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Protein

Band 4.1-like protein 4A

Gene

EPB41L4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129595-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Band 4.1-like protein 4A
Alternative name(s):
Protein NBL4
Gene namesi
Name:EPB41L4A
Synonyms:EPB41L4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:13278. EPB41L4A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi64097.
OpenTargetsiENSG00000129595.
PharmGKBiPA134994123.

Polymorphism and mutation databases

BioMutaiEPB41L4A.
DMDMi292495006.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194011 – 686Band 4.1-like protein 4AAdd BLAST686

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei304PhosphoserineCombined sources1
Modified residuei389PhosphoserineCombined sources1
Modified residuei393PhosphoserineCombined sources1
Modified residuei402PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9HCS5.
PaxDbiQ9HCS5.
PeptideAtlasiQ9HCS5.
PRIDEiQ9HCS5.

PTM databases

iPTMnetiQ9HCS5.
PhosphoSitePlusiQ9HCS5.

Expressioni

Tissue specificityi

Expressed in many tissues. High levels of expression in brain, liver, thymus and peripheral blood leukocytes and low levels of expression in heart, kidney, testis and colon.

Gene expression databases

BgeeiENSG00000129595.
CleanExiHS_EPB41L4A.
GenevisibleiQ9HCS5. HS.

Organism-specific databases

HPAiHPA036580.

Interactioni

Protein-protein interaction databases

BioGridi122058. 4 interactors.
IntActiQ9HCS5. 4 interactors.
STRINGi9606.ENSP00000261486.

Structurei

3D structure databases

ProteinModelPortaliQ9HCS5.
SMRiQ9HCS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 299FERMPROSITE-ProRule annotationAdd BLAST289

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQ5Z. Eukaryota.
ENOG410XRF6. LUCA.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000231632.
HOVERGENiHBG051433.
InParanoidiQ9HCS5.
OMAiKVETQGD.
OrthoDBiEOG091G04NZ.
PhylomeDBiQ9HCS5.
TreeFamiTF319780.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR000798. Ez/rad/moesin-like.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
SM01195. FA. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HCS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCFCAVPEE FYCEVLLLDE SKLTLTTQQQ GIKKSTKGSV VLDHVFHHVN
60 70 80 90 100
LVEIDYFGLR YCDRSHQTYW LDPAKTLAEH KELINTGPPY TLYFGIKFYA
110 120 130 140 150
EDPCKLKEEI TRYQFFLQVK QDVLQGRLPC PVNTAAQLGA YAIQSELGDY
160 170 180 190 200
DPYKHTAGYV SEYRFVPDQK EELEEAIERI HKTLMGQIPS EAELNYLRTA
210 220 230 240 250
KSLEMYGVDL HPVYGENKSE YFLGLTPVGV VVYKNKKQVG KYFWPRITKV
260 270 280 290 300
HFKETQFELR VLGKDCNETS FFFEARSKTA CKHLWKCSVE HHTFFRMPEN
310 320 330 340 350
ESNSLSRKLS KFGSIRYKHR YSGRTALQMS RDLSIQLPRP DQNVTRSRSK
360 370 380 390 400
TYPKRIAQTQ PAESNSISRI TANMENGENE GTIKIIAPSP VKSFKKAKNE
410 420 430 440 450
NSPDTQRSKS HAPWEENGPQ SGLYNSPSDR TKSPKFPYTR RRNPSCGSDN
460 470 480 490 500
DSVQPVRRRK AHNSGEDSDL KQRRRSRSRC NTSSGSESEN SNREYRKKRN
510 520 530 540 550
RIRQENDMVD SAPQWEAVLR RQKEKNQADP NNRRSRHRSR SRSPDIQAKE
560 570 580 590 600
ELWKHIQKEL VDPSGLSEEQ LKEIPYTKIE TQGDPIRIRH SHSPRSYRQY
610 620 630 640 650
RRSQCSDGER SVLSEVNSKT DLVPPLPVTR SSDAQGSGDA TVHQRRNGSK
660 670 680
DSLMEEKPQT STNNLAGKHT AKTIKTIQAS RLKTET
Length:686
Mass (Da):79,059
Last modified:March 23, 2010 - v2
Checksum:i4EDC84D0FD2B99EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti366S → T in BAB17229 (PubMed:10874211).Curated1
Sequence conflicti411 – 413HAP → LMHS in BAB17229 (PubMed:10874211).Curated3
Sequence conflicti495Y → H in BAB17229 (PubMed:10874211).Curated1
Sequence conflicti564S → F in AAI14943 (PubMed:15489334).Curated1
Sequence conflicti589R → T in BAB17229 (PubMed:10874211).Curated1
Sequence conflicti595 – 596RS → KL in BAB17229 (PubMed:10874211).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055537132V → I.Corresponds to variant rs34008454dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010261 Genomic DNA. No translation available.
AC010265 Genomic DNA. No translation available.
AC104126 Genomic DNA. No translation available.
BC114632 mRNA. No translation available.
BC114942 mRNA. Translation: AAI14943.1.
AB030240 mRNA. Translation: BAB17229.1.
CCDSiCCDS43350.1.
RefSeqiNP_071423.3. NM_022140.3.
UniGeneiHs.584954.

Genome annotation databases

EnsembliENST00000261486; ENSP00000261486; ENSG00000129595.
ENST00000621003; ENSP00000482810; ENSG00000129595.
GeneIDi64097.
KEGGihsa:64097.
UCSCiuc003kpv.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010261 Genomic DNA. No translation available.
AC010265 Genomic DNA. No translation available.
AC104126 Genomic DNA. No translation available.
BC114632 mRNA. No translation available.
BC114942 mRNA. Translation: AAI14943.1.
AB030240 mRNA. Translation: BAB17229.1.
CCDSiCCDS43350.1.
RefSeqiNP_071423.3. NM_022140.3.
UniGeneiHs.584954.

3D structure databases

ProteinModelPortaliQ9HCS5.
SMRiQ9HCS5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122058. 4 interactors.
IntActiQ9HCS5. 4 interactors.
STRINGi9606.ENSP00000261486.

PTM databases

iPTMnetiQ9HCS5.
PhosphoSitePlusiQ9HCS5.

Polymorphism and mutation databases

BioMutaiEPB41L4A.
DMDMi292495006.

Proteomic databases

MaxQBiQ9HCS5.
PaxDbiQ9HCS5.
PeptideAtlasiQ9HCS5.
PRIDEiQ9HCS5.

Protocols and materials databases

DNASUi64097.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261486; ENSP00000261486; ENSG00000129595.
ENST00000621003; ENSP00000482810; ENSG00000129595.
GeneIDi64097.
KEGGihsa:64097.
UCSCiuc003kpv.1. human.

Organism-specific databases

CTDi64097.
DisGeNETi64097.
GeneCardsiEPB41L4A.
HGNCiHGNC:13278. EPB41L4A.
HPAiHPA036580.
MIMi612141. gene.
neXtProtiNX_Q9HCS5.
OpenTargetsiENSG00000129595.
PharmGKBiPA134994123.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ5Z. Eukaryota.
ENOG410XRF6. LUCA.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000231632.
HOVERGENiHBG051433.
InParanoidiQ9HCS5.
OMAiKVETQGD.
OrthoDBiEOG091G04NZ.
PhylomeDBiQ9HCS5.
TreeFamiTF319780.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129595-MONOMER.

Miscellaneous databases

ChiTaRSiEPB41L4A. human.
GenomeRNAii64097.
PROiQ9HCS5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129595.
CleanExiHS_EPB41L4A.
GenevisibleiQ9HCS5. HS.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR000798. Ez/rad/moesin-like.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiSM00295. B41. 1 hit.
SM01195. FA. 1 hit.
SM01196. FERM_C. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE41LA_HUMAN
AccessioniPrimary (citable) accession number: Q9HCS5
Secondary accession number(s): A4FUI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: March 23, 2010
Last modified: November 2, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.