Q9HCM2 (PLXA4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Plexin-A4

Gene names

Name:	PLXNA4
Synonyms:	KIAA1550, PLXNA4A, PLXNA4B
ORF Names:	UNQ2820/PRO34003

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1894 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm By similarity.
Subunit structure	Interacts with NRP1 and NRP2 By similarity.
Subcellular location	Cell membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the plexin family. Contains 4 IPT/TIG domains. Contains 3 PSI domains. Contains 1 Sema domain.
Sequence caution	The sequence AAQ89209.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Acetylation Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior commissure morphogenesis Inferred from electronic annotation. Source: Compara axon guidance Traceable author statement. Source: Reactome chemorepulsion of branchiomotor axon Inferred from electronic annotation. Source: Compara facial nerve morphogenesis Inferred from electronic annotation. Source: Compara glossopharyngeal nerve morphogenesis Inferred from electronic annotation. Source: Compara postganglionic parasympathetic nervous system development Inferred from electronic annotation. Source: Compara regulation of axon extension involved in axon guidance Inferred from electronic annotation. Source: Compara regulation of negative chemotaxis Inferred from electronic annotation. Source: Compara semaphorin-plexin signaling pathway Non-traceable author statement PubMed 19909241. Source: BHF-UCL sympathetic nervous system development Inferred from electronic annotation. Source: Compara trigeminal nerve morphogenesis Inferred from electronic annotation. Source: Compara vagus nerve morphogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intracellular Inferred from electronic annotation. Source: InterPro plasma membrane Traceable author statement. Source: Reactome semaphorin receptor complex Traceable author statement PubMed 19909241. Source: BHF-UCL
Molecular_function	semaphorin receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9HCM2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9HCM2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     458-492: IRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHE → MPGTSLCPTLELQTGPRSHRATVTLELLFSSCSSN
     493-1894: Missing.

Isoform 3 (identifier: Q9HCM2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     458-522: IRVDGPRGNA...YQSCGECLGS → SFGTGPQGGI...CFLNVPGNSS
     523-1894: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9HCM2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1550: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 23

23

Potential

Chain

24 – 1894

1871

Plexin-A4

PRO_0000240283

Regions

Topological domain

24 – 1237

1214

Extracellular Potential

Transmembrane

1238 – 1258

21

Helical; Potential

Topological domain

1259 – 1894

636

Cytoplasmic Potential

Domain

24 – 507

484

Sema

Domain

509 – 559

51

PSI 1

Domain

655 – 702

48

PSI 2

Domain

803 – 856

54

PSI 3

Domain

858 – 952

95

IPT/TIG 1

Domain

954 – 1037

84

IPT/TIG 2

Domain

1040 – 1139

100

IPT/TIG 3

Domain

1142 – 1230

89

IPT/TIG 4

Amino acid modifications

Modified residue

1350

1

N6-acetyllysine Ref.8

Glycosylation

655

1

N-linked (GlcNAc...) Potential

Glycosylation

1007

1

N-linked (GlcNAc...) Potential

Glycosylation

1132

1

N-linked (GlcNAc...) Potential

Glycosylation

1180

1

N-linked (GlcNAc...) Potential

Disulfide bond

95 ↔ 104

By similarity

Disulfide bond

130 ↔ 138

By similarity

Disulfide bond

284 ↔ 405

By similarity

Disulfide bond

300 ↔ 356

By similarity

Disulfide bond

374 ↔ 393

By similarity

Disulfide bond

510 ↔ 527

By similarity

Disulfide bond

516 ↔ 558

By similarity

Disulfide bond

519 ↔ 536

By similarity

Disulfide bond

530 ↔ 542

By similarity

Disulfide bond

593 ↔ 612

By similarity

Natural variations

Alternative sequence

1 – 1550

1550

Missing in isoform 4.

VSP_019334

Alternative sequence

458 – 522

65

IRVDG…ECLGS → SFGTGPQGGITQEWIGVAGD PPGANIASQEQMLCVYLQCS SHKAISDQRVQPLLCCFLNV PGNSS in isoform 3.

VSP_019330

Alternative sequence

458 – 492

35

IRVDG…SKDHE → MPGTSLCPTLELQTGPRSHR ATVTLELLFSSCSSN in isoform 2.

VSP_019331

Alternative sequence

493 – 1894

1402

Missing in isoform 2.

VSP_019332

Alternative sequence

523 – 1894

1372

Missing in isoform 3.

VSP_019333

Experimental info

Sequence conflict

1750

1

N → D in CAD39161. Ref.5

Sequence conflict

1804

1

I → V in CAD39161. Ref.5

Isoform 2:

Sequence conflict

458

1

M → V in BAC85615. Ref.1

Sequence conflict

458

1

M → V in AAQ89209. Ref.4

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1894

Helix Strand Turn

Details...

Beta strand

1499 – 1504

6

Beta strand

1515 – 1520

6

Helix

1525 – 1536

12

Turn

1537 – 1539

3

Helix

1542 – 1544

3

Helix

1548 – 1550

3

Beta strand

1551 – 1556

6

Beta strand

1562 – 1565

4

Beta strand

1567 – 1569

3

Helix

1584 – 1587

4

Beta strand

1594 – 1599

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 13, 2006. Version 4. Checksum: 7B45C8929C5847DF	FASTA	1,894	212,455
	10 20 30 40 50 60 MKAMPWNWTC LLSHLLMVGM GSSTLLTRQP APLSQKQRSF VTFRGEPAEG FNHLVVDERT 70 80 90 100 110 120 GHIYLGAVNR IYKLSSDLKV LVTHETGPDE DNPKCYPPRI VQTCNEPLTT TNNVNKMLLI 130 140 150 160 170 180 DYKENRLIAC GSLYQGICKL LRLEDLFKLG EPYHKKEHYL SGVNESGSVF GVIVSYSNLD 190 200 210 220 230 240 DKLFIATAVD GKPEYFPTIS SRKLTKNSEA DGMFAYVFHD EFVASMIKIP SDTFTIIPDF 250 260 270 280 290 300 DIYYVYGFSS GNFVYFLTLQ PEMVSPPGST TKEQVYTSKL VRLCKEDTAF NSYVEVPIGC 310 320 330 340 350 360 ERSGVEYRLL QAAYLSKAGA VLGRTLGVHP DDDLLFTVFS KGQKRKMKSL DESALCIFIL 370 380 390 400 410 420 KQINDRIKER LQSCYRGEGT LDLAWLKVKD IPCSSALLTI DDNFCGLDMN APLGVSDMVR 430 440 450 460 470 480 GIPVFTEDRD RMTSVIAYVY KNHSLAFVGT KSGKLKKIRV DGPRGNALQY ETVQVVDPGP 490 500 510 520 530 540 VLRDMAFSKD HEQLYIMSER QLTRVPVESC GQYQSCGECL GSGDPHCGWC VLHNTCTRKE 550 560 570 580 590 600 RCERSKEPRR FASEMKQCVR LTVHPNNISV SQYNVLLVLE TYNVPELSAG VNCTFEDLSE 610 620 630 640 650 660 MDGLVVGNQI QCYSPAAKEV PRIITENGDH HVVQLQLKSK ETGMTFASTS FVFYNCSVHN 670 680 690 700 710 720 SCLSCVESPY RCHWCKYRHV CTHDPKTCSF QEGRVKLPED CPQLLRVDKI LVPVEVIKPI 730 740 750 760 770 780 TLKAKNLPQP QSGQRGYECI LNIQGSEQRV PALRFNSSSV QCQNTSYSYE GMEINNLPVE 790 800 810 820 830 840 LTVVWNGHFN IDNPAQNKVH LYKCGAMRES CGLCLKADPD FACGWCQGPG QCTLRQHCPA 850 860 870 880 890 900 QESQWLELSG AKSKCTNPRI TEIIPVTGPR EGGTKVTIRG ENLGLEFRDI ASHVKVAGVE 910 920 930 940 950 960 CSPLVDGYIP AEQIVCEMGE AKPSQHAGFV EICVAVCRPE FMARSSQLYY FMTLTLSDLK 970 980 990 1000 1010 1020 PSRGPMSGGT QVTITGTNLN AGSNVVVMFG KQPCLFHRRS PSYIVCNTTS SDEVLEMKVS 1030 1040 1050 1060 1070 1080 VQVDRAKIHQ DLVFQYVEDP TIVRIEPEWS IVSGNTPIAV WGTHLDLIQN PQIRAKHGGK 1090 1100 1110 1120 1130 1140 EHINICEVLN ATEMTCQAPA LALGPDHQSD LTERPEEFGF ILDNVQSLLI LNKTNFTYYP 1150 1160 1170 1180 1190 1200 NPVFEAFGPS GILELKPGTP IILKGKNLIP PVAGGNVKLN YTVLVGEKPC TVTVSDVQLL 1210 1220 1230 1240 1250 1260 CESPNLIGRH KVMARVGGME YSPGMVYIAP DSPLSLPAIV SIAVAGGLLI IFIVAVLIAY 1270 1280 1290 1300 1310 1320 KRKSRESDLT LKRLQMQMDN LESRVALECK EAFAELQTDI HELTSDLDGA GIPFLDYRTY 1330 1340 1350 1360 1370 1380 TMRVLFPGIE DHPVLRDLEV PGYRQERVEK GLKLFAQLIN NKVFLLSFIR TLESQRSFSM 1390 1400 1410 1420 1430 1440 RDRGNVASLI MTVLQSKLEY ATDVLKQLLA DLIDKNLESK NHPKLLLRRT ESVAEKMLTN 1450 1460 1470 1480 1490 1500 WFTFLLYKFL KECAGEPLFS LFCAIKQQME KGPIDAITGE ARYSLSEDKL IRQQIDYKTL 1510 1520 1530 1540 1550 1560 VLSCVSPDNA NSPEVPVKIL NCDTITQVKE KILDAIFKNV PCSHRPKAAD MDLEWRQGSG 1570 1580 1590 1600 1610 1620 ARMILQDEDI TTKIENDWKR LNTLAHYQVP DGSVVALVSK QVTAYNAVNN STVSRTSASK 1630 1640 1650 1660 1670 1680 YENMIRYTGS PDSLRSRTPM ITPDLESGVK MWHLVKNHEH GDQKEGDRGS KMVSEIYLTR 1690 1700 1710 1720 1730 1740 LLATKGTLQK FVDDLFETIF STAHRGSALP LAIKYMFDFL DEQADKHGIH DPHVRHTWKS 1750 1760 1770 1780 1790 1800 NCLPLRFWVN MIKNPQFVFD IHKNSITDAC LSVVAQTFMD SCSTSEHRLG KDSPSNKLLY 1810 1820 1830 1840 1850 1860 AKDIPSYKNW VERYYSDIGK MPAISDQDMN AYLAEQSRMH MNEFNTMSAL SEIFSYVGKY 1870 1880 1890 SEEILGPLDH DDQCGKQKLA YKLEQVITLM SLDS
	Isoform 2 [UniParc]. Checksum: EA48649E41364BCA	FASTA	492	55,034
	10 20 30 40 50 60 MKAMPWNWTC LLSHLLMVGM GSSTLLTRQP APLSQKQRSF VTFRGEPAEG FNHLVVDERT 70 80 90 100 110 120 GHIYLGAVNR IYKLSSDLKV LVTHETGPDE DNPKCYPPRI VQTCNEPLTT TNNVNKMLLI 130 140 150 160 170 180 DYKENRLIAC GSLYQGICKL LRLEDLFKLG EPYHKKEHYL SGVNESGSVF GVIVSYSNLD 190 200 210 220 230 240 DKLFIATAVD GKPEYFPTIS SRKLTKNSEA DGMFAYVFHD EFVASMIKIP SDTFTIIPDF 250 260 270 280 290 300 DIYYVYGFSS GNFVYFLTLQ PEMVSPPGST TKEQVYTSKL VRLCKEDTAF NSYVEVPIGC 310 320 330 340 350 360 ERSGVEYRLL QAAYLSKAGA VLGRTLGVHP DDDLLFTVFS KGQKRKMKSL DESALCIFIL 370 380 390 400 410 420 KQINDRIKER LQSCYRGEGT LDLAWLKVKD IPCSSALLTI DDNFCGLDMN APLGVSDMVR 430 440 450 460 470 480 GIPVFTEDRD RMTSVIAYVY KNHSLAFVGT KSGKLKKMPG TSLCPTLELQ TGPRSHRATV 490 TLELLFSSCS SN
	Isoform 3 [UniParc]. Checksum: B4EE93A47088FE4E	FASTA	522	58,107
	10 20 30 40 50 60 MKAMPWNWTC LLSHLLMVGM GSSTLLTRQP APLSQKQRSF VTFRGEPAEG FNHLVVDERT 70 80 90 100 110 120 GHIYLGAVNR IYKLSSDLKV LVTHETGPDE DNPKCYPPRI VQTCNEPLTT TNNVNKMLLI 130 140 150 160 170 180 DYKENRLIAC GSLYQGICKL LRLEDLFKLG EPYHKKEHYL SGVNESGSVF GVIVSYSNLD 190 200 210 220 230 240 DKLFIATAVD GKPEYFPTIS SRKLTKNSEA DGMFAYVFHD EFVASMIKIP SDTFTIIPDF 250 260 270 280 290 300 DIYYVYGFSS GNFVYFLTLQ PEMVSPPGST TKEQVYTSKL VRLCKEDTAF NSYVEVPIGC 310 320 330 340 350 360 ERSGVEYRLL QAAYLSKAGA VLGRTLGVHP DDDLLFTVFS KGQKRKMKSL DESALCIFIL 370 380 390 400 410 420 KQINDRIKER LQSCYRGEGT LDLAWLKVKD IPCSSALLTI DDNFCGLDMN APLGVSDMVR 430 440 450 460 470 480 GIPVFTEDRD RMTSVIAYVY KNHSLAFVGT KSGKLKKSFG TGPQGGITQE WIGVAGDPPG 490 500 510 520 ANIASQEQML CVYLQCSSHK AISDQRVQPL LCCFLNVPGN SS
	Isoform 4 [UniParc]. Checksum: 500F224FA6A400E8	FASTA	344	39,312
	10 20 30 40 50 60 MDLEWRQGSG ARMILQDEDI TTKIENDWKR LNTLAHYQVP DGSVVALVSK QVTAYNAVNN 70 80 90 100 110 120 STVSRTSASK YENMIRYTGS PDSLRSRTPM ITPDLESGVK MWHLVKNHEH GDQKEGDRGS 130 140 150 160 170 180 KMVSEIYLTR LLATKGTLQK FVDDLFETIF STAHRGSALP LAIKYMFDFL DEQADKHGIH 190 200 210 220 230 240 DPHVRHTWKS NCLPLRFWVN MIKNPQFVFD IHKNSITDAC LSVVAQTFMD SCSTSEHRLG 250 260 270 280 290 300 KDSPSNKLLY AKDIPSYKNW VERYYSDIGK MPAISDQDMN AYLAEQSRMH MNEFNTMSAL 310 320 330 340 SEIFSYVGKY SEEILGPLDH DDQCGKQKLA YKLEQVITLM SLDS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4). Tissue: Brain and Hippocampus.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Testis.
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 194-1894 (ISOFORM 2).
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 206-1894 (ISOFORM 3), PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Kidney and Testis.
[6]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 433-1894 (ISOFORM 1). Tissue: Brain.
[7]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[8]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1350, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK095606 mRNA. Translation: BAC04587.1.
AK123428 mRNA. Translation: BAC85615.1.
AC009364 Genomic DNA. No translation available.
AC009365 Genomic DNA. No translation available.
AC009785 Genomic DNA. No translation available.
AC011625 Genomic DNA. No translation available.
AC018643 Genomic DNA. No translation available.
AC026239 Genomic DNA. No translation available.
BC028744 mRNA. Translation: AAH28744.1.
AY358850 mRNA. Translation: AAQ89209.1. Different initiation.
AL137352 mRNA. Translation: CAB70707.1.
AL834504 mRNA. Translation: CAD39161.3.
AB046770 mRNA. Translation: BAB13376.3.

IPI

IPI00165931.
IPI00446588.
IPI00748846.
IPI00759587.

PIR

T46426.

RefSeq

NP_001099013.1. NM_001105543.1.
NP_065962.1. NM_020911.1.
NP_861440.2. NM_181775.3.

UniGene

Hs.511454.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4E74	X-ray	1.58	A	1488-1603	[»]

ProteinModelPortal

Q9HCM2.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000323194.

PTM databases

PhosphoSite

Q9HCM2.

Polymorphism databases

DMDM

108860890.

Proteomic databases

PaxDb

Q9HCM2.

PRIDE

Q9HCM2.

Protocols and materials databases

DNASU

91584.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000321063; ENSP00000323194; ENSG00000221866.
ENST00000359827; ENSP00000352882; ENSG00000221866.
ENST00000423507; ENSP00000392772; ENSG00000221866.

GeneID

91584.

KEGG

hsa:91584.

UCSC

uc003vqz.4. human.
uc003vra.4. human.

Organism-specific databases

CTD

91584.

GeneCards

GC07M131720.

H-InvDB

HIX0007090.

HGNC

HGNC:9102. PLXNA4.

HPA

HPA029919.

MIM

604280. gene.

neXtProt

NX_Q9HCM2.

PharmGKB

PA162399757.
PA33428.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG254546.

HOVERGEN

HBG105711.

InParanoid

Q9HCM2.

OMA

LEWRQGS.

OrthoDB

EOG4N30N0.

Enzyme and pathway databases

Reactome

REACT_111045. Developmental Biology.

Gene expression databases

ArrayExpress

Q9HCM2.

Bgee

Q9HCM2.

CleanEx

HS_PLXNA4.

Genevestigator

Q9HCM2.

GermOnline

ENSG00000189437. Homo sapiens.

Family and domain databases

Gene3D

2.130.10.10. 1 hit.
2.60.40.10. 4 hits.

InterPro

IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT_TIG_rcpt.
IPR003659. Plexin-like.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semaphorin/CD100_Ag.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]

Pfam

PF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 3 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 4 hits.
[Graphical view]

SMART

SM00429. IPT. 4 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]

SUPFAM

SSF81296. Ig_E-set. 4 hits.
SSF103575. Plexin-like_fold. 2 hits.
SSF48350. Rho_GAP. 1 hit.
SSF101912. Sema. 1 hit.

PROSITE

PS51004. SEMA. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

PLXNA4. human.

GenomeRNAi

91584.

NextBio

77311.

SOURCE

Search...

Entry information

Entry name

PLXA4_HUMAN

Accession

Primary (citable) accession number: Q9HCM2
Secondary accession number(s): E9PAM2 , Q6UWC6, Q6ZW89, Q8N969, Q8ND00, Q8NEN3, Q9NTD4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	June 13, 2006
Last modified:	May 1, 2013
This is version 97 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.