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Protein

Fibroblast growth factor 22

Gene

FGF22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_110235. Phospholipase C-mediated cascade: FGFR1.
REACT_120863. Activated point mutants of FGFR2.
REACT_147727. Constitutive Signaling by Aberrant PI3K in Cancer.
REACT_355069. FRS-mediated FGFR2 signaling.
REACT_355146. Phospholipase C-mediated cascade, FGFR2.
REACT_355194. SHC-mediated cascade:FGFR1.
REACT_355202. Signaling by FGFR4 mutants.
REACT_355218. Negative regulation of FGFR1 signaling.
REACT_355225. SHC-mediated cascade:FGFR2.
REACT_355227. Negative regulation of FGFR2 signaling.
REACT_355450. PI-3K cascade:FGFR2.
REACT_355511. Signaling by FGFR2 mutants.
REACT_355552. PI-3K cascade:FGFR1.
REACT_355584. FRS-mediated FGFR1 signaling.
REACT_75829. PIP3 activates AKT signaling.
REACT_9400. FGFR1b ligand binding and activation.
REACT_9416. FGFR2b ligand binding and activation.
REACT_976. PI3K Cascade.
SignaLinkiQ9HCT0.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 22
Short name:
FGF-22
Gene namesi
Name:FGF22
ORF Names:UNQ2500/PRO5800
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:3679. FGF22.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: Ensembl
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • Golgi apparatus Source: Ensembl
  • nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28118.

Polymorphism and mutation databases

BioMutaiFGF22.
DMDMi13626689.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 170148Fibroblast growth factor 22PRO_0000008996Add
BLAST

Proteomic databases

PaxDbiQ9HCT0.
PRIDEiQ9HCT0.

Expressioni

Gene expression databases

BgeeiQ9HCT0.
CleanExiHS_FGF22.
ExpressionAtlasiQ9HCT0. baseline and differential.
GenevisibleiQ9HCT0. HS.

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.2 Publications

Protein-protein interaction databases

STRINGi9606.ENSP00000215530.

Structurei

3D structure databases

ProteinModelPortaliQ9HCT0.
SMRiQ9HCT0. Positions 32-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG287769.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiQ9HCT0.
OMAiYSPSCKF.
PhylomeDBiQ9HCT0.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028296. FGF22.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF41. PTHR11486:SF41. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HCT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRRLWLGLA WLLLARAPDA AGTPSASRGP RSYPHLEGDV RWRRLFSSTH
60 70 80 90 100
FFLRVDPGGR VQGTRWRHGQ DSILEIRSVH VGVVVIKAVS SGFYVAMNRR
110 120 130 140 150
GRLYGSRLYT VDCRFRERIE ENGHNTYASQ RWRRRGQPMF LALDRRGGPR
160 170
PGGRTRRYHL SAHFLPVLVS
Length:170
Mass (Da):19,663
Last modified:March 1, 2001 - v1
Checksum:iCB88918C2D5A4CE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021925 mRNA. Translation: BAB13479.1.
AY359084 mRNA. Translation: AAQ89955.1.
AY426986 Genomic DNA. Translation: AAQ93357.1.
CH471242 Genomic DNA. Translation: EAW61175.1.
BC137444 mRNA. Translation: AAI37445.1.
BC137445 mRNA. Translation: AAI37446.1.
CCDSiCCDS12037.1.
RefSeqiNP_065688.1. NM_020637.1.
UniGeneiHs.248087.

Genome annotation databases

EnsembliENST00000215530; ENSP00000215530; ENSG00000070388.
GeneIDi27006.
UCSCiuc010xfq.2. human.

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021925 mRNA. Translation: BAB13479.1.
AY359084 mRNA. Translation: AAQ89955.1.
AY426986 Genomic DNA. Translation: AAQ93357.1.
CH471242 Genomic DNA. Translation: EAW61175.1.
BC137444 mRNA. Translation: AAI37445.1.
BC137445 mRNA. Translation: AAI37446.1.
CCDSiCCDS12037.1.
RefSeqiNP_065688.1. NM_020637.1.
UniGeneiHs.248087.

3D structure databases

ProteinModelPortaliQ9HCT0.
SMRiQ9HCT0. Positions 32-169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000215530.

Chemistry

ChEMBLiCHEMBL2362983.

Polymorphism and mutation databases

BioMutaiFGF22.
DMDMi13626689.

Proteomic databases

PaxDbiQ9HCT0.
PRIDEiQ9HCT0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215530; ENSP00000215530; ENSG00000070388.
GeneIDi27006.
UCSCiuc010xfq.2. human.

Organism-specific databases

CTDi27006.
GeneCardsiGC19P000639.
HGNCiHGNC:3679. FGF22.
MIMi605831. gene.
neXtProtiNX_Q9HCT0.
PharmGKBiPA28118.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG287769.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiQ9HCT0.
OMAiYSPSCKF.
PhylomeDBiQ9HCT0.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiREACT_110235. Phospholipase C-mediated cascade: FGFR1.
REACT_120863. Activated point mutants of FGFR2.
REACT_147727. Constitutive Signaling by Aberrant PI3K in Cancer.
REACT_355069. FRS-mediated FGFR2 signaling.
REACT_355146. Phospholipase C-mediated cascade, FGFR2.
REACT_355194. SHC-mediated cascade:FGFR1.
REACT_355202. Signaling by FGFR4 mutants.
REACT_355218. Negative regulation of FGFR1 signaling.
REACT_355225. SHC-mediated cascade:FGFR2.
REACT_355227. Negative regulation of FGFR2 signaling.
REACT_355450. PI-3K cascade:FGFR2.
REACT_355511. Signaling by FGFR2 mutants.
REACT_355552. PI-3K cascade:FGFR1.
REACT_355584. FRS-mediated FGFR1 signaling.
REACT_75829. PIP3 activates AKT signaling.
REACT_9400. FGFR1b ligand binding and activation.
REACT_9416. FGFR2b ligand binding and activation.
REACT_976. PI3K Cascade.
SignaLinkiQ9HCT0.

Miscellaneous databases

GenomeRNAii27006.
NextBioi49512.
PROiQ9HCT0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HCT0.
CleanExiHS_FGF22.
ExpressionAtlasiQ9HCT0. baseline and differential.
GenevisibleiQ9HCT0. HS.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028296. FGF22.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF41. PTHR11486:SF41. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle."
    Nakatake Y., Hoshikawa M., Asaki T., Kassai Y., Itoh N.
    Biochim. Biophys. Acta 1517:460-463(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. NIEHS SNPs program
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Testis.
  6. "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair."
    Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S.
    Oncogene 24:5269-5277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FGFBP1.
  7. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
    Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
    J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FGFR1 AND FGFR2, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
  8. "Fibroblast growth factor signalling: from development to cancer."
    Turner N., Grose R.
    Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiFGF22_HUMAN
AccessioniPrimary (citable) accession number: Q9HCT0
Secondary accession number(s): B2RPH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: July 22, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.