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Q9HCT0

- FGF22_HUMAN

UniProt

Q9HCT0 - FGF22_HUMAN

Protein

Fibroblast growth factor 22

Gene

FGF22

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development.1 Publication

    GO - Biological processi

    1. cell differentiation Source: UniProtKB
    2. epidermal growth factor receptor signaling pathway Source: Reactome
    3. Fc-epsilon receptor signaling pathway Source: Reactome
    4. fibroblast growth factor receptor signaling pathway Source: Reactome
    5. innate immune response Source: Reactome
    6. insulin receptor signaling pathway Source: Reactome
    7. neurotrophin TRK receptor signaling pathway Source: Reactome
    8. phosphatidylinositol-mediated signaling Source: Reactome

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_111184. Negative regulation of FGFR signaling.
    REACT_120863. Activated point mutants of FGFR2.
    REACT_121398. Signaling by FGFR mutants.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_21247. FRS2-mediated cascade.
    REACT_21270. PI-3K cascade.
    REACT_21310. Phospholipase C-mediated cascade.
    REACT_21374. SHC-mediated cascade.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_9400. FGFR1b ligand binding and activation.
    REACT_9416. FGFR2b ligand binding and activation.
    REACT_976. PI3K Cascade.
    SignaLinkiQ9HCT0.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 22
    Short name:
    FGF-22
    Gene namesi
    Name:FGF22
    ORF Names:UNQ2500/PRO5800
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:3679. FGF22.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. extracellular region Source: Reactome
    3. extracellular space Source: UniProtKB
    4. Golgi apparatus Source: Ensembl
    5. nucleolus Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28118.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 170148Fibroblast growth factor 22PRO_0000008996Add
    BLAST

    Proteomic databases

    PaxDbiQ9HCT0.
    PRIDEiQ9HCT0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9HCT0.
    BgeeiQ9HCT0.
    CleanExiHS_FGF22.
    GenevestigatoriQ9HCT0.

    Interactioni

    Subunit structurei

    Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.2 Publications

    Protein-protein interaction databases

    BioGridi117951. 1 interaction.
    STRINGi9606.ENSP00000215530.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HCT0.
    SMRiQ9HCT0. Positions 32-169.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG287769.
    HOGENOMiHOG000236341.
    HOVERGENiHBG007580.
    InParanoidiQ9HCT0.
    KOiK04358.
    OMAiMEVVIGC.
    PhylomeDBiQ9HCT0.
    TreeFamiTF317805.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028296. FGF22.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF41. PTHR11486:SF41. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9HCT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRRLWLGLA WLLLARAPDA AGTPSASRGP RSYPHLEGDV RWRRLFSSTH    50
    FFLRVDPGGR VQGTRWRHGQ DSILEIRSVH VGVVVIKAVS SGFYVAMNRR 100
    GRLYGSRLYT VDCRFRERIE ENGHNTYASQ RWRRRGQPMF LALDRRGGPR 150
    PGGRTRRYHL SAHFLPVLVS 170
    Length:170
    Mass (Da):19,663
    Last modified:March 1, 2001 - v1
    Checksum:iCB88918C2D5A4CE7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB021925 mRNA. Translation: BAB13479.1.
    AY359084 mRNA. Translation: AAQ89955.1.
    AY426986 Genomic DNA. Translation: AAQ93357.1.
    CH471242 Genomic DNA. Translation: EAW61175.1.
    BC137444 mRNA. Translation: AAI37445.1.
    BC137445 mRNA. Translation: AAI37446.1.
    CCDSiCCDS12037.1.
    RefSeqiNP_065688.1. NM_020637.1.
    UniGeneiHs.248087.

    Genome annotation databases

    EnsembliENST00000215530; ENSP00000215530; ENSG00000070388.
    GeneIDi27006.
    KEGGihsa:27006.
    UCSCiuc010xfq.2. human.

    Polymorphism databases

    DMDMi13626689.

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB021925 mRNA. Translation: BAB13479.1 .
    AY359084 mRNA. Translation: AAQ89955.1 .
    AY426986 Genomic DNA. Translation: AAQ93357.1 .
    CH471242 Genomic DNA. Translation: EAW61175.1 .
    BC137444 mRNA. Translation: AAI37445.1 .
    BC137445 mRNA. Translation: AAI37446.1 .
    CCDSi CCDS12037.1.
    RefSeqi NP_065688.1. NM_020637.1.
    UniGenei Hs.248087.

    3D structure databases

    ProteinModelPortali Q9HCT0.
    SMRi Q9HCT0. Positions 32-169.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117951. 1 interaction.
    STRINGi 9606.ENSP00000215530.

    Chemistry

    ChEMBLi CHEMBL2362983.

    Polymorphism databases

    DMDMi 13626689.

    Proteomic databases

    PaxDbi Q9HCT0.
    PRIDEi Q9HCT0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000215530 ; ENSP00000215530 ; ENSG00000070388 .
    GeneIDi 27006.
    KEGGi hsa:27006.
    UCSCi uc010xfq.2. human.

    Organism-specific databases

    CTDi 27006.
    GeneCardsi GC19P000639.
    HGNCi HGNC:3679. FGF22.
    MIMi 605831. gene.
    neXtProti NX_Q9HCT0.
    PharmGKBi PA28118.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG287769.
    HOGENOMi HOG000236341.
    HOVERGENi HBG007580.
    InParanoidi Q9HCT0.
    KOi K04358.
    OMAi MEVVIGC.
    PhylomeDBi Q9HCT0.
    TreeFami TF317805.

    Enzyme and pathway databases

    Reactomei REACT_111184. Negative regulation of FGFR signaling.
    REACT_120863. Activated point mutants of FGFR2.
    REACT_121398. Signaling by FGFR mutants.
    REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_21247. FRS2-mediated cascade.
    REACT_21270. PI-3K cascade.
    REACT_21310. Phospholipase C-mediated cascade.
    REACT_21374. SHC-mediated cascade.
    REACT_75829. PIP3 activates AKT signaling.
    REACT_9400. FGFR1b ligand binding and activation.
    REACT_9416. FGFR2b ligand binding and activation.
    REACT_976. PI3K Cascade.
    SignaLinki Q9HCT0.

    Miscellaneous databases

    GenomeRNAii 27006.
    NextBioi 49512.
    PROi Q9HCT0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9HCT0.
    Bgeei Q9HCT0.
    CleanExi HS_FGF22.
    Genevestigatori Q9HCT0.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028296. FGF22.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF41. PTHR11486:SF41. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle."
      Nakatake Y., Hoshikawa M., Asaki T., Kassai Y., Itoh N.
      Biochim. Biophys. Acta 1517:460-463(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. NIEHS SNPs program
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Testis.
    6. "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair."
      Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S.
      Oncogene 24:5269-5277(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FGFBP1.
    7. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
      Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
      J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FGFR1 AND FGFR2, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
    8. "Fibroblast growth factor signalling: from development to cancer."
      Turner N., Grose R.
      Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiFGF22_HUMAN
    AccessioniPrimary (citable) accession number: Q9HCT0
    Secondary accession number(s): B2RPH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3