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Protein

Fibroblast growth factor 22

Gene

FGF22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-190370 FGFR1b ligand binding and activation
R-HSA-190377 FGFR2b ligand binding and activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkiQ9HCT0

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 22
Short name:
FGF-22
Gene namesi
Name:FGF22
ORF Names:UNQ2500/PRO5800
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000070388.11
HGNCiHGNC:3679 FGF22
MIMi605831 gene
neXtProtiNX_Q9HCT0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000070388
PharmGKBiPA28118

Chemistry databases

ChEMBLiCHEMBL2362983

Polymorphism and mutation databases

BioMutaiFGF22
DMDMi13626689

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000899623 – 170Fibroblast growth factor 22Add BLAST148

Proteomic databases

PaxDbiQ9HCT0
PRIDEiQ9HCT0
ProteomicsDBi81797

PTM databases

iPTMnetiQ9HCT0
PhosphoSitePlusiQ9HCT0

Expressioni

Gene expression databases

BgeeiENSG00000070388
CleanExiHS_FGF22
ExpressionAtlasiQ9HCT0 baseline and differential
GenevisibleiQ9HCT0 HS

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000215530

Structurei

3D structure databases

ProteinModelPortaliQ9HCT0
SMRiQ9HCT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiQ9HCT0
KOiK04358
OMAiGRTQRHH
OrthoDBiEOG091G0NAY
PhylomeDBiQ9HCT0
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028296 FGF22
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF41 PTHR11486:SF41, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HCT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRRLWLGLA WLLLARAPDA AGTPSASRGP RSYPHLEGDV RWRRLFSSTH
60 70 80 90 100
FFLRVDPGGR VQGTRWRHGQ DSILEIRSVH VGVVVIKAVS SGFYVAMNRR
110 120 130 140 150
GRLYGSRLYT VDCRFRERIE ENGHNTYASQ RWRRRGQPMF LALDRRGGPR
160 170
PGGRTRRYHL SAHFLPVLVS
Length:170
Mass (Da):19,663
Last modified:March 1, 2001 - v1
Checksum:iCB88918C2D5A4CE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021925 mRNA Translation: BAB13479.1
AY359084 mRNA Translation: AAQ89955.1
AY426986 Genomic DNA Translation: AAQ93357.1
CH471242 Genomic DNA Translation: EAW61175.1
BC137444 mRNA Translation: AAI37445.1
BC137445 mRNA Translation: AAI37446.1
CCDSiCCDS12037.1
RefSeqiNP_065688.1, NM_020637.1
UniGeneiHs.248087

Genome annotation databases

EnsembliENST00000215530; ENSP00000215530; ENSG00000070388
GeneIDi27006
KEGGihsa:27006
UCSCiuc010xfq.3 human

Similar proteinsi

Entry informationi

Entry nameiFGF22_HUMAN
AccessioniPrimary (citable) accession number: Q9HCT0
Secondary accession number(s): B2RPH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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