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Q9HCN6

- GPVI_HUMAN

UniProt

Q9HCN6 - GPVI_HUMAN

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Protein

Platelet glycoprotein VI

Gene

GP6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.1 Publication

GO - Molecular functioni

  1. collagen binding Source: UniProtKB
  2. receptor activity Source: UniProtKB
  3. transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. enzyme linked receptor protein signaling pathway Source: ProtInc
  3. leukocyte migration Source: Reactome
  4. platelet activation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Blood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiREACT_12051. Cell surface interactions at the vascular wall.
REACT_1230. Platelet Adhesion to exposed collagen.
REACT_1695. GPVI-mediated activation cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein VI
Short name:
GPVI
Alternative name(s):
Glycoprotein 6
Gene namesi
Name:GP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:14388. GP6.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProtKB
  3. integral component of plasma membrane Source: ProtInc
  4. plasma membrane Source: Reactome
  5. tetraspanin-enriched microdomain Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Bleeding disorder, platelet-type 11 (BDPLT11) [MIM:614201]: A mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti58 – 581R → C in BDPLT11; results in abnormal protein migration and a loss of collagen binding. 1 Publication
VAR_066590
Natural varianti175 – 1751S → N in BDPLT11; shows strongly reduced membrane expression and decreased interaction with the snake toxin convulxin. 1 Publication
VAR_066591

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi61 – 611K → A: Increases collagen binding. 1 Publication
Mutagenesisi79 – 791K → E: Dramatically reduces collagen binding. 1 Publication
Mutagenesisi80 – 801R → A: Reduces collagen binding. 1 Publication
Mutagenesisi92 – 921N → A: Reduces collagen binding (65 to 70%). 1 Publication
Mutagenesisi94 – 941S → A: Reduces collagen binding (65 to 70%). 1 Publication
Mutagenesisi95 – 951L → H: No effect on collagen binding. 1 Publication
Mutagenesisi186 – 1861R → A: Reduces collagen binding. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi614201. phenotype.
Orphaneti98885. Bleeding diathesis due to glycoprotein VI deficiency.
PharmGKBiPA28824.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 339319Platelet glycoprotein VIPRO_0000232383Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi48 ↔ 881 Publication
Glycosylationi92 – 921N-linked (GlcNAc...)1 Publication
Disulfide bondi134 ↔ 1801 Publication

Post-translational modificationi

N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9HCN6.
PRIDEiQ9HCN6.

PTM databases

PhosphoSiteiQ9HCN6.

Expressioni

Tissue specificityi

Megakaryocytes and platelets.1 Publication

Gene expression databases

BgeeiQ9HCN6.
CleanExiHS_GP6.
ExpressionAtlasiQ9HCN6. baseline.
GenevestigatoriQ9HCN6.

Interactioni

Subunit structurei

Associated with Fc receptor gamma chain. The GPVI-FcRgamma complex is associated with the Src kinase family Fyn and Lyn.

Binary interactionsi

WithEntry#Exp.IntActNotes
LYNP079482EBI-515278,EBI-79452

Protein-protein interaction databases

BioGridi119379. 8 interactions.
DIPiDIP-33875N.
IntActiQ9HCN6. 4 interactions.
MINTiMINT-258007.
STRINGi9606.ENSP00000308782.

Structurei

Secondary structure

1
339
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 346
Beta strandi36 – 394
Beta strandi44 – 496
Beta strandi55 – 617
Turni62 – 643
Beta strandi67 – 7711
Helixi80 – 823
Beta strandi84 – 929
Beta strandi95 – 973
Beta strandi103 – 1119
Beta strandi115 – 1195
Beta strandi130 – 1356
Beta strandi142 – 1476
Beta strandi159 – 17012
Beta strandi175 – 1839
Beta strandi198 – 2025

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GI7X-ray2.40A/B21-203[»]
ProteinModelPortaliQ9HCN6.
SMRiQ9HCN6. Positions 22-261.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HCN6.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 267247ExtracellularSequence AnalysisAdd
BLAST
Topological domaini289 – 33951CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei268 – 28821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 10479Ig-like C2-type 1Add
BLAST
Domaini114 – 19683Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG79029.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiQ9HCN6.
KOiK06264.
OMAiASSWCSI.
PhylomeDBiQ9HCN6.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9HCN6-1) [UniParc]FASTAAdd to Basket

Also known as: VI-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPSPTALFC LGLCLGRVPA QSGPLPKPSL QALPSSLVPL EKPVTLRCQG
60 70 80 90 100
PPGVDLYRLE KLSSSRYQDQ AVLFIPAMKR SLAGRYRCSY QNGSLWSLPS
110 120 130 140 150
DQLELVATGV FAKPSLSAQP GPAVSSGGDV TLQCQTRYGF DQFALYKEGD
160 170 180 190 200
PAPYKNPERW YRASFPIITV TAAHSGTYRC YSFSSRDPYL WSAPSDPLEL
210 220 230 240 250
VVTGTSVTPS RLPTEPPSPV AEFSEATAEL TVSFTNEVFT TETSRSITAS
260 270 280 290 300
PKESDSPAGP ARQYYTKGNL VRICLGAVIL IILAGFLAED WHSRRKRLRH
310 320 330
RGRAVQRPLP PLPPLPLTRK SNGGQDGGRQ DVHSRGLCS
Length:339
Mass (Da):36,866
Last modified:April 5, 2011 - v4
Checksum:i3EFE2DD0E1676BA8
GO
Isoform 2 (identifier: Q9HCN6-2) [UniParc]FASTAAdd to Basket

Also known as: VI-2

The sequence of this isoform differs from the canonical sequence as follows:
     204-221: Missing.

Show »
Length:321
Mass (Da):35,091
Checksum:iEEE281373112DB21
GO
Isoform 3 (identifier: Q9HCN6-3) [UniParc]FASTAAdd to Basket

Also known as: VI-3

The sequence of this isoform differs from the canonical sequence as follows:
     260-339: PARQYYTKGN...QDVHSRGLCS → ESCPPVLHQG...TGMNMSITLI

Note: Has no transmembrane domain. Does not interact with Fc receptor gamma chain. Does not bind to collagen-like peptides.Curated

Show »
Length:620
Mass (Da):67,476
Checksum:iF6DBAE2547664D7A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 3 (identifier: Q9HCN6-3)
Sequence conflicti314 – 3141P → A in BAB12247. (PubMed:11027634)Curated
Sequence conflicti323 – 3231K → T in BAB12247. (PubMed:11027634)Curated
Sequence conflicti573 – 5731R → G in BAB12247. (PubMed:11027634)Curated
Sequence conflicti606 – 6061F → L in BAB12247. (PubMed:11027634)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti58 – 581R → C in BDPLT11; results in abnormal protein migration and a loss of collagen binding. 1 Publication
VAR_066590
Natural varianti175 – 1751S → N in BDPLT11; shows strongly reduced membrane expression and decreased interaction with the snake toxin convulxin. 1 Publication
VAR_066591
Natural varianti219 – 2191P → S.3 Publications
Corresponds to variant rs1613662 [ dbSNP | Ensembl ].
VAR_060352
Natural varianti237 – 2371E → K.3 Publications
Corresponds to variant rs1654416 [ dbSNP | Ensembl ].
VAR_060353
Natural varianti249 – 2491A → T.3 Publications
Corresponds to variant rs2304167 [ dbSNP | Ensembl ].
VAR_060354
Natural varianti317 – 3171L → Q.3 Publications
Corresponds to variant rs1654413 [ dbSNP | Ensembl ].
VAR_059389
Natural varianti322 – 3221N → H.3 Publications
Corresponds to variant rs1671152 [ dbSNP | Ensembl ].
VAR_059390
Natural varianti335 – 3351R → G.
Corresponds to variant rs1654412 [ dbSNP | Ensembl ].
VAR_060355

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei204 – 22118Missing in isoform 2. 1 PublicationVSP_017879Add
BLAST
Alternative sequencei260 – 33980PARQY…RGLCS → ESCPPVLHQGQPGPDMPRGC DPNNPGGVSGRGLAQPEEAP AAQGQGCAEAASAPPAPPAD PEIKRGSGWRPTGCSQPRVM FMTAEPQARSYPREGSWHGR RLKDWRVWSVEAGGQRLQLW KRGHAASSWCSIREPFGQCL SVCLPLCLRAPSIWDGRNLW RPHPPPCTLWMTWYPGWTTY WPLSSTSLIWAPDGSLRFPA LRVDSVPSSVQNPPVLPFGP LCSCLVFPRNSHPHSISHCG LTNLLSSLRTGLAGSLGMSF IFLSVKLARCPLPFTLENKI SLCNMVKPHLYQQNKKTQKL ARCGGASLYSQQLRGLRWEN GLSLGGRGCSELRSHHCTLA RVTKPDFVSKNTGMNMSITL I in isoform 3. 1 PublicationVSP_017880Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB043819 mRNA. Translation: BAB12245.1.
AB043820 mRNA. Translation: BAB12246.1.
AB043821 mRNA. Translation: BAB12247.1.
AB035073 mRNA. Translation: BAA89353.1.
AC011476 Genomic DNA. No translation available.
BC104832 mRNA. Translation: AAI04833.1.
BC111963 mRNA. Translation: AAI11964.1.
CCDSiCCDS42626.1. [Q9HCN6-3]
CCDS46184.1. [Q9HCN6-1]
CCDS58678.1. [Q9HCN6-2]
PIRiJC7509.
RefSeqiNP_001077368.2. NM_001083899.2. [Q9HCN6-3]
NP_001242946.2. NM_001256017.2. [Q9HCN6-2]
NP_057447.5. NM_016363.5. [Q9HCN6-1]
UniGeneiHs.661752.

Genome annotation databases

EnsembliENST00000310373; ENSP00000308782; ENSG00000088053. [Q9HCN6-3]
ENST00000333884; ENSP00000334552; ENSG00000088053. [Q9HCN6-2]
ENST00000417454; ENSP00000394922; ENSG00000088053. [Q9HCN6-1]
ENST00000612184; ENSP00000479873; ENSG00000277439. [Q9HCN6-2]
ENST00000616456; ENSP00000483314; ENSG00000277439. [Q9HCN6-1]
ENST00000622279; ENSP00000484029; ENSG00000277439. [Q9HCN6-3]
GeneIDi51206.
KEGGihsa:51206.
UCSCiuc002qik.3. human. [Q9HCN6-1]
uc002qil.3. human. [Q9HCN6-3]
uc010esq.3. human. [Q9HCN6-2]

Polymorphism databases

DMDMi327478600.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB043819 mRNA. Translation: BAB12245.1 .
AB043820 mRNA. Translation: BAB12246.1 .
AB043821 mRNA. Translation: BAB12247.1 .
AB035073 mRNA. Translation: BAA89353.1 .
AC011476 Genomic DNA. No translation available.
BC104832 mRNA. Translation: AAI04833.1 .
BC111963 mRNA. Translation: AAI11964.1 .
CCDSi CCDS42626.1. [Q9HCN6-3 ]
CCDS46184.1. [Q9HCN6-1 ]
CCDS58678.1. [Q9HCN6-2 ]
PIRi JC7509.
RefSeqi NP_001077368.2. NM_001083899.2. [Q9HCN6-3 ]
NP_001242946.2. NM_001256017.2. [Q9HCN6-2 ]
NP_057447.5. NM_016363.5. [Q9HCN6-1 ]
UniGenei Hs.661752.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2GI7 X-ray 2.40 A/B 21-203 [» ]
ProteinModelPortali Q9HCN6.
SMRi Q9HCN6. Positions 22-261.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119379. 8 interactions.
DIPi DIP-33875N.
IntActi Q9HCN6. 4 interactions.
MINTi MINT-258007.
STRINGi 9606.ENSP00000308782.

PTM databases

PhosphoSitei Q9HCN6.

Polymorphism databases

DMDMi 327478600.

Proteomic databases

PaxDbi Q9HCN6.
PRIDEi Q9HCN6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000310373 ; ENSP00000308782 ; ENSG00000088053 . [Q9HCN6-3 ]
ENST00000333884 ; ENSP00000334552 ; ENSG00000088053 . [Q9HCN6-2 ]
ENST00000417454 ; ENSP00000394922 ; ENSG00000088053 . [Q9HCN6-1 ]
ENST00000612184 ; ENSP00000479873 ; ENSG00000277439 . [Q9HCN6-2 ]
ENST00000616456 ; ENSP00000483314 ; ENSG00000277439 . [Q9HCN6-1 ]
ENST00000622279 ; ENSP00000484029 ; ENSG00000277439 . [Q9HCN6-3 ]
GeneIDi 51206.
KEGGi hsa:51206.
UCSCi uc002qik.3. human. [Q9HCN6-1 ]
uc002qil.3. human. [Q9HCN6-3 ]
uc010esq.3. human. [Q9HCN6-2 ]

Organism-specific databases

CTDi 51206.
GeneCardsi GC19M055525.
HGNCi HGNC:14388. GP6.
MIMi 605546. gene.
614201. phenotype.
neXtProti NX_Q9HCN6.
Orphaneti 98885. Bleeding diathesis due to glycoprotein VI deficiency.
PharmGKBi PA28824.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG79029.
GeneTreei ENSGT00760000119033.
HOGENOMi HOG000234395.
HOVERGENi HBG074353.
InParanoidi Q9HCN6.
KOi K06264.
OMAi ASSWCSI.
PhylomeDBi Q9HCN6.
TreeFami TF336644.

Enzyme and pathway databases

Reactomei REACT_12051. Cell surface interactions at the vascular wall.
REACT_1230. Platelet Adhesion to exposed collagen.
REACT_1695. GPVI-mediated activation cascade.

Miscellaneous databases

EvolutionaryTracei Q9HCN6.
GeneWikii GPVI.
GenomeRNAii 51206.
NextBioi 54258.
PROi Q9HCN6.
SOURCEi Search...

Gene expression databases

Bgeei Q9HCN6.
CleanExi HS_GP6.
ExpressionAtlasi Q9HCN6. baseline.
Genevestigatori Q9HCN6.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI."
    Ezumi Y., Uchiyama T., Takayama H.
    Biochem. Biophys. Res. Commun. 277:27-36(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), PROTEIN SEQUENCE OF 28-41; 62-79 AND 114-142, VARIANTS SER-219; LYS-237; THR-249; GLN-317 AND HIS-322.
  2. "Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily."
    Jandrot-Perrus M., Busfield S., Lagrue A.-H., Xiong X., Debili N., Chickering T., Le Couedic J.-P., Goodearl A., Dussault B., Fraser C., Vainchenker W., Villeval J.-L.
    Blood 96:1798-1807(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH FC RECEPTOR GAMMA CHAIN, TISSUE SPECIFICITY.
    Tissue: Megakaryocyte.
  3. "Platelet glycoprotein VI."
    Miura Y.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS SER-219; LYS-237; THR-249; GLN-317 AND HIS-322.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-219; LYS-237; THR-249; GLN-317 AND HIS-322.
  6. "A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets."
    Tsuji M., Ezumi Y., Arai M., Takayama H.
    J. Biol. Chem. 272:23528-23531(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FC RECEPTOR GAMMA CHAIN.
  7. "The influence of N-linked glycosylation on the function of platelet glycoprotein VI."
    Kunicki T.J., Cheli Y., Moroi M., Furihata K.
    Blood 106:2744-2749(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-92, MUTAGENESIS OF ASN-92; SER-94 AND LEU-95.
  8. "Gain- and loss-of-function mutants confirm the importance of apical residues to the primary interaction of human glycoprotein VI with collagen."
    O'connor M.N., Smethurst P.A., Farndale R.W., Ouwehand W.H.
    J. Thromb. Haemost. 4:869-873(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF LYS-61; LYS-79; ARG-80 AND ARG-186.
  9. "Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI."
    Horii K., Kahn M.L., Herr A.B.
    Blood 108:936-942(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 21-203, DISULFIDE BONDS.
  10. "Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations."
    Dumont B., Lasne D., Rothschild C., Bouabdelli M., Ollivier V., Oudin C., Ajzenberg N., Grandchamp B., Jandrot-Perrus M.
    Blood 114:1900-1903(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT BDPLT11 CYS-58, CHARACTERIZATION OF VARIANT BDPLT11 CYS-58.
  11. "A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder."
    Hermans C., Wittevrongel C., Thys C., Smethurst P.A., Van Geet C., Freson K.
    J. Thromb. Haemost. 7:1356-1363(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT BDPLT11 ASN-175, CHARACTERIZATION OF VARIANT BDPLT11 ASN-175.

Entry informationi

Entry nameiGPVI_HUMAN
AccessioniPrimary (citable) accession number: Q9HCN6
Secondary accession number(s): Q9HCN7, Q9UIF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 115 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3