Q9HCM3 (K1549_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UPF0606 protein KIAA1549

Gene names

Name:

KIAA1549

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1950 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Involvement in disease	A chromosomal aberration involving KIAA1549 is found in pilocytic astrocytoma. A tandem duplication of 2 Mb at 7q34 leads to the expression of a KIAA1549-BRAF fusion protein with a constitutive kinase activity and inducing cell transformation. Ref.1
Sequence similarities	Belongs to the UPF0606 family.
Sequence caution	The sequence AAH38232.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative promoter usage Alternative splicing Chromosomal rearrangement Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative promoter usage and alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9HCM3-1)

Also known as: v2 long-form;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9HCM3-2)

Also known as: v1 long-form;

The sequence of this isoform differs from the canonical sequence as follows:
     1867-1882: Missing.

Isoform 3 (identifier: Q9HCM3-3)

Also known as: v1 short-form;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1216: Missing.
     1217-1222: AGNSVV → MVSAIF
     1867-1882: Missing.

Note: Produced by alternative promoter usage.

Isoform 4 (identifier: Q9HCM3-4)

Also known as: v2 short-form;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1216: Missing.
     1217-1222: AGNSVV → MVSAIF

Note: Produced by alternative promoter usage.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1950	1950	UPF0606 protein KIAA1549		PRO_0000342405
Regions
	Transmembrane	998 – 1018	21	Helical; Potential
	Transmembrane	1299 – 1319	21	Helical; Potential
	Compositional bias	494 – 764	271	Ser-rich
Sites
	Site	1643 – 1644	2	Breakpoint for translocation to form KIAA1549-BRAF fusion protein
	Site	1749 – 1750	2	Breakpoint for translocation to form KIAA1549-BRAF fusion protein
Amino acid modifications
	Modified residue	1395	1	Phosphoserine Ref.6
	Modified residue	1584	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 1216	1216	Missing in isoform 3 and isoform 4.		VSP_040885
	Alternative sequence	1217 – 1222	6	AGNSVV → MVSAIF in isoform 3 and isoform 4.		VSP_040886
	Alternative sequence	1867 – 1882	16	Missing in isoform 2 and isoform 3.		VSP_034448
	Natural variant	448	1	A → P. Corresponds to variant rs2718131 [ dbSNP | Ensembl ].		VAR_044187
	Natural variant	652	1	P → L. Ref.3 Corresponds to variant rs2774960 [ dbSNP | Ensembl ].		VAR_057812
	Natural variant	851	1	V → G. Corresponds to variant rs2354336 [ dbSNP | Ensembl ].		VAR_044188
Experimental info
	Sequence conflict	486	1	P → A in BAB13375. Ref.3
	Sequence conflict	617	1	R → G in BAB13375. Ref.3
	Sequence conflict	849	1	S → L in BAB13375. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (v2 long-form) [UniParc]. Last modified April 5, 2011. Version 4. Checksum: 3F7FD3A94CE4EE93	FASTA	1,950	210,755
	10 20 30 40 50 60 MPGARRRRRG AAMEGKPRAG VALAPGPSGR RPSARCARRR RPGLLLPGLW LLLLARPASC 70 80 90 100 110 120 APDELSPEQH NLSLYSMELV LKKSTGHSAA QVALTETAPG SQHSSPLHVT APPSATTFDT 130 140 150 160 170 180 AFFNQGKQTK STADPSIFVA TYVSVTSKEV AVNDDEMDNF LPDTHWTTPR MVSPIQYITV 190 200 210 220 230 240 SPPGLPREAL EPMLTPSLPM VSLQDEEVTS GWQNTTRQPA AYAESASHFH TFRSAFRTSE 250 260 270 280 290 300 GIVPTPGRNL VLYPTDAYSH LSSRTLPEIV ASLTEGVETT LFLSSRSLMP QPLGDGITIP 310 320 330 340 350 360 LPSLGEVSQP PEEVWATSAD RYTDVTTVLS QSLEETISPR TYPTVTASHA ALAFSRTHSP 370 380 390 400 410 420 LLSTPLAFAS SASPTDVSSN PFLPSDSSKT SELHSNSALP GPVDNTHILS PVSSFRPYTW 430 440 450 460 470 480 CAACTVPSPQ QVLATSLMEK DVGSGDGAET LCMTVLEESS ISLMSSVVAD FSEFEEDPQV 490 500 510 520 530 540 FNTLFPSRPI VPLSSRSMEI SETSVGISAE VDMSSVTTTQ VPPAHGRLSV PASLDPTAGS 550 560 570 580 590 600 LSVAETQVTP SSVTTAFFSV ITSILLDSSF SVIANKNTPS LAVRDPSVFT PYSLVPSVES 610 620 630 640 650 660 SLFSDQERSS FSEHKPRGAL DFASSFFSTP PLELSGSISS PSEAPASLSL MPSDLSPFTS 670 680 690 700 710 720 QSFSPLVETF TLFDSSDLQS SQLSLPSSTN LEFSQLQPSS ELPLNTIMLL PSRSEVSPWS 730 740 750 760 770 780 SFPSDSLEFV EASTVSLTDS EAHFTSAFIE TTSYLESSLI SHESAVTALV PPGSESFDIL 790 800 810 820 830 840 TAGIQATSPL TTVHTTPILT ESSLFSTLTP PDDQISALDG HVSVLASFSK AIPTGTVLIT 850 860 870 880 890 900 DAYLPSGSSF VSEATPFPLP TELTVVGPSL TPTEVPLNTS TEVSTTSTGA ATGGPLDSTL 910 920 930 940 950 960 MGDAASQSPP ESSAAPPLPS LRPVTAFTLE ATVDTPTLAT AKPPYVCDIT VPDAYLITTV 970 980 990 1000 1010 1020 LARRAVQEYI ITAIKEVLRI HFNRAVELKV YELFTDFTFL VTSGPFVYTA ISVINVLINS 1030 1040 1050 1060 1070 1080 KLVRDQTPLI LSVKPSFLVP ESRFQVQTVL QFVPPSVDTG FCNFTQRIEK GLMTALFEVR 1090 1100 1110 1120 1130 1140 KHHQGTYNLT VQILNITISS SRVTPRRGPV NIIFAVKSTQ GFLNGSEVSE LLRNLSVVEF 1150 1160 1170 1180 1190 1200 SFYLGYPVLQ IAEPFQYPQL NLSQLLKSSW VRTVLLGVME KQLQNEVFQA EMERKLAQLL 1210 1220 1230 1240 1250 1260 SEVSTRRRMW RRATVAAGNS VVQVVNVSRL EGDDNPVQLI YFVEDQDGER LSAVKSSDLI 1270 1280 1290 1300 1310 1320 NKMDLQRAAI ILGYRIQGVI AQPVDRVKRP SPESQSNNLW VIVGVVIPVL VVMVIVVILY 1330 1340 1350 1360 1370 1380 WKLCRTDKLD FQPDTVANIQ QRQKLQIPSV KGFDFAKQHL GQHNKDDILI IHEPAPLPGP 1390 1400 1410 1420 1430 1440 LKDHTTPSEN GDVPSPKSKI PSKNVRHRGR VSPSDADSTV SEESSERDAG DKTPGAVNDG 1450 1460 1470 1480 1490 1500 RSHRAPQSGP PLPSSGNEQH SSASIFEHVD RISRPPEASR RVPSKIQLIA MQPIPAPPVQ 1510 1520 1530 1540 1550 1560 RPSPADRVAE SNKINKEIQT ALRHKSEIEH HRNKIRLRAK RRGHYEFPVV DDLSSGDTKE 1570 1580 1590 1600 1610 1620 RHRVYRRAQM QIDKILDPTA SVPSVFIEPR KSSRIKRSPK PRRKHQVNGC PADAEKDRLI 1630 1640 1650 1660 1670 1680 TTDSDGTYRR PPGVHNSAYI GCPSDPDLPA DVQTPSSVEL GRYPALPFPA SQYIPPQPSI 1690 1700 1710 1720 1730 1740 EEARQTMHSL LDDAFALVAP SSQPASTAGV GPGVPPGLPA NSTPSQEERR ATQWGSFYSP 1750 1760 1770 1780 1790 1800 AQTANNPCSR YEDYGMTPPT GPLPRPGFGP GLLQSTELVP PDPQQPQASA EAPFAARGIY 1810 1820 1830 1840 1850 1860 SEEMPSVARP RPVGGTTGSQ IQHLTQVGIA SRIGAQPVEI PPSRGSQYGG PGWPSYGEDE 1870 1880 1890 1900 1910 1920 AGRREATHML GHQEYSSSPL FQVPRTSGRE PSAPSGNLPH RGLQGPGLGY PTSSTEDLQP 1930 1940 1950 GHSSASLIKA IREELLRLSQ KQSTVQNFHS
	Isoform 2 (v1 long-form) [UniParc]. Checksum: 9BF63EB0F22D2BFB	FASTA	1,934	208,911
	10 20 30 40 50 60 MPGARRRRRG AAMEGKPRAG VALAPGPSGR RPSARCARRR RPGLLLPGLW LLLLARPASC 70 80 90 100 110 120 APDELSPEQH NLSLYSMELV LKKSTGHSAA QVALTETAPG SQHSSPLHVT APPSATTFDT 130 140 150 160 170 180 AFFNQGKQTK STADPSIFVA TYVSVTSKEV AVNDDEMDNF LPDTHWTTPR MVSPIQYITV 190 200 210 220 230 240 SPPGLPREAL EPMLTPSLPM VSLQDEEVTS GWQNTTRQPA AYAESASHFH TFRSAFRTSE 250 260 270 280 290 300 GIVPTPGRNL VLYPTDAYSH LSSRTLPEIV ASLTEGVETT LFLSSRSLMP QPLGDGITIP 310 320 330 340 350 360 LPSLGEVSQP PEEVWATSAD RYTDVTTVLS QSLEETISPR TYPTVTASHA ALAFSRTHSP 370 380 390 400 410 420 LLSTPLAFAS SASPTDVSSN PFLPSDSSKT SELHSNSALP GPVDNTHILS PVSSFRPYTW 430 440 450 460 470 480 CAACTVPSPQ QVLATSLMEK DVGSGDGAET LCMTVLEESS ISLMSSVVAD FSEFEEDPQV 490 500 510 520 530 540 FNTLFPSRPI VPLSSRSMEI SETSVGISAE VDMSSVTTTQ VPPAHGRLSV PASLDPTAGS 550 560 570 580 590 600 LSVAETQVTP SSVTTAFFSV ITSILLDSSF SVIANKNTPS LAVRDPSVFT PYSLVPSVES 610 620 630 640 650 660 SLFSDQERSS FSEHKPRGAL DFASSFFSTP PLELSGSISS PSEAPASLSL MPSDLSPFTS 670 680 690 700 710 720 QSFSPLVETF TLFDSSDLQS SQLSLPSSTN LEFSQLQPSS ELPLNTIMLL PSRSEVSPWS 730 740 750 760 770 780 SFPSDSLEFV EASTVSLTDS EAHFTSAFIE TTSYLESSLI SHESAVTALV PPGSESFDIL 790 800 810 820 830 840 TAGIQATSPL TTVHTTPILT ESSLFSTLTP PDDQISALDG HVSVLASFSK AIPTGTVLIT 850 860 870 880 890 900 DAYLPSGSSF VSEATPFPLP TELTVVGPSL TPTEVPLNTS TEVSTTSTGA ATGGPLDSTL 910 920 930 940 950 960 MGDAASQSPP ESSAAPPLPS LRPVTAFTLE ATVDTPTLAT AKPPYVCDIT VPDAYLITTV 970 980 990 1000 1010 1020 LARRAVQEYI ITAIKEVLRI HFNRAVELKV YELFTDFTFL VTSGPFVYTA ISVINVLINS 1030 1040 1050 1060 1070 1080 KLVRDQTPLI LSVKPSFLVP ESRFQVQTVL QFVPPSVDTG FCNFTQRIEK GLMTALFEVR 1090 1100 1110 1120 1130 1140 KHHQGTYNLT VQILNITISS SRVTPRRGPV NIIFAVKSTQ GFLNGSEVSE LLRNLSVVEF 1150 1160 1170 1180 1190 1200 SFYLGYPVLQ IAEPFQYPQL NLSQLLKSSW VRTVLLGVME KQLQNEVFQA EMERKLAQLL 1210 1220 1230 1240 1250 1260 SEVSTRRRMW RRATVAAGNS VVQVVNVSRL EGDDNPVQLI YFVEDQDGER LSAVKSSDLI 1270 1280 1290 1300 1310 1320 NKMDLQRAAI ILGYRIQGVI AQPVDRVKRP SPESQSNNLW VIVGVVIPVL VVMVIVVILY 1330 1340 1350 1360 1370 1380 WKLCRTDKLD FQPDTVANIQ QRQKLQIPSV KGFDFAKQHL GQHNKDDILI IHEPAPLPGP 1390 1400 1410 1420 1430 1440 LKDHTTPSEN GDVPSPKSKI PSKNVRHRGR VSPSDADSTV SEESSERDAG DKTPGAVNDG 1450 1460 1470 1480 1490 1500 RSHRAPQSGP PLPSSGNEQH SSASIFEHVD RISRPPEASR RVPSKIQLIA MQPIPAPPVQ 1510 1520 1530 1540 1550 1560 RPSPADRVAE SNKINKEIQT ALRHKSEIEH HRNKIRLRAK RRGHYEFPVV DDLSSGDTKE 1570 1580 1590 1600 1610 1620 RHRVYRRAQM QIDKILDPTA SVPSVFIEPR KSSRIKRSPK PRRKHQVNGC PADAEKDRLI 1630 1640 1650 1660 1670 1680 TTDSDGTYRR PPGVHNSAYI GCPSDPDLPA DVQTPSSVEL GRYPALPFPA SQYIPPQPSI 1690 1700 1710 1720 1730 1740 EEARQTMHSL LDDAFALVAP SSQPASTAGV GPGVPPGLPA NSTPSQEERR ATQWGSFYSP 1750 1760 1770 1780 1790 1800 AQTANNPCSR YEDYGMTPPT GPLPRPGFGP GLLQSTELVP PDPQQPQASA EAPFAARGIY 1810 1820 1830 1840 1850 1860 SEEMPSVARP RPVGGTTGSQ IQHLTQVGIA SRIGAQPVEI PPSRGSQYGG PGWPSYGEDE 1870 1880 1890 1900 1910 1920 AGRREAVPRT SGREPSAPSG NLPHRGLQGP GLGYPTSSTE DLQPGHSSAS LIKAIREELL 1930 RLSQKQSTVQ NFHS
	Isoform 3 (v1 short-form) [UniParc]. Checksum: 3D303D67C703FA9D	FASTA	718	78,291
	10 20 30 40 50 60 MVSAIFQVVN VSRLEGDDNP VQLIYFVEDQ DGERLSAVKS SDLINKMDLQ RAAIILGYRI 70 80 90 100 110 120 QGVIAQPVDR VKRPSPESQS NNLWVIVGVV IPVLVVMVIV VILYWKLCRT DKLDFQPDTV 130 140 150 160 170 180 ANIQQRQKLQ IPSVKGFDFA KQHLGQHNKD DILIIHEPAP LPGPLKDHTT PSENGDVPSP 190 200 210 220 230 240 KSKIPSKNVR HRGRVSPSDA DSTVSEESSE RDAGDKTPGA VNDGRSHRAP QSGPPLPSSG 250 260 270 280 290 300 NEQHSSASIF EHVDRISRPP EASRRVPSKI QLIAMQPIPA PPVQRPSPAD RVAESNKINK 310 320 330 340 350 360 EIQTALRHKS EIEHHRNKIR LRAKRRGHYE FPVVDDLSSG DTKERHRVYR RAQMQIDKIL 370 380 390 400 410 420 DPTASVPSVF IEPRKSSRIK RSPKPRRKHQ VNGCPADAEK DRLITTDSDG TYRRPPGVHN 430 440 450 460 470 480 SAYIGCPSDP DLPADVQTPS SVELGRYPAL PFPASQYIPP QPSIEEARQT MHSLLDDAFA 490 500 510 520 530 540 LVAPSSQPAS TAGVGPGVPP GLPANSTPSQ EERRATQWGS FYSPAQTANN PCSRYEDYGM 550 560 570 580 590 600 TPPTGPLPRP GFGPGLLQST ELVPPDPQQP QASAEAPFAA RGIYSEEMPS VARPRPVGGT 610 620 630 640 650 660 TGSQIQHLTQ VGIASRIGAQ PVEIPPSRGS QYGGPGWPSY GEDEAGRREA VPRTSGREPS 670 680 690 700 710 APSGNLPHRG LQGPGLGYPT SSTEDLQPGH SSASLIKAIR EELLRLSQKQ STVQNFHS
	Isoform 4 (v2 short-form) [UniParc]. Checksum: FB158E873F601E38	FASTA	734	80,135
	10 20 30 40 50 60 MVSAIFQVVN VSRLEGDDNP VQLIYFVEDQ DGERLSAVKS SDLINKMDLQ RAAIILGYRI 70 80 90 100 110 120 QGVIAQPVDR VKRPSPESQS NNLWVIVGVV IPVLVVMVIV VILYWKLCRT DKLDFQPDTV 130 140 150 160 170 180 ANIQQRQKLQ IPSVKGFDFA KQHLGQHNKD DILIIHEPAP LPGPLKDHTT PSENGDVPSP 190 200 210 220 230 240 KSKIPSKNVR HRGRVSPSDA DSTVSEESSE RDAGDKTPGA VNDGRSHRAP QSGPPLPSSG 250 260 270 280 290 300 NEQHSSASIF EHVDRISRPP EASRRVPSKI QLIAMQPIPA PPVQRPSPAD RVAESNKINK 310 320 330 340 350 360 EIQTALRHKS EIEHHRNKIR LRAKRRGHYE FPVVDDLSSG DTKERHRVYR RAQMQIDKIL 370 380 390 400 410 420 DPTASVPSVF IEPRKSSRIK RSPKPRRKHQ VNGCPADAEK DRLITTDSDG TYRRPPGVHN 430 440 450 460 470 480 SAYIGCPSDP DLPADVQTPS SVELGRYPAL PFPASQYIPP QPSIEEARQT MHSLLDDAFA 490 500 510 520 530 540 LVAPSSQPAS TAGVGPGVPP GLPANSTPSQ EERRATQWGS FYSPAQTANN PCSRYEDYGM 550 560 570 580 590 600 TPPTGPLPRP GFGPGLLQST ELVPPDPQQP QASAEAPFAA RGIYSEEMPS VARPRPVGGT 610 620 630 640 650 660 TGSQIQHLTQ VGIASRIGAQ PVEIPPSRGS QYGGPGWPSY GEDEAGRREA THMLGHQEYS 670 680 690 700 710 720 SSPLFQVPRT SGREPSAPSG NLPHRGLQGP GLGYPTSSTE DLQPGHSSAS LIKAIREELL 730 RLSQKQSTVQ NFHS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas." Jones D.T.W., Kocialkowski S., Liu L., Pearson D.M., Backlund L.M., Ichimura K., Collins V.P. Cancer Res. 68:8673-8677(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3 AND 4), DISEASE, CHROMOSOMAL REARRANGEMENT. Tissue: Brain.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-1950 (ISOFORM 2), VARIANT LEU-652. Tissue: Brain.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1128-1950 (ISOFORM 1). Tissue: Brain and Duodenum.
[5]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1811-1950 (ISOFORM 2). Tissue: Testis.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1395, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM989467 Genomic DNA. Translation: CAQ43105.1. AM989467 Genomic DNA. Translation: CAQ43106.1. AM989468 mRNA. Translation: CAQ43107.1. AM989469 mRNA. Translation: CAQ43108.1. AM989470 mRNA. Translation: CAQ43109.1. AM989471 mRNA. Translation: CAQ43110.1. AM989472 mRNA. Translation: CAQ43111.1. Different termination. AM989473 mRNA. Translation: CAQ43112.1. Different termination. AM989474 mRNA. Translation: CAQ43113.1. Different termination. AM989475 mRNA. Translation: CAQ43114.1. Different termination. AM989476 mRNA. Translation: CAQ43115.1. Different termination. AM989477 mRNA. Translation: CAQ43116.1. Different termination. AC018663 Genomic DNA. No translation available. AC083868 Genomic DNA. No translation available. AC093144 Genomic DNA. No translation available. AB046769 mRNA. Translation: BAB13375.2. BC038232 mRNA. Translation: AAH38232.1. Different initiation. BC091523 mRNA. Translation: AAH91523.1. AL136736 mRNA. Translation: CAB66670.2.
IPI	IPI00896475. IPI00926338. IPI01008832. IPI01009059.
RefSeq	NP_001158137.1. NM_001164665.1. NP_065961.2. NM_020910.2.
UniGene	Hs.605380.
3D structure databases
ProteinModelPortal	Q9HCM3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9HCM3. 9 interactions.
STRING	9606.ENSP00000242365.
PTM databases
PhosphoSite	Q9HCM3.
Polymorphism databases
DMDM	193806180.
Proteomic databases
PaxDb	Q9HCM3.
PRIDE	Q9HCM3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000422774; ENSP00000416040; ENSG00000122778. ENST00000440172; ENSP00000406661; ENSG00000122778.
GeneID	57670.
KEGG	hsa:57670.
UCSC	uc011kqi.2. human. uc011kqj.2. human. uc011kqk.2. human. uc011kql.2. human.
Organism-specific databases
CTD	57670.
GeneCards	GC07M138516.
HGNC	HGNC:22219. KIAA1549.
HPA	HPA019560.
MIM	613344. gene.
neXtProt	NX_Q9HCM3.
PharmGKB	PA162393138.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG70685.
HOVERGEN	HBG108038.
InParanoid	Q9HCM3.
OMA	MWRRATV.
OrthoDB	EOG4GMTW2.
Gene expression databases
Bgee	Q9HCM3.
CleanEx	HS_KIAA1549.
Genevestigator	Q9HCM3.
Family and domain databases
InterPro	IPR024606. DUF3827. [Graphical view]
PANTHER	PTHR21590. PTHR21590. 1 hit.
Pfam	PF12877. DUF3827. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	57670.
NextBio	2776.
SOURCE	Search...

Entry information

Entry name

K1549_HUMAN

Accession

Primary (citable) accession number: Q9HCM3
Secondary accession number(s): B6HY55 , B6HY56, B6HY58, B6HY60, B6HY61, B6HY62, B6HY63, B6HY64, B6HY65, B6HY66, Q5BJD6, Q8IY15, Q9H0M3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 70 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.