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Protein

Fibrosin-1-like protein

Gene

FBRSL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrosin-1-like protein
Alternative name(s):
AUTS2-like protein
HBV X-transactivated gene 9 protein
HBV XAg-transactivated protein 9
Gene namesi
Name:FBRSL1
Synonyms:AUTS2L, KIAA1545, XTP9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29308. FBRSL1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164720011.

Polymorphism and mutation databases

BioMutaiFBRSL1.
DMDMi317373568.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10451045Fibrosin-1-like proteinPRO_0000321962Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei340 – 3401PhosphoserineCombined sources
Modified residuei790 – 7901PhosphoserineCombined sources
Modified residuei937 – 9371PhosphoserineCombined sources
Modified residuei977 – 9771PhosphoserineCombined sources
Modified residuei989 – 9891PhosphothreonineCombined sources
Modified residuei1010 – 10101PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9HCM7.
MaxQBiQ9HCM7.
PaxDbiQ9HCM7.
PeptideAtlasiQ9HCM7.
PRIDEiQ9HCM7.

PTM databases

iPTMnetiQ9HCM7.
PhosphoSiteiQ9HCM7.

Expressioni

Gene expression databases

BgeeiQ9HCM7.
GenevisibleiQ9HCM7. HS.

Organism-specific databases

HPAiHPA049880.

Interactioni

Protein-protein interaction databases

BioGridi121699. 8 interactions.
IntActiQ9HCM7. 2 interactions.
STRINGi9606.ENSP00000396160.

Structurei

3D structure databases

ProteinModelPortaliQ9HCM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi263 – 517255Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the AUTS2 family.Curated

Phylogenomic databases

eggNOGiENOG410IGMF. Eukaryota.
ENOG4111MEB. LUCA.
GeneTreeiENSGT00390000001466.
HOGENOMiHOG000034234.
InParanoidiQ9HCM7.
OMAiHDYNHEN.
PhylomeDBiQ9HCM7.
TreeFamiTF331929.

Family and domain databases

InterProiIPR023246. AUTS2.
[Graphical view]
PRINTSiPR02044. FIBROSIN1LPF.

Sequencei

Sequence statusi: Complete.

Q9HCM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAKVRPSRR SRAQRDRGRR REAARDARAQ SPSSGDEPEP SPGKENAGLR
60 70 80 90 100
GAPPRGAAPA PRTARPPRRR RRESSSQEEE VIDGFAIASF STLEALEKDM
110 120 130 140 150
ALKPHERKEK WERRLIKKPR ESETCPPAEP SENRRPLEAG SPGQDLEPAC
160 170 180 190 200
DGARKVPLQP SKQMKVTVSK GGDRDSDDDS VLEATSSRDP LSDSSAHAVS
210 220 230 240 250
GRGYSCDSES GPDDKASVGS EKLFAPGTDK GPALEKSEAK AGPVPKVSGL
260 270 280 290 300
ERSRELSAES FLPTASPAPH AAPCPGPPPG SRANPLVKKE PPAPHRHTPQ
310 320 330 340 350
PPPPQPRGLL PTHVPASLGA FAGHSQAAAN GLHGLSRSSS APLGLGKHVS
360 370 380 390 400
LSPHGPGPHL STSHLALRSQ AQHQLHAAMF AAPPTLPPPP ALPASSLVLP
410 420 430 440 450
GHPADHELLR QELNTRFLVQ SAERPGASLG PGALLRAEFH QHQHTHQHTH
460 470 480 490 500
QHTHQHQHTF APFPAGLPPT PPAAPPPFDK YAPKLDSPYF RHSSVSFFPS
510 520 530 540 550
FPPAIPGLPT LLPHPGPFGS LQGAFQPKVS DPYRAVVKVS TCWEGPWQGR
560 570 580 590 600
TLVPPGRPRG ARDSRSLQKT WVGVAPAPLS ASILSQKPGR WCAVHVQIAW
610 620 630 640 650
QIYRHQQKIK EMQLDPHKLE VGAKLDLFGR PPAPGVFAGF HYPQDLARPL
660 670 680 690 700
FPSTGAAHPA SNPFGPSAHP GSFLPTGPLT DPFSRPSTFG GLGSLSSHAF
710 720 730 740 750
GGLGSHALAP GGSIFAPKEG SSVHGLPSPH EAWNRLHRAP PSFPAPPPWP
760 770 780 790 800
KSVDAERVSA LTNHDREPDN GKEEQERDLL EKTRLLSRAS PATPAGHPVS
810 820 830 840 850
GLLLRAQSEL GRSGAPAERE AEPRVKESRS PAKEEAAKMP ARASPPHSKA
860 870 880 890 900
APGDVKVKEE RGEDEASEPP AGGLHPAPLQ LGLGRERLGA PGFAWEPFRG
910 920 930 940 950
LELPRRAFPA AAPAPGSAAL LEPPERPYRD REPHGYSPER LRGELERARA
960 970 980 990 1000
PHLPPAAPAL DGALLPSLGA LHFPRLSPAA LHNGLLARTP PAAAALGAPP
1010 1020 1030 1040
PLVTAAGPPT PPGPPRSRTT PLGGLGPGEA RDYSPSRNPP EVEAR
Length:1,045
Mass (Da):110,907
Last modified:January 11, 2011 - v4
Checksum:i2339F7EC7A0E7899
GO

Sequence cautioni

The sequence EAW54843.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti836 – 8361A → V in BAB13371 (PubMed:10997877).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti367 – 3671L → P.
Corresponds to variant rs3751315 [ dbSNP | Ensembl ].
VAR_039390

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079031 Genomic DNA. No translation available.
AC131212 Genomic DNA. No translation available.
CH471218 Genomic DNA. Translation: EAW54843.1. Sequence problems.
AB046765 mRNA. Translation: BAB13371.2.
AF490258 mRNA. Translation: AAO85466.1.
CCDSiCCDS45010.1.
RefSeqiNP_001136113.1. NM_001142641.1.
UniGeneiHs.411138.
Hs.656668.

Genome annotation databases

EnsembliENST00000434748; ENSP00000396160; ENSG00000112787.
GeneIDi57666.
KEGGihsa:57666.
UCSCiuc001ukf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079031 Genomic DNA. No translation available.
AC131212 Genomic DNA. No translation available.
CH471218 Genomic DNA. Translation: EAW54843.1. Sequence problems.
AB046765 mRNA. Translation: BAB13371.2.
AF490258 mRNA. Translation: AAO85466.1.
CCDSiCCDS45010.1.
RefSeqiNP_001136113.1. NM_001142641.1.
UniGeneiHs.411138.
Hs.656668.

3D structure databases

ProteinModelPortaliQ9HCM7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121699. 8 interactions.
IntActiQ9HCM7. 2 interactions.
STRINGi9606.ENSP00000396160.

PTM databases

iPTMnetiQ9HCM7.
PhosphoSiteiQ9HCM7.

Polymorphism and mutation databases

BioMutaiFBRSL1.
DMDMi317373568.

Proteomic databases

EPDiQ9HCM7.
MaxQBiQ9HCM7.
PaxDbiQ9HCM7.
PeptideAtlasiQ9HCM7.
PRIDEiQ9HCM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000434748; ENSP00000396160; ENSG00000112787.
GeneIDi57666.
KEGGihsa:57666.
UCSCiuc001ukf.4. human.

Organism-specific databases

CTDi57666.
GeneCardsiFBRSL1.
HGNCiHGNC:29308. FBRSL1.
HPAiHPA049880.
neXtProtiNX_Q9HCM7.
PharmGKBiPA164720011.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGMF. Eukaryota.
ENOG4111MEB. LUCA.
GeneTreeiENSGT00390000001466.
HOGENOMiHOG000034234.
InParanoidiQ9HCM7.
OMAiHDYNHEN.
PhylomeDBiQ9HCM7.
TreeFamiTF331929.

Miscellaneous databases

ChiTaRSiFBRSL1. human.
GenomeRNAii57666.
PROiQ9HCM7.

Gene expression databases

BgeeiQ9HCM7.
GenevisibleiQ9HCM7. HS.

Family and domain databases

InterProiIPR023246. AUTS2.
[Graphical view]
PRINTSiPR02044. FIBROSIN1LPF.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 78-1045.
    Tissue: Brain.
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  5. "Cloning and identification of human gene 9 transactivated by hepatitis B virus X antigen."
    Liu Y., Cheng J., Lu Y., Wang G., Zhang L., Chen J., Li L.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 379-1045.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-989 AND THR-1010, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-937, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-340; SER-790; SER-937; SER-977 AND THR-1010, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.

Entry informationi

Entry nameiFBSL_HUMAN
AccessioniPrimary (citable) accession number: Q9HCM7
Secondary accession number(s): Q86XQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 11, 2011
Last modified: July 6, 2016
This is version 91 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.