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Q9HCN3

- TMM8A_HUMAN

UniProt

Q9HCN3 - TMM8A_HUMAN

Protein

Transmembrane protein 8A

Gene

TMEM8A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    May be a cell surface adhesion molecule. May be involved in the maintenance of the resting T-cell state.

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 8A
    Alternative name(s):
    Protein M83
    Transmembrane protein 6
    Transmembrane protein 8
    Gene namesi
    Name:TMEM8A
    Synonyms:TMEM6, TMEM8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:17205. TMEM8A.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. lysosomal membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38211.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 771737Transmembrane protein 8APRO_0000022539Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi407 – 4071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi431 – 4311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi498 ↔ 508PROSITE-ProRule annotation
    Disulfide bondi502 ↔ 521PROSITE-ProRule annotation
    Disulfide bondi523 ↔ 532PROSITE-ProRule annotation

    Post-translational modificationi

    Glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9HCN3.
    PaxDbiQ9HCN3.
    PRIDEiQ9HCN3.

    PTM databases

    PhosphoSiteiQ9HCN3.

    Expressioni

    Tissue specificityi

    Expressed in pancreas, placenta, spleen, liver, kidney, bone marrow, peripheral blood leukocytes and tonsil.1 Publication

    Inductioni

    Repressed during activation of CD4+ and CD8+ T-lymphocytes.

    Gene expression databases

    ArrayExpressiQ9HCN3.
    BgeeiQ9HCN3.
    CleanExiHS_TMEM8.
    GenevestigatoriQ9HCN3.

    Organism-specific databases

    HPAiHPA051281.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000401338.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9HCN3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini35 – 545511ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini567 – 5682CytoplasmicSequence Analysis
    Topological domaini590 – 60516ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini627 – 6293CytoplasmicSequence Analysis
    Topological domaini651 – 6533ExtracellularSequence Analysis
    Topological domaini675 – 69016CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini712 – 7176ExtracellularSequence Analysis
    Topological domaini739 – 77133CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei546 – 56621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei569 – 58921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei606 – 62621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei630 – 65021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei654 – 67421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei691 – 71121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei718 – 73821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini497 – 53337EGF-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TMEM8 family.Curated
    Contains 1 EGF-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG77604.
    InParanoidiQ9HCN3.
    OMAiYPETDNW.
    OrthoDBiEOG7FNC6S.
    PhylomeDBiQ9HCN3.
    TreeFamiTF331003.

    Family and domain databases

    InterProiIPR021910. DUF3522.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    [Graphical view]
    PfamiPF12036. DUF3522. 1 hit.
    [Graphical view]
    SMARTiSM00181. EGF. 1 hit.
    [Graphical view]
    PROSITEiPS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9HCN3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRAGTGTGG EAVAAVVAGP LLLLLLARPP PASAGYSGKS EVGLVSEHFS    50
    QAPQRLSFYS WYGSARLFRF RVPPDAVLLR WLLQVSRESG AACTDAEITV 100
    HFRSGAPPVI NPLGTSFPDD TAVQPSFQVG VPLSTTPRSN ASVNVSHPAP 150
    GDWFVAAHLP PSSQKIELKG LAPTCAYVFQ PELLVTRVVE ISIMEPDVPL 200
    PQTLLSHPSY LKVFVPDYTR ELLLELRDCV SNGSLGCPVR LTVGPVTLPS 250
    NFQKVLTCTG APWPCRLLLP SPPWDRWLQV TAESLVGPLG TVAFSAVAAL 300
    TACRPRSVTI QPLLQSSQNQ SFNASSGLLS PSPDHQDLGR SGRVDRSPFC 350
    LTNYPVTRED MDVVSVHFQP LDRVSVRVCS DTPSVMRLRL NTGMDSGGSL 400
    TISLRANKTE MRNETVVVAC VNAASPFLGF NTSLNCTTAF FQGYPLSLSA 450
    WSRRANLIIP YPETDNWYLS LQLMCPENAE DCEQAVVHVE TTLYLVPCLN 500
    DCGPYGQCLL LRRHSYLYAS CSCKAGWRGW SCTDNSTAQT VAQQRAATLL 550
    LTLSNLMFLA PIAVSVRRFF LVEASVYAYT MFFSTFYHAC DQPGEAVLCI 600
    LSYDTLQYCD FLGSGAAIWV TILCMARLKT VLKYVLFLLG TLVIAMSLQL 650
    DRRGMWNMLG PCLFAFVIMA SMWAYRCGHR RQCYPTSWQR WAFYLLPGVS 700
    MASVGIAIYT SMMTSDNYYY THSIWHILLA GSAALLLPPP DQPAEPWACS 750
    QKFPCHYQIC KNDREELYAV T 771
    Length:771
    Mass (Da):84,761
    Last modified:May 18, 2010 - v3
    Checksum:i2A21814C449724F8
    GO

    Sequence cautioni

    The sequence BAB14975.1 differs from that shown. Reason: Erroneous termination at position 750. Translated as Ser.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti460 – 4601P → A in BAB14975. (PubMed:14702039)Curated
    Sequence conflicti654 – 6541G → D in BAB16376. (PubMed:11006113)Curated
    Sequence conflicti687 – 6871S → L in BAB14975. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti136 – 1361T → A.3 Publications
    Corresponds to variant rs11248931 [ dbSNP | Ensembl ].
    VAR_025307
    Natural varianti310 – 3101I → V.3 Publications
    Corresponds to variant rs2071915 [ dbSNP | Ensembl ].
    VAR_025308
    Natural varianti567 – 5671R → W.1 Publication
    Corresponds to variant rs3743887 [ dbSNP | Ensembl ].
    VAR_057810

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB045292 mRNA. Translation: BAB16376.1.
    AE006463 Genomic DNA. Translation: AAK61227.1.
    Z97634 Genomic DNA. Translation: CAI95598.1.
    CH471112 Genomic DNA. Translation: EAW85824.1.
    CH471112 Genomic DNA. Translation: EAW85825.1.
    BC021557 mRNA. Translation: AAH21557.1.
    BC004276 mRNA. Translation: AAH04276.1.
    AK024725 mRNA. Translation: BAB14975.1. Sequence problems.
    CCDSiCCDS10407.1.
    PIRiJC7388.
    RefSeqiNP_067082.2. NM_021259.2.
    UniGeneiHs.288940.

    Genome annotation databases

    EnsembliENST00000431232; ENSP00000401338; ENSG00000129925.
    GeneIDi58986.
    KEGGihsa:58986.
    UCSCiuc002cgu.4. human.

    Polymorphism databases

    DMDMi296453013.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB045292 mRNA. Translation: BAB16376.1 .
    AE006463 Genomic DNA. Translation: AAK61227.1 .
    Z97634 Genomic DNA. Translation: CAI95598.1 .
    CH471112 Genomic DNA. Translation: EAW85824.1 .
    CH471112 Genomic DNA. Translation: EAW85825.1 .
    BC021557 mRNA. Translation: AAH21557.1 .
    BC004276 mRNA. Translation: AAH04276.1 .
    AK024725 mRNA. Translation: BAB14975.1 . Sequence problems.
    CCDSi CCDS10407.1.
    PIRi JC7388.
    RefSeqi NP_067082.2. NM_021259.2.
    UniGenei Hs.288940.

    3D structure databases

    ProteinModelPortali Q9HCN3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000401338.

    PTM databases

    PhosphoSitei Q9HCN3.

    Polymorphism databases

    DMDMi 296453013.

    Proteomic databases

    MaxQBi Q9HCN3.
    PaxDbi Q9HCN3.
    PRIDEi Q9HCN3.

    Protocols and materials databases

    DNASUi 58986.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000431232 ; ENSP00000401338 ; ENSG00000129925 .
    GeneIDi 58986.
    KEGGi hsa:58986.
    UCSCi uc002cgu.4. human.

    Organism-specific databases

    CTDi 58986.
    GeneCardsi GC16M000360.
    H-InvDB HIX0202255.
    HGNCi HGNC:17205. TMEM8A.
    HPAi HPA051281.
    neXtProti NX_Q9HCN3.
    PharmGKBi PA38211.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG77604.
    InParanoidi Q9HCN3.
    OMAi YPETDNW.
    OrthoDBi EOG7FNC6S.
    PhylomeDBi Q9HCN3.
    TreeFami TF331003.

    Miscellaneous databases

    GenomeRNAii 58986.
    NextBioi 65130.
    PROi Q9HCN3.

    Gene expression databases

    ArrayExpressi Q9HCN3.
    Bgeei Q9HCN3.
    CleanExi HS_TMEM8.
    Genevestigatori Q9HCN3.

    Family and domain databases

    InterProi IPR021910. DUF3522.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    [Graphical view ]
    Pfami PF12036. DUF3522. 1 hit.
    [Graphical view ]
    SMARTi SM00181. EGF. 1 hit.
    [Graphical view ]
    PROSITEi PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and chromosomal mapping of a novel five-span transmembrane protein gene, M83."
      Motohashi T., Miyoshi S., Osawa M., Eyre H.J., Sutherland G.R., Matsuda Y., Nakamura Y., Shibuya A., Iwama A., Nakauchi H.
      Biochem. Biophys. Res. Commun. 276:244-250(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GLYCOSYLATION, VARIANTS VARIANT ALA-136 AND VAL-310.
    2. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
      Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
      Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-136.
    4. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-136 AND VAL-310.
      Tissue: Pancreas and Skin.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 192-771, VARIANTS VAL-310 AND TRP-567.
      Tissue: Coronary artery.

    Entry informationi

    Entry nameiTMM8A_HUMAN
    AccessioniPrimary (citable) accession number: Q9HCN3
    Secondary accession number(s): D3DU49
    , Q4TT35, Q8WU24, Q96S25, Q9BR03, Q9BT97, Q9H7B9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3