Q9HCN8 (SDF2L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Stromal cell-derived factor 2-like protein 1
Short name=SDF2-like protein 1

Alternative name(s):
PWP1-interacting protein 8

Gene names

Name:	SDF2L1
ORF Names:	UNQ1941/PRO4424

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Endoplasmic reticulum lumen Potential.
Tissue specificity	Ubiquitously expressed with high expression in testis, moderate expression in the pancreas, spleen, prostate, small intestine and colon. Very low expression is seen in brain and skeletal muscle. Ref.1
Sequence similarities	Contains 3 MIR domains.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Repeat Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 221	193	Stromal cell-derived factor 2-like protein 1		PRO_0000031957
Regions
	Domain	33 – 87	55	MIR 1
	Domain	95 – 150	56	MIR 2
	Domain	151 – 205	55	MIR 3
	Motif	218 – 221	4	Prevents secretion from ER Potential
Experimental info
	Sequence conflict	94	1	R → C in BAB18277. Ref.1
	Sequence conflict	162	1	F → L in BAB18277. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9HCN8 [UniParc]. Last modified April 13, 2004. Version 2. Checksum: D6F15E1EB48428EE	FASTA	221	23,598
	10 20 30 40 50 60 MWSAGRGGAA WPVLLGLLLA LLVPGGGAAK TGAELVTCGS VLKLLNTHHR VRLHSHDIKY 70 80 90 100 110 120 GSGSGQQSVT GVEASDDANS YWRIRGGSEG GCPRGSPVRC GQAVRLTHVL TGKNLHTHHF 130 140 150 160 170 180 PSPLSNNQEV SAFGEDGEGD DLDLWTVRCS GQHWEREAAV RFQHVGTSVF LSVTGEQYGS 190 200 210 220 PIRGQHEVHG MPSANTHNTW KAMEGIFIKP SVEPSAGHDE L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Murine and human SDF2L1 is an endoplasmic reticulum stress-inducible gene and encodes a new member of the Pmt/rt protein family." Fukuda S., Sumii M., Masuda Y., Takahashi M., Koike N., Teishima J., Yasumoto H., Itamoto T., Asahara T., Dohi K., Kamiya K. Biochem. Biophys. Res. Commun. 280:407-414(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Testis.
[2]	"hPWP1-interacting protein 8." Honore B. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Uterus.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Lung.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB043007 mRNA. Translation: BAB18277.1. AF277316 mRNA. Translation: AAK69113.1. AY359118 mRNA. Translation: AAQ89476.1. CR456570 mRNA. Translation: CAG30456.1. BC006248 mRNA. No translation available. CH471095 Genomic DNA. Translation: EAW59467.1. BC132849 mRNA. Translation: AAI32850.1. BC132851 mRNA. Translation: AAI32852.1.
IPI	IPI00106642.
PIR	JC7587.
RefSeq	NP_071327.2. NM_022044.2.
UniGene	Hs.303116.
3D structure databases
ProteinModelPortal	Q9HCN8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9HCN8. 4 interactions.
STRING	9606.ENSP00000248958.
Polymorphism databases
DMDM	46397883.
Proteomic databases
PaxDb	Q9HCN8.
PRIDE	Q9HCN8.
Protocols and materials databases
DNASU	23753.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000248958; ENSP00000248958; ENSG00000128228.
GeneID	23753.
KEGG	hsa:23753.
UCSC	uc002zvf.3. human.
Organism-specific databases
CTD	23753.
GeneCards	GC22P021996.
HGNC	HGNC:10676. SDF2L1.
HPA	HPA005638.
MIM	607551. gene.
neXtProt	NX_Q9HCN8.
PharmGKB	PA35604.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG136457.
HOGENOM	HOG000236354.
HOVERGEN	HBG024385.
InParanoid	Q9HCN8.
OMA	CGQAIRI.
OrthoDB	EOG4NVZMD.
PhylomeDB	Q9HCN8.
Gene expression databases
Bgee	Q9HCN8.
CleanEx	HS_SDF2L1.
Genevestigator	Q9HCN8.
GermOnline	ENSG00000128228. Homo sapiens.
Family and domain databases
InterPro	IPR027005. GlyclTrfase_39_like. IPR016093. MIR_motif. [Graphical view]
PANTHER	PTHR10050. PTHR10050. 1 hit.
Pfam	PF02815. MIR. 1 hit. [Graphical view]
SMART	SM00472. MIR. 3 hits. [Graphical view]
SUPFAM	SSF82109. MIR. 1 hit.
PROSITE	PS00014. ER_TARGET. 1 hit. PS50919. MIR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SDF2L1. human.
GenomeRNAi	23753.
NextBio	46685.
SOURCE	Search...

Entry information

Entry name

SDF2L_HUMAN

Accession

Primary (citable) accession number: Q9HCN8
Secondary accession number(s): A2RUD3, Q9BRI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
Last sequence update:	April 13, 2004
Last modified:	May 1, 2013
This is version 104 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.