Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein-cysteine N-palmitoyltransferase HHAT-like protein

Gene

HHATL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000010282-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-cysteine N-palmitoyltransferase HHAT-like protein
Alternative name(s):
Glycerol uptake/transporter homolog
Hedgehog acyltransferase-like protein
Gene namesi
Name:HHATL
Synonyms:C3orf3, GUP1, KIAA1173
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:13242. HHATL.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 31HelicalSequence analysisAdd BLAST20
Transmembranei65 – 87HelicalSequence analysisAdd BLAST23
Transmembranei100 – 122HelicalSequence analysisAdd BLAST23
Transmembranei127 – 149HelicalSequence analysisAdd BLAST23
Transmembranei251 – 273HelicalSequence analysisAdd BLAST23
Transmembranei288 – 310HelicalSequence analysisAdd BLAST23
Transmembranei429 – 446HelicalSequence analysisAdd BLAST18
Transmembranei461 – 483HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000010282.
PharmGKBiPA162390892.

Polymorphism and mutation databases

BioMutaiHHATL.
DMDMi23396970.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002131301 – 504Protein-cysteine N-palmitoyltransferase HHAT-like proteinAdd BLAST504

Proteomic databases

PaxDbiQ9HCP6.
PeptideAtlasiQ9HCP6.
PRIDEiQ9HCP6.

PTM databases

PhosphoSitePlusiQ9HCP6.

Expressioni

Tissue specificityi

Heart-specific.1 Publication

Gene expression databases

BgeeiENSG00000010282.
CleanExiHS_HHATL.
ExpressionAtlasiQ9HCP6. baseline and differential.
GenevisibleiQ9HCP6. HS.

Organism-specific databases

HPAiHPA018174.

Interactioni

Subunit structurei

Interacts with SHH.By similarity

Protein-protein interaction databases

BioGridi121537. 1 interactor.
IntActiQ9HCP6. 1 interactor.
STRINGi9606.ENSP00000310621.

Structurei

3D structure databases

ProteinModelPortaliQ9HCP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3860. Eukaryota.
COG1696. LUCA.
GeneTreeiENSGT00530000063629.
HOGENOMiHOG000112894.
HOVERGENiHBG052197.
InParanoidiQ9HCP6.
OMAiAEWGPLA.
OrthoDBiEOG091G0AFA.
PhylomeDBiQ9HCP6.
TreeFamiTF315826.

Family and domain databases

InterProiIPR032980. HHAT-like.
IPR004299. MBOAT_fam.
[Graphical view]
PANTHERiPTHR13285:SF19. PTHR13285:SF19. 1 hit.
PfamiPF03062. MBOAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HCP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIKTALPAA ELGLYSLVLS GALAYAGRGL LEASQDGAHR KAFRESVRPG
60 70 80 90 100
WEYIGRKMDV ADFEWVMWFT SFRNVIIFAL SGHVLFAKLC TMVAPKLRSW
110 120 130 140 150
MYAVYGALAV MGTMGPWYLL LLLGHCVGLY VASLLGQPWL CLGLGLASLA
160 170 180 190 200
SFKMDPLISW QSGFVTGTFD LQEVLFHGGS SFTVLRCTSF ALESCAHPDR
210 220 230 240 250
HYSLADLLKY NFYLPFFFFG PIMTFDRFHA QVSQVEPVRR EGELWHIRAQ
260 270 280 290 300
AGLSVVAIMA VDIFFHFFYI LTIPSDLKFA NRLPDSALAG LAYSNLVYDW
310 320 330 340 350
VKAAVLFGVV NTVACLDHLD PPQPPKCITA LYVFAETHFD RGINDWLCKY
360 370 380 390 400
VYNHIGGEHS AVIPELAATV ATFAITTLWL GPCDIVYLWS FLNCFGLNFE
410 420 430 440 450
LWMQKLAEWG PLARIEASLS VQMSRRVRAL FGAMNFWAII MYNLVSLNSL
460 470 480 490 500
KFTELVARRL LLTGFPQTTL SILFVTYCGV QLVKERERTL ALEEEQKQDK

EKPE
Length:504
Mass (Da):56,703
Last modified:March 1, 2001 - v1
Checksum:i91B7D9D7D55D42BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188T → A in AAH22529 (PubMed:15489334).Curated1
Sequence conflicti335A → T in AAH22529 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014947403M → V.Corresponds to variant rs11079dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042554 mRNA. Translation: BAB17758.1.
BC022529 mRNA. Translation: AAH22529.1.
AB032999 mRNA. Translation: BAA86487.1.
CCDSiCCDS2704.1.
RefSeqiNP_065758.3. NM_020707.3.
XP_006713337.1. XM_006713274.2.
XP_016862425.1. XM_017006936.1.
UniGeneiHs.476041.

Genome annotation databases

EnsembliENST00000310417; ENSP00000310621; ENSG00000010282.
ENST00000441594; ENSP00000405423; ENSG00000010282.
GeneIDi57467.
KEGGihsa:57467.
UCSCiuc003clw.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042554 mRNA. Translation: BAB17758.1.
BC022529 mRNA. Translation: AAH22529.1.
AB032999 mRNA. Translation: BAA86487.1.
CCDSiCCDS2704.1.
RefSeqiNP_065758.3. NM_020707.3.
XP_006713337.1. XM_006713274.2.
XP_016862425.1. XM_017006936.1.
UniGeneiHs.476041.

3D structure databases

ProteinModelPortaliQ9HCP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121537. 1 interactor.
IntActiQ9HCP6. 1 interactor.
STRINGi9606.ENSP00000310621.

PTM databases

PhosphoSitePlusiQ9HCP6.

Polymorphism and mutation databases

BioMutaiHHATL.
DMDMi23396970.

Proteomic databases

PaxDbiQ9HCP6.
PeptideAtlasiQ9HCP6.
PRIDEiQ9HCP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310417; ENSP00000310621; ENSG00000010282.
ENST00000441594; ENSP00000405423; ENSG00000010282.
GeneIDi57467.
KEGGihsa:57467.
UCSCiuc003clw.3. human.

Organism-specific databases

CTDi57467.
GeneCardsiHHATL.
HGNCiHGNC:13242. HHATL.
HPAiHPA018174.
MIMi608116. gene.
neXtProtiNX_Q9HCP6.
OpenTargetsiENSG00000010282.
PharmGKBiPA162390892.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3860. Eukaryota.
COG1696. LUCA.
GeneTreeiENSGT00530000063629.
HOGENOMiHOG000112894.
HOVERGENiHBG052197.
InParanoidiQ9HCP6.
OMAiAEWGPLA.
OrthoDBiEOG091G0AFA.
PhylomeDBiQ9HCP6.
TreeFamiTF315826.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000010282-MONOMER.

Miscellaneous databases

GenomeRNAii57467.
PROiQ9HCP6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000010282.
CleanExiHS_HHATL.
ExpressionAtlasiQ9HCP6. baseline and differential.
GenevisibleiQ9HCP6. HS.

Family and domain databases

InterProiIPR032980. HHAT-like.
IPR004299. MBOAT_fam.
[Graphical view]
PANTHERiPTHR13285:SF19. PTHR13285:SF19. 1 hit.
PfamiPF03062. MBOAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHHATL_HUMAN
AccessioniPrimary (citable) accession number: Q9HCP6
Secondary accession number(s): Q8TBG3, Q9ULP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.