Reviewed, UniProtKB/Swiss-Prot Q9HCT0 (FGF22_HUMAN)

Names and origin

Protein names

Recommended name:
    Fibroblast growth factor 22
      Short name=FGF-22

Gene names

Name:	FGF22
ORF Names:	UNQ2500/PRO5800

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	170 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be involved in hair development.
Subunit structure	Interacts with FGFBP1. Ref.4
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
Gene Ontology (GO)
Biological process	cell differentiation Ref.1 Non-traceable author statement. Source: UniProtKB fibroblast growth factor receptor signaling pathway Inferred from Experiment. Source: Reactome
Cellular component	extracellular space Ref.1 Non-traceable author statement. Source: UniProtKB
Molecular function	growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 170	148	Fibroblast growth factor 22		PRO_0000008996

Sequences

	Sequence		Length	Mass (Da)
	Q9HCT0-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: CB88918C2D5A4CE7	FASTA	170	19,663
	10 20 30 40 50 60 MRRRLWLGLA WLLLARAPDA AGTPSASRGP RSYPHLEGDV RWRRLFSSTH FFLRVDPGGR 70 80 90 100 110 120 VQGTRWRHGQ DSILEIRSVH VGVVVIKAVS SGFYVAMNRR GRLYGSRLYT VDCRFRERIE 130 140 150 160 170 ENGHNTYASQ RWRRRGQPMF LALDRRGGPR PGGRTRRYHL SAHFLPVLVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle." Nakatake Y., Hoshikawa M., Asaki T., Kassai Y., Itoh N. Biochim. Biophys. Acta 1517:460-463(2001) [PubMed: 11342227] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	NIEHS SNPs program Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair." Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S. Oncogene 24:5269-5277(2005) [PubMed: 15806171] [Abstract] Cited for: INTERACTION WITH FGFBP1.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB021925 mRNA. Translation: BAB13479.1. AY359084 mRNA. Translation: AAQ89955.1. AY426986 Genomic DNA. Translation: AAQ93357.1.
IPI	IPI00030814.
RefSeq	NP_065688.1.
UniGene	Hs.248087
3D structure databases
HSSP	HSSP built from PDB template 1NUN based on UniProtKB O15520.
ModBase	Search...
Proteomic databases
PRIDE	Q9HCT0.
Genome annotation databases
Ensembl	ENSG00000070388. Homo sapiens. [Contig view]
GeneID	27006.
KEGG	hsa:27006.
Organism-specific databases
GeneCards	GC19P000590.
H-InvDB	HIX0039926.
HGNC	HGNC:3679. FGF22.
MIM	605831. gene.
PharmGKB	PA28118.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9HCT0.
HOVERGEN	Q9HCT0.
OMA	Q9HCT0. RHGQDSI.
Enzyme and pathway databases
Reactome	REACT_9470. Signaling by FGFR.
Gene expression databases
Bgee	Q9HCT0.
CleanEx	HS_FGF22.
GermOnline	ENSG00000070388. Homo sapiens.
Family and domain databases
InterPro	IPR002209. GF_heparin_bd. IPR002348. IL1_HBGF. [Graphical view]
PANTHER	PTHR11486. IL1_HBGF. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
PRINTS	PR00263. HBGFFGF. PR00262. IL1HBGF.
ProDom	PD000831. IL1_HBGF. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00442. FGF. 1 hit. [Graphical view]
PROSITE	PS00247. HBGF_FGF. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	49512.
SOURCE	Search...

Entry information

Entry name

FGF22_HUMAN

Accession

Primary (citable) accession number: Q9HCT0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	March 1, 2001
Last modified:	June 16, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)