445.1; -; mRNA.
DR   EMBL; BC137445; AAI37446.1; -; mRNA.
DR   IPI; IPI00030814; -.
DR   RefSeq; NP_065688.1; NM_020637.1.
DR   UniGene; Hs.248087; -.
DR   ProteinModelPortal; Q9HCT0; -.
DR   SMR; Q9HCT0; 32-170.
DR   STRING; Q9HCT0; -.
DR   DMDM; 13626689; -.
DR   PRIDE; Q9HCT0; -.
DR   Ensembl; ENST00000215530; ENSP00000215530; ENSG00000070388.
DR   GeneID; 27006; -.
DR   KEGG; hsa:27006; -.
DR   UCSC; uc002lpg.1; human.
DR   CTD; 27006; -.
DR   GeneCards; GC19P000590; -.
DR   H-InvDB; HIX0039926; -.
DR   HGNC; HGNC:3679; FGF22.
DR   MIM; 605831; gene.
DR   neXtProt; NX_Q9HCT0; -.
DR   PharmGKB; PA28118; -.
DR   GeneTree; ENSGT00600000084030; -.
DR   HOGENOM; HBG715603; -.
DR   HOVERGEN; HBG007580; -.
DR   InParanoid; Q9HCT0; -.
DR   OMA; GTRWRHG; -.
DR   OrthoDB; EOG41C6XD; -.
DR   PhylomeDB; Q9HCT0; -.
DR   Reactome; REACT_111102; Signal Transduction.
DR   NextBio; 49512; -.
DR   ArrayExpress; Q9HCT0; -.
DR   Bgee; Q9HCT0; -.
DR   CleanEx; HS_FGF22; -.
DR   Genevestigator; Q9HCT0; -.
DR   GermOnline; ENSG00000070388; Homo sapiens.
DR   GO; GO:0005615; C:extracellular space; NAS:UniProtKB.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; NAS:UniProtKB.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.
DR   InterPro; IPR008996; Cytokine_IL1-like.
DR   InterPro; IPR002209; GF_heparin-bd.
DR   InterPro; IPR002348; IL1_HBGF.
DR   KO; K04358; -.
DR   PANTHER; PTHR11486; IL1_HBGF; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   PRINTS; PR00262; IL1HBGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; Cytok_IL1_like; 1.
DR   PROSITE; PS00247; HBGF_FGF; FALSE_NEG.
PE   1: Evidence at protein level;
KW   Complete proteome; Growth factor; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL        1     22       Potential.
FT   CHAIN        23    170       Fibroblast growth factor 22.
FT                                /FTId=PRO_0000008996.
SQ   SEQUENCE   170 AA;  19663 MW;  CB88918C2D5A4CE7 CRC64;
     MRRRLWLGLA WLLLARAPDA AGTPSASRGP RSYPHLEGDV RWRRLFSSTH FFLRVDPGGR
     VQGTRWRHGQ DSILEIRSVH VGVVVIKAVS SGFYVAMNRR GRLYGSRLYT VDCRFRERIE
     ENGHNTYASQ RWRRRGQPMF LALDRRGGPR PGGRTRRYHL SAHFLPVLVS
//