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Q9HCN3

- TMM8A_HUMAN

UniProt

Q9HCN3 - TMM8A_HUMAN

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Protein

Transmembrane protein 8A

Gene

TMEM8A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be a cell surface adhesion molecule. May be involved in the maintenance of the resting T-cell state.

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 8A
Alternative name(s):
Protein M83
Transmembrane protein 6
Transmembrane protein 8
Gene namesi
Name:TMEM8A
Synonyms:TMEM6, TMEM8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:17205. TMEM8A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 545511ExtracellularSequence AnalysisAdd
BLAST
Transmembranei546 – 56621HelicalSequence AnalysisAdd
BLAST
Topological domaini567 – 5682CytoplasmicSequence Analysis
Transmembranei569 – 58921HelicalSequence AnalysisAdd
BLAST
Topological domaini590 – 60516ExtracellularSequence AnalysisAdd
BLAST
Transmembranei606 – 62621HelicalSequence AnalysisAdd
BLAST
Topological domaini627 – 6293CytoplasmicSequence Analysis
Transmembranei630 – 65021HelicalSequence AnalysisAdd
BLAST
Topological domaini651 – 6533ExtracellularSequence Analysis
Transmembranei654 – 67421HelicalSequence AnalysisAdd
BLAST
Topological domaini675 – 69016CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei691 – 71121HelicalSequence AnalysisAdd
BLAST
Topological domaini712 – 7176ExtracellularSequence Analysis
Transmembranei718 – 73821HelicalSequence AnalysisAdd
BLAST
Topological domaini739 – 77133CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of plasma membrane Source: UniProtKB
  3. lysosomal membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38211.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 771737Transmembrane protein 8APRO_0000022539Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi407 – 4071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi431 – 4311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi498 ↔ 508PROSITE-ProRule annotation
Disulfide bondi502 ↔ 521PROSITE-ProRule annotation
Disulfide bondi523 ↔ 532PROSITE-ProRule annotation

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9HCN3.
PaxDbiQ9HCN3.
PRIDEiQ9HCN3.

PTM databases

PhosphoSiteiQ9HCN3.

Expressioni

Tissue specificityi

Expressed in pancreas, placenta, spleen, liver, kidney, bone marrow, peripheral blood leukocytes and tonsil.1 Publication

Inductioni

Repressed during activation of CD4+ and CD8+ T-lymphocytes.

Gene expression databases

BgeeiQ9HCN3.
CleanExiHS_TMEM8.
ExpressionAtlasiQ9HCN3. baseline and differential.
GenevestigatoriQ9HCN3.

Organism-specific databases

HPAiHPA051281.

Interactioni

Protein-protein interaction databases

BioGridi121856. 1 interaction.
STRINGi9606.ENSP00000401338.

Structurei

3D structure databases

ProteinModelPortaliQ9HCN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini497 – 53337EGF-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TMEM8 family.Curated
Contains 1 EGF-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG77604.
GeneTreeiENSGT00390000004668.
InParanoidiQ9HCN3.
OMAiYPETDNW.
OrthoDBiEOG7FNC6S.
PhylomeDBiQ9HCN3.
TreeFamiTF331003.

Family and domain databases

InterProiIPR021910. DUF3522.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
[Graphical view]
PfamiPF12036. DUF3522. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9HCN3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRAGTGTGG EAVAAVVAGP LLLLLLARPP PASAGYSGKS EVGLVSEHFS
60 70 80 90 100
QAPQRLSFYS WYGSARLFRF RVPPDAVLLR WLLQVSRESG AACTDAEITV
110 120 130 140 150
HFRSGAPPVI NPLGTSFPDD TAVQPSFQVG VPLSTTPRSN ASVNVSHPAP
160 170 180 190 200
GDWFVAAHLP PSSQKIELKG LAPTCAYVFQ PELLVTRVVE ISIMEPDVPL
210 220 230 240 250
PQTLLSHPSY LKVFVPDYTR ELLLELRDCV SNGSLGCPVR LTVGPVTLPS
260 270 280 290 300
NFQKVLTCTG APWPCRLLLP SPPWDRWLQV TAESLVGPLG TVAFSAVAAL
310 320 330 340 350
TACRPRSVTI QPLLQSSQNQ SFNASSGLLS PSPDHQDLGR SGRVDRSPFC
360 370 380 390 400
LTNYPVTRED MDVVSVHFQP LDRVSVRVCS DTPSVMRLRL NTGMDSGGSL
410 420 430 440 450
TISLRANKTE MRNETVVVAC VNAASPFLGF NTSLNCTTAF FQGYPLSLSA
460 470 480 490 500
WSRRANLIIP YPETDNWYLS LQLMCPENAE DCEQAVVHVE TTLYLVPCLN
510 520 530 540 550
DCGPYGQCLL LRRHSYLYAS CSCKAGWRGW SCTDNSTAQT VAQQRAATLL
560 570 580 590 600
LTLSNLMFLA PIAVSVRRFF LVEASVYAYT MFFSTFYHAC DQPGEAVLCI
610 620 630 640 650
LSYDTLQYCD FLGSGAAIWV TILCMARLKT VLKYVLFLLG TLVIAMSLQL
660 670 680 690 700
DRRGMWNMLG PCLFAFVIMA SMWAYRCGHR RQCYPTSWQR WAFYLLPGVS
710 720 730 740 750
MASVGIAIYT SMMTSDNYYY THSIWHILLA GSAALLLPPP DQPAEPWACS
760 770
QKFPCHYQIC KNDREELYAV T
Length:771
Mass (Da):84,761
Last modified:May 18, 2010 - v3
Checksum:i2A21814C449724F8
GO

Sequence cautioni

The sequence BAB14975.1 differs from that shown. Reason: Erroneous termination at position 750. Translated as Ser.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti460 – 4601P → A in BAB14975. (PubMed:14702039)Curated
Sequence conflicti654 – 6541G → D in BAB16376. (PubMed:11006113)Curated
Sequence conflicti687 – 6871S → L in BAB14975. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti136 – 1361T → A.3 Publications
Corresponds to variant rs11248931 [ dbSNP | Ensembl ].
VAR_025307
Natural varianti310 – 3101I → V.3 Publications
Corresponds to variant rs2071915 [ dbSNP | Ensembl ].
VAR_025308
Natural varianti567 – 5671R → W.1 Publication
Corresponds to variant rs3743887 [ dbSNP | Ensembl ].
VAR_057810

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045292 mRNA. Translation: BAB16376.1.
AE006463 Genomic DNA. Translation: AAK61227.1.
Z97634 Genomic DNA. Translation: CAI95598.1.
CH471112 Genomic DNA. Translation: EAW85824.1.
CH471112 Genomic DNA. Translation: EAW85825.1.
BC021557 mRNA. Translation: AAH21557.1.
BC004276 mRNA. Translation: AAH04276.1.
AK024725 mRNA. Translation: BAB14975.1. Sequence problems.
CCDSiCCDS10407.1.
PIRiJC7388.
RefSeqiNP_067082.2. NM_021259.2.
UniGeneiHs.288940.

Genome annotation databases

EnsembliENST00000431232; ENSP00000401338; ENSG00000129925.
GeneIDi58986.
KEGGihsa:58986.
UCSCiuc002cgu.4. human.

Polymorphism databases

DMDMi296453013.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045292 mRNA. Translation: BAB16376.1 .
AE006463 Genomic DNA. Translation: AAK61227.1 .
Z97634 Genomic DNA. Translation: CAI95598.1 .
CH471112 Genomic DNA. Translation: EAW85824.1 .
CH471112 Genomic DNA. Translation: EAW85825.1 .
BC021557 mRNA. Translation: AAH21557.1 .
BC004276 mRNA. Translation: AAH04276.1 .
AK024725 mRNA. Translation: BAB14975.1 . Sequence problems.
CCDSi CCDS10407.1.
PIRi JC7388.
RefSeqi NP_067082.2. NM_021259.2.
UniGenei Hs.288940.

3D structure databases

ProteinModelPortali Q9HCN3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121856. 1 interaction.
STRINGi 9606.ENSP00000401338.

PTM databases

PhosphoSitei Q9HCN3.

Polymorphism databases

DMDMi 296453013.

Proteomic databases

MaxQBi Q9HCN3.
PaxDbi Q9HCN3.
PRIDEi Q9HCN3.

Protocols and materials databases

DNASUi 58986.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000431232 ; ENSP00000401338 ; ENSG00000129925 .
GeneIDi 58986.
KEGGi hsa:58986.
UCSCi uc002cgu.4. human.

Organism-specific databases

CTDi 58986.
GeneCardsi GC16M000360.
H-InvDB HIX0202255.
HGNCi HGNC:17205. TMEM8A.
HPAi HPA051281.
neXtProti NX_Q9HCN3.
PharmGKBi PA38211.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG77604.
GeneTreei ENSGT00390000004668.
InParanoidi Q9HCN3.
OMAi YPETDNW.
OrthoDBi EOG7FNC6S.
PhylomeDBi Q9HCN3.
TreeFami TF331003.

Miscellaneous databases

ChiTaRSi TMEM8A. human.
GenomeRNAii 58986.
NextBioi 65130.
PROi Q9HCN3.

Gene expression databases

Bgeei Q9HCN3.
CleanExi HS_TMEM8.
ExpressionAtlasi Q9HCN3. baseline and differential.
Genevestigatori Q9HCN3.

Family and domain databases

InterProi IPR021910. DUF3522.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
[Graphical view ]
Pfami PF12036. DUF3522. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and chromosomal mapping of a novel five-span transmembrane protein gene, M83."
    Motohashi T., Miyoshi S., Osawa M., Eyre H.J., Sutherland G.R., Matsuda Y., Nakamura Y., Shibuya A., Iwama A., Nakauchi H.
    Biochem. Biophys. Res. Commun. 276:244-250(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GLYCOSYLATION, VARIANTS VARIANT ALA-136 AND VAL-310.
  2. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
    Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
    Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-136.
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-136 AND VAL-310.
    Tissue: Pancreas and Skin.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 192-771, VARIANTS VAL-310 AND TRP-567.
    Tissue: Coronary artery.

Entry informationi

Entry nameiTMM8A_HUMAN
AccessioniPrimary (citable) accession number: Q9HCN3
Secondary accession number(s): D3DU49
, Q4TT35, Q8WU24, Q96S25, Q9BR03, Q9BT97, Q9H7B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3