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Q9HCN3 (TMM8A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 8A
Alternative name(s):
Protein M83
Transmembrane protein 6
Transmembrane protein 8
Gene names
Name:TMEM8A
Synonyms:TMEM6, TMEM8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length771 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be a cell surface adhesion molecule. May be involved in the maintenance of the resting T-cell state.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Expressed in pancreas, placenta, spleen, liver, kidney, bone marrow, peripheral blood leukocytes and tonsil. Ref.1

Induction

Repressed during activation of CD4+ and CD8+ T-lymphocytes.

Post-translational modification

Glycosylated. Ref.1

Sequence similarities

Belongs to the TMEM8 family.

Contains 1 EGF-like domain.

Sequence caution

The sequence BAB14975.1 differs from that shown. Reason: Erroneous termination at position 750. Translated as Ser.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainEGF-like domain
Signal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of plasma membrane

Non-traceable author statement Ref.1. Source: UniProtKB

lysosomal membrane

Inferred from direct assay PubMed 17897319. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 771737Transmembrane protein 8A
PRO_0000022539

Regions

Topological domain35 – 545511Extracellular Potential
Transmembrane546 – 56621Helical; Potential
Topological domain567 – 5682Cytoplasmic Potential
Transmembrane569 – 58921Helical; Potential
Topological domain590 – 60516Extracellular Potential
Transmembrane606 – 62621Helical; Potential
Topological domain627 – 6293Cytoplasmic Potential
Transmembrane630 – 65021Helical; Potential
Topological domain651 – 6533Extracellular Potential
Transmembrane654 – 67421Helical; Potential
Topological domain675 – 69016Cytoplasmic Potential
Transmembrane691 – 71121Helical; Potential
Topological domain712 – 7176Extracellular Potential
Transmembrane718 – 73821Helical; Potential
Topological domain739 – 77133Cytoplasmic Potential
Domain497 – 53337EGF-like

Amino acid modifications

Glycosylation1441N-linked (GlcNAc...) Potential
Glycosylation4071N-linked (GlcNAc...) Potential
Glycosylation4311N-linked (GlcNAc...) Potential
Disulfide bond498 ↔ 508 Potential
Disulfide bond502 ↔ 521 Potential
Disulfide bond523 ↔ 532 Potential

Natural variations

Natural variant1361T → A. Ref.1 Ref.3 Ref.5
Corresponds to variant rs11248931 [ dbSNP | Ensembl ].
VAR_025307
Natural variant3101I → V. Ref.1 Ref.5 Ref.6
Corresponds to variant rs2071915 [ dbSNP | Ensembl ].
VAR_025308
Natural variant5671R → W. Ref.6
Corresponds to variant rs3743887 [ dbSNP | Ensembl ].
VAR_057810

Experimental info

Sequence conflict4601P → A in BAB14975. Ref.6
Sequence conflict6541G → D in BAB16376. Ref.1
Sequence conflict6871S → L in BAB14975. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Q9HCN3 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 2A21814C449724F8

FASTA77184,761
        10         20         30         40         50         60 
MGRAGTGTGG EAVAAVVAGP LLLLLLARPP PASAGYSGKS EVGLVSEHFS QAPQRLSFYS 

        70         80         90        100        110        120 
WYGSARLFRF RVPPDAVLLR WLLQVSRESG AACTDAEITV HFRSGAPPVI NPLGTSFPDD 

       130        140        150        160        170        180 
TAVQPSFQVG VPLSTTPRSN ASVNVSHPAP GDWFVAAHLP PSSQKIELKG LAPTCAYVFQ 

       190        200        210        220        230        240 
PELLVTRVVE ISIMEPDVPL PQTLLSHPSY LKVFVPDYTR ELLLELRDCV SNGSLGCPVR 

       250        260        270        280        290        300 
LTVGPVTLPS NFQKVLTCTG APWPCRLLLP SPPWDRWLQV TAESLVGPLG TVAFSAVAAL 

       310        320        330        340        350        360 
TACRPRSVTI QPLLQSSQNQ SFNASSGLLS PSPDHQDLGR SGRVDRSPFC LTNYPVTRED 

       370        380        390        400        410        420 
MDVVSVHFQP LDRVSVRVCS DTPSVMRLRL NTGMDSGGSL TISLRANKTE MRNETVVVAC 

       430        440        450        460        470        480 
VNAASPFLGF NTSLNCTTAF FQGYPLSLSA WSRRANLIIP YPETDNWYLS LQLMCPENAE 

       490        500        510        520        530        540 
DCEQAVVHVE TTLYLVPCLN DCGPYGQCLL LRRHSYLYAS CSCKAGWRGW SCTDNSTAQT 

       550        560        570        580        590        600 
VAQQRAATLL LTLSNLMFLA PIAVSVRRFF LVEASVYAYT MFFSTFYHAC DQPGEAVLCI 

       610        620        630        640        650        660 
LSYDTLQYCD FLGSGAAIWV TILCMARLKT VLKYVLFLLG TLVIAMSLQL DRRGMWNMLG 

       670        680        690        700        710        720 
PCLFAFVIMA SMWAYRCGHR RQCYPTSWQR WAFYLLPGVS MASVGIAIYT SMMTSDNYYY 

       730        740        750        760        770 
THSIWHILLA GSAALLLPPP DQPAEPWACS QKFPCHYQIC KNDREELYAV T 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and chromosomal mapping of a novel five-span transmembrane protein gene, M83."
Motohashi T., Miyoshi S., Osawa M., Eyre H.J., Sutherland G.R., Matsuda Y., Nakamura Y., Shibuya A., Iwama A., Nakauchi H.
Biochem. Biophys. Res. Commun. 276:244-250(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GLYCOSYLATION, VARIANTS VARIANT ALA-136 AND VAL-310.
[2]"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-136.
[4]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-136 AND VAL-310.
Tissue: Pancreas and Skin.
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 192-771, VARIANTS VAL-310 AND TRP-567.
Tissue: Coronary artery.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB045292 mRNA. Translation: BAB16376.1.
AE006463 Genomic DNA. Translation: AAK61227.1.
Z97634 Genomic DNA. Translation: CAI95598.1.
CH471112 Genomic DNA. Translation: EAW85824.1.
CH471112 Genomic DNA. Translation: EAW85825.1.
BC021557 mRNA. Translation: AAH21557.1.
BC004276 mRNA. Translation: AAH04276.1.
AK024725 mRNA. Translation: BAB14975.1. Sequence problems.
CCDSCCDS10407.1.
PIRJC7388.
RefSeqNP_067082.2. NM_021259.2.
UniGeneHs.288940.

3D structure databases

ProteinModelPortalQ9HCN3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000401338.

PTM databases

PhosphoSiteQ9HCN3.

Polymorphism databases

DMDM296453013.

Proteomic databases

MaxQBQ9HCN3.
PaxDbQ9HCN3.
PRIDEQ9HCN3.

Protocols and materials databases

DNASU58986.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000431232; ENSP00000401338; ENSG00000129925.
GeneID58986.
KEGGhsa:58986.
UCSCuc002cgu.4. human.

Organism-specific databases

CTD58986.
GeneCardsGC16M000360.
H-InvDBHIX0202255.
HGNCHGNC:17205. TMEM8A.
HPAHPA051281.
neXtProtNX_Q9HCN3.
PharmGKBPA38211.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG77604.
InParanoidQ9HCN3.
OMAYPETDNW.
OrthoDBEOG7FNC6S.
PhylomeDBQ9HCN3.
TreeFamTF331003.

Gene expression databases

ArrayExpressQ9HCN3.
BgeeQ9HCN3.
CleanExHS_TMEM8.
GenevestigatorQ9HCN3.

Family and domain databases

InterProIPR021910. DUF3522.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
[Graphical view]
PfamPF12036. DUF3522. 1 hit.
[Graphical view]
SMARTSM00181. EGF. 1 hit.
[Graphical view]
PROSITEPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi58986.
NextBio65130.
PROQ9HCN3.

Entry information

Entry nameTMM8A_HUMAN
AccessionPrimary (citable) accession number: Q9HCN3
Secondary accession number(s): D3DU49 expand/collapse secondary AC list , Q4TT35, Q8WU24, Q96S25, Q9BR03, Q9BT97, Q9H7B9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM