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Q9HCN8

- SDF2L_HUMAN

UniProt

Q9HCN8 - SDF2L_HUMAN

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Protein
Stromal cell-derived factor 2-like protein 1
Gene
SDF2L1, UNQ1941/PRO4424
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Stromal cell-derived factor 2-like protein 1
Short name:
SDF2-like protein 1
Alternative name(s):
PWP1-interacting protein 8
Gene namesi
Name:SDF2L1
ORF Names:UNQ1941/PRO4424
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:10676. SDF2L1.

Subcellular locationi

Endoplasmic reticulum lumen Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35604.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed prediction
Add
BLAST
Chaini29 – 221193Stromal cell-derived factor 2-like protein 1
PRO_0000031957Add
BLAST

Proteomic databases

MaxQBiQ9HCN8.
PaxDbiQ9HCN8.
PRIDEiQ9HCN8.

Expressioni

Tissue specificityi

Ubiquitously expressed with high expression in testis, moderate expression in the pancreas, spleen, prostate, small intestine and colon. Very low expression is seen in brain and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9HCN8.
CleanExiHS_SDF2L1.
GenevestigatoriQ9HCN8.

Organism-specific databases

HPAiHPA005638.

Interactioni

Protein-protein interaction databases

BioGridi117254. 10 interactions.
IntActiQ9HCN8. 5 interactions.
STRINGi9606.ENSP00000248958.

Structurei

3D structure databases

ProteinModelPortaliQ9HCN8.
SMRiQ9HCN8. Positions 34-206.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 8755MIR 1
Add
BLAST
Domaini95 – 15056MIR 2
Add
BLAST
Domaini151 – 20555MIR 3
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi218 – 2214Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Contains 3 MIR domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG136457.
HOGENOMiHOG000236354.
HOVERGENiHBG024385.
InParanoidiQ9HCN8.
OMAiSGQHWER.
OrthoDBiEOG71VSV4.
PhylomeDBiQ9HCN8.
TreeFamiTF314557.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39_like.
IPR016093. MIR_motif.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02815. MIR. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50919. MIR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HCN8-1 [UniParc]FASTAAdd to Basket

« Hide

MWSAGRGGAA WPVLLGLLLA LLVPGGGAAK TGAELVTCGS VLKLLNTHHR    50
VRLHSHDIKY GSGSGQQSVT GVEASDDANS YWRIRGGSEG GCPRGSPVRC 100
GQAVRLTHVL TGKNLHTHHF PSPLSNNQEV SAFGEDGEGD DLDLWTVRCS 150
GQHWEREAAV RFQHVGTSVF LSVTGEQYGS PIRGQHEVHG MPSANTHNTW 200
KAMEGIFIKP SVEPSAGHDE L 221
Length:221
Mass (Da):23,598
Last modified:April 13, 2004 - v2
Checksum:iD6F15E1EB48428EE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941R → C in BAB18277. 1 Publication
Sequence conflicti162 – 1621F → L in BAB18277. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB043007 mRNA. Translation: BAB18277.1.
AF277316 mRNA. Translation: AAK69113.1.
AY359118 mRNA. Translation: AAQ89476.1.
CR456570 mRNA. Translation: CAG30456.1.
BC006248 mRNA. No translation available.
CH471095 Genomic DNA. Translation: EAW59467.1.
BC132849 mRNA. Translation: AAI32850.1.
BC132851 mRNA. Translation: AAI32852.1.
CCDSiCCDS13792.1.
PIRiJC7587.
RefSeqiNP_071327.2. NM_022044.2.
UniGeneiHs.303116.

Genome annotation databases

EnsembliENST00000248958; ENSP00000248958; ENSG00000128228.
GeneIDi23753.
KEGGihsa:23753.
UCSCiuc002zvf.3. human.

Polymorphism databases

DMDMi46397883.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB043007 mRNA. Translation: BAB18277.1 .
AF277316 mRNA. Translation: AAK69113.1 .
AY359118 mRNA. Translation: AAQ89476.1 .
CR456570 mRNA. Translation: CAG30456.1 .
BC006248 mRNA. No translation available.
CH471095 Genomic DNA. Translation: EAW59467.1 .
BC132849 mRNA. Translation: AAI32850.1 .
BC132851 mRNA. Translation: AAI32852.1 .
CCDSi CCDS13792.1.
PIRi JC7587.
RefSeqi NP_071327.2. NM_022044.2.
UniGenei Hs.303116.

3D structure databases

ProteinModelPortali Q9HCN8.
SMRi Q9HCN8. Positions 34-206.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117254. 10 interactions.
IntActi Q9HCN8. 5 interactions.
STRINGi 9606.ENSP00000248958.

Polymorphism databases

DMDMi 46397883.

Proteomic databases

MaxQBi Q9HCN8.
PaxDbi Q9HCN8.
PRIDEi Q9HCN8.

Protocols and materials databases

DNASUi 23753.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000248958 ; ENSP00000248958 ; ENSG00000128228 .
GeneIDi 23753.
KEGGi hsa:23753.
UCSCi uc002zvf.3. human.

Organism-specific databases

CTDi 23753.
GeneCardsi GC22P021996.
HGNCi HGNC:10676. SDF2L1.
HPAi HPA005638.
MIMi 607551. gene.
neXtProti NX_Q9HCN8.
PharmGKBi PA35604.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG136457.
HOGENOMi HOG000236354.
HOVERGENi HBG024385.
InParanoidi Q9HCN8.
OMAi SGQHWER.
OrthoDBi EOG71VSV4.
PhylomeDBi Q9HCN8.
TreeFami TF314557.

Miscellaneous databases

ChiTaRSi SDF2L1. human.
GenomeRNAii 23753.
NextBioi 46685.
PROi Q9HCN8.
SOURCEi Search...

Gene expression databases

Bgeei Q9HCN8.
CleanExi HS_SDF2L1.
Genevestigatori Q9HCN8.

Family and domain databases

InterProi IPR027005. GlyclTrfase_39_like.
IPR016093. MIR_motif.
[Graphical view ]
PANTHERi PTHR10050. PTHR10050. 1 hit.
Pfami PF02815. MIR. 1 hit.
[Graphical view ]
SMARTi SM00472. MIR. 3 hits.
[Graphical view ]
SUPFAMi SSF82109. SSF82109. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS50919. MIR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine and human SDF2L1 is an endoplasmic reticulum stress-inducible gene and encodes a new member of the Pmt/rt protein family."
    Fukuda S., Sumii M., Masuda Y., Takahashi M., Koike N., Teishima J., Yasumoto H., Itamoto T., Asahara T., Dohi K., Kamiya K.
    Biochem. Biophys. Res. Commun. 280:407-414(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "hPWP1-interacting protein 8."
    Honore B.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Uterus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Lung.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSDF2L_HUMAN
AccessioniPrimary (citable) accession number: Q9HCN8
Secondary accession number(s): A2RUD3, Q9BRI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: April 13, 2004
Last modified: September 3, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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