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Protein

Protocadherin-18

Gene

PCDH18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-18
Gene namesi
Name:PCDH18
Synonyms:KIAA1562
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:14268. PCDH18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 699672ExtracellularSequence analysisAdd
BLAST
Transmembranei700 – 72021HelicalSequence analysisAdd
BLAST
Topological domaini721 – 1135415CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33002.

Polymorphism and mutation databases

BioMutaiPCDH18.
DMDMi212276496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 11351108Protocadherin-18PRO_0000004002Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence analysis
Glycosylationi420 – 4201N-linked (GlcNAc...)Sequence analysis
Glycosylationi559 – 5591N-linked (GlcNAc...)Sequence analysis
Glycosylationi583 – 5831N-linked (GlcNAc...)Sequence analysis
Glycosylationi641 – 6411N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9HCL0.
PeptideAtlasiQ9HCL0.
PRIDEiQ9HCL0.

PTM databases

iPTMnetiQ9HCL0.
PhosphoSiteiQ9HCL0.

Expressioni

Tissue specificityi

Expressed in all tissues, with highest expression in lung and ovary.1 Publication

Gene expression databases

BgeeiQ9HCL0.
CleanExiHS_PCDH18.
ExpressionAtlasiQ9HCL0. baseline and differential.
GenevisibleiQ9HCL0. HS.

Organism-specific databases

HPAiHPA017976.

Interactioni

Subunit structurei

Interacts with DAB1.By similarity

Protein-protein interaction databases

BioGridi120005. 1 interaction.
IntActiQ9HCL0. 2 interactions.
STRINGi9606.ENSP00000355082.

Structurei

3D structure databases

ProteinModelPortaliQ9HCL0.
SMRiQ9HCL0. Positions 34-666.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 137110Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 246109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini247 – 354108Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini361 – 465105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini466 – 576111Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini582 – 688107Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni893 – 1135243Interaction with DAB1By similarityAdd
BLAST

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129695.
HOGENOMiHOG000220893.
HOVERGENiHBG054878.
InParanoidiQ9HCL0.
KOiK16499.
OMAiCGPPLGT.
OrthoDBiEOG7J445X.
PhylomeDBiQ9HCL0.
TreeFamiTF352008.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030714. Protocadherin-18.
[Graphical view]
PANTHERiPTHR24028:SF9. PTHR24028:SF9. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9HCL0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHQMNAKMHF RFVFALLIVS FNHDVLGKNL KYRIYEEQRV GSVIARLSED
60 70 80 90 100
VADVLLKLPN PSTVRFRAMQ RGNSPLLVVN EDNGEISIGA TIDREQLCQK
110 120 130 140 150
NLNCSIEFDV ITLPTEHLQL FHIEVEVLDI NDNSPQFSRS LIPIEISESA
160 170 180 190 200
AVGTRIPLDS AFDPDVGENS LHTYSLSAND FFNIEVRTRT DGAKYAELIV
210 220 230 240 250
VRELDRELKS SYELQLTASD MGVPQRSGSS ILKISISDSN DNSPAFEQQS
260 270 280 290 300
YIIQLLENSP VGTLLLDLNA TDPDEGANGK IVYSFSSHVS PKIMETFKID
310 320 330 340 350
SERGHLTLFK QVDYEITKSY EIDVQAQDLG PNSIPAHCKI IIKVVDVNDN
360 370 380 390 400
KPEININLMS PGKEEISYIF EGDPIDTFVA LVRVQDKDSG LNGEIVCKLH
410 420 430 440 450
GHGHFKLQKT YENNYLILTN ATLDREKRSE YSLTVIAEDR GTPSLSTVKH
460 470 480 490 500
FTVQINDIND NPPHFQRSRY EFVISENNSP GAYITTVTAT DPDLGENGQV
510 520 530 540 550
TYTILESFIL GSSITTYVTI DPSNGAIYAL RIFDHEEVSQ ITFVVEARDG
560 570 580 590 600
GSPKQLVSNT TVVLTIIDEN DNVPVVIGPA LRNNTAEITI PKGAESGFHV
610 620 630 640 650
TRIRAIDRDS GVNAELSCAI VAGNEENIFI IDPRSCDIHT NVSMDSVPYT
660 670 680 690 700
EWELSVIIQD KGNPQLHTKV LLKCMIFEYA ESVTSTAMTS VSQASLDVSM
710 720 730 740 750
IIIISLGAIC AVLLVIMVLF ATRCNREKKD TRSYNCRVAE STYQHHPKRP
760 770 780 790 800
SRQIHKGDIT LVPTINGTLP IRSHHRSSPS SSPTLERGQM GSRQSHNSHQ
810 820 830 840 850
SLNSLVTISS NHVPENFSLE LTHATPAVEQ VSQLLSMLHQ GQYQPRPSFR
860 870 880 890 900
GNKYSRSYRY ALQDMDKFSL KDSGRGDSEA GDSDYDLGRD SPIDRLLGEG
910 920 930 940 950
FSDLFLTDGR IPAAMRLCTE ECRVLGHSDQ CWMPPLPSPS SDYRSNMFIP
960 970 980 990 1000
GEEFPTQPQQ QHPHQSLEDD AQPADSGEKK KSFSTFGKDS PNDEDTGDTS
1010 1020 1030 1040 1050
TSSLLSEMSS VFQRLLPPSL DTYSECSEVD RSNSLERRKG PLPAKTVGYP
1060 1070 1080 1090 1100
QGVAAWAAST HFQNPTTNCG PPLGTHSSVQ PSSKWLPAME EIPENYEEDD
1110 1120 1130
FDNVLNHLND GKHELMDASE LVAEINKLLQ DVRQS
Length:1,135
Mass (Da):126,149
Last modified:November 4, 2008 - v3
Checksum:i7C268409AC3EEB7D
GO
Isoform 2 (identifier: Q9HCL0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     830-830: Missing.

Show »
Length:1,134
Mass (Da):126,021
Checksum:iC89C22F2A2D025AC
GO

Sequence cautioni

The sequence BAB13388.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei830 – 8301Missing in isoform 2. 2 PublicationsVSP_035648

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046782 mRNA. Translation: BAB13388.1. Different initiation.
AK292018 mRNA. Translation: BAF84707.1.
AC142278 Genomic DNA. No translation available.
AC144556 Genomic DNA. No translation available.
BC093815 mRNA. Translation: AAH93815.1.
BC143361 mRNA. Translation: AAI43362.1.
CCDSiCCDS34064.1. [Q9HCL0-1]
CCDS75193.1. [Q9HCL0-2]
RefSeqiNP_001287757.1. NM_001300828.1. [Q9HCL0-2]
NP_061908.1. NM_019035.4. [Q9HCL0-1]
UniGeneiHs.591691.
Hs.738416.

Genome annotation databases

EnsembliENST00000344876; ENSP00000355082; ENSG00000189184. [Q9HCL0-1]
ENST00000412923; ENSP00000390688; ENSG00000189184. [Q9HCL0-2]
GeneIDi54510.
KEGGihsa:54510.
UCSCiuc003ihe.5. human. [Q9HCL0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046782 mRNA. Translation: BAB13388.1. Different initiation.
AK292018 mRNA. Translation: BAF84707.1.
AC142278 Genomic DNA. No translation available.
AC144556 Genomic DNA. No translation available.
BC093815 mRNA. Translation: AAH93815.1.
BC143361 mRNA. Translation: AAI43362.1.
CCDSiCCDS34064.1. [Q9HCL0-1]
CCDS75193.1. [Q9HCL0-2]
RefSeqiNP_001287757.1. NM_001300828.1. [Q9HCL0-2]
NP_061908.1. NM_019035.4. [Q9HCL0-1]
UniGeneiHs.591691.
Hs.738416.

3D structure databases

ProteinModelPortaliQ9HCL0.
SMRiQ9HCL0. Positions 34-666.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120005. 1 interaction.
IntActiQ9HCL0. 2 interactions.
STRINGi9606.ENSP00000355082.

PTM databases

iPTMnetiQ9HCL0.
PhosphoSiteiQ9HCL0.

Polymorphism and mutation databases

BioMutaiPCDH18.
DMDMi212276496.

Proteomic databases

PaxDbiQ9HCL0.
PeptideAtlasiQ9HCL0.
PRIDEiQ9HCL0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344876; ENSP00000355082; ENSG00000189184. [Q9HCL0-1]
ENST00000412923; ENSP00000390688; ENSG00000189184. [Q9HCL0-2]
GeneIDi54510.
KEGGihsa:54510.
UCSCiuc003ihe.5. human. [Q9HCL0-1]

Organism-specific databases

CTDi54510.
GeneCardsiPCDH18.
HGNCiHGNC:14268. PCDH18.
HPAiHPA017976.
MIMi608287. gene.
neXtProtiNX_Q9HCL0.
PharmGKBiPA33002.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129695.
HOGENOMiHOG000220893.
HOVERGENiHBG054878.
InParanoidiQ9HCL0.
KOiK16499.
OMAiCGPPLGT.
OrthoDBiEOG7J445X.
PhylomeDBiQ9HCL0.
TreeFamiTF352008.

Miscellaneous databases

GeneWikiiPCDH18.
GenomeRNAii54510.
PROiQ9HCL0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9HCL0.
CleanExiHS_PCDH18.
ExpressionAtlasiQ9HCL0. baseline and differential.
GenevisibleiQ9HCL0. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
IPR030714. Protocadherin-18.
[Graphical view]
PANTHERiPTHR24028:SF9. PTHR24028:SF9. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
    DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spleen.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Colon.
  5. "Identification and characterization of three members of a novel subclass of protocadherins."
    Wolverton T., Lalande M.
    Genomics 76:66-72(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE STRUCTURE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiPCD18_HUMAN
AccessioniPrimary (citable) accession number: Q9HCL0
Secondary accession number(s): A8K7K3, B7ZKT1, Q52LS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 4, 2008
Last modified: July 6, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.