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Protein

Transmembrane protein 8A

Gene

TMEM8A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a cell surface adhesion molecule. May be involved in the maintenance of the resting T-cell state.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129925-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 8A
Alternative name(s):
Protein M83
Transmembrane protein 6
Transmembrane protein 8
Gene namesi
Name:TMEM8A
Synonyms:TMEM6, TMEM8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:17205. TMEM8A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 545ExtracellularSequence analysisAdd BLAST511
Transmembranei546 – 566HelicalSequence analysisAdd BLAST21
Topological domaini567 – 568CytoplasmicSequence analysis2
Transmembranei569 – 589HelicalSequence analysisAdd BLAST21
Topological domaini590 – 605ExtracellularSequence analysisAdd BLAST16
Transmembranei606 – 626HelicalSequence analysisAdd BLAST21
Topological domaini627 – 629CytoplasmicSequence analysis3
Transmembranei630 – 650HelicalSequence analysisAdd BLAST21
Topological domaini651 – 653ExtracellularSequence analysis3
Transmembranei654 – 674HelicalSequence analysisAdd BLAST21
Topological domaini675 – 690CytoplasmicSequence analysisAdd BLAST16
Transmembranei691 – 711HelicalSequence analysisAdd BLAST21
Topological domaini712 – 717ExtracellularSequence analysis6
Transmembranei718 – 738HelicalSequence analysisAdd BLAST21
Topological domaini739 – 771CytoplasmicSequence analysisAdd BLAST33

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • lysosomal membrane Source: UniProtKB
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000129925.
PharmGKBiPA38211.

Polymorphism and mutation databases

BioMutaiTMEM8A.
DMDMi296453013.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000002253935 – 771Transmembrane protein 8AAdd BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi144N-linked (GlcNAc...)Sequence analysis1
Glycosylationi407N-linked (GlcNAc...)Sequence analysis1
Glycosylationi431N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi498 ↔ 508PROSITE-ProRule annotation
Disulfide bondi502 ↔ 521PROSITE-ProRule annotation
Disulfide bondi523 ↔ 532PROSITE-ProRule annotation

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9HCN3.
MaxQBiQ9HCN3.
PaxDbiQ9HCN3.
PeptideAtlasiQ9HCN3.
PRIDEiQ9HCN3.

PTM databases

iPTMnetiQ9HCN3.
PhosphoSitePlusiQ9HCN3.

Expressioni

Tissue specificityi

Expressed in pancreas, placenta, spleen, liver, kidney, bone marrow, peripheral blood leukocytes and tonsil.1 Publication

Inductioni

Repressed during activation of CD4+ and CD8+ T-lymphocytes.

Gene expression databases

BgeeiENSG00000129925.
CleanExiHS_TMEM8.
ExpressionAtlasiQ9HCN3. baseline and differential.
GenevisibleiQ9HCN3. HS.

Organism-specific databases

HPAiHPA051281.
HPA064673.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-10310808,EBI-10172290
RELQ048643EBI-10310808,EBI-307352

Protein-protein interaction databases

BioGridi121856. 8 interactors.
IntActiQ9HCN3. 6 interactors.
STRINGi9606.ENSP00000401338.

Structurei

3D structure databases

ProteinModelPortaliQ9HCN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini497 – 533EGF-likePROSITE-ProRule annotationAdd BLAST37

Sequence similaritiesi

Belongs to the TMEM8 family.Curated
Contains 1 EGF-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHJ3. Eukaryota.
ENOG4111FA8. LUCA.
GeneTreeiENSGT00390000004668.
InParanoidiQ9HCN3.
OMAiVSEHFSQ.
OrthoDBiEOG091G0KZA.
PhylomeDBiQ9HCN3.
TreeFamiTF331003.

Family and domain databases

InterProiIPR021910. DUF3522.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
[Graphical view]
PfamiPF12036. DUF3522. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HCN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRAGTGTGG EAVAAVVAGP LLLLLLARPP PASAGYSGKS EVGLVSEHFS
60 70 80 90 100
QAPQRLSFYS WYGSARLFRF RVPPDAVLLR WLLQVSRESG AACTDAEITV
110 120 130 140 150
HFRSGAPPVI NPLGTSFPDD TAVQPSFQVG VPLSTTPRSN ASVNVSHPAP
160 170 180 190 200
GDWFVAAHLP PSSQKIELKG LAPTCAYVFQ PELLVTRVVE ISIMEPDVPL
210 220 230 240 250
PQTLLSHPSY LKVFVPDYTR ELLLELRDCV SNGSLGCPVR LTVGPVTLPS
260 270 280 290 300
NFQKVLTCTG APWPCRLLLP SPPWDRWLQV TAESLVGPLG TVAFSAVAAL
310 320 330 340 350
TACRPRSVTI QPLLQSSQNQ SFNASSGLLS PSPDHQDLGR SGRVDRSPFC
360 370 380 390 400
LTNYPVTRED MDVVSVHFQP LDRVSVRVCS DTPSVMRLRL NTGMDSGGSL
410 420 430 440 450
TISLRANKTE MRNETVVVAC VNAASPFLGF NTSLNCTTAF FQGYPLSLSA
460 470 480 490 500
WSRRANLIIP YPETDNWYLS LQLMCPENAE DCEQAVVHVE TTLYLVPCLN
510 520 530 540 550
DCGPYGQCLL LRRHSYLYAS CSCKAGWRGW SCTDNSTAQT VAQQRAATLL
560 570 580 590 600
LTLSNLMFLA PIAVSVRRFF LVEASVYAYT MFFSTFYHAC DQPGEAVLCI
610 620 630 640 650
LSYDTLQYCD FLGSGAAIWV TILCMARLKT VLKYVLFLLG TLVIAMSLQL
660 670 680 690 700
DRRGMWNMLG PCLFAFVIMA SMWAYRCGHR RQCYPTSWQR WAFYLLPGVS
710 720 730 740 750
MASVGIAIYT SMMTSDNYYY THSIWHILLA GSAALLLPPP DQPAEPWACS
760 770
QKFPCHYQIC KNDREELYAV T
Length:771
Mass (Da):84,761
Last modified:May 18, 2010 - v3
Checksum:i2A21814C449724F8
GO

Sequence cautioni

The sequence BAB14975 differs from that shown. Reason: Erroneous termination at position 750. Translated as Ser.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti460P → A in BAB14975 (PubMed:14702039).Curated1
Sequence conflicti654G → D in BAB16376 (PubMed:11006113).Curated1
Sequence conflicti687S → L in BAB14975 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025307136T → A.3 PublicationsCorresponds to variant rs11248931dbSNPEnsembl.1
Natural variantiVAR_025308310I → V.3 PublicationsCorresponds to variant rs2071915dbSNPEnsembl.1
Natural variantiVAR_057810567R → W.1 PublicationCorresponds to variant rs3743887dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045292 mRNA. Translation: BAB16376.1.
AE006463 Genomic DNA. Translation: AAK61227.1.
Z97634 Genomic DNA. Translation: CAI95598.1.
CH471112 Genomic DNA. Translation: EAW85824.1.
CH471112 Genomic DNA. Translation: EAW85825.1.
BC021557 mRNA. Translation: AAH21557.1.
BC004276 mRNA. Translation: AAH04276.1.
AK024725 mRNA. Translation: BAB14975.1. Sequence problems.
CCDSiCCDS10407.1.
PIRiJC7388.
RefSeqiNP_067082.2. NM_021259.2.
UniGeneiHs.288940.

Genome annotation databases

EnsembliENST00000431232; ENSP00000401338; ENSG00000129925.
GeneIDi58986.
KEGGihsa:58986.
UCSCiuc002cgu.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045292 mRNA. Translation: BAB16376.1.
AE006463 Genomic DNA. Translation: AAK61227.1.
Z97634 Genomic DNA. Translation: CAI95598.1.
CH471112 Genomic DNA. Translation: EAW85824.1.
CH471112 Genomic DNA. Translation: EAW85825.1.
BC021557 mRNA. Translation: AAH21557.1.
BC004276 mRNA. Translation: AAH04276.1.
AK024725 mRNA. Translation: BAB14975.1. Sequence problems.
CCDSiCCDS10407.1.
PIRiJC7388.
RefSeqiNP_067082.2. NM_021259.2.
UniGeneiHs.288940.

3D structure databases

ProteinModelPortaliQ9HCN3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121856. 8 interactors.
IntActiQ9HCN3. 6 interactors.
STRINGi9606.ENSP00000401338.

PTM databases

iPTMnetiQ9HCN3.
PhosphoSitePlusiQ9HCN3.

Polymorphism and mutation databases

BioMutaiTMEM8A.
DMDMi296453013.

Proteomic databases

EPDiQ9HCN3.
MaxQBiQ9HCN3.
PaxDbiQ9HCN3.
PeptideAtlasiQ9HCN3.
PRIDEiQ9HCN3.

Protocols and materials databases

DNASUi58986.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000431232; ENSP00000401338; ENSG00000129925.
GeneIDi58986.
KEGGihsa:58986.
UCSCiuc002cgu.5. human.

Organism-specific databases

CTDi58986.
GeneCardsiTMEM8A.
H-InvDBHIX0202255.
HGNCiHGNC:17205. TMEM8A.
HPAiHPA051281.
HPA064673.
neXtProtiNX_Q9HCN3.
OpenTargetsiENSG00000129925.
PharmGKBiPA38211.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHJ3. Eukaryota.
ENOG4111FA8. LUCA.
GeneTreeiENSGT00390000004668.
InParanoidiQ9HCN3.
OMAiVSEHFSQ.
OrthoDBiEOG091G0KZA.
PhylomeDBiQ9HCN3.
TreeFamiTF331003.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129925-MONOMER.

Miscellaneous databases

ChiTaRSiTMEM8A. human.
GenomeRNAii58986.
PROiQ9HCN3.

Gene expression databases

BgeeiENSG00000129925.
CleanExiHS_TMEM8.
ExpressionAtlasiQ9HCN3. baseline and differential.
GenevisibleiQ9HCN3. HS.

Family and domain databases

InterProiIPR021910. DUF3522.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
[Graphical view]
PfamiPF12036. DUF3522. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMM8A_HUMAN
AccessioniPrimary (citable) accession number: Q9HCN3
Secondary accession number(s): D3DU49
, Q4TT35, Q8WU24, Q96S25, Q9BR03, Q9BT97, Q9H7B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.