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Protein

Platelet glycoprotein VI

Gene

GP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.1 Publication

GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • receptor activity Source: UniProtKB
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • blood coagulation Source: Reactome
  • enzyme linked receptor protein signaling pathway Source: ProtInc
  • leukocyte migration Source: Reactome
  • platelet activation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Blood coagulation, Hemostasis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000088053-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-75892. Platelet Adhesion to exposed collagen.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein VI
Short name:
GPVI
Alternative name(s):
Glycoprotein 6
Gene namesi
Name:GP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:14388. GP6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 267ExtracellularSequence analysisAdd BLAST247
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Topological domaini289 – 339CytoplasmicSequence analysisAdd BLAST51

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
  • tetraspanin-enriched microdomain Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Bleeding disorder, platelet-type 11 (BDPLT11)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen.
See also OMIM:614201
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06659058R → C in BDPLT11; results in abnormal protein migration and a loss of collagen binding. 1 PublicationCorresponds to variant rs199588110dbSNPEnsembl.1
Natural variantiVAR_066591175S → N in BDPLT11; shows strongly reduced membrane expression and decreased interaction with the snake toxin convulxin. 1 PublicationCorresponds to variant rs387906919dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi61K → A: Increases collagen binding. 1 Publication1
Mutagenesisi79K → E: Dramatically reduces collagen binding. 1 Publication1
Mutagenesisi80R → A: Reduces collagen binding. 1 Publication1
Mutagenesisi92N → A: Reduces collagen binding (65 to 70%). 1 Publication1
Mutagenesisi94S → A: Reduces collagen binding (65 to 70%). 1 Publication1
Mutagenesisi95L → H: No effect on collagen binding. 1 Publication1
Mutagenesisi186R → A: Reduces collagen binding. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi51206.
MalaCardsiGP6.
MIMi614201. phenotype.
OpenTargetsiENSG00000088053.
ENSG00000274050.
ENSG00000274566.
ENSG00000275633.
ENSG00000275931.
ENSG00000276065.
ENSG00000276211.
ENSG00000277439.
ENSG00000278316.
ENSG00000278670.
Orphaneti98885. Bleeding diathesis due to glycoprotein VI deficiency.
PharmGKBiPA28824.

Polymorphism and mutation databases

BioMutaiGP6.
DMDMi327478600.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000023238321 – 339Platelet glycoprotein VIAdd BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 881 Publication
Glycosylationi92N-linked (GlcNAc...)1 Publication1
Disulfide bondi134 ↔ 1801 Publication

Post-translational modificationi

N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9HCN6.
PeptideAtlasiQ9HCN6.
PRIDEiQ9HCN6.

PTM databases

iPTMnetiQ9HCN6.

Expressioni

Tissue specificityi

Megakaryocytes and platelets.1 Publication

Gene expression databases

BgeeiENSG00000088053.
CleanExiHS_GP6.
ExpressionAtlasiQ9HCN6. baseline and differential.
GenevisibleiQ9HCN6. HS.

Organism-specific databases

HPAiHPA066482.

Interactioni

Subunit structurei

Associated with Fc receptor gamma chain. The GPVI-FcRgamma complex is associated with the Src kinase family Fyn and Lyn.

Binary interactionsi

WithEntry#Exp.IntActNotes
LYNP079482EBI-515278,EBI-79452

GO - Molecular functioni

  • collagen binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119379. 8 interactors.
DIPiDIP-33875N.
IntActiQ9HCN6. 4 interactors.
MINTiMINT-258007.

Structurei

Secondary structure

1339
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 34Combined sources6
Beta strandi36 – 39Combined sources4
Beta strandi44 – 49Combined sources6
Beta strandi55 – 61Combined sources7
Turni62 – 64Combined sources3
Beta strandi67 – 77Combined sources11
Helixi80 – 82Combined sources3
Beta strandi84 – 92Combined sources9
Beta strandi95 – 97Combined sources3
Beta strandi103 – 111Combined sources9
Beta strandi115 – 119Combined sources5
Beta strandi130 – 135Combined sources6
Beta strandi142 – 147Combined sources6
Beta strandi159 – 170Combined sources12
Beta strandi175 – 183Combined sources9
Beta strandi198 – 202Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GI7X-ray2.40A/B21-203[»]
ProteinModelPortaliQ9HCN6.
SMRiQ9HCN6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HCN6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 104Ig-like C2-type 1Add BLAST79
Domaini114 – 196Ig-like C2-type 2Add BLAST83

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHKK. Eukaryota.
ENOG411142H. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiQ9HCN6.
KOiK06264.
OMAiASSWCSI.
OrthoDBiEOG091G0HU0.
PhylomeDBiQ9HCN6.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HCN6-1) [UniParc]FASTAAdd to basket
Also known as: VI-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPSPTALFC LGLCLGRVPA QSGPLPKPSL QALPSSLVPL EKPVTLRCQG
60 70 80 90 100
PPGVDLYRLE KLSSSRYQDQ AVLFIPAMKR SLAGRYRCSY QNGSLWSLPS
110 120 130 140 150
DQLELVATGV FAKPSLSAQP GPAVSSGGDV TLQCQTRYGF DQFALYKEGD
160 170 180 190 200
PAPYKNPERW YRASFPIITV TAAHSGTYRC YSFSSRDPYL WSAPSDPLEL
210 220 230 240 250
VVTGTSVTPS RLPTEPPSPV AEFSEATAEL TVSFTNEVFT TETSRSITAS
260 270 280 290 300
PKESDSPAGP ARQYYTKGNL VRICLGAVIL IILAGFLAED WHSRRKRLRH
310 320 330
RGRAVQRPLP PLPPLPLTRK SNGGQDGGRQ DVHSRGLCS
Length:339
Mass (Da):36,866
Last modified:April 5, 2011 - v4
Checksum:i3EFE2DD0E1676BA8
GO
Isoform 2 (identifier: Q9HCN6-2) [UniParc]FASTAAdd to basket
Also known as: VI-2

The sequence of this isoform differs from the canonical sequence as follows:
     204-221: Missing.

Show »
Length:321
Mass (Da):35,091
Checksum:iEEE281373112DB21
GO
Isoform 3 (identifier: Q9HCN6-3) [UniParc]FASTAAdd to basket
Also known as: VI-3

The sequence of this isoform differs from the canonical sequence as follows:
     260-339: PARQYYTKGN...QDVHSRGLCS → ESCPPVLHQG...TGMNMSITLI

Note: Has no transmembrane domain. Does not interact with Fc receptor gamma chain. Does not bind to collagen-like peptides.Curated
Show »
Length:620
Mass (Da):67,476
Checksum:iF6DBAE2547664D7A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 3 (identifier: Q9HCN6-3)
Sequence conflicti314P → A in BAB12247 (PubMed:11027634).Curated1
Sequence conflicti323K → T in BAB12247 (PubMed:11027634).Curated1
Sequence conflicti573R → G in BAB12247 (PubMed:11027634).Curated1
Sequence conflicti606F → L in BAB12247 (PubMed:11027634).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06659058R → C in BDPLT11; results in abnormal protein migration and a loss of collagen binding. 1 PublicationCorresponds to variant rs199588110dbSNPEnsembl.1
Natural variantiVAR_066591175S → N in BDPLT11; shows strongly reduced membrane expression and decreased interaction with the snake toxin convulxin. 1 PublicationCorresponds to variant rs387906919dbSNPEnsembl.1
Natural variantiVAR_060352219P → S.3 PublicationsCorresponds to variant rs1613662dbSNPEnsembl.1
Natural variantiVAR_060353237E → K.3 PublicationsCorresponds to variant rs1654416dbSNPEnsembl.1
Natural variantiVAR_060354249A → T.3 PublicationsCorresponds to variant rs2304167dbSNPEnsembl.1
Natural variantiVAR_059389317L → Q.3 PublicationsCorresponds to variant rs1654413dbSNPEnsembl.1
Natural variantiVAR_059390322N → H.3 PublicationsCorresponds to variant rs1671152dbSNPEnsembl.1
Natural variantiVAR_060355335R → G.Corresponds to variant rs1654412dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017879204 – 221Missing in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_017880260 – 339PARQY…RGLCS → ESCPPVLHQGQPGPDMPRGC DPNNPGGVSGRGLAQPEEAP AAQGQGCAEAASAPPAPPAD PEIKRGSGWRPTGCSQPRVM FMTAEPQARSYPREGSWHGR RLKDWRVWSVEAGGQRLQLW KRGHAASSWCSIREPFGQCL SVCLPLCLRAPSIWDGRNLW RPHPPPCTLWMTWYPGWTTY WPLSSTSLIWAPDGSLRFPA LRVDSVPSSVQNPPVLPFGP LCSCLVFPRNSHPHSISHCG LTNLLSSLRTGLAGSLGMSF IFLSVKLARCPLPFTLENKI SLCNMVKPHLYQQNKKTQKL ARCGGASLYSQQLRGLRWEN GLSLGGRGCSELRSHHCTLA RVTKPDFVSKNTGMNMSITL I in isoform 3. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043819 mRNA. Translation: BAB12245.1.
AB043820 mRNA. Translation: BAB12246.1.
AB043821 mRNA. Translation: BAB12247.1.
AB035073 mRNA. Translation: BAA89353.1.
AC011476 Genomic DNA. No translation available.
BC104832 mRNA. Translation: AAI04833.1.
BC111963 mRNA. Translation: AAI11964.1.
CCDSiCCDS42626.1. [Q9HCN6-3]
CCDS46184.1. [Q9HCN6-1]
CCDS58678.1. [Q9HCN6-2]
PIRiJC7509.
RefSeqiNP_001077368.2. NM_001083899.2. [Q9HCN6-3]
NP_001242946.2. NM_001256017.2. [Q9HCN6-2]
NP_057447.5. NM_016363.5. [Q9HCN6-1]
UniGeneiHs.661752.

Genome annotation databases

EnsembliENST00000310373; ENSP00000308782; ENSG00000088053. [Q9HCN6-3]
ENST00000333884; ENSP00000334552; ENSG00000088053. [Q9HCN6-2]
ENST00000417454; ENSP00000394922; ENSG00000088053. [Q9HCN6-1]
ENST00000610596; ENSP00000480178; ENSG00000275633. [Q9HCN6-2]
ENST00000610746; ENSP00000479975; ENSG00000276211. [Q9HCN6-3]
ENST00000611436; ENSP00000482601; ENSG00000275931. [Q9HCN6-3]
ENST00000612096; ENSP00000481583; ENSG00000276065. [Q9HCN6-2]
ENST00000612184; ENSP00000479873; ENSG00000277439. [Q9HCN6-2]
ENST00000612862; ENSP00000483612; ENSG00000274050. [Q9HCN6-2]
ENST00000613649; ENSP00000479668; ENSG00000274566. [Q9HCN6-3]
ENST00000613801; ENSP00000478918; ENSG00000278670. [Q9HCN6-2]
ENST00000614662; ENSP00000478025; ENSG00000276065. [Q9HCN6-3]
ENST00000614889; ENSP00000478674; ENSG00000274566. [Q9HCN6-2]
ENST00000615407; ENSP00000481524; ENSG00000278670. [Q9HCN6-3]
ENST00000616319; ENSP00000481125; ENSG00000278316. [Q9HCN6-2]
ENST00000616456; ENSP00000483314; ENSG00000277439. [Q9HCN6-1]
ENST00000617954; ENSP00000480243; ENSG00000275633. [Q9HCN6-3]
ENST00000619136; ENSP00000479034; ENSG00000278316. [Q9HCN6-3]
ENST00000621278; ENSP00000479513; ENSG00000276211. [Q9HCN6-2]
ENST00000622279; ENSP00000484029; ENSG00000277439. [Q9HCN6-3]
ENST00000622589; ENSP00000481075; ENSG00000274050. [Q9HCN6-3]
ENST00000622653; ENSP00000478709; ENSG00000275931. [Q9HCN6-2]
GeneIDi51206.
KEGGihsa:51206.
UCSCiuc002qik.4. human. [Q9HCN6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043819 mRNA. Translation: BAB12245.1.
AB043820 mRNA. Translation: BAB12246.1.
AB043821 mRNA. Translation: BAB12247.1.
AB035073 mRNA. Translation: BAA89353.1.
AC011476 Genomic DNA. No translation available.
BC104832 mRNA. Translation: AAI04833.1.
BC111963 mRNA. Translation: AAI11964.1.
CCDSiCCDS42626.1. [Q9HCN6-3]
CCDS46184.1. [Q9HCN6-1]
CCDS58678.1. [Q9HCN6-2]
PIRiJC7509.
RefSeqiNP_001077368.2. NM_001083899.2. [Q9HCN6-3]
NP_001242946.2. NM_001256017.2. [Q9HCN6-2]
NP_057447.5. NM_016363.5. [Q9HCN6-1]
UniGeneiHs.661752.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GI7X-ray2.40A/B21-203[»]
ProteinModelPortaliQ9HCN6.
SMRiQ9HCN6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119379. 8 interactors.
DIPiDIP-33875N.
IntActiQ9HCN6. 4 interactors.
MINTiMINT-258007.

PTM databases

iPTMnetiQ9HCN6.

Polymorphism and mutation databases

BioMutaiGP6.
DMDMi327478600.

Proteomic databases

PaxDbiQ9HCN6.
PeptideAtlasiQ9HCN6.
PRIDEiQ9HCN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310373; ENSP00000308782; ENSG00000088053. [Q9HCN6-3]
ENST00000333884; ENSP00000334552; ENSG00000088053. [Q9HCN6-2]
ENST00000417454; ENSP00000394922; ENSG00000088053. [Q9HCN6-1]
ENST00000610596; ENSP00000480178; ENSG00000275633. [Q9HCN6-2]
ENST00000610746; ENSP00000479975; ENSG00000276211. [Q9HCN6-3]
ENST00000611436; ENSP00000482601; ENSG00000275931. [Q9HCN6-3]
ENST00000612096; ENSP00000481583; ENSG00000276065. [Q9HCN6-2]
ENST00000612184; ENSP00000479873; ENSG00000277439. [Q9HCN6-2]
ENST00000612862; ENSP00000483612; ENSG00000274050. [Q9HCN6-2]
ENST00000613649; ENSP00000479668; ENSG00000274566. [Q9HCN6-3]
ENST00000613801; ENSP00000478918; ENSG00000278670. [Q9HCN6-2]
ENST00000614662; ENSP00000478025; ENSG00000276065. [Q9HCN6-3]
ENST00000614889; ENSP00000478674; ENSG00000274566. [Q9HCN6-2]
ENST00000615407; ENSP00000481524; ENSG00000278670. [Q9HCN6-3]
ENST00000616319; ENSP00000481125; ENSG00000278316. [Q9HCN6-2]
ENST00000616456; ENSP00000483314; ENSG00000277439. [Q9HCN6-1]
ENST00000617954; ENSP00000480243; ENSG00000275633. [Q9HCN6-3]
ENST00000619136; ENSP00000479034; ENSG00000278316. [Q9HCN6-3]
ENST00000621278; ENSP00000479513; ENSG00000276211. [Q9HCN6-2]
ENST00000622279; ENSP00000484029; ENSG00000277439. [Q9HCN6-3]
ENST00000622589; ENSP00000481075; ENSG00000274050. [Q9HCN6-3]
ENST00000622653; ENSP00000478709; ENSG00000275931. [Q9HCN6-2]
GeneIDi51206.
KEGGihsa:51206.
UCSCiuc002qik.4. human. [Q9HCN6-1]

Organism-specific databases

CTDi51206.
DisGeNETi51206.
GeneCardsiGP6.
HGNCiHGNC:14388. GP6.
HPAiHPA066482.
MalaCardsiGP6.
MIMi605546. gene.
614201. phenotype.
neXtProtiNX_Q9HCN6.
OpenTargetsiENSG00000088053.
ENSG00000274050.
ENSG00000274566.
ENSG00000275633.
ENSG00000275931.
ENSG00000276065.
ENSG00000276211.
ENSG00000277439.
ENSG00000278316.
ENSG00000278670.
Orphaneti98885. Bleeding diathesis due to glycoprotein VI deficiency.
PharmGKBiPA28824.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHKK. Eukaryota.
ENOG411142H. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiQ9HCN6.
KOiK06264.
OMAiASSWCSI.
OrthoDBiEOG091G0HU0.
PhylomeDBiQ9HCN6.
TreeFamiTF336644.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000088053-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-75892. Platelet Adhesion to exposed collagen.

Miscellaneous databases

EvolutionaryTraceiQ9HCN6.
GeneWikiiGPVI.
GenomeRNAii51206.
PROiQ9HCN6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000088053.
CleanExiHS_GP6.
ExpressionAtlasiQ9HCN6. baseline and differential.
GenevisibleiQ9HCN6. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiGPVI_HUMAN
AccessioniPrimary (citable) accession number: Q9HCN6
Secondary accession number(s): Q9HCN7, Q9UIF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 5, 2011
Last modified: November 2, 2016
This is version 135 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.