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Protein

Stromal cell-derived factor 2-like protein 1

Gene

SDF2L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. ER-associated misfolded protein catabolic process Source: Ensembl
  2. regulation of apoptotic process Source: Ensembl
  3. response to endoplasmic reticulum stress Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Stromal cell-derived factor 2-like protein 1
Short name:
SDF2-like protein 1
Alternative name(s):
PWP1-interacting protein 8
Gene namesi
Name:SDF2L1
ORF Names:UNQ1941/PRO4424
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:10676. SDF2L1.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35604.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 221193Stromal cell-derived factor 2-like protein 1PRO_0000031957Add
BLAST

Proteomic databases

MaxQBiQ9HCN8.
PaxDbiQ9HCN8.
PRIDEiQ9HCN8.

Expressioni

Tissue specificityi

Ubiquitously expressed with high expression in testis, moderate expression in the pancreas, spleen, prostate, small intestine and colon. Very low expression is seen in brain and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9HCN8.
CleanExiHS_SDF2L1.
GenevestigatoriQ9HCN8.

Organism-specific databases

HPAiHPA005638.

Interactioni

Protein-protein interaction databases

BioGridi117254. 16 interactions.
IntActiQ9HCN8. 5 interactions.
STRINGi9606.ENSP00000248958.

Structurei

3D structure databases

ProteinModelPortaliQ9HCN8.
SMRiQ9HCN8. Positions 34-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 8755MIR 1PROSITE-ProRule annotationAdd
BLAST
Domaini95 – 15056MIR 2PROSITE-ProRule annotationAdd
BLAST
Domaini151 – 20555MIR 3PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi218 – 2214Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Contains 3 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG136457.
GeneTreeiENSGT00510000046663.
HOGENOMiHOG000236354.
HOVERGENiHBG024385.
InParanoidiQ9HCN8.
OMAiSGQHWER.
OrthoDBiEOG71VSV4.
PhylomeDBiQ9HCN8.
TreeFamiTF314557.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39_like.
IPR016093. MIR_motif.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02815. MIR. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50919. MIR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HCN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWSAGRGGAA WPVLLGLLLA LLVPGGGAAK TGAELVTCGS VLKLLNTHHR
60 70 80 90 100
VRLHSHDIKY GSGSGQQSVT GVEASDDANS YWRIRGGSEG GCPRGSPVRC
110 120 130 140 150
GQAVRLTHVL TGKNLHTHHF PSPLSNNQEV SAFGEDGEGD DLDLWTVRCS
160 170 180 190 200
GQHWEREAAV RFQHVGTSVF LSVTGEQYGS PIRGQHEVHG MPSANTHNTW
210 220
KAMEGIFIKP SVEPSAGHDE L
Length:221
Mass (Da):23,598
Last modified:April 13, 2004 - v2
Checksum:iD6F15E1EB48428EE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941R → C in BAB18277 (PubMed:11162531).Curated
Sequence conflicti162 – 1621F → L in BAB18277 (PubMed:11162531).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043007 mRNA. Translation: BAB18277.1.
AF277316 mRNA. Translation: AAK69113.1.
AY359118 mRNA. Translation: AAQ89476.1.
CR456570 mRNA. Translation: CAG30456.1.
BC006248 mRNA. No translation available.
CH471095 Genomic DNA. Translation: EAW59467.1.
BC132849 mRNA. Translation: AAI32850.1.
BC132851 mRNA. Translation: AAI32852.1.
CCDSiCCDS13792.1.
PIRiJC7587.
RefSeqiNP_071327.2. NM_022044.2.
UniGeneiHs.303116.

Genome annotation databases

EnsembliENST00000248958; ENSP00000248958; ENSG00000128228.
GeneIDi23753.
KEGGihsa:23753.
UCSCiuc002zvf.3. human.

Polymorphism databases

DMDMi46397883.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043007 mRNA. Translation: BAB18277.1.
AF277316 mRNA. Translation: AAK69113.1.
AY359118 mRNA. Translation: AAQ89476.1.
CR456570 mRNA. Translation: CAG30456.1.
BC006248 mRNA. No translation available.
CH471095 Genomic DNA. Translation: EAW59467.1.
BC132849 mRNA. Translation: AAI32850.1.
BC132851 mRNA. Translation: AAI32852.1.
CCDSiCCDS13792.1.
PIRiJC7587.
RefSeqiNP_071327.2. NM_022044.2.
UniGeneiHs.303116.

3D structure databases

ProteinModelPortaliQ9HCN8.
SMRiQ9HCN8. Positions 34-206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117254. 16 interactions.
IntActiQ9HCN8. 5 interactions.
STRINGi9606.ENSP00000248958.

Polymorphism databases

DMDMi46397883.

Proteomic databases

MaxQBiQ9HCN8.
PaxDbiQ9HCN8.
PRIDEiQ9HCN8.

Protocols and materials databases

DNASUi23753.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248958; ENSP00000248958; ENSG00000128228.
GeneIDi23753.
KEGGihsa:23753.
UCSCiuc002zvf.3. human.

Organism-specific databases

CTDi23753.
GeneCardsiGC22P021996.
HGNCiHGNC:10676. SDF2L1.
HPAiHPA005638.
MIMi607551. gene.
neXtProtiNX_Q9HCN8.
PharmGKBiPA35604.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG136457.
GeneTreeiENSGT00510000046663.
HOGENOMiHOG000236354.
HOVERGENiHBG024385.
InParanoidiQ9HCN8.
OMAiSGQHWER.
OrthoDBiEOG71VSV4.
PhylomeDBiQ9HCN8.
TreeFamiTF314557.

Miscellaneous databases

ChiTaRSiSDF2L1. human.
GenomeRNAii23753.
NextBioi46685.
PROiQ9HCN8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HCN8.
CleanExiHS_SDF2L1.
GenevestigatoriQ9HCN8.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39_like.
IPR016093. MIR_motif.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02815. MIR. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50919. MIR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Murine and human SDF2L1 is an endoplasmic reticulum stress-inducible gene and encodes a new member of the Pmt/rt protein family."
    Fukuda S., Sumii M., Masuda Y., Takahashi M., Koike N., Teishima J., Yasumoto H., Itamoto T., Asahara T., Dohi K., Kamiya K.
    Biochem. Biophys. Res. Commun. 280:407-414(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "hPWP1-interacting protein 8."
    Honore B.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Uterus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Lung.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSDF2L_HUMAN
AccessioniPrimary (citable) accession number: Q9HCN8
Secondary accession number(s): A2RUD3, Q9BRI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: April 13, 2004
Last modified: January 7, 2015
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.