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Protein

Zinc finger protein 14 homolog

Gene

ZFP14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri172 – 19423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri508 – 53023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 14 homolog
Short name:
Zfp-14
Alternative name(s):
Zinc finger protein 531
Gene namesi
Name:ZFP14
Synonyms:KIAA1559, ZNF531
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29312. ZFP14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145147576.

Polymorphism and mutation databases

BioMutaiZFP14.
DMDMi20140808.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533Zinc finger protein 14 homologPRO_0000047285Add
BLAST

Proteomic databases

PaxDbiQ9HCL3.
PRIDEiQ9HCL3.

PTM databases

iPTMnetiQ9HCL3.
PhosphoSiteiQ9HCL3.

Expressioni

Gene expression databases

BgeeiQ9HCL3.
CleanExiHS_ZFP14.
ExpressionAtlasiQ9HCL3. baseline and differential.
GenevisibleiQ9HCL3. HS.

Organism-specific databases

HPAiHPA030637.

Interactioni

Protein-protein interaction databases

BioGridi121706. 1 interaction.
IntActiQ9HCL3. 1 interaction.
STRINGi9606.ENSP00000270001.

Structurei

3D structure databases

ProteinModelPortaliQ9HCL3.
SMRiQ9HCL3. Positions 6-46, 152-532.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7873KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri172 – 19423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri508 – 53023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9HCL3.
OMAiQKIHNGI.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9HCL3.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9HCL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHGSVTFRD VAIDFSQEEW EFLDPAQRDL YRDVMWENYS NFISLGPSIS
60 70 80 90 100
KPDVITLLDE ERKEPGMVVR EGTRRYCPDL ESRYRTNTLS PEKDIYEIYS
110 120 130 140 150
FQWDIMERIK SYSLQGSIFR NDWECKSKIE GEKEQQEGYF GQVKITSEKM
160 170 180 190 200
TTYKRHNFLT EYQIVHNGEK VYECKECRKT FIRRSTLSQH LRIHTGEKPY
210 220 230 240 250
KCKECGQAFR QRAHLIRHHK LHTGEKPYEC KECGKAFTVL QELTQHQRLH
260 270 280 290 300
TGEKPYECKE CGKAFRVHQQ LARHQRIHTG EKPYECKDCG KTFRQCTHLT
310 320 330 340 350
RHQRLHTAEK LYECKECGKA FVCGPDLRVH QKIHFGEKPY ECKECGKAFR
360 370 380 390 400
ICQQLTVHQS IHTGEKPYEC KECGKTFRLR QQLVRHQRIH TREKPYECME
410 420 430 440 450
CWKTFSSYSQ LISHQSIHIG ERPYECEECG KAFRLLSQLT QHQSIHTGEK
460 470 480 490 500
PYECKECRKP FRLLSQLTQH QSIHTGEKPY ECKECGKAFR LYSFLTQHQR
510 520 530
IHTGEKPYKC KECKKAFRQH SHLTQHQKIH NGI
Length:533
Mass (Da):63,463
Last modified:February 21, 2002 - v2
Checksum:iE40EF5EC22A99F10
GO

Sequence cautioni

The sequence BAB13385.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046779 mRNA. Translation: BAB13385.1. Different initiation.
BC152446 mRNA. Translation: AAI52447.1.
CCDSiCCDS33002.1.
RefSeqiNP_065968.1. NM_020917.2.
UniGeneiHs.35524.

Genome annotation databases

EnsembliENST00000270001; ENSP00000270001; ENSG00000142065.
GeneIDi57677.
UCSCiuc010eex.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046779 mRNA. Translation: BAB13385.1. Different initiation.
BC152446 mRNA. Translation: AAI52447.1.
CCDSiCCDS33002.1.
RefSeqiNP_065968.1. NM_020917.2.
UniGeneiHs.35524.

3D structure databases

ProteinModelPortaliQ9HCL3.
SMRiQ9HCL3. Positions 6-46, 152-532.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121706. 1 interaction.
IntActiQ9HCL3. 1 interaction.
STRINGi9606.ENSP00000270001.

PTM databases

iPTMnetiQ9HCL3.
PhosphoSiteiQ9HCL3.

Polymorphism and mutation databases

BioMutaiZFP14.
DMDMi20140808.

Proteomic databases

PaxDbiQ9HCL3.
PRIDEiQ9HCL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270001; ENSP00000270001; ENSG00000142065.
GeneIDi57677.
UCSCiuc010eex.3. human.

Organism-specific databases

CTDi57677.
GeneCardsiZFP14.
HGNCiHGNC:29312. ZFP14.
HPAiHPA030637.
neXtProtiNX_Q9HCL3.
PharmGKBiPA145147576.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9HCL3.
OMAiQKIHNGI.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9HCL3.
TreeFamiTF341817.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZFP14. human.
GenomeRNAii57677.
NextBioi64482.
PROiQ9HCL3.

Gene expression databases

BgeeiQ9HCL3.
CleanExiHS_ZFP14.
ExpressionAtlasiQ9HCL3. baseline and differential.
GenevisibleiQ9HCL3. HS.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiZFP14_HUMAN
AccessioniPrimary (citable) accession number: Q9HCL3
Secondary accession number(s): A7MD23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: May 11, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.