Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9HCT0 (FGF22_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 22

Short name=FGF-22
Gene names
Name:FGF22
ORF Names:UNQ2500/PRO5800
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length170 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development. Ref.7

Subunit structure

Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. Ref.6 Ref.7

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 170148Fibroblast growth factor 22
PRO_0000008996

Sequences

Sequence LengthMass (Da)Tools
Q9HCT0 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: CB88918C2D5A4CE7

FASTA17019,663
        10         20         30         40         50         60 
MRRRLWLGLA WLLLARAPDA AGTPSASRGP RSYPHLEGDV RWRRLFSSTH FFLRVDPGGR 

        70         80         90        100        110        120 
VQGTRWRHGQ DSILEIRSVH VGVVVIKAVS SGFYVAMNRR GRLYGSRLYT VDCRFRERIE 

       130        140        150        160        170 
ENGHNTYASQ RWRRRGQPMF LALDRRGGPR PGGRTRRYHL SAHFLPVLVS 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle."
Nakatake Y., Hoshikawa M., Asaki T., Kassai Y., Itoh N.
Biochim. Biophys. Acta 1517:460-463(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]NIEHS SNPs program
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Testis.
[6]"The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair."
Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S.
Oncogene 24:5269-5277(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FGFBP1.
[7]"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.
J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FGFR1 AND FGFR2, FUNCTION IN STIMULATION OF CELL PROLIFERATION.
[8]"Fibroblast growth factor signalling: from development to cancer."
Turner N., Grose R.
Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB021925 mRNA. Translation: BAB13479.1.
AY359084 mRNA. Translation: AAQ89955.1.
AY426986 Genomic DNA. Translation: AAQ93357.1.
CH471242 Genomic DNA. Translation: EAW61175.1.
BC137444 mRNA. Translation: AAI37445.1.
BC137445 mRNA. Translation: AAI37446.1.
RefSeqNP_065688.1. NM_020637.1.
UniGeneHs.248087.

3D structure databases

ProteinModelPortalQ9HCT0.
SMRQ9HCT0. Positions 32-169.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117951. 1 interaction.
STRING9606.ENSP00000215530.

Chemistry

ChEMBLCHEMBL2362983.

Polymorphism databases

DMDM13626689.

Proteomic databases

PaxDbQ9HCT0.
PRIDEQ9HCT0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000215530; ENSP00000215530; ENSG00000070388.
GeneID27006.
KEGGhsa:27006.
UCSCuc010xfq.2. human.

Organism-specific databases

CTD27006.
GeneCardsGC19P000639.
HGNCHGNC:3679. FGF22.
MIM605831. gene.
neXtProtNX_Q9HCT0.
PharmGKBPA28118.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG287769.
HOGENOMHOG000236341.
HOVERGENHBG007580.
InParanoidQ9HCT0.
KOK04358.
OMARHGQDSI.
PhylomeDBQ9HCT0.
TreeFamTF317805.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_6900. Immune System.
SignaLinkQ9HCT0.

Gene expression databases

ArrayExpressQ9HCT0.
BgeeQ9HCT0.
CleanExHS_FGF22.
GenevestigatorQ9HCT0.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028296. FGF22.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF22. PTHR11486:SF22. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi27006.
NextBio49512.
PROQ9HCT0.
SOURCESearch...

Entry information

Entry nameFGF22_HUMAN
AccessionPrimary (citable) accession number: Q9HCT0
Secondary accession number(s): B2RPH4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM