Q9HCT0 (FGF22_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibroblast growth factor 22
Short name=FGF-22

Gene names

Name:	FGF22
ORF Names:	UNQ2500/PRO5800

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	170 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development. Ref.7
Subunit structure	Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. Ref.6 Ref.7
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell differentiation Non-traceable author statement Ref.1. Source: UniProtKB fibroblast growth factor receptor signaling pathway Traceable author statement. Source: Reactome insulin receptor signaling pathway Traceable author statement. Source: Reactome
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara cell surface Inferred from electronic annotation. Source: Compara extracellular space Non-traceable author statement Ref.1. Source: UniProtKB nucleolus Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 170	148	Fibroblast growth factor 22		PRO_0000008996

Sequences

	Sequence		Length	Mass (Da)
	Q9HCT0 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: CB88918C2D5A4CE7	FASTA	170	19,663
	10 20 30 40 50 60 MRRRLWLGLA WLLLARAPDA AGTPSASRGP RSYPHLEGDV RWRRLFSSTH FFLRVDPGGR 70 80 90 100 110 120 VQGTRWRHGQ DSILEIRSVH VGVVVIKAVS SGFYVAMNRR GRLYGSRLYT VDCRFRERIE 130 140 150 160 170 ENGHNTYASQ RWRRRGQPMF LALDRRGGPR PGGRTRRYHL SAHFLPVLVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle." Nakatake Y., Hoshikawa M., Asaki T., Kassai Y., Itoh N. Biochim. Biophys. Acta 1517:460-463(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	NIEHS SNPs program Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Testis.
[6]	"The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair." Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S. Oncogene 24:5269-5277(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FGFBP1.
[7]	"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family." Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M. J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FGFR1 AND FGFR2, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
[8]	"Fibroblast growth factor signalling: from development to cancer." Turner N., Grose R. Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB021925 mRNA. Translation: BAB13479.1. AY359084 mRNA. Translation: AAQ89955.1. AY426986 Genomic DNA. Translation: AAQ93357.1. CH471242 Genomic DNA. Translation: EAW61175.1. BC137444 mRNA. Translation: AAI37445.1. BC137445 mRNA. Translation: AAI37446.1.
IPI	IPI00030814.
RefSeq	NP_065688.1. NM_020637.1.
UniGene	Hs.248087.
3D structure databases
ProteinModelPortal	Q9HCT0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000215530.
Polymorphism databases
DMDM	13626689.
Proteomic databases
PaxDb	Q9HCT0.
PRIDE	Q9HCT0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000215530; ENSP00000215530; ENSG00000070388.
GeneID	27006.
KEGG	hsa:27006.
UCSC	uc010xfq.2. human.
Organism-specific databases
CTD	27006.
GeneCards	GC19P000639.
HGNC	HGNC:3679. FGF22.
MIM	605831. gene.
neXtProt	NX_Q9HCT0.
PharmGKB	PA28118.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG287769.
HOGENOM	HOG000236341.
HOVERGEN	HBG007580.
InParanoid	Q9HCT0.
KO	K04358.
OMA	GTRWRHG.
OrthoDB	EOG41C6XD.
PhylomeDB	Q9HCT0.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction. REACT_116125. Disease. REACT_6900. Immune System.
Gene expression databases
ArrayExpress	Q9HCT0.
Bgee	Q9HCT0.
CleanEx	HS_FGF22.
Genevestigator	Q9HCT0.
GermOnline	ENSG00000070388. Homo sapiens.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR002209. GF_heparin-bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. PTHR11486. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
SMART	SM00442. FGF. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00247. HBGF_FGF. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	27006.
NextBio	49512.
SOURCE	Search...

Entry information

Entry name

FGF22_HUMAN

Accession

Primary (citable) accession number: Q9HCT0
Secondary accession number(s): B2RPH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.