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Reviewed, UniProtKB/Swiss-Prot Q9HCT0 (FGF22_HUMAN)

Last modified June 16, 2009. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Fibroblast growth factor 22
      Short name=FGF-22
Gene names
Name: FGF22
ORF Names: UNQ2500/PRO5800
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length170 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May be involved in hair development.

Subunit structure

Interacts with FGFBP1. Ref.4

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionGrowth factor
Gene Ontology (GO)
   Biological processcell differentiation Ref.1

Non-traceable author statement. Source: UniProtKB

fibroblast growth factor receptor signaling pathway

Inferred from Experiment. Source: Reactome

   Cellular componentextracellular space Ref.1

Non-traceable author statement. Source: UniProtKB

   Molecular functiongrowth factor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 170148Fibroblast growth factor 22
PRO_0000008996

Sequences

Sequence LengthMass (Da)Tools
Q9HCT0-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: CB88918C2D5A4CE7

FASTA17019,663
        10         20         30         40         50         60 
MRRRLWLGLA WLLLARAPDA AGTPSASRGP RSYPHLEGDV RWRRLFSSTH FFLRVDPGGR 

        70         80         90        100        110        120 
VQGTRWRHGQ DSILEIRSVH VGVVVIKAVS SGFYVAMNRR GRLYGSRLYT VDCRFRERIE 

       130        140        150        160        170 
ENGHNTYASQ RWRRRGQPMF LALDRRGGPR PGGRTRRYHL SAHFLPVLVS 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle."
Nakatake Y., Hoshikawa M., Asaki T., Kassai Y., Itoh N.
Biochim. Biophys. Acta 1517:460-463(2001) [PubMed: 11342227] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]NIEHS SNPs program
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair."
Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S.
Oncogene 24:5269-5277(2005) [PubMed: 15806171] [Abstract]
Cited for: INTERACTION WITH FGFBP1.

Web resources

Cross-references

Sequence databases

AB021925 mRNA. Translation: BAB13479.1.
AY359084 mRNA. Translation: AAQ89955.1.
AY426986 Genomic DNA. Translation: AAQ93357.1.
IPIIPI00030814.
RefSeqNP_065688.1.
UniGeneHs.248087

3D structure databases

HSSPHSSP built from PDB template 1NUN based on UniProtKB O15520.
ModBaseSearch...

Proteomic databases

PRIDEQ9HCT0.

Genome annotation databases

EnsemblENSG00000070388. Homo sapiens. [Contig view]
GeneID27006.
KEGGhsa:27006.

Organism-specific databases

GeneCardsGC19P000590.
H-InvDBHIX0039926.
HGNCHGNC:3679. FGF22.
MIM605831. gene.
PharmGKBPA28118.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9HCT0.
HOVERGENQ9HCT0.
OMAQ9HCT0. RHGQDSI.

Enzyme and pathway databases

ReactomeREACT_9470. Signaling by FGFR.

Gene expression databases

BgeeQ9HCT0.
CleanExHS_FGF22.
GermOnlineENSG00000070388. Homo sapiens.

Family and domain databases

InterProIPR002209. GF_heparin_bd.
IPR002348. IL1_HBGF.
[Graphical view]
PANTHERPTHR11486. IL1_HBGF. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
ProDomPD000831. IL1_HBGF. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00442. FGF. 1 hit.
[Graphical view]
PROSITEPS00247. HBGF_FGF. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio49512.
SOURCESearch...

Entry information

Entry nameFGF22_HUMAN
AccessionPrimary (citable) accession number: Q9HCT0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: June 16, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents