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Protein

p53-regulated apoptosis-inducing protein 1

Gene

TP53AIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in mediating p53/TP53-dependent apoptosis.1 Publication

GO - Biological processi

  • apoptotic process Source: UniProtKB
  • regulation of apoptotic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-HSA-6803204. TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.

Names & Taxonomyi

Protein namesi
Recommended name:
p53-regulated apoptosis-inducing protein 1
Short name:
p53AIP1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:29984. TP53AIP1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: Reactome
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164726680.

Polymorphism and mutation databases

BioMutaiTP53AIP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 124124p53-regulated apoptosis-inducing protein 1PRO_0000300813Add
BLAST

Proteomic databases

PaxDbiQ9HCN2.
PRIDEiQ9HCN2.

PTM databases

iPTMnetiQ9HCN2.
PhosphoSiteiQ9HCN2.

Expressioni

Tissue specificityi

Only found to be expressed in thymus.1 Publication

Inductioni

By p53/TP53.1 Publication

Gene expression databases

BgeeiQ9HCN2.
GenevisibleiQ9HCN2. HS.

Organism-specific databases

HPAiHPA044300.

Interactioni

Protein-protein interaction databases

BioGridi122018. 2 interactions.
STRINGi9606.ENSP00000432743.

Structurei

3D structure databases

ProteinModelPortaliQ9HCN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410KC77. Eukaryota.
ENOG4110P9G. LUCA.
GeneTreeiENSGT00390000000643.
HOGENOMiHOG000154669.
InParanoidiQ9HCN2.
KOiK13773.
OMAiWSSATVW.
OrthoDBiEOG77M8QV.
PhylomeDBiQ9HCN2.

Family and domain databases

InterProiIPR029284. TP53AIP1.
[Graphical view]
PfamiPF15338. TPIP1. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HCN2-1) [UniParc]FASTAAdd to basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSSSEASFR SAQASCSGAR RQGLGRGDQN LSVMPPNGRA QTHTPGWVSD
60 70 80 90 100
PLVLGAQVHG GCRGIEALSV SSGSWSSATV WILTGLGLGL SRPFLPGATV
110 120
LRDRPLGSAF ELSYDQKKAP LRLQ
Length:124
Mass (Da):12,935
Last modified:March 1, 2001 - v1
Checksum:iBE3858F03F4036C5
GO
Isoform 2 (identifier: Q9HCN2-2) [UniParc]FASTAAdd to basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     85-86: GL → VQ
     87-124: Missing.

Show »
Length:86
Mass (Da):8,841
Checksum:i3C53054B32433276
GO
Isoform 3 (identifier: Q9HCN2-3) [UniParc]FASTAAdd to basket

Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     50-124: DPLVLGAQVH...DQKKAPLRLQ → PCSENRDGLL...QFRALDRAGN

Note: Dubious isoform. Could be a cloning artifact.
Show »
Length:108
Mass (Da):11,288
Checksum:iAC665F271598351C
GO
Isoform 4 (identifier: Q9HCN2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     86-89: Missing.

Show »
Length:120
Mass (Da):12,594
Checksum:iF6B84A682DAF1BFD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71A → V.1 Publication
Corresponds to variant rs35942033 [ dbSNP | Ensembl ].
VAR_059735

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei50 – 12475DPLVL…PLRLQ → PCSENRDGLLPATAPGRLCS HRGADIPSFQTHQDPVTASG SSELHADCPQFRALDRAGN in isoform 3. 2 PublicationsVSP_027865Add
BLAST
Alternative sequencei85 – 862GL → VQ in isoform 2. 1 PublicationVSP_027866
Alternative sequencei86 – 894Missing in isoform 4. 1 PublicationVSP_027868
Alternative sequencei87 – 12438Missing in isoform 2. 1 PublicationVSP_027867Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045830 mRNA. Translation: BAB16421.1.
AB045831 mRNA. Translation: BAB16422.1.
AB045832 mRNA. Translation: BAB16423.1.
AY302135 mRNA. Translation: AAP57627.1.
AP000920 Genomic DNA. No translation available.
BC069399 mRNA. Translation: AAH69399.1.
BC069426 mRNA. Translation: AAH69426.1.
CCDSiCCDS55797.1. [Q9HCN2-2]
CCDS55798.1. [Q9HCN2-4]
CCDS58195.1. [Q9HCN2-3]
CCDS8480.2. [Q9HCN2-1]
RefSeqiNP_001182123.1. NM_001195194.1. [Q9HCN2-4]
NP_001182124.1. NM_001195195.1. [Q9HCN2-2]
NP_001238893.1. NM_001251964.1. [Q9HCN2-3]
NP_071395.2. NM_022112.2. [Q9HCN2-1]
UniGeneiHs.160953.

Genome annotation databases

EnsembliENST00000458238; ENSP00000390694; ENSG00000120471. [Q9HCN2-2]
ENST00000527504; ENSP00000435175; ENSG00000120471. [Q9HCN2-3]
ENST00000530777; ENSP00000432908; ENSG00000120471. [Q9HCN2-4]
ENST00000531399; ENSP00000432743; ENSG00000120471. [Q9HCN2-1]
ENST00000602346; ENSP00000473353; ENSG00000120471. [Q9HCN2-3]
ENST00000621818; ENSP00000479350; ENSG00000120471. [Q9HCN2-2]
GeneIDi63970.
KEGGihsa:63970.
UCSCiuc001qex.5. human. [Q9HCN2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045830 mRNA. Translation: BAB16421.1.
AB045831 mRNA. Translation: BAB16422.1.
AB045832 mRNA. Translation: BAB16423.1.
AY302135 mRNA. Translation: AAP57627.1.
AP000920 Genomic DNA. No translation available.
BC069399 mRNA. Translation: AAH69399.1.
BC069426 mRNA. Translation: AAH69426.1.
CCDSiCCDS55797.1. [Q9HCN2-2]
CCDS55798.1. [Q9HCN2-4]
CCDS58195.1. [Q9HCN2-3]
CCDS8480.2. [Q9HCN2-1]
RefSeqiNP_001182123.1. NM_001195194.1. [Q9HCN2-4]
NP_001182124.1. NM_001195195.1. [Q9HCN2-2]
NP_001238893.1. NM_001251964.1. [Q9HCN2-3]
NP_071395.2. NM_022112.2. [Q9HCN2-1]
UniGeneiHs.160953.

3D structure databases

ProteinModelPortaliQ9HCN2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122018. 2 interactions.
STRINGi9606.ENSP00000432743.

PTM databases

iPTMnetiQ9HCN2.
PhosphoSiteiQ9HCN2.

Polymorphism and mutation databases

BioMutaiTP53AIP1.

Proteomic databases

PaxDbiQ9HCN2.
PRIDEiQ9HCN2.

Protocols and materials databases

DNASUi63970.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000458238; ENSP00000390694; ENSG00000120471. [Q9HCN2-2]
ENST00000527504; ENSP00000435175; ENSG00000120471. [Q9HCN2-3]
ENST00000530777; ENSP00000432908; ENSG00000120471. [Q9HCN2-4]
ENST00000531399; ENSP00000432743; ENSG00000120471. [Q9HCN2-1]
ENST00000602346; ENSP00000473353; ENSG00000120471. [Q9HCN2-3]
ENST00000621818; ENSP00000479350; ENSG00000120471. [Q9HCN2-2]
GeneIDi63970.
KEGGihsa:63970.
UCSCiuc001qex.5. human. [Q9HCN2-1]

Organism-specific databases

CTDi63970.
GeneCardsiTP53AIP1.
HGNCiHGNC:29984. TP53AIP1.
HPAiHPA044300.
MIMi605426. gene.
neXtProtiNX_Q9HCN2.
PharmGKBiPA164726680.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KC77. Eukaryota.
ENOG4110P9G. LUCA.
GeneTreeiENSGT00390000000643.
HOGENOMiHOG000154669.
InParanoidiQ9HCN2.
KOiK13773.
OMAiWSSATVW.
OrthoDBiEOG77M8QV.
PhylomeDBiQ9HCN2.

Enzyme and pathway databases

ReactomeiR-HSA-6803204. TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.

Miscellaneous databases

GeneWikiiP53AIP1.
GenomeRNAii63970.
PROiQ9HCN2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HCN2.
GenevisibleiQ9HCN2. HS.

Family and domain databases

InterProiIPR029284. TP53AIP1.
[Graphical view]
PfamiPF15338. TPIP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53."
    Oda K., Arakawa H., Tanaka T., Matsuda K., Tanikawa C., Mori T., Nishimori H., Tamai K., Tokino T., Nakamura Y., Taya Y.
    Cell 102:849-862(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
  2. Zhou G., Xiao W., Li H., Shen C., Zhong G., Yu R., Lin L., Yang S.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT VAL-7.

Entry informationi

Entry nameiTPIP1_HUMAN
AccessioniPrimary (citable) accession number: Q9HCN2
Secondary accession number(s): Q6NT40
, Q7Z6F7, Q9HCN0, Q9HCN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.