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Protein

Fibrosin-1-like protein

Gene

FBRSL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrosin-1-like protein
Alternative name(s):
AUTS2-like protein
HBV X-transactivated gene 9 protein
HBV XAg-transactivated protein 9
Gene namesi
Name:FBRSL1
Synonyms:AUTS2L, KIAA1545, XTP9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000112787.12
HGNCiHGNC:29308 FBRSL1
neXtProtiNX_Q9HCM7

Pathology & Biotechi

Organism-specific databases

DisGeNETi57666
OpenTargetsiENSG00000112787
PharmGKBiPA164720011

Polymorphism and mutation databases

BioMutaiFBRSL1
DMDMi317373568

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003219621 – 1045Fibrosin-1-like proteinAdd BLAST1045

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei340PhosphoserineCombined sources1
Modified residuei790PhosphoserineCombined sources1
Cross-linki858Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei937PhosphoserineCombined sources1
Modified residuei977PhosphoserineCombined sources1
Modified residuei989PhosphothreonineCombined sources1
Modified residuei1010PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9HCM7
MaxQBiQ9HCM7
PaxDbiQ9HCM7
PeptideAtlasiQ9HCM7
PRIDEiQ9HCM7

PTM databases

iPTMnetiQ9HCM7
PhosphoSitePlusiQ9HCM7

Expressioni

Gene expression databases

BgeeiENSG00000112787
ExpressionAtlasiQ9HCM7 baseline and differential
GenevisibleiQ9HCM7 HS

Organism-specific databases

HPAiHPA049880

Interactioni

Protein-protein interaction databases

BioGridi121699, 11 interactors
IntActiQ9HCM7, 11 interactors
STRINGi9606.ENSP00000396160

Structurei

3D structure databases

ProteinModelPortaliQ9HCM7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi263 – 517Pro-richAdd BLAST255

Sequence similaritiesi

Belongs to the AUTS2 family.Curated

Phylogenomic databases

eggNOGiENOG410IGMF Eukaryota
ENOG4111MEB LUCA
GeneTreeiENSGT00390000001466
HOGENOMiHOG000034234
InParanoidiQ9HCM7
OMAiHDYNHEN
OrthoDBiEOG091G01SH
PhylomeDBiQ9HCM7
TreeFamiTF331929

Family and domain databases

InterProiView protein in InterPro
IPR023246 AUTS2
PANTHERiPTHR14429 PTHR14429, 1 hit
PfamiView protein in Pfam
PF15336 Auts2, 1 hit
PRINTSiPR02044 FIBROSIN1LPF

Sequencei

Sequence statusi: Complete.

Q9HCM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAKVRPSRR SRAQRDRGRR REAARDARAQ SPSSGDEPEP SPGKENAGLR
60 70 80 90 100
GAPPRGAAPA PRTARPPRRR RRESSSQEEE VIDGFAIASF STLEALEKDM
110 120 130 140 150
ALKPHERKEK WERRLIKKPR ESETCPPAEP SENRRPLEAG SPGQDLEPAC
160 170 180 190 200
DGARKVPLQP SKQMKVTVSK GGDRDSDDDS VLEATSSRDP LSDSSAHAVS
210 220 230 240 250
GRGYSCDSES GPDDKASVGS EKLFAPGTDK GPALEKSEAK AGPVPKVSGL
260 270 280 290 300
ERSRELSAES FLPTASPAPH AAPCPGPPPG SRANPLVKKE PPAPHRHTPQ
310 320 330 340 350
PPPPQPRGLL PTHVPASLGA FAGHSQAAAN GLHGLSRSSS APLGLGKHVS
360 370 380 390 400
LSPHGPGPHL STSHLALRSQ AQHQLHAAMF AAPPTLPPPP ALPASSLVLP
410 420 430 440 450
GHPADHELLR QELNTRFLVQ SAERPGASLG PGALLRAEFH QHQHTHQHTH
460 470 480 490 500
QHTHQHQHTF APFPAGLPPT PPAAPPPFDK YAPKLDSPYF RHSSVSFFPS
510 520 530 540 550
FPPAIPGLPT LLPHPGPFGS LQGAFQPKVS DPYRAVVKVS TCWEGPWQGR
560 570 580 590 600
TLVPPGRPRG ARDSRSLQKT WVGVAPAPLS ASILSQKPGR WCAVHVQIAW
610 620 630 640 650
QIYRHQQKIK EMQLDPHKLE VGAKLDLFGR PPAPGVFAGF HYPQDLARPL
660 670 680 690 700
FPSTGAAHPA SNPFGPSAHP GSFLPTGPLT DPFSRPSTFG GLGSLSSHAF
710 720 730 740 750
GGLGSHALAP GGSIFAPKEG SSVHGLPSPH EAWNRLHRAP PSFPAPPPWP
760 770 780 790 800
KSVDAERVSA LTNHDREPDN GKEEQERDLL EKTRLLSRAS PATPAGHPVS
810 820 830 840 850
GLLLRAQSEL GRSGAPAERE AEPRVKESRS PAKEEAAKMP ARASPPHSKA
860 870 880 890 900
APGDVKVKEE RGEDEASEPP AGGLHPAPLQ LGLGRERLGA PGFAWEPFRG
910 920 930 940 950
LELPRRAFPA AAPAPGSAAL LEPPERPYRD REPHGYSPER LRGELERARA
960 970 980 990 1000
PHLPPAAPAL DGALLPSLGA LHFPRLSPAA LHNGLLARTP PAAAALGAPP
1010 1020 1030 1040
PLVTAAGPPT PPGPPRSRTT PLGGLGPGEA RDYSPSRNPP EVEAR
Length:1,045
Mass (Da):110,907
Last modified:January 11, 2011 - v4
Checksum:i2339F7EC7A0E7899
GO

Sequence cautioni

The sequence EAW54843 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti836A → V in BAB13371 (PubMed:10997877).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039390367L → P. Corresponds to variant dbSNP:rs3751315Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079031 Genomic DNA No translation available.
AC131212 Genomic DNA No translation available.
CH471218 Genomic DNA Translation: EAW54843.1 Sequence problems.
AB046765 mRNA Translation: BAB13371.2
AF490258 mRNA Translation: AAO85466.1
CCDSiCCDS45010.1
RefSeqiNP_001136113.1, NM_001142641.1
UniGeneiHs.411138
Hs.656668
Hs.661809

Genome annotation databases

EnsembliENST00000434748; ENSP00000396160; ENSG00000112787
GeneIDi57666
KEGGihsa:57666
UCSCiuc001ukf.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFBSL_HUMAN
AccessioniPrimary (citable) accession number: Q9HCM7
Secondary accession number(s): Q86XQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 11, 2011
Last modified: March 28, 2018
This is version 102 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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