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Protein

E3 ubiquitin-protein ligase TRIM39

Gene

TRIM39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1.2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri29 – 70RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri102 – 143B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • ligase activity Source: UniProtKB-KW
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137398-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM39 (EC:6.3.2.-)
Alternative name(s):
RING finger protein 23
Testis-abundant finger protein
Tripartite motif-containing protein 39
Gene namesi
Name:TRIM39
Synonyms:RNF23, TFP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:10065. TRIM39.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: BHF-UCL
  • mitochondrion Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi56658.
OpenTargetsiENSG00000204599.
ENSG00000206495.
ENSG00000224994.
ENSG00000226437.
ENSG00000229929.
ENSG00000230308.
ENSG00000232839.
PharmGKBiPA35535.

Polymorphism and mutation databases

BioMutaiTRIM39.
DMDMi56405385.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562571 – 518E3 ubiquitin-protein ligase TRIM39Add BLAST518

Post-translational modificationi

Autoubiquitinated.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ9HCM9.
MaxQBiQ9HCM9.
PaxDbiQ9HCM9.
PeptideAtlasiQ9HCM9.
PRIDEiQ9HCM9.

PTM databases

iPTMnetiQ9HCM9.
PhosphoSitePlusiQ9HCM9.

Expressioni

Tissue specificityi

Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis.1 Publication

Gene expression databases

BgeeiENSG00000204599.
CleanExiHS_TRIM39.
ExpressionAtlasiQ9HCM9. baseline and differential.
GenevisibleiQ9HCM9. HS.

Organism-specific databases

HPAiHPA051120.

Interactioni

Subunit structurei

Interacts with MOAP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself6EBI-739510,EBI-739510
A8K2R33EBI-739510,EBI-9977437
CCNCP248633EBI-739510,EBI-395261
DC-UbPB2R8863EBI-739510,EBI-10175550
DCUN1D1Q96GG94EBI-739510,EBI-740086
DIP2AQ14689-63EBI-739510,EBI-10233719
EIF4A2Q142403EBI-739510,EBI-73473
EIF4A2Q14240-23EBI-739510,EBI-10232522
EPHB6O15197-23EBI-739510,EBI-10182490
LNX1Q8TBB13EBI-739510,EBI-739832
LXNQ9BS403EBI-739510,EBI-1044504
MED18Q9BUE03EBI-739510,EBI-394640
NCK1P163332EBI-739510,EBI-389883
POLIQ9UNA44EBI-739510,EBI-741774
PRPF3O433954EBI-739510,EBI-744322
PSMA6P609003EBI-739510,EBI-357793
PSMD9O002334EBI-739510,EBI-750973
RECKQ6P9E23EBI-739510,EBI-10253121
SMCO3A2RU483EBI-739510,EBI-10173195
TRIM17Q9Y5776EBI-739510,EBI-743894
TRIM21P194744EBI-739510,EBI-81290
TTC32Q5I0X73EBI-739510,EBI-8636434
UBAC1Q9BSL13EBI-739510,EBI-749370
UBE2D1P516686EBI-739510,EBI-743540
UBE2D3P610775EBI-739510,EBI-348268
UBE2D4Q9Y2X85EBI-739510,EBI-745527
UBE2E2Q96LR55EBI-739510,EBI-2129763
UBE2E3Q969T44EBI-739510,EBI-348496
UBE2KP610863EBI-739510,EBI-473850
UBTD1Q9HAC84EBI-739510,EBI-745871
UBXN1Q043233EBI-739510,EBI-1058647
UBXN6Q9BZV13EBI-739510,EBI-1993899
WDFY3Q8IZQ1-23EBI-739510,EBI-10264625
ZKSCAN4Q969J23EBI-739510,EBI-2818641
ZNF26P170313EBI-739510,EBI-2841331

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi121170. 79 interactors.
IntActiQ9HCM9. 53 interactors.
MINTiMINT-1433641.
STRINGi9606.ENSP00000365844.

Structurei

Secondary structure

1518
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 32Combined sources3
Helixi50 – 56Combined sources7
Turni108 – 110Combined sources3
Beta strandi116 – 121Combined sources6
Beta strandi123 – 125Combined sources3
Helixi127 – 130Combined sources4
Turni134 – 137Combined sources4
Beta strandi140 – 142Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DIDNMR-A104-143[»]
2DIFNMR-A104-143[»]
2ECJNMR-A19-69[»]
ProteinModelPortaliQ9HCM9.
SMRiQ9HCM9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9HCM9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini319 – 514B30.2/SPRYPROSITE-ProRule annotationAdd BLAST196

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili181 – 250Sequence analysisAdd BLAST70

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri29 – 70RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri102 – 143B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITFV. Eukaryota.
ENOG410YDPJ. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ9HCM9.
KOiK12015.
OMAiTICPRDH.
OrthoDBiEOG091G05W2.
PhylomeDBiQ9HCM9.
TreeFamiTF342569.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HCM9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAETSLLEAG ASAASTAAAL ENLQVEASCS VCLEYLKEPV IIECGHNFCK
60 70 80 90 100
ACITRWWEDL ERDFPCPVCR KTSRYRSLRP NRQLGSMVEI AKQLQAVKRK
110 120 130 140 150
IRDESLCPQH HEALSLFCYE DQEAVCLICA ISHTHRAHTV VPLDDATQEY
160 170 180 190 200
KEKLQKCLEP LEQKLQEITR CKSSEEKKPG ELKRLVESRR QQILREFEEL
210 220 230 240 250
HRRLDEEQQV LLSRLEEEEQ DILQRLRENA AHLGDKRRDL AHLAAEVEGK
260 270 280 290 300
CLQSGFEMLK DVKSTLEKNI PRKFGGSLST ICPRDHKALL GLVKEINRCE
310 320 330 340 350
KVKTMEVTSV SIELEKNFSN FPRQYFALRK ILKQLIADVT LDPETAHPNL
360 370 380 390 400
VLSEDRKSVK FVETRLRDLP DTPRRFTFYP CVLATEGFTS GRHYWEVEVG
410 420 430 440 450
DKTHWAVGVC RDSVSRKGEL TPLPETGYWR VRLWNGDKYA ATTTPFTPLH
460 470 480 490 500
IKVKPKRVGI FLDYEAGTLS FYNVTDRSHI YTFTDTFTEK LWPLFYPGIR
510
AGRKNAAPLT IRPPTDWE
Length:518
Mass (Da):59,690
Last modified:December 7, 2004 - v2
Checksum:i2F946F518B217153
GO
Isoform 2 (identifier: Q9HCM9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-298: Missing.

Show »
Length:488
Mass (Da):56,374
Checksum:i102AA8E5C8786A3E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137A → P in BAB16374 (PubMed:11006080).Curated1
Sequence conflicti419E → K in BAD13703 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005755269 – 298Missing in isoform 2. 2 PublicationsAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046381 mRNA. Translation: BAB16374.1.
BT007370 mRNA. Translation: AAP36034.1.
AB110937 Genomic DNA. Translation: BAD13703.1.
AK292512 mRNA. Translation: BAF85201.1.
AB110938 Genomic DNA. Translation: BAD13704.1.
AB202089 Genomic DNA. Translation: BAE78608.1.
AL662832 Genomic DNA. Translation: CAI17501.1.
AL662795 Genomic DNA. Translation: CAI18251.1.
AL773535 Genomic DNA. Translation: CAI41818.1.
AL773535 Genomic DNA. Translation: CAI41819.1.
BX248580 Genomic DNA. Translation: CAM25899.1.
BX248580 Genomic DNA. Translation: CAM25900.1.
CR759928 Genomic DNA. Translation: CAQ08313.1.
CR759928 Genomic DNA. Translation: CAQ08314.1.
BX927214 Genomic DNA. Translation: CAQ08383.1.
BX927214 Genomic DNA. Translation: CAQ08384.1.
CR759281 Genomic DNA. Translation: CAQ09020.1.
CR759281 Genomic DNA. Translation: CAQ09021.1.
CH471081 Genomic DNA. Translation: EAX03283.1.
CH471081 Genomic DNA. Translation: EAX03284.1.
BC007661 mRNA. Translation: AAH07661.1.
BC034985 mRNA. Translation: AAH34985.1.
CCDSiCCDS34377.1. [Q9HCM9-1]
CCDS34378.1. [Q9HCM9-2]
PIRiJC7387.
RefSeqiNP_067076.2. NM_021253.3. [Q9HCM9-1]
NP_742013.1. NM_172016.2. [Q9HCM9-2]
UniGeneiHs.413493.

Genome annotation databases

EnsembliENST00000376656; ENSP00000365844; ENSG00000204599. [Q9HCM9-1]
ENST00000376659; ENSP00000365847; ENSG00000204599. [Q9HCM9-2]
ENST00000383601; ENSP00000373095; ENSG00000206495. [Q9HCM9-2]
ENST00000383602; ENSP00000373096; ENSG00000206495. [Q9HCM9-1]
ENST00000383603; ENSP00000373097; ENSG00000206495. [Q9HCM9-2]
ENST00000396547; ENSP00000379796; ENSG00000204599. [Q9HCM9-1]
ENST00000396548; ENSP00000379797; ENSG00000204599. [Q9HCM9-2]
ENST00000396551; ENSP00000379800; ENSG00000204599. [Q9HCM9-2]
ENST00000400644; ENSP00000383486; ENSG00000206495. [Q9HCM9-2]
ENST00000413715; ENSP00000411949; ENSG00000224994. [Q9HCM9-1]
ENST00000414015; ENSP00000401071; ENSG00000224994. [Q9HCM9-2]
ENST00000419790; ENSP00000401184; ENSG00000229929. [Q9HCM9-2]
ENST00000424575; ENSP00000409902; ENSG00000230308. [Q9HCM9-1]
ENST00000426469; ENSP00000397043; ENSG00000229929. [Q9HCM9-1]
ENST00000430502; ENSP00000398956; ENSG00000232839. [Q9HCM9-2]
ENST00000431272; ENSP00000396986; ENSG00000230308. [Q9HCM9-2]
ENST00000433900; ENSP00000389852; ENSG00000232839. [Q9HCM9-2]
ENST00000438076; ENSP00000389198; ENSG00000232839. [Q9HCM9-2]
ENST00000438859; ENSP00000411582; ENSG00000226437. [Q9HCM9-2]
ENST00000440117; ENSP00000392130; ENSG00000224994. [Q9HCM9-2]
ENST00000443109; ENSP00000414525; ENSG00000229929. [Q9HCM9-2]
ENST00000445206; ENSP00000391917; ENSG00000226437. [Q9HCM9-1]
ENST00000446397; ENSP00000412743; ENSG00000230308. [Q9HCM9-2]
ENST00000449318; ENSP00000404904; ENSG00000224994. [Q9HCM9-2]
ENST00000450778; ENSP00000387445; ENSG00000226437. [Q9HCM9-2]
ENST00000451132; ENSP00000394353; ENSG00000226437. [Q9HCM9-2]
ENST00000451715; ENSP00000398355; ENSG00000232839. [Q9HCM9-1]
ENST00000452705; ENSP00000415259; ENSG00000229929. [Q9HCM9-2]
ENST00000458607; ENSP00000404340; ENSG00000230308. [Q9HCM9-2]
ENST00000547030; ENSP00000449847; ENSG00000224994. [Q9HCM9-1]
ENST00000548002; ENSP00000447835; ENSG00000232839. [Q9HCM9-1]
ENST00000549841; ENSP00000448572; ENSG00000230308. [Q9HCM9-1]
ENST00000550282; ENSP00000449272; ENSG00000206495. [Q9HCM9-1]
ENST00000552337; ENSP00000450288; ENSG00000226437. [Q9HCM9-1]
ENST00000552520; ENSP00000448462; ENSG00000229929. [Q9HCM9-1]
GeneIDi56658.
KEGGihsa:56658.
UCSCiuc003nqb.4. human. [Q9HCM9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046381 mRNA. Translation: BAB16374.1.
BT007370 mRNA. Translation: AAP36034.1.
AB110937 Genomic DNA. Translation: BAD13703.1.
AK292512 mRNA. Translation: BAF85201.1.
AB110938 Genomic DNA. Translation: BAD13704.1.
AB202089 Genomic DNA. Translation: BAE78608.1.
AL662832 Genomic DNA. Translation: CAI17501.1.
AL662795 Genomic DNA. Translation: CAI18251.1.
AL773535 Genomic DNA. Translation: CAI41818.1.
AL773535 Genomic DNA. Translation: CAI41819.1.
BX248580 Genomic DNA. Translation: CAM25899.1.
BX248580 Genomic DNA. Translation: CAM25900.1.
CR759928 Genomic DNA. Translation: CAQ08313.1.
CR759928 Genomic DNA. Translation: CAQ08314.1.
BX927214 Genomic DNA. Translation: CAQ08383.1.
BX927214 Genomic DNA. Translation: CAQ08384.1.
CR759281 Genomic DNA. Translation: CAQ09020.1.
CR759281 Genomic DNA. Translation: CAQ09021.1.
CH471081 Genomic DNA. Translation: EAX03283.1.
CH471081 Genomic DNA. Translation: EAX03284.1.
BC007661 mRNA. Translation: AAH07661.1.
BC034985 mRNA. Translation: AAH34985.1.
CCDSiCCDS34377.1. [Q9HCM9-1]
CCDS34378.1. [Q9HCM9-2]
PIRiJC7387.
RefSeqiNP_067076.2. NM_021253.3. [Q9HCM9-1]
NP_742013.1. NM_172016.2. [Q9HCM9-2]
UniGeneiHs.413493.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DIDNMR-A104-143[»]
2DIFNMR-A104-143[»]
2ECJNMR-A19-69[»]
ProteinModelPortaliQ9HCM9.
SMRiQ9HCM9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121170. 79 interactors.
IntActiQ9HCM9. 53 interactors.
MINTiMINT-1433641.
STRINGi9606.ENSP00000365844.

PTM databases

iPTMnetiQ9HCM9.
PhosphoSitePlusiQ9HCM9.

Polymorphism and mutation databases

BioMutaiTRIM39.
DMDMi56405385.

Proteomic databases

EPDiQ9HCM9.
MaxQBiQ9HCM9.
PaxDbiQ9HCM9.
PeptideAtlasiQ9HCM9.
PRIDEiQ9HCM9.

Protocols and materials databases

DNASUi56658.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376656; ENSP00000365844; ENSG00000204599. [Q9HCM9-1]
ENST00000376659; ENSP00000365847; ENSG00000204599. [Q9HCM9-2]
ENST00000383601; ENSP00000373095; ENSG00000206495. [Q9HCM9-2]
ENST00000383602; ENSP00000373096; ENSG00000206495. [Q9HCM9-1]
ENST00000383603; ENSP00000373097; ENSG00000206495. [Q9HCM9-2]
ENST00000396547; ENSP00000379796; ENSG00000204599. [Q9HCM9-1]
ENST00000396548; ENSP00000379797; ENSG00000204599. [Q9HCM9-2]
ENST00000396551; ENSP00000379800; ENSG00000204599. [Q9HCM9-2]
ENST00000400644; ENSP00000383486; ENSG00000206495. [Q9HCM9-2]
ENST00000413715; ENSP00000411949; ENSG00000224994. [Q9HCM9-1]
ENST00000414015; ENSP00000401071; ENSG00000224994. [Q9HCM9-2]
ENST00000419790; ENSP00000401184; ENSG00000229929. [Q9HCM9-2]
ENST00000424575; ENSP00000409902; ENSG00000230308. [Q9HCM9-1]
ENST00000426469; ENSP00000397043; ENSG00000229929. [Q9HCM9-1]
ENST00000430502; ENSP00000398956; ENSG00000232839. [Q9HCM9-2]
ENST00000431272; ENSP00000396986; ENSG00000230308. [Q9HCM9-2]
ENST00000433900; ENSP00000389852; ENSG00000232839. [Q9HCM9-2]
ENST00000438076; ENSP00000389198; ENSG00000232839. [Q9HCM9-2]
ENST00000438859; ENSP00000411582; ENSG00000226437. [Q9HCM9-2]
ENST00000440117; ENSP00000392130; ENSG00000224994. [Q9HCM9-2]
ENST00000443109; ENSP00000414525; ENSG00000229929. [Q9HCM9-2]
ENST00000445206; ENSP00000391917; ENSG00000226437. [Q9HCM9-1]
ENST00000446397; ENSP00000412743; ENSG00000230308. [Q9HCM9-2]
ENST00000449318; ENSP00000404904; ENSG00000224994. [Q9HCM9-2]
ENST00000450778; ENSP00000387445; ENSG00000226437. [Q9HCM9-2]
ENST00000451132; ENSP00000394353; ENSG00000226437. [Q9HCM9-2]
ENST00000451715; ENSP00000398355; ENSG00000232839. [Q9HCM9-1]
ENST00000452705; ENSP00000415259; ENSG00000229929. [Q9HCM9-2]
ENST00000458607; ENSP00000404340; ENSG00000230308. [Q9HCM9-2]
ENST00000547030; ENSP00000449847; ENSG00000224994. [Q9HCM9-1]
ENST00000548002; ENSP00000447835; ENSG00000232839. [Q9HCM9-1]
ENST00000549841; ENSP00000448572; ENSG00000230308. [Q9HCM9-1]
ENST00000550282; ENSP00000449272; ENSG00000206495. [Q9HCM9-1]
ENST00000552337; ENSP00000450288; ENSG00000226437. [Q9HCM9-1]
ENST00000552520; ENSP00000448462; ENSG00000229929. [Q9HCM9-1]
GeneIDi56658.
KEGGihsa:56658.
UCSCiuc003nqb.4. human. [Q9HCM9-1]

Organism-specific databases

CTDi56658.
DisGeNETi56658.
GeneCardsiTRIM39.
HGNCiHGNC:10065. TRIM39.
HPAiHPA051120.
MIMi605700. gene.
neXtProtiNX_Q9HCM9.
OpenTargetsiENSG00000204599.
ENSG00000206495.
ENSG00000224994.
ENSG00000226437.
ENSG00000229929.
ENSG00000230308.
ENSG00000232839.
PharmGKBiPA35535.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITFV. Eukaryota.
ENOG410YDPJ. LUCA.
GeneTreeiENSGT00760000118893.
HOGENOMiHOG000234133.
HOVERGENiHBG001357.
InParanoidiQ9HCM9.
KOiK12015.
OMAiTICPRDH.
OrthoDBiEOG091G05W2.
PhylomeDBiQ9HCM9.
TreeFamiTF342569.

Enzyme and pathway databases

UniPathwayiUPA00143.
BioCyciZFISH:ENSG00000137398-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiTRIM39. human.
EvolutionaryTraceiQ9HCM9.
GenomeRNAii56658.
PROiQ9HCM9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204599.
CleanExiHS_TRIM39.
ExpressionAtlasiQ9HCM9. baseline and differential.
GenevisibleiQ9HCM9. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI39_HUMAN
AccessioniPrimary (citable) accession number: Q9HCM9
Secondary accession number(s): Q5STG3
, Q5STG4, Q76BL3, Q8IYT9, Q96IB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: December 7, 2004
Last modified: November 30, 2016
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.