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Protein

Zinc finger protein 14 homolog

Gene

ZFP14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 14 homolog
Short name:
Zfp-14
Alternative name(s):
Zinc finger protein 531
Gene namesi
Name:ZFP14
Synonyms:KIAA1559, ZNF531
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000142065.13
HGNCiHGNC:29312 ZFP14
neXtProtiNX_Q9HCL3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000142065
PharmGKBiPA145147576

Polymorphism and mutation databases

BioMutaiZFP14
DMDMi20140808

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472851 – 533Zinc finger protein 14 homologAdd BLAST533

Proteomic databases

EPDiQ9HCL3
MaxQBiQ9HCL3
PaxDbiQ9HCL3
PeptideAtlasiQ9HCL3
PRIDEiQ9HCL3

PTM databases

iPTMnetiQ9HCL3
PhosphoSitePlusiQ9HCL3

Expressioni

Gene expression databases

BgeeiENSG00000142065
CleanExiHS_ZFP14
ExpressionAtlasiQ9HCL3 baseline and differential
GenevisibleiQ9HCL3 HS

Organism-specific databases

HPAiHPA030637

Interactioni

Protein-protein interaction databases

BioGridi121706, 1 interactor
IntActiQ9HCL3, 3 interactors
STRINGi9606.ENSP00000270001

Structurei

3D structure databases

ProteinModelPortaliQ9HCL3
SMRiQ9HCL3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 78KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9HCL3
KOiK09228
OMAiYKRHNFL
OrthoDBiEOG091G02KC
PhylomeDBiQ9HCL3
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequencei

Sequence statusi: Complete.

Q9HCL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHGSVTFRD VAIDFSQEEW EFLDPAQRDL YRDVMWENYS NFISLGPSIS
60 70 80 90 100
KPDVITLLDE ERKEPGMVVR EGTRRYCPDL ESRYRTNTLS PEKDIYEIYS
110 120 130 140 150
FQWDIMERIK SYSLQGSIFR NDWECKSKIE GEKEQQEGYF GQVKITSEKM
160 170 180 190 200
TTYKRHNFLT EYQIVHNGEK VYECKECRKT FIRRSTLSQH LRIHTGEKPY
210 220 230 240 250
KCKECGQAFR QRAHLIRHHK LHTGEKPYEC KECGKAFTVL QELTQHQRLH
260 270 280 290 300
TGEKPYECKE CGKAFRVHQQ LARHQRIHTG EKPYECKDCG KTFRQCTHLT
310 320 330 340 350
RHQRLHTAEK LYECKECGKA FVCGPDLRVH QKIHFGEKPY ECKECGKAFR
360 370 380 390 400
ICQQLTVHQS IHTGEKPYEC KECGKTFRLR QQLVRHQRIH TREKPYECME
410 420 430 440 450
CWKTFSSYSQ LISHQSIHIG ERPYECEECG KAFRLLSQLT QHQSIHTGEK
460 470 480 490 500
PYECKECRKP FRLLSQLTQH QSIHTGEKPY ECKECGKAFR LYSFLTQHQR
510 520 530
IHTGEKPYKC KECKKAFRQH SHLTQHQKIH NGI
Length:533
Mass (Da):63,463
Last modified:February 21, 2002 - v2
Checksum:iE40EF5EC22A99F10
GO

Sequence cautioni

The sequence BAB13385 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046779 mRNA Translation: BAB13385.1 Different initiation.
BC152446 mRNA Translation: AAI52447.1
CCDSiCCDS33002.1
RefSeqiNP_065968.1, NM_020917.2
XP_016882527.1, XM_017027038.1
UniGeneiHs.35524

Genome annotation databases

EnsembliENST00000270001; ENSP00000270001; ENSG00000142065
GeneIDi57677
KEGGihsa:57677
UCSCiuc010eex.3 human

Similar proteinsi

Entry informationi

Entry nameiZFP14_HUMAN
AccessioniPrimary (citable) accession number: Q9HCL3
Secondary accession number(s): A7MD23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: May 23, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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