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Q9HCN8

- SDF2L_HUMAN

UniProt

Q9HCN8 - SDF2L_HUMAN

Protein

Stromal cell-derived factor 2-like protein 1

Gene

SDF2L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (13 Apr 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Stromal cell-derived factor 2-like protein 1
    Short name:
    SDF2-like protein 1
    Alternative name(s):
    PWP1-interacting protein 8
    Gene namesi
    Name:SDF2L1
    ORF Names:UNQ1941/PRO4424
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:10676. SDF2L1.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Endoplasmic reticulum

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35604.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 221193Stromal cell-derived factor 2-like protein 1PRO_0000031957Add
    BLAST

    Proteomic databases

    MaxQBiQ9HCN8.
    PaxDbiQ9HCN8.
    PRIDEiQ9HCN8.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed with high expression in testis, moderate expression in the pancreas, spleen, prostate, small intestine and colon. Very low expression is seen in brain and skeletal muscle.1 Publication

    Gene expression databases

    BgeeiQ9HCN8.
    CleanExiHS_SDF2L1.
    GenevestigatoriQ9HCN8.

    Organism-specific databases

    HPAiHPA005638.

    Interactioni

    Protein-protein interaction databases

    BioGridi117254. 10 interactions.
    IntActiQ9HCN8. 5 interactions.
    STRINGi9606.ENSP00000248958.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HCN8.
    SMRiQ9HCN8. Positions 34-206.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 8755MIR 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini95 – 15056MIR 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini151 – 20555MIR 3PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi218 – 2214Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Contains 3 MIR domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG136457.
    HOGENOMiHOG000236354.
    HOVERGENiHBG024385.
    InParanoidiQ9HCN8.
    OMAiSGQHWER.
    OrthoDBiEOG71VSV4.
    PhylomeDBiQ9HCN8.
    TreeFamiTF314557.

    Family and domain databases

    InterProiIPR027005. GlyclTrfase_39_like.
    IPR016093. MIR_motif.
    [Graphical view]
    PANTHERiPTHR10050. PTHR10050. 1 hit.
    PfamiPF02815. MIR. 1 hit.
    [Graphical view]
    SMARTiSM00472. MIR. 3 hits.
    [Graphical view]
    SUPFAMiSSF82109. SSF82109. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS50919. MIR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9HCN8-1 [UniParc]FASTAAdd to Basket

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    MWSAGRGGAA WPVLLGLLLA LLVPGGGAAK TGAELVTCGS VLKLLNTHHR    50
    VRLHSHDIKY GSGSGQQSVT GVEASDDANS YWRIRGGSEG GCPRGSPVRC 100
    GQAVRLTHVL TGKNLHTHHF PSPLSNNQEV SAFGEDGEGD DLDLWTVRCS 150
    GQHWEREAAV RFQHVGTSVF LSVTGEQYGS PIRGQHEVHG MPSANTHNTW 200
    KAMEGIFIKP SVEPSAGHDE L 221
    Length:221
    Mass (Da):23,598
    Last modified:April 13, 2004 - v2
    Checksum:iD6F15E1EB48428EE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti94 – 941R → C in BAB18277. (PubMed:11162531)Curated
    Sequence conflicti162 – 1621F → L in BAB18277. (PubMed:11162531)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB043007 mRNA. Translation: BAB18277.1.
    AF277316 mRNA. Translation: AAK69113.1.
    AY359118 mRNA. Translation: AAQ89476.1.
    CR456570 mRNA. Translation: CAG30456.1.
    BC006248 mRNA. No translation available.
    CH471095 Genomic DNA. Translation: EAW59467.1.
    BC132849 mRNA. Translation: AAI32850.1.
    BC132851 mRNA. Translation: AAI32852.1.
    CCDSiCCDS13792.1.
    PIRiJC7587.
    RefSeqiNP_071327.2. NM_022044.2.
    UniGeneiHs.303116.

    Genome annotation databases

    EnsembliENST00000248958; ENSP00000248958; ENSG00000128228.
    GeneIDi23753.
    KEGGihsa:23753.
    UCSCiuc002zvf.3. human.

    Polymorphism databases

    DMDMi46397883.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB043007 mRNA. Translation: BAB18277.1 .
    AF277316 mRNA. Translation: AAK69113.1 .
    AY359118 mRNA. Translation: AAQ89476.1 .
    CR456570 mRNA. Translation: CAG30456.1 .
    BC006248 mRNA. No translation available.
    CH471095 Genomic DNA. Translation: EAW59467.1 .
    BC132849 mRNA. Translation: AAI32850.1 .
    BC132851 mRNA. Translation: AAI32852.1 .
    CCDSi CCDS13792.1.
    PIRi JC7587.
    RefSeqi NP_071327.2. NM_022044.2.
    UniGenei Hs.303116.

    3D structure databases

    ProteinModelPortali Q9HCN8.
    SMRi Q9HCN8. Positions 34-206.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117254. 10 interactions.
    IntActi Q9HCN8. 5 interactions.
    STRINGi 9606.ENSP00000248958.

    Polymorphism databases

    DMDMi 46397883.

    Proteomic databases

    MaxQBi Q9HCN8.
    PaxDbi Q9HCN8.
    PRIDEi Q9HCN8.

    Protocols and materials databases

    DNASUi 23753.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000248958 ; ENSP00000248958 ; ENSG00000128228 .
    GeneIDi 23753.
    KEGGi hsa:23753.
    UCSCi uc002zvf.3. human.

    Organism-specific databases

    CTDi 23753.
    GeneCardsi GC22P021996.
    HGNCi HGNC:10676. SDF2L1.
    HPAi HPA005638.
    MIMi 607551. gene.
    neXtProti NX_Q9HCN8.
    PharmGKBi PA35604.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG136457.
    HOGENOMi HOG000236354.
    HOVERGENi HBG024385.
    InParanoidi Q9HCN8.
    OMAi SGQHWER.
    OrthoDBi EOG71VSV4.
    PhylomeDBi Q9HCN8.
    TreeFami TF314557.

    Miscellaneous databases

    ChiTaRSi SDF2L1. human.
    GenomeRNAii 23753.
    NextBioi 46685.
    PROi Q9HCN8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9HCN8.
    CleanExi HS_SDF2L1.
    Genevestigatori Q9HCN8.

    Family and domain databases

    InterProi IPR027005. GlyclTrfase_39_like.
    IPR016093. MIR_motif.
    [Graphical view ]
    PANTHERi PTHR10050. PTHR10050. 1 hit.
    Pfami PF02815. MIR. 1 hit.
    [Graphical view ]
    SMARTi SM00472. MIR. 3 hits.
    [Graphical view ]
    SUPFAMi SSF82109. SSF82109. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS50919. MIR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine and human SDF2L1 is an endoplasmic reticulum stress-inducible gene and encodes a new member of the Pmt/rt protein family."
      Fukuda S., Sumii M., Masuda Y., Takahashi M., Koike N., Teishima J., Yasumoto H., Itamoto T., Asahara T., Dohi K., Kamiya K.
      Biochem. Biophys. Res. Commun. 280:407-414(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Testis.
    2. "hPWP1-interacting protein 8."
      Honore B.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Uterus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Lung.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSDF2L_HUMAN
    AccessioniPrimary (citable) accession number: Q9HCN8
    Secondary accession number(s): A2RUD3, Q9BRI5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2002
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3