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Q9HCN8 (SDF2L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Stromal cell-derived factor 2-like protein 1

Short name=SDF2-like protein 1
Alternative name(s):
PWP1-interacting protein 8
Gene names
Name:SDF2L1
ORF Names:UNQ1941/PRO4424
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Endoplasmic reticulum lumen Potential.

Tissue specificity

Ubiquitously expressed with high expression in testis, moderate expression in the pancreas, spleen, prostate, small intestine and colon. Very low expression is seen in brain and skeletal muscle. Ref.1

Sequence similarities

Contains 3 MIR domains.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainRepeat
Signal
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 221193Stromal cell-derived factor 2-like protein 1
PRO_0000031957

Regions

Domain33 – 8755MIR 1
Domain95 – 15056MIR 2
Domain151 – 20555MIR 3
Motif218 – 2214Prevents secretion from ER Potential

Experimental info

Sequence conflict941R → C in BAB18277. Ref.1
Sequence conflict1621F → L in BAB18277. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9HCN8 [UniParc].

Last modified April 13, 2004. Version 2.
Checksum: D6F15E1EB48428EE

FASTA22123,598
        10         20         30         40         50         60 
MWSAGRGGAA WPVLLGLLLA LLVPGGGAAK TGAELVTCGS VLKLLNTHHR VRLHSHDIKY 

        70         80         90        100        110        120 
GSGSGQQSVT GVEASDDANS YWRIRGGSEG GCPRGSPVRC GQAVRLTHVL TGKNLHTHHF 

       130        140        150        160        170        180 
PSPLSNNQEV SAFGEDGEGD DLDLWTVRCS GQHWEREAAV RFQHVGTSVF LSVTGEQYGS 

       190        200        210        220 
PIRGQHEVHG MPSANTHNTW KAMEGIFIKP SVEPSAGHDE L 

« Hide

References

« Hide 'large scale' references
[1]"Murine and human SDF2L1 is an endoplasmic reticulum stress-inducible gene and encodes a new member of the Pmt/rt protein family."
Fukuda S., Sumii M., Masuda Y., Takahashi M., Koike N., Teishima J., Yasumoto H., Itamoto T., Asahara T., Dohi K., Kamiya K.
Biochem. Biophys. Res. Commun. 280:407-414(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Testis.
[2]"hPWP1-interacting protein 8."
Honore B.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Uterus.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Lung.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB043007 mRNA. Translation: BAB18277.1.
AF277316 mRNA. Translation: AAK69113.1.
AY359118 mRNA. Translation: AAQ89476.1.
CR456570 mRNA. Translation: CAG30456.1.
BC006248 mRNA. No translation available.
CH471095 Genomic DNA. Translation: EAW59467.1.
BC132849 mRNA. Translation: AAI32850.1.
BC132851 mRNA. Translation: AAI32852.1.
CCDSCCDS13792.1.
PIRJC7587.
RefSeqNP_071327.2. NM_022044.2.
UniGeneHs.303116.

3D structure databases

ProteinModelPortalQ9HCN8.
SMRQ9HCN8. Positions 34-206.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117254. 9 interactions.
IntActQ9HCN8. 5 interactions.
STRING9606.ENSP00000248958.

Polymorphism databases

DMDM46397883.

Proteomic databases

MaxQBQ9HCN8.
PaxDbQ9HCN8.
PRIDEQ9HCN8.

Protocols and materials databases

DNASU23753.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000248958; ENSP00000248958; ENSG00000128228.
GeneID23753.
KEGGhsa:23753.
UCSCuc002zvf.3. human.

Organism-specific databases

CTD23753.
GeneCardsGC22P021996.
HGNCHGNC:10676. SDF2L1.
HPAHPA005638.
MIM607551. gene.
neXtProtNX_Q9HCN8.
PharmGKBPA35604.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG136457.
HOGENOMHOG000236354.
HOVERGENHBG024385.
InParanoidQ9HCN8.
OMASGQHWER.
OrthoDBEOG71VSV4.
PhylomeDBQ9HCN8.
TreeFamTF314557.

Gene expression databases

BgeeQ9HCN8.
CleanExHS_SDF2L1.
GenevestigatorQ9HCN8.

Family and domain databases

InterProIPR027005. GlyclTrfase_39_like.
IPR016093. MIR_motif.
[Graphical view]
PANTHERPTHR10050. PTHR10050. 1 hit.
PfamPF02815. MIR. 1 hit.
[Graphical view]
SMARTSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMSSF82109. SSF82109. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS50919. MIR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSDF2L1. human.
GenomeRNAi23753.
NextBio46685.
PROQ9HCN8.
SOURCESearch...

Entry information

Entry nameSDF2L_HUMAN
AccessionPrimary (citable) accession number: Q9HCN8
Secondary accession number(s): A2RUD3, Q9BRI5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: April 13, 2004
Last modified: July 9, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM