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Protein

Stromal cell-derived factor 2-like protein 1

Gene

SDF2L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128228-MONOMER.
SIGNORiQ9HCN8.

Names & Taxonomyi

Protein namesi
Recommended name:
Stromal cell-derived factor 2-like protein 1
Short name:
SDF2-like protein 1
Alternative name(s):
PWP1-interacting protein 8
Gene namesi
Name:SDF2L1
ORF Names:UNQ1941/PRO4424
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:10676. SDF2L1.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi23753.
OpenTargetsiENSG00000128228.
PharmGKBiPA35604.

Polymorphism and mutation databases

BioMutaiSDF2L1.
DMDMi46397883.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000003195729 – 221Stromal cell-derived factor 2-like protein 1Add BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei215PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HCN8.
MaxQBiQ9HCN8.
PaxDbiQ9HCN8.
PeptideAtlasiQ9HCN8.
PRIDEiQ9HCN8.
TopDownProteomicsiQ9HCN8.

PTM databases

iPTMnetiQ9HCN8.
PhosphoSitePlusiQ9HCN8.
SwissPalmiQ9HCN8.

Expressioni

Tissue specificityi

Ubiquitously expressed with high expression in testis, moderate expression in the pancreas, spleen, prostate, small intestine and colon. Very low expression is seen in brain and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000128228.
CleanExiHS_SDF2L1.
GenevisibleiQ9HCN8. HS.

Organism-specific databases

HPAiHPA005638.

Interactioni

Protein-protein interaction databases

BioGridi117254. 39 interactors.
IntActiQ9HCN8. 14 interactors.
STRINGi9606.ENSP00000248958.

Structurei

3D structure databases

ProteinModelPortaliQ9HCN8.
SMRiQ9HCN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 87MIR 1PROSITE-ProRule annotationAdd BLAST55
Domaini95 – 150MIR 2PROSITE-ProRule annotationAdd BLAST56
Domaini151 – 205MIR 3PROSITE-ProRule annotationAdd BLAST55

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi218 – 221Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Contains 3 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3358. Eukaryota.
ENOG410ZBU3. LUCA.
GeneTreeiENSGT00510000046663.
HOGENOMiHOG000236354.
HOVERGENiHBG024385.
InParanoidiQ9HCN8.
OMAiWTVRCSG.
OrthoDBiEOG091G0MFB.
PhylomeDBiQ9HCN8.
TreeFamiTF314557.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39-like.
IPR016093. MIR_motif.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02815. MIR. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50919. MIR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HCN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWSAGRGGAA WPVLLGLLLA LLVPGGGAAK TGAELVTCGS VLKLLNTHHR
60 70 80 90 100
VRLHSHDIKY GSGSGQQSVT GVEASDDANS YWRIRGGSEG GCPRGSPVRC
110 120 130 140 150
GQAVRLTHVL TGKNLHTHHF PSPLSNNQEV SAFGEDGEGD DLDLWTVRCS
160 170 180 190 200
GQHWEREAAV RFQHVGTSVF LSVTGEQYGS PIRGQHEVHG MPSANTHNTW
210 220
KAMEGIFIKP SVEPSAGHDE L
Length:221
Mass (Da):23,598
Last modified:April 13, 2004 - v2
Checksum:iD6F15E1EB48428EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94R → C in BAB18277 (PubMed:11162531).Curated1
Sequence conflicti162F → L in BAB18277 (PubMed:11162531).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043007 mRNA. Translation: BAB18277.1.
AF277316 mRNA. Translation: AAK69113.1.
AY359118 mRNA. Translation: AAQ89476.1.
CR456570 mRNA. Translation: CAG30456.1.
BC006248 mRNA. No translation available.
CH471095 Genomic DNA. Translation: EAW59467.1.
BC132849 mRNA. Translation: AAI32850.1.
BC132851 mRNA. Translation: AAI32852.1.
CCDSiCCDS13792.1.
PIRiJC7587.
RefSeqiNP_071327.2. NM_022044.2.
UniGeneiHs.303116.

Genome annotation databases

EnsembliENST00000248958; ENSP00000248958; ENSG00000128228.
GeneIDi23753.
KEGGihsa:23753.
UCSCiuc002zvf.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043007 mRNA. Translation: BAB18277.1.
AF277316 mRNA. Translation: AAK69113.1.
AY359118 mRNA. Translation: AAQ89476.1.
CR456570 mRNA. Translation: CAG30456.1.
BC006248 mRNA. No translation available.
CH471095 Genomic DNA. Translation: EAW59467.1.
BC132849 mRNA. Translation: AAI32850.1.
BC132851 mRNA. Translation: AAI32852.1.
CCDSiCCDS13792.1.
PIRiJC7587.
RefSeqiNP_071327.2. NM_022044.2.
UniGeneiHs.303116.

3D structure databases

ProteinModelPortaliQ9HCN8.
SMRiQ9HCN8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117254. 39 interactors.
IntActiQ9HCN8. 14 interactors.
STRINGi9606.ENSP00000248958.

PTM databases

iPTMnetiQ9HCN8.
PhosphoSitePlusiQ9HCN8.
SwissPalmiQ9HCN8.

Polymorphism and mutation databases

BioMutaiSDF2L1.
DMDMi46397883.

Proteomic databases

EPDiQ9HCN8.
MaxQBiQ9HCN8.
PaxDbiQ9HCN8.
PeptideAtlasiQ9HCN8.
PRIDEiQ9HCN8.
TopDownProteomicsiQ9HCN8.

Protocols and materials databases

DNASUi23753.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248958; ENSP00000248958; ENSG00000128228.
GeneIDi23753.
KEGGihsa:23753.
UCSCiuc002zvf.4. human.

Organism-specific databases

CTDi23753.
DisGeNETi23753.
GeneCardsiSDF2L1.
HGNCiHGNC:10676. SDF2L1.
HPAiHPA005638.
MIMi607551. gene.
neXtProtiNX_Q9HCN8.
OpenTargetsiENSG00000128228.
PharmGKBiPA35604.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3358. Eukaryota.
ENOG410ZBU3. LUCA.
GeneTreeiENSGT00510000046663.
HOGENOMiHOG000236354.
HOVERGENiHBG024385.
InParanoidiQ9HCN8.
OMAiWTVRCSG.
OrthoDBiEOG091G0MFB.
PhylomeDBiQ9HCN8.
TreeFamiTF314557.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000128228-MONOMER.
SIGNORiQ9HCN8.

Miscellaneous databases

ChiTaRSiSDF2L1. human.
GenomeRNAii23753.
PROiQ9HCN8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128228.
CleanExiHS_SDF2L1.
GenevisibleiQ9HCN8. HS.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39-like.
IPR016093. MIR_motif.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02815. MIR. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50919. MIR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDF2L_HUMAN
AccessioniPrimary (citable) accession number: Q9HCN8
Secondary accession number(s): A2RUD3, Q9BRI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: April 13, 2004
Last modified: November 30, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.