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Q9HCT0

- FGF22_HUMAN

UniProt

Q9HCT0 - FGF22_HUMAN

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Protein

Fibroblast growth factor 22

Gene

FGF22

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development.1 Publication

GO - Biological processi

  1. cell differentiation Source: UniProtKB
  2. epidermal growth factor receptor signaling pathway Source: Reactome
  3. Fc-epsilon receptor signaling pathway Source: Reactome
  4. fibroblast growth factor receptor signaling pathway Source: Reactome
  5. innate immune response Source: Reactome
  6. insulin receptor signaling pathway Source: Reactome
  7. neurotrophin TRK receptor signaling pathway Source: Reactome
  8. phosphatidylinositol-mediated signaling Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_111184. Negative regulation of FGFR signaling.
REACT_120863. Activated point mutants of FGFR2.
REACT_121398. Signaling by FGFR mutants.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_21247. FRS2-mediated cascade.
REACT_21270. PI-3K cascade.
REACT_21310. Phospholipase C-mediated cascade.
REACT_21374. SHC-mediated cascade.
REACT_75829. PIP3 activates AKT signaling.
REACT_9400. FGFR1b ligand binding and activation.
REACT_9416. FGFR2b ligand binding and activation.
REACT_976. PI3K Cascade.
SignaLinkiQ9HCT0.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 22
Short name:
FGF-22
Gene namesi
Name:FGF22
ORF Names:UNQ2500/PRO5800
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:3679. FGF22.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. extracellular region Source: Reactome
  3. extracellular space Source: UniProtKB
  4. Golgi apparatus Source: Ensembl
  5. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28118.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 170148Fibroblast growth factor 22PRO_0000008996Add
BLAST

Proteomic databases

PaxDbiQ9HCT0.
PRIDEiQ9HCT0.

Expressioni

Gene expression databases

BgeeiQ9HCT0.
CleanExiHS_FGF22.
ExpressionAtlasiQ9HCT0. baseline and differential.
GenevestigatoriQ9HCT0.

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.2 Publications

Protein-protein interaction databases

BioGridi117951. 1 interaction.
STRINGi9606.ENSP00000215530.

Structurei

3D structure databases

ProteinModelPortaliQ9HCT0.
SMRiQ9HCT0. Positions 32-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG287769.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiQ9HCT0.
KOiK04358.
OMAiMEVVIGC.
PhylomeDBiQ9HCT0.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028296. FGF22.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF41. PTHR11486:SF41. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HCT0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRRLWLGLA WLLLARAPDA AGTPSASRGP RSYPHLEGDV RWRRLFSSTH
60 70 80 90 100
FFLRVDPGGR VQGTRWRHGQ DSILEIRSVH VGVVVIKAVS SGFYVAMNRR
110 120 130 140 150
GRLYGSRLYT VDCRFRERIE ENGHNTYASQ RWRRRGQPMF LALDRRGGPR
160 170
PGGRTRRYHL SAHFLPVLVS
Length:170
Mass (Da):19,663
Last modified:March 1, 2001 - v1
Checksum:iCB88918C2D5A4CE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021925 mRNA. Translation: BAB13479.1.
AY359084 mRNA. Translation: AAQ89955.1.
AY426986 Genomic DNA. Translation: AAQ93357.1.
CH471242 Genomic DNA. Translation: EAW61175.1.
BC137444 mRNA. Translation: AAI37445.1.
BC137445 mRNA. Translation: AAI37446.1.
CCDSiCCDS12037.1.
RefSeqiNP_065688.1. NM_020637.1.
UniGeneiHs.248087.

Genome annotation databases

EnsembliENST00000215530; ENSP00000215530; ENSG00000070388.
GeneIDi27006.
KEGGihsa:27006.
UCSCiuc010xfq.2. human.

Polymorphism databases

DMDMi13626689.

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021925 mRNA. Translation: BAB13479.1 .
AY359084 mRNA. Translation: AAQ89955.1 .
AY426986 Genomic DNA. Translation: AAQ93357.1 .
CH471242 Genomic DNA. Translation: EAW61175.1 .
BC137444 mRNA. Translation: AAI37445.1 .
BC137445 mRNA. Translation: AAI37446.1 .
CCDSi CCDS12037.1.
RefSeqi NP_065688.1. NM_020637.1.
UniGenei Hs.248087.

3D structure databases

ProteinModelPortali Q9HCT0.
SMRi Q9HCT0. Positions 32-169.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117951. 1 interaction.
STRINGi 9606.ENSP00000215530.

Chemistry

ChEMBLi CHEMBL2362983.

Polymorphism databases

DMDMi 13626689.

Proteomic databases

PaxDbi Q9HCT0.
PRIDEi Q9HCT0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000215530 ; ENSP00000215530 ; ENSG00000070388 .
GeneIDi 27006.
KEGGi hsa:27006.
UCSCi uc010xfq.2. human.

Organism-specific databases

CTDi 27006.
GeneCardsi GC19P000639.
HGNCi HGNC:3679. FGF22.
MIMi 605831. gene.
neXtProti NX_Q9HCT0.
PharmGKBi PA28118.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG287769.
GeneTreei ENSGT00760000118859.
HOGENOMi HOG000236341.
HOVERGENi HBG007580.
InParanoidi Q9HCT0.
KOi K04358.
OMAi MEVVIGC.
PhylomeDBi Q9HCT0.
TreeFami TF317805.

Enzyme and pathway databases

Reactomei REACT_111184. Negative regulation of FGFR signaling.
REACT_120863. Activated point mutants of FGFR2.
REACT_121398. Signaling by FGFR mutants.
REACT_147727. Constitutive PI3K/AKT Signaling in Cancer.
REACT_21247. FRS2-mediated cascade.
REACT_21270. PI-3K cascade.
REACT_21310. Phospholipase C-mediated cascade.
REACT_21374. SHC-mediated cascade.
REACT_75829. PIP3 activates AKT signaling.
REACT_9400. FGFR1b ligand binding and activation.
REACT_9416. FGFR2b ligand binding and activation.
REACT_976. PI3K Cascade.
SignaLinki Q9HCT0.

Miscellaneous databases

GenomeRNAii 27006.
NextBioi 49512.
PROi Q9HCT0.
SOURCEi Search...

Gene expression databases

Bgeei Q9HCT0.
CleanExi HS_FGF22.
ExpressionAtlasi Q9HCT0. baseline and differential.
Genevestigatori Q9HCT0.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR028296. FGF22.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view ]
PANTHERi PTHR11486. PTHR11486. 1 hit.
PTHR11486:SF41. PTHR11486:SF41. 1 hit.
PRINTSi PR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTi SM00442. FGF. 1 hit.
[Graphical view ]
SUPFAMi SSF50353. SSF50353. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle."
    Nakatake Y., Hoshikawa M., Asaki T., Kassai Y., Itoh N.
    Biochim. Biophys. Acta 1517:460-463(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. NIEHS SNPs program
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Testis.
  6. "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair."
    Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S.
    Oncogene 24:5269-5277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FGFBP1.
  7. "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
    Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
    J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FGFR1 AND FGFR2, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
  8. "Fibroblast growth factor signalling: from development to cancer."
    Turner N., Grose R.
    Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiFGF22_HUMAN
AccessioniPrimary (citable) accession number: Q9HCT0
Secondary accession number(s): B2RPH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3